Research & Literature

Key clinical features a general internist needs to know about Brugada syndrome: a case-based discussion.

Fan W, Chachula L, Wu Y, Khalighi K

Journal of community hospital internal medicine perspectives 2015; (5(3)):27241 doi:10.3402/jchimp.v5.27241.

The role of genetic testing in unexplained sudden death.

Miles CJ, Behr ER

Translational research : the journal of laboratory and clinical medicine 2016; (168()):59-73 doi:10.1016/j.trsl.2015.06.007.

Genetics of Brugada syndrome.

Watanabe H, Minamino T

Journal of human genetics 2016; (61(1)):57-60 doi:10.1038/jhg.2015.97.

[Brugada syndrome--a rare cause of syncope and sudden death].

Levin CG, Khalili P, Floderer E

Lakartidningen 2015; (112()).

Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects.

Antzelevitch C, Patocskai B

Current problems in cardiology 2016; (41(1)):7-57.

Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes.

Peters CH, Abdelsayed M, Ruben PC

Progress in biophysics and molecular biology 2016; (120(1-3)):77-88.

Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis.

Sroubek J, Probst V, Mazzanti A, et al.

Circulation 2016; (133(7)):622-30 doi:10.1161/CIRCULATIONAHA.115.017885.

[Brugada phenocopy].

Tomcsányi J

Orvosi hetilap 2016; (157(13)):495-9 doi:10.1556/650.2016.30385.

Clinical Presentation and Outcome of Brugada Syndrome Diagnosed With the New 2013 Criteria.

Curcio A, Mazzanti A, Bloise R, et al.

Journal of cardiovascular electrophysiology 2016; (27(8)):937-43 doi:10.1111/jce.12997.

Molecular Autopsy of Desmosomal Protein Plakophilin-2 in Sudden Unexplained Nocturnal Death Syndrome.

Huang L, Tang S, Peng L, et al.

Journal of forensic sciences 2016; (61(3)):687-91 doi:10.1111/1556-4029.13027.

Type 1 Brugada pattern ECG due to supra-therapeutic phenytoin level.

Swe T, Bhattarai B, Dufresne A

BMJ case reports 2016; (2016()).

A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG.

Turker I, Makiyama T, Vatta M, et al.

PloS one 2016; (11(8)):e0161872 doi:10.1371/journal.pone.0161872.

Combined Right Ventricular Outflow Tract Epicardial and Endocardial Late Potential Ablation for Treatment of Brugada Storm: A Case Report and Review of the Literature.

Saha SA, Krishnan K, Madias C, Trohman RG

Cardiology and therapy 2016; (5(2)):229-243 doi:10.1007/s40119-016-0072-4.

Molecular autopsy in victims of inherited arrhythmias.

Semsarian C, Ingles J

Journal of arrhythmia 2016; (32(5)):359-365 doi:10.1016/j.joa.2015.09.010.

Genetics of Brugada syndrome.

Juang JJ, Horie M

Journal of arrhythmia 2016; (32(5)):418-425 doi:10.1016/j.joa.2016.07.012.

Brugada Syndrome:Risk Stratification And Management.

Letsas KP, Georgopoulos S, Vlachos K, et al.

Journal of atrial fibrillation 2016; (9(2)):1413 doi:10.4022/jafib.1413.

Type 1 Brugada pattern electrocardiogram induced by hypokalemia.

Swe T, Dogar MH

Journal of family medicine and primary care 2016; (5(3)):709-711 doi:10.4103/2249-4863.197295.

[Acute chest pain revealing a Brugada syndrome].

Daniella RM, Anjaramalala R, Ramiandrisoa , et al.

The Pan African medical journal 2016; (25()):95 doi:10.11604/pamj.2016.25.95.9442.

Brugada syndrome and the story of Dave.

Dhamapurkar SK, Wilson BA, Rose A, Florschutz G

Neuropsychological rehabilitation 2018; (28(2)):259-267 doi:10.1080/09602011.2017.1323649.

Brugada syndrome: A general cardiologist's perspective.

Polovina MM, Vukicevic M, Banko B, et al.

European journal of internal medicine 2017; (44()):19-27 doi:10.1016/j.ejim.2017.06.019.

Brugada syndrome in children - Stepping into unchartered territory.

Behere SP, Weindling SN

Annals of pediatric cardiology 2017; (10(3)):248-258 doi:10.4103/apc.APC_49_17.

Identification of electrocardiographic risk markers for the initial and recurrent episodes of ventricular fibrillation in patients with Brugada syndrome.

Morita H, Watanabe A, Kawada S, et al.

Journal of cardiovascular electrophysiology 2018; (29(1)):107-114 doi:10.1111/jce.13349.

Brugada type 1 electrocardiogram: Should we treat the electrocardiogram or the patient?

Delise P, Allocca G, Sitta N

World journal of cardiology 2017; (9(9)):737-741 doi:10.4330/wjc.v9.i9.737.

Epicardial radiofrequency catheter ablation of Brugada syndrome with electrical storm during ventricular fibrillation: A case report.

Jiang S, Yin X, Dong C, et al.

Medicine 2017; (96(46)):e8688 doi:10.1097/MD.0000000000008688.

Induced Brugada syndrome: Possible sources of arrhythmogenesis.

Tomé G, Freitas J

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 2017; (36(12)):945-956 doi:10.1016/j.repc.2017.06.015.

Critical Roles of Xirp Proteins in Cardiac Conduction and Their Rare Variants Identified in Sudden Unexplained Nocturnal Death Syndrome and Brugada Syndrome in Chinese Han Population.

Huang L, Wu KH, Zhang L, et al.

Journal of the American Heart Association 2018; (7(1)) doi:10.1161/JAHA.117.006320.

Performance of electrophysiologic study in an asymptomatic patient with type 2 intermittent Brugada syndrome: To do or not to do.

Hosseini K, Jahangiri M, Vasheghani Farahani A

Caspian journal of internal medicine 2018; (9(1)):92-95 doi:10.22088/cjim.9.1.92.

Worldwide Prevalence of Brugada Syndrome: A Systematic Review and Meta-Analysis.

Vutthikraivit W, Rattanawong P, Putthapiban P, et al.

Acta Cardiologica Sinica 2018; (34(3)):267-277 doi:10.6515/ACS.201805_34(3).20180302B.

Shanghai Score System for Diagnosis of Brugada Syndrome: Validation of the Score System and System and Reclassification of the Patients.

Kawada S, Morita H, Antzelevitch C, et al.

JACC. Clinical electrophysiology 2018; (4(6)):724-730 doi:10.1016/j.jacep.2018.02.009.

Risk Stratification in Brugada Syndrome: Current Status and Emerging Approaches.

Honarbakhsh S, Providencia R, Lambiase PD

Arrhythmia & electrophysiology review 2018; (7(2)):79-83 doi:10.15420/aer.2018.2.2.

Multiple serial ECGs aid with the diagnosis and prognosis of Brugada syndrome.

Castro Hevia J, Dorantes Sanchez M, Martinez Lopez F, et al.

International journal of cardiology 2019; (277()):130-135 doi:10.1016/j.ijcard.2018.08.089.

SCN5A Variants: Association With Cardiac Disorders.

Li W, Yin L, Shen C, et al.

Frontiers in physiology 2018; (9()):1372 doi:10.3389/fphys.2018.01372.

Low-Voltage Type 1 ECG Is Associated With Fatal Ventricular Tachyarrhythmia in Brugada Syndrome.

Nagase S, Kamakura T, Kataoka N, et al.

Journal of the American Heart Association 2018; (7(21)):e009713 doi:10.1161/JAHA.118.009713.

Epinephrine Administered for Anaphylaxis Unmasking a Type 1 Brugada Pattern on Electrocardiogram.

Bui PV, Haas NL, Herrman NWC, et al.

The Journal of emergency medicine 2019; (56(4)):444-447 doi:10.1016/j.jemermed.2018.12.045.

[A man with fever-dependent ECG abnormalities].

de Jong Y, Bilsen M, Grauss RW

Nederlands tijdschrift voor geneeskunde 2019; (163()).

Brugada Syndrome: Progress in Genetics, Risk Stratification and Management.

Romero J, Li DL, Avendano R, et al.

Arrhythmia & electrophysiology review 2019; (8(1)):19-27 doi:10.15420/aer.2018.66.2.

Sudden Cardiac Death in Brugada Syndrome.

Kabra N, Gupta R, Aronow WS, Frishman WH

Cardiology in review 2020; (28(4)):203-207 doi:10.1097/CRD.0000000000000259.

Brugada syndrome in a young patient with type 1 myotonic dystrophy requiring an implantable cardioverter defibrillator for primary prevention: a case report.

Korantzopoulos P, Bechlioulis A, Lakkas L, Naka KK

European heart journal. Case reports 2019; (3(2)) doi:10.1093/ehjcr/ytz086.

Electrocardiographic Effects of Propofol versus Etomidate in Patients with Brugada Syndrome.

Flamée P, Varnavas V, Dewals W, et al.

Anesthesiology 2020; (132(3)):440-451 doi:10.1097/ALN.0000000000003030.

Arrhythmic events in Brugada syndrome patients induced by fever.

Roterberg G, El-Battrawy I, Veith M, et al.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2020; (25(3)):e12723 doi:10.1111/anec.12723.

Ablation for the treatment of Brugada syndrome: current status and future prospects.

Rizzo A, de Asmundis C, Brugada P, et al.

Expert review of medical devices 2020; (17(2)):123-130 doi:10.1080/17434440.2020.1719831.

Brugada Phenocopy Induced by a Lethal Methanol Intoxication.

Monterrubio-Villar J, Llinares-Moya D

European journal of case reports in internal medicine 2020; (7(2)):001374 doi:10.12890/2020_001374.

Fever Unmasked Brugada Syndrome in Pediatric Patient: A Case Report.

Mirzapolos O, Marshall P, Brill A

Clinical practice and cases in emergency medicine 2020; (4(2)):244-246 doi:10.5811/cpcem.2020.2.44418.

Cannabinoid-Induced Brugada Syndrome: A Case Report.

Stockholm SC, Rosenblum A, Byrd A, et al.

Cureus 2020; (12(6)):e8615 doi:10.7759/cureus.8615.

Epicardial Ablation in Brugada Syndrome.

Lambiase PD, Providência R

Cardiac electrophysiology clinics 2020; (12(3)):345-356 doi:10.1016/j.ccep.2020.04.006.

Brugada Syndrome: Clinical Features, Risk Stratification, and Management.

Malik BR, Ali Rudwan AM, Abdelghani MS, et al.

Heart views : the official journal of the Gulf Heart Association 2020; (21(2)):88-96 doi:10.4103/HEARTVIEWS.HEARTVIEWS_44_20.

Brugada syndrome and syncope: a practical approach for diagnosis and treatment.

Mascia G, Bona RD, Ameri P, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2021; (23(7)):996-1002 doi:10.1093/europace/euaa370.

Long-term follow-up in patients with Brugada Syndrome in South China.

Zhao D, Liang B, Peng J, et al.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2021; (26(3)):e12823 doi:10.1111/anec.12823.

Brugada syndrome clinical update.

Rojas R, Kaul R, Frenkel D, et al.

Hospital practice (1995) 2021; (49(4)):255-261 doi:10.1080/21548331.2021.1906012.

A 32-Year-Old Man Diagnosed with Type II Brugada Syndrome on Preoperative Electrocardiogram 1 Week Before Elective Tympanoplasty.

Yuasa H, Kitaura A, Kitayama C, et al.

The American journal of case reports 2021; (22()):e927756 doi:10.12659/AJCR.927756.

Brugada syndrome associated with out-of-hospital cardiac arrest: A case report.

Ni GH, Jiang H, Men L, et al.

World journal of clinical cases 2021; (9(19)):5345-5351 doi:10.12998/wjcc.v9.i19.5345.

Ajmaline-induced Brugada Phenocopy, Right Bundle Branch Block, or Both?

Kafes H, Can ID, Yaman NM, et al.

The Journal of innovations in cardiac rhythm management 2021; (12(9)):4682-4684 doi:10.19102/icrm.2021.120906.

Brugada Syndrome: Fatal Consequences of a Must-Not-Miss Diagnosis.

Smith LD, Gast S, Guy DF

Critical care nurse 2021; (41(5)):15-22 doi:10.4037/ccn2021499.

A case report of a young patient with both Brugada and long QT3 syndrome: between the hammer and the anvil.

Abu Dogoshh A, Konstantino Y, Haim M

European heart journal. Case reports 2021; (5(3)):ytab053 doi:10.1093/ehjcr/ytab053.

Dominant negative effects of SCN5A missense variants.

O'Neill MJ, Muhammad A, Li B, et al.

Genetics in medicine : official journal of the American College of Medical Genetics 2022; (24(6)):1238-1248 doi:10.1016/j.gim.2022.02.010.

Brugada Syndrome.

Krahn AD, Behr ER, Hamilton R, et al.

JACC. Clinical electrophysiology 2022; (8(3)):386-405 doi:10.1016/j.jacep.2021.12.001.

Pyrexia Unmasking Brugada Syndrome: A Literature Review.

Jain A, Yagnik K, Hussain KM, et al.

Cureus 2022; (14(2)):e22489 doi:10.7759/cureus.22489.

Labor Analgesia in Brugada Syndrome and the Importance of Contingency Planning.

Mena S, Costa A, DeLemos M, et al.

Case reports in anesthesiology 2022; (2022()):8940704 doi:10.1155/2022/8940704.

COVID-19 Vaccination-Induced Ventricular Fibrillation in an Afebrile Patient With Brugada Syndrome.

Lim KH, Park JS

Journal of Korean medical science 2022; (37(42)):e306 doi:10.3346/jkms.2022.37.e306.

Identification of a novel missense SCN5A mutation in a Chinese Han family with Brugada syndrome.

Zhu J, Shen Y, Xiong H, et al.

Biochemical and biophysical research communications 2023; (649()):55-61 doi:10.1016/j.bbrc.2023.01.026.

Brugada Syndrome: From Molecular Mechanisms and Genetics to Risk Stratification.

Popa IP, Șerban DN, Mărănducă MA, et al.

International journal of molecular sciences 2023; (24(4)) doi:10.3390/ijms24043328.

Long-Term Outcomes of Brugada Substrate Ablation: A Report from BRAVO (Brugada Ablation of VF Substrate Ongoing Multicenter Registry).

Nademanee K, Chung FP, Sacher F, et al.

Circulation 2023; (147(21)):1568-1578 doi:10.1161/CIRCULATIONAHA.122.063367.

Cardiac Arrest Due to Brugada Syndrome Associated With Influenza Infection: A Case Report and Literature Review.

Ono R, Hori Y, Yamazaki T, et al.

Cureus 2023; (15(4)):e37158 doi:10.7759/cureus.37158.

Brugada syndrome uncovered in patient with pseudohypoaldosteronism due to hyperkalaemia.

Barforoshi S, Thangathurai J, Khakpour H, Shah S

BMJ case reports 2023; (16(6)) doi:10.1136/bcr-2023-255111.

Unmasking a Silent Killer and Understanding Sudden Cardiac Death in Brugada Syndrome: A Traditional Review.

Moturu A, Bhuchakra HP, Bodar YP, et al.

Cureus 2023; (15(6)):e41076 doi:10.7759/cureus.41076.

Autolytic attempt mimicking Brugada type 1 electrocardiogram pattern due to flecainide toxicity. A case report.

López Guillén JL, Sastre Albiach JM, Torres García MB, Maravall Llagaria MD

European heart journal. Case reports 2023; (7(8)):ytad337 doi:10.1093/ehjcr/ytad337.

Syncope following Pfizer BioNTech (bnt162b2) vaccination unmasking Brugada syndrome.

Altermanini M, Habib MB, Alkhiyami D, et al.

Heliyon 2023; (9(8)):e18716 doi:10.1016/j.heliyon.2023.e18716.

Brugada Phenocopy Induced by Hypovolemic Hyponatremia.

Yılmaz E, Özdemir F

Cureus 2023; (15(9)):e45667 doi:10.7759/cureus.45667.

Syncope and loss of consciousness after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: Prevalence and characteristics in long-term follow-up.

Asada S, Morita H, Mizuno T, et al.

Heart rhythm O2 2023; (4(10)):641-649 doi:10.1016/j.hroo.2023.09.007.

More than 30 years of Brugada syndrome: a critical appraisal of achievements and open issues.

Eckardt L, Veltmann C

Herzschrittmachertherapie & Elektrophysiologie 2024; (35(1)):9-18 doi:10.1007/s00399-023-00983-y.

To cool or not to cool: Targeted temperature management to prevent ventricular tachycardia associated with Brugada syndrome.

Kiefer NJ, Ahuja T, Caballero A, Pashun RA

Clinical case reports 2023; (11(12)):e8338 doi:10.1002/ccr3.8338.

Brugada Syndrome: Focus for the General Pediatrician.

Speranzon A, Chicco D, Bonazza P, et al.

Children (Basel, Switzerland) 2024; (11(3)) doi:10.3390/children11030281.

Brugada syndrome: a review and the role of epicardial ablation in management.

Abuzuagaia OJ, Abozguia K, Darrat Y

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2024; (76(1)):55 doi:10.1186/s43044-024-00485-3.

Brugada Phenotype Following a Cocaine Overdose.

Chauhdri AF, Bruss P, Tran A

Cureus 2024; (16(7)):e63861 doi:10.7759/cureus.63861.

Brugada Syndrome and Sudden Cardiac Death: An Electrocardiographic History.

Moubarek ML, Wong GX, Ford JS

Clinical practice and cases in emergency medicine 2024; (8(3)):314-317 doi:10.5811/cpcem.19477.

Impact of hypokalemia on Brugada syndrome: case report unveiling mechanisms beyond QT interval prolongation.

Siregar MNI, Wahidji VH

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2024; (76(1)):143 doi:10.1186/s43044-024-00574-3.

Epicardial Ablation for Arrhythmogenic Disorders in Patients with Brugada Syndrome.

Matteucci A, Mariani MV, Sgarra L, et al.

Biomedicines 2024; (13(1)) doi:10.3390/biomedicines13010027.

A Vision Transformer Model for the Prediction of Fatal Arrhythmic Events in Patients with Brugada Syndrome.

Randazzo V, Caligari S, Pasero E, et al.

Sensors (Basel, Switzerland) 2025; (25(3)) doi:10.3390/s25030824.

Hyperkalemia-induced Brugada phenocopy: a systematic review of case reports.

Alnajjar AZ, Ibrahim AI, Ellebedy M

Clinical research in cardiology : official journal of the German Cardiac Society 2025; doi:10.1007/s00392-025-02607-6.

SCN5A missense variants and their contribution to deaths in Sudden Unexplained Nocturnal Death Syndrome (SUNDS).

Chaloemthanetphong A, Choowongkomon K, Worrapitirungsi W, et al.

Forensic science international. Genetics 2025; (76()):103237 doi:10.1016/j.fsigen.2025.103237.

A case report on the safety and efficacy of aripiprazole for depression in Brugada syndrome.

Fahmy M, Bessada Y, Ramsey C, Zigun JR

The mental health clinician 2025; (15(2)):62-68 doi:10.9740/mhc.2025.04.062.

Entrectinib-Induced Brugada Syndrome Leading to Ventricular Tachycardia in A Patient with ROS1 Fusion-Positive Lung Adenocarcinoma.

Ishiguro N, Mori T, Kaneshiro M, et al.

European journal of case reports in internal medicine 2025; (12(5)):005232 doi:10.12890/2025_005232.

Regional Anesthesia in Brugada Syndrome-Worth the Risk? A Dual-Case Report.

Repine KM, Tooley GE, Beagley B, et al.

A&A practice 2025; (19(7)):e02005 doi:10.1213/XAA.0000000000002005.

Forensic pathological and genetic landmarks in sudden cardiac death in the young: An update.

Grassi S, Campuzano O, Ferri E, et al.

Forensic science international. Genetics 2026; (80()):103334 doi:10.1016/j.fsigen.2025.103334.

Pyrexia-Induced Brugada Syndrome Unmasked by Community-Acquired Pneumonia: A Case Report.

Mohamed H, Elnour A, Karar M, et al.

Cureus 2025; (17(8)):e89907 doi:10.7759/cureus.89907.

Low-dose oral flecainide provocation test for Brugada syndrome: a case series.

Nguyen Thanh X, Ngoc Tran T, Nguyen Van T, et al.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2025; (77(1)):91 doi:10.1186/s43044-025-00679-3.

Fever, Syncope, and the Brugada Dilemma: Navigating the Complexities of ICD Decision-Making in an Atypical Presentation.

Devkota L, Hoffer-Hawlik M, Yang F, Jung AS

Case reports in cardiology 2025; (2025()):5536305 doi:10.1155/cric/5536305.

Unmasking Type 1 Brugada Pattern Following Pilsicainide Administration for Paroxysmal Atrial Fibrillation: A Case Report.

Matsushita Y, Otani N, Tomoe T, et al.

JMA journal 2025; (8(4)):1459-1462 doi:10.31662/jmaj.2025-0287.

Case series of Type 1 Brugada pattern provoked by exercise: a role for diagnostic treadmill stress testing.

Mehta OH, Ambrosio A, Burnell L, et al.

European heart journal. Case reports 2026; (10(1)):ytaf640 doi:10.1093/ehjcr/ytaf640.

Contemporary Perspectives on J-Wave Syndromes: An Expert Consensus Statement.

Nademanee K, Wilde AA, Ackerman MJ, et al.

Journal of arrhythmia 2026; (42(1)):e70284 doi:10.1002/joa3.70284.