Research & Literature

The importance of the multidisciplinary approach to deal with the new epidemiological scenario of Chagas disease (global health).

Pinazo MJ, Gascon J

Acta tropica 2015; (151()):16-20.

Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease.

Keating SM, Deng X, Fernandes F, et al.

International journal of cardiology 2015; (199()):451-9.

Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy.

Morillo CA, Marin-Neto JA, Avezum A, et al.

The New England journal of medicine 2015; (373(14)):1295-306 doi:10.1056/NEJMoa1507574.

The burden of Chagas disease: estimates and challenges.

Stanaway JD, Roth G

Global heart 2015; (10(3)):139-44.

Chagas disease: morbidity profile in an endemic area of Northeastern Brazil.

Andrade Cde M, Câmara AC, Nunes DF, et al.

Revista da Sociedade Brasileira de Medicina Tropical 2015; (48(6)):706-15.

Current drug therapy and pharmaceutical challenges for Chagas disease.

Bermudez J, Davies C, Simonazzi A, et al.

Acta tropica 2016; (156()):1-16.

Success of benznidazole chemotherapy in chronic Trypanosoma cruzi-infected patients with a sustained negative PCR result.

Murcia L, Carrilero B, Ferrer F, et al.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2016; (35(11)):1819-1827 doi:10.1007/s10096-016-2733-6.

EARLY AND LATE ASSESSMENT OF ESOPHAGOCARDIOPLASTY IN THE SURGICAL TREATMENT OF ADVANCED RECURRENT MEGAESOPHAGUS.

Aquino JL, Said MM, Pereira DA, et al.

Arquivos de gastroenterologia 2016; (53(4)):235-239 doi:10.1590/S0004-28032016000400005.

Early polymerase chain reaction detection of Chagas disease reactivation in heart transplant patients.

da Costa PA, Segatto M, Durso DF, et al.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017; (36(7)):797-805 doi:10.1016/j.healun.2017.02.018.

[Chagas disease affecting the central nervous system in a patient with AIDS demonstrated by quantitative molecular methods].

Fica A, Salinas M, Jercic MI, et al.

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia 2017; (34(1)):69-76 doi:10.4067/S0716-10182017000100011.

Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' disease.

Sperandio da Silva GM, Mediano MFF, Hasslocher-Moreno AM, et al.

The Journal of antimicrobial chemotherapy 2017; (72(9)):2596-2601 doi:10.1093/jac/dkx180.

Prevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study.

Álvarez MG, Vigliano C, Lococo B, et al.

Acta tropica 2017; (174()):149-152 doi:10.1016/j.actatropica.2017.07.004.

Chagas Heart Failure in Patients from Latin America.

Bestetti RB

Cardiac failure review 2016; (2(2)):90-94 doi:10.15420/cfr.2016:14:2.

Esophageal transit time in patients with chagasic megaesophagus: Lack of linear correlation between dysphagia and grade of dilatation.

Martins P, Ferreira CS, Cunha-Melo JR,

Medicine 2018; (97(10)):e0084 doi:10.1097/MD.0000000000010084.

Severe immune thrombocytopaenia in a patient taking benznidazole for chronic Chagas disease.

Crespillo-Andújar C, Calbacho Robles M, Norman FF, Pérez-Molina JA

BMJ case reports 2018; (2018()) doi:10.1136/bcr-2017-223788.

Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail.

Crespillo-Andújar C, Chamorro-Tojeiro S, Norman F, et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018; (24(12)):1344.e1-1344.e4 doi:10.1016/j.cmi.2018.06.006.

Current advances in drug discovery for Chagas disease.

Scarim CB, Jornada DH, Chelucci RC, et al.

European journal of medicinal chemistry 2018; (155()):824-838 doi:10.1016/j.ejmech.2018.06.040.

Haematological alterations in non-human hosts infected with Trypanosoma cruzi: a systematic review.

Villalba-Alemán E, Justinico DL, Sarandy MM, et al.

Parasitology 2019; (146(2)):142-160 doi:10.1017/S0031182018001294.

Congenital Chagas disease: current diagnostics, limitations and future perspectives.

Messenger LA, Bern C

Current opinion in infectious diseases 2018; (31(5)):415-421 doi:10.1097/QCO.0000000000000478.

Reactivation of Chagas disease among heart transplant recipients in the United States, 2012-2016.

Gray EB, La Hoz RM, Green JS, et al.

Transplant infectious disease : an official journal of the Transplantation Society 2018; (20(6)):e12996 doi:10.1111/tid.12996.

Treatment of Chagas Disease in the United States.

Meymandi S, Hernandez S, Park S, et al.

Current treatment options in infectious diseases 2018; (10(3)):373-388 doi:10.1007/s40506-018-0170-z.

American trypanosomiasis and Chagas disease: Sexual transmission.

Gomes C, Almeida AB, Rosa AC, et al.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2019; (81()):81-84 doi:10.1016/j.ijid.2019.01.021.

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates.

Almeida AB, Araújo PF, Bernal FM, et al.

Journal of visualized experiments : JoVE 2019; doi:10.3791/57985.

Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement.

Antunes D, Marins-Dos-Santos A, Ramos MT, et al.

Frontiers in immunology 2019; (10()):1073 doi:10.3389/fimmu.2019.01073.

Epidemiology of congenital Chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015.

Basile L, Ciruela P, Requena-Méndez A, et al.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2019; (24(26)) doi:10.2807/1560-7917.ES.2019.24.26.19-00011.

Chagas disease: comments on the 2018 PAHO Guidelines for diagnosis and management.

Norman FF, López-Vélez R

Journal of travel medicine 2019; (26(7)) doi:10.1093/jtm/taz060.

An evaluation of benznidazole as a Chagas disease therapeutic.

Caldas IS, Santos EG, Novaes RD

Expert opinion on pharmacotherapy 2019; (20(15)):1797-1807 doi:10.1080/14656566.2019.1650915.

Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas' disease.

Jackson Y, Wyssa B, Chappuis F

The Journal of antimicrobial chemotherapy 2020; (75(3)):690-696 doi:10.1093/jac/dkz473.

Megacolon with infectious etiology that is infrequent in our country: Chagas disease.

Díaz Alcázar MDM, Zúñiga de Mora Figueroa B, García Robles A

Revista espanola de enfermedades digestivas 2020; (112(5)):423-424 doi:10.17235/reed.2020.6643/2019.

Chagas Disease in the New York City Metropolitan Area.

Zheng C, Quintero O, Revere EK, et al.

Open forum infectious diseases 2020; (7(5)):ofaa156 doi:10.1093/ofid/ofaa156.

Benznidazole as Prophylaxis for Chagas Disease Infection Reactivation in Heart Transplant Patients: A Case Series in Brazil.

Rossi Neto JM, Finger MA, Dos Santos CC

Tropical medicine and infectious disease 2020; (5(3)) doi:10.3390/tropicalmed5030132.

Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease: A Systematic Review and Meta-analysis.

Chadalawada S, Sillau S, Archuleta S, et al.

JAMA network open 2020; (3(8)):e2015072 doi:10.1001/jamanetworkopen.2020.15072.

Role of FAK signaling in chagasic cardiac hypertrophy.

Tucci AR, Oliveira FOR, Lechuga GC, et al.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2020; (24(5)):386-397 doi:10.1016/j.bjid.2020.08.007.

Trypanosoma cruzi infection in Latin American pregnant women living outside endemic countries and frequency of congenital transmission: a systematic review and meta-analysis.

Colombo V, Giacomelli A, Casazza G, et al.

Journal of travel medicine 2021; (28(1)) doi:10.1093/jtm/taaa170.

Prevalence of Chagas heart disease in dilated cardiomyopathy.

González-Zambrano H, Amaya-Tapia G, Franco-Ramos MC, López León-Murguía OJ

Archivos de cardiologia de Mexico 2020; (91(1)):50-57 doi:10.24875/ACM.20000042.

First report of natural infection by Trypanosoma cruzi in secretions of the scent glands and myocardium of Philander opossum (Marsupialia: Didelphidae): Parasitological and clinicopathological findings.

Barros FNL, Sampaio Júnior FD, Costa SM, et al.

Veterinary parasitology, regional studies and reports 2020; (22()):100463 doi:10.1016/j.vprsr.2020.100463.

The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon.

Martins PR, Fakhry J, de Oliveira AJ, et al.

Histochemistry and cell biology 2021; (155(4)):451-462 doi:10.1007/s00418-020-01947-w.

Disagreement between PCR and serological diagnosis of Trypanosoma cruzi infection in blood donors from a Colombian endemic region.

García Sánchez LT, Aguilar Jiménez JR, Bueno MY, et al.

Biomedica : revista del Instituto Nacional de Salud 2021; (41(Supl. 1)):47-59 doi:10.7705/biomedica.5441.

Natural infection with Trypanosoma cruzi in bats captured in Campeche and Yucatán, México.

Torres-Castro M, Cuevas-Koh N, Hernández-Betancourt S, et al.

Biomedica : revista del Instituto Nacional de Salud 2021; (41(Supl. 1)):131-140 doi:10.7705/biomedica.5450.

Trypanosoma cruzi in Nonischemic Cardiomyopathy Patients, Houston, Texas, USA.

Nolan MS, Aguilar D, Misra A, et al.

Emerging infectious diseases 2021; (27(7)):1958-1960 doi:10.3201/eid2707.203244.

Congenital Chagas disease: progress toward implementation of pregnancy-based screening.

Edwards MS, Montgomery SP

Current opinion in infectious diseases 2021; (34(5)):538-545 doi:10.1097/QCO.0000000000000769.

Recommendations for Screening and Diagnosis of Chagas Disease in the United States.

Forsyth CJ, Manne-Goehler J, Bern C, et al.

The Journal of infectious diseases 2022; (225(9)):1601-1610 doi:10.1093/infdis/jiab513.

Immunomodulation and Antioxidant Activities as Possible Trypanocidal and Cardioprotective Mechanisms of Major Terpenes from Lippia alba Essential Oils in an Experimental Model of Chronic Chagas Disease.

Espinel-Mesa DX, González Rugeles CI, Mantilla Hernández JC, et al.

Antioxidants (Basel, Switzerland) 2021; (10(11)) doi:10.3390/antiox10111851.

SYMPTOMS ASSOCIATED WITH DIFFERENT DEGREES OF MEGAESOPHAGUS IN CHAGAS DISEASE.

Oliveira JA, Gharib AZGE, Dantas RO

Arquivos de gastroenterologia 2021; (58(4)):491-494 doi:10.1590/S0004-2803.202100000-88.

Evaluation of the Performance of Ortho T. cruzi ELISA Test System for the Detection of Antibodies to Trypanosoma cruzi.

Rivera HN, McAuliffe I, Aderohunmu T, et al.

Journal of clinical microbiology 2022; (60(8)):e0013422 doi:10.1128/jcm.00134-22.

Transplantation for chagas' disease: closing the knowledge gap.

La Hoz RM

Current opinion in infectious diseases 2022; (35(5)):397-403 doi:10.1097/QCO.0000000000000868.

Case report: diagnosis of chronic Chagas cardiomyopathy using a multimodality imaging approach.

Li SX, Soles EO, Sharma PS, Rao AK

European heart journal. Case reports 2023; (7(1)):ytac487 doi:10.1093/ehjcr/ytac487.

Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection.

Beatty NL, Alcala RF, Luque NA, et al.

The American journal of tropical medicine and hygiene 2023; (108(3)):543-547 doi:10.4269/ajtmh.22-0461.

Acute Myopericarditis Secondary to Chagas Disease.

Elizalde Uribe IA, Osorno Gonzalez de Leon MF, Barrios Perez KV, et al.

Cureus 2023; (15(10)):e46301 doi:10.7759/cureus.46301.

Assessment of Community Awareness and Screening of Chagas Disease in the Latin American Community of Greater New Orleans.

Herrera C, Bernabé KJ, Dumonteil E, et al.

Tropical medicine and infectious disease 2023; (8(12)) doi:10.3390/tropicalmed8120515.

[Seroprevalence of Chagas disease at the Instituto Nacional de Cardiología Ignacio Chávez from 2004 to 2010].

Reséndiz-Solís DV, Ruiz-Sánchez A, Ballinas-Verdugo MA

Archivos de cardiologia de Mexico 2024; (94(3)):324-330 doi:10.24875/ACM.23000181.

Chagas disease in immunocompromised patients.

Clark EH, Messenger LA, Whitman JD, Bern C

Clinical microbiology reviews 2024; (37(2)):e0009923 doi:10.1128/cmr.00099-23.

Deferral of blood donors who have ever stayed in a Trypanosoma cruzi endemic area: An international survey.

Lewin A, Tonnetti L, Renaud C, et al.

Vox sanguinis 2024; (119(9)):921-926 doi:10.1111/vox.13692.

Chagas disease in the immunocompromised host.

Clark EH, Bern C

Current opinion in infectious diseases 2024; (37(5)):333-341 doi:10.1097/QCO.0000000000001035.

Cardiac involvement in Chagas disease and African trypanosomiasis.

Sabino EC, Nunes MCP, Blum J, et al.

Nature reviews. Cardiology 2024; (21(12)):865-879 doi:10.1038/s41569-024-01057-3.

Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: A meta-analysis of observational studies.

Moraes FCA, Souza MEC, Dal Moro L, et al.

PLoS neglected tropical diseases 2024; (18(9)):e0012407 doi:10.1371/journal.pntd.0012407.

Unraveling the Missing Pieces: Exploring the Gaps in Understanding Chagas Cardiomyopathy.

Veluswami K, Rao S, Aggarwal S, et al.

Cureus 2024; (16(8)):e66955 doi:10.7759/cureus.66955.

Causality and Severity of Adverse Reactions and Biochemical Changes to Benznidazole Treatment in Patients with Chronic Chagas Disease.

Belmino ACDC, Sousa EKS, Silva Filho JDD, et al.

Arquivos brasileiros de cardiologia 2024; (121(8)):e20230787 doi:10.36660/abc.20230787.

Bridging the critical gap between infectious disease blood donation screening and connection to healthcare services: the American Chagas disease example.

Lynn MK, Parker M, Stramer SL, et al.

Journal of public health policy 2025; (46(1)):168-179 doi:10.1057/s41271-024-00539-5.

Diagnosis and management of chagasic cardiomyopathy patients in several institutions in Argentina.

Chuit R, Antonietti L, Agüero RN, et al.

Frontiers in parasitology 2023; (2()):1195646 doi:10.3389/fpara.2023.1195646.

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic Targets.

Frade AF, Guérin H, Nunes JPS, et al.

Mediators of inflammation 2025; (2025()):8862004 doi:10.1155/mi/8862004.

Antitrypanosomal therapy for Chagas disease: A single center experience with adverse drug reactions and strategies for enhancing treatment completion.

Reifler K, Wheelock A, Hall SM, et al.

PLoS neglected tropical diseases 2025; (19(7)):e0013218 doi:10.1371/journal.pntd.0013218.

Fulminant and fatal Trypanosoma cruzi reactivation in a patient with lymphoma.

Lukose G, Mertelsmann A, Rolon RMM, et al.

ASM case reports 2026; (1(2)) doi:10.1128/asmcr.00157-25.

Screening for Trypanosoma cruzi infection (Chagas disease) in the Latin American population living with HIV in London.

Elkheir N, Singh S, Barbini B, et al.

HIV medicine 2026; doi:10.1111/hiv.70201.

Catch-Up Screening to Improve Detection of Congenital Chagas Disease in a Nonendemic Setting.

Boté-Casamitjana A, Martin J, Touray J, et al.

The American journal of tropical medicine and hygiene 2026;.