Research & Literature

Pregnancy-Related Venous Thromboembolism Risk in Asymptomatic Women With Antithrombin Deficiency: A Systematic Review.

Rhéaume M, Weber F, Durand M, Mahone M

Obstetrics and gynecology 2016; (127(4)):649-656 doi:10.1097/AOG.0000000000001347.

Combined oral contraceptives, thrombophilia and the risk of venous thromboembolism: a systematic review and meta-analysis.

van Vlijmen EF, Wiewel-Verschueren S, Monster TB, Meijer K

Journal of thrombosis and haemostasis : JTH 2016; (14(7)):1393-403 doi:10.1111/jth.13349.

Issues in the Diagnosis and Management of Hereditary Antithrombin Deficiency.

Bauer KA, Nguyen-Cao TM, Spears JB

The Annals of pharmacotherapy 2016; (50(9)):758-67 doi:10.1177/1060028016651276.

Heparin-resistant Thrombosis Due to Homozygous Antithrombin Deficiency Treated With Rivaroxaban: A Case Report.

Van Bruwaene L, Huisman A, Urbanus RT, Versluys B

Journal of pediatric hematology/oncology 2016; (38(8)):658-660 doi:10.1097/MPH.0000000000000608.

Heparin Resistance and Anticoagulation Failure in a Challenging Case of Cerebral Venous Sinus Thrombosis.

King AB, O'Duffy AE, Kumar AB

The Neurohospitalist 2016; (6(3)):118-21 doi:10.1177/1941874415591500.

Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium.

Gerhardt A, Scharf RE, Greer IA, Zotz RB

Blood 2016; (128(19)):2343-2349 doi:10.1182/blood-2016-03-703728.

Direct oral anticoagulants and heparins: laboratory values and pitfalls in 'bridging therapy'.

Eller T, Flieder T, Fox V, et al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2017; (51(4)):624-632 doi:10.1093/ejcts/ezw368.

Thrombophilia Screening: Universal, Selected, or Neither?

Colucci G, Tsakiris DA

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2017; (23(8)):893-899 doi:10.1177/1076029616683803.

Non-vitamin K antagonist oral anticoagulants in patients with severe inherited thrombophilia: a series of 33 patients.

Undas A, Goralczyk T

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2017; (28(6)):438-442 doi:10.1097/MBC.0000000000000613.

Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature.

Refaei M, Xing L, Lim W, et al.

Case reports in hematology 2017; (2017()):9261351 doi:10.1155/2017/9261351.

SERPINC1 gene mutations in antithrombin deficiency.

Mulder R, Croles FN, Mulder AB, et al.

British journal of haematology 2017; (178(2)):279-285 doi:10.1111/bjh.14658.

SerpinC1/Antithrombin III in kidney-related diseases.

Lu Z, Wang F, Liang M

Clinical science (London, England : 1979) 2017; (131(9)):823-831 doi:10.1042/CS20160669.

Adverse pregnancy outcomes and inherited thrombophilia.

Dłuski D, Mierzyński R, Poniedziałek-Czajkowska E, Leszczyńska-Gorzelak B

Journal of perinatal medicine 2018; (46(4)):411-417 doi:10.1515/jpm-2017-0059.

Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.

Croles FN, Nasserinejad K, Duvekot JJ, et al.

BMJ (Clinical research ed.) 2017; (359()):j4452 doi:10.1136/bmj.j4452.

Strategy for Cardiovascular Surgery in Patients with Antithrombin III Deficiency.

Nishimura Y, Takagi Y

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 2018; (24(4)):187-192 doi:10.5761/atcs.oa.18-00030.

Heparin Resistance During Surgical Resection of Inferior Vena Cava and Right Atrial Tumor Thrombus: A Case Report.

Bello Dias MB, Mendes J, Gouveia J, et al.

Revista portuguesa de cirurgia cardio-toracica e vascular : orgao oficial da Sociedade Portuguesa de Cirurgia Cardio-Toracica e Vascular 2017; (24(3-4)):199.

Association of hereditary antithrombin deficiency with intrauterine growth restriction.

Said HM, El-Gharbawi NM, Moneim SEAE, Hafez AA

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2018; (29(5)):442-445 doi:10.1097/MBC.0000000000000740.

β-Antithrombin, subtype of antithrombin deficiency and the risk of venous thromboembolism in hereditary antithrombin deficiency: A family cohort study.

Croles FN, Mulder R, Mulder AB, et al.

Thrombosis research 2018; (168()):47-52 doi:10.1016/j.thromres.2018.06.004.

Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis.

Akinshina S, Makatsariya A, Bitsadze V, et al.

Journal of perinatal medicine 2018; (46(8)):893-899 doi:10.1515/jpm-2017-0329.

Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency.

Yamaguchi J, Hara N, Yamaguchi T, et al.

Journal of cardiology cases 2017; (16(5)):144-147 doi:10.1016/j.jccase.2017.06.008.

Left subclavian and right femoral vein thrombosis in a pregnant patient with antithrombin deficiency.

Watanabe C, Ichiba T, Naito H

Journal of cardiology cases 2018; (18(4)):149-151 doi:10.1016/j.jccase.2018.06.004.

Acute coronary syndrome in a young woman with antithrombin III deficiency.

Fennich N, Salwa A, Nadia B, et al.

Journal of cardiology cases 2013; (7(4)):e101-e103 doi:10.1016/j.jccase.2012.11.005.

Re-Examining Genetic Screening and Oral Contraceptives: A Patient-Centered Review.

Hiedemann B, Vernon E, Bowie BH

Journal of personalized medicine 2019; (9(1)) doi:10.3390/jpm9010004.

SERPINC1 variants causing hereditary antithrombin deficiency in a Danish population.

Kjaergaard AD, Larsen OH, Hvas AM, Nissen PH

Thrombosis research 2019; (175()):68-75 doi:10.1016/j.thromres.2019.01.022.

Severe antithrombin deficiency in pregnancy: Achieving adequate anticoagulation.

Pearson-Stuttard B, Bagot C, Ciantar E, et al.

Obstetric medicine 2019; (12(1)):45-51 doi:10.1177/1753495X17741025.

Efficacy and safety of apixaban in a patient with systemic venous thromboembolism associated with hereditary antithrombin deficiency.

Nojima Y, Ihara M, Adachi H, et al.

Journal of cardiology cases 2019; (19(3)):106-109 doi:10.1016/j.jccase.2018.12.007.

Incidence and features of thrombosis in children with inherited antithrombin deficiency.

de la Morena-Barrio B, Orlando C, de la Morena-Barrio ME, et al.

Haematologica 2019; (104(12)):2512-2518 doi:10.3324/haematol.2018.210666.

A case report of atrial fibrillation in a patient with heparin resistance associated with an antithrombin III deficiency successfully treated by radiofrequency catheter ablation using a direct thrombin inhibitor.

Kang H, Takemoto M, Tayama KI, Kosuga KI

European heart journal. Case reports 2019; (3(1)):yty166 doi:10.1093/ehjcr/yty166.

Management of antithrombin deficiency: an update for clinicians.

Bravo-Pérez C, Vicente V, Corral J

Expert review of hematology 2019; (12(6)):397-405 doi:10.1080/17474086.2019.1611424.

Isolated pulmonary embolism in a patient with progestin intrauterine device and factor V Leiden.

Jean S

Journal of community hospital internal medicine perspectives 2019; (9(3)):264-266 doi:10.1080/20009666.2019.1601059.

Antithrombin concentrate during pregnancy in congenital antithrombin deficiency: a single-center experience.

Bruzzese A, Santoro C, Baldacci E, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2019; (30(6)):304-307 doi:10.1097/MBC.0000000000000835.

Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy.

Yamashita M, Komaki T, Tashiro K, et al.

Internal medicine (Tokyo, Japan) 2020; (59(2)):235-239 doi:10.2169/internalmedicine.3268-19.

How I treat patients with hereditary antithrombin deficiency.

Pabinger I, Thaler J

Blood 2019; (134(26)):2346-2353 doi:10.1182/blood.2019002927.

Risk of pregnancy-related venous thromboembolism and obstetrical complications in women with inherited type I antithrombin deficiency: a retrospective, single-centre, cohort study.

Abbattista M, Gianniello F, Novembrino C, et al.

The Lancet. Haematology 2020; (7(4)):e320-e328 doi:10.1016/S2352-3026(20)30007-7.

New genetic variant in the SERPINC1 gene: hereditary Antithrombin deficiency case report, familial thrombosis and considerations on genetic counseling.

Polyak ME, Zaklyazminskaya EV

BMC medical genetics 2020; (21(1)):73 doi:10.1186/s12881-020-01001-5.

Antithrombin Deficiency in Trauma and Surgical Critical Care.

Ehrhardt JD, Boneva D, McKenney M, Elkbuli A

The Journal of surgical research 2020; (256()):536-542 doi:10.1016/j.jss.2020.07.010.

Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications: a systematic review and meta-analysis.

Cruz-Lemini M, Vázquez JC, Ullmo J, Llurba E

American journal of obstetrics and gynecology 2022; (226(2S)):S1126-S1144.e17 doi:10.1016/j.ajog.2020.11.006.

Patients with SERPINC1 rs2227589 polymorphism found to have multiple cerebral venous sinus thromboses despite a normal antithrombin level: A case report.

Liao F, Zeng JL, Pan JG, et al.

World journal of clinical cases 2022; (10(2)):618-624 doi:10.12998/wjcc.v10.i2.618.

Prevention of venous thromboembolism in pregnant women with congenital antithrombin deficiency: a retrospective study of a candidate protocol.

Morikawa M, Ieko M, Nakagawa-Akabane K, et al.

International journal of hematology 2022; (116(1)):60-70 doi:10.1007/s12185-022-03327-7.

Lupus anticoagulant testing during anticoagulation, including direct oral anticoagulants.

Favaloro EJ, Pasalic L

Research and practice in thrombosis and haemostasis 2022; (6(2)):e12676 doi:10.1002/rth2.12676.

Dabigatran in Cerebral Sinus Vein Thrombosis and Thrombophilia.

Kellermair L, Zeller MWG, Kulyk C, et al.

Life (Basel, Switzerland) 2022; (12(7)) doi:10.3390/life12070970.

Five Challenging Cases of Hereditary Antithrombin Deficiency Characterized by Thrombosis or Complicated Pregnancy.

Roberts JC, von Drygalski A, Zhou JY, et al.

Journal of blood medicine 2022; (13()):611-618 doi:10.2147/JBM.S365996.

Prevalence, Genetic Background, and Clinical Phenotype of Congenital Thrombophilia in Chronic Thromboembolic Pulmonary Hypertension.

Lian TY, Liu JZ, Guo F, et al.

JACC. Asia 2022; (2(3)):247-255 doi:10.1016/j.jacasi.2022.02.010.

Fatal Cerebral Venous Thrombosis in a Pregnant Woman with Inherited Antithrombin Deficiency after BNT162b2 mRNA COVID-19 Vaccination.

Takikawa K, Doijiri R, Kimura N, et al.

The Tohoku journal of experimental medicine 2022; (258(4)):327-332 doi:10.1620/tjem.2022.J095.

Venous Thrombosis Has a Constellation of Different Risk Factors: A Case Report and State-of-the-Art Review.

Silva Cruz M, Rodrigues Santos L, Esteves Rodrigues T, et al.

Cureus 2022; (14(10)):e30766 doi:10.7759/cureus.30766.

A Case of Chronic Pulmonary Embolism Resulting in Pulmonary Hypertension and Decompensated Right Heart Failure.

Hosna AU, Miller D, Makhoul K, Noff N

Cureus 2022; (14(12)):e32771 doi:10.7759/cureus.32771.

The Proper Diagnosis of Thrombophilic Status in Preventing Fetal Growth Restriction.

Mihai BM, Salmen T, Cioca AM, Bohîlțea RE

Diagnostics (Basel, Switzerland) 2023; (13(3)) doi:10.3390/diagnostics13030512.

Investigation of real-world heparin resistance and anticoagulation management prior to cardiopulmonary bypass: report from a nationwide survey by the Japanese Association for Thoracic Surgery heparin resistance working group.

Ito K, Sasaki K, Ono M, et al.

General thoracic and cardiovascular surgery 2024; (72(1)):8-14 doi:10.1007/s11748-023-01936-5.

Antithrombin Deficiency: Frequency in Patients with Thrombosis and Thrombophilic Families.

Pejková MA, Ivanová E, Sadílek P, et al.

Acta medica (Hradec Kralove) 2023; (66(1)):19-23 doi:10.14712/18059694.2023.10.

Antithrombin III deficiency in a patient with recurrent venous thromboembolism: A case report.

Luo JQ, Mao SS, Chen JY, et al.

World journal of clinical cases 2023; (11(20)):4956-4960 doi:10.12998/wjcc.v11.i20.4956.

Antithrombin Deficiency and Thrombosis: A Wide Clinical Scenario Reported in a Single Institution.

Marco-Rico A, Marco-Vera P

Journal of blood medicine 2023; (14()):499-506 doi:10.2147/JBM.S416355.

Case report: A case of new mutation in SERPINC1 leading to thrombotic microangiopathy.

Li B, Zhang X, Lv H, et al.

Frontiers in genetics 2023; (14()):1278511 doi:10.3389/fgene.2023.1278511.

Hereditary Antithrombin Deficiency Presenting with Cerebral Venous Thrombosis in Three Members of a Family.

Ashraf VV, Salam KA, Kizhedath R, Puthussery K

Neurology India 2023; (71(5)):984-986 doi:10.4103/0028-3886.388110.

A pyruvylated and sulfated galactan from the green alga Dictyosphaeria cavernosa: Structure, anticoagulant property and inhibitory effect on zebrafish thrombosis.

Yang Y, Qin L, Lu X, et al.

Carbohydrate polymers 2024; (324()):121492 doi:10.1016/j.carbpol.2023.121492.

An acute presentation of Chronic Thromboembolic Pulmonary Hypertension complicated by cerebellar infarction.

Gleeson M, Murray J, Gaine S

Respiratory medicine case reports 2023; (46()):101931 doi:10.1016/j.rmcr.2023.101931.

Exploring antithrombin: insights into its physiological features, clinical implications and analytical techniques.

Saboor M, Hamali HA, Mobarki AA, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2024; (35(2)):43-48 doi:10.1097/MBC.0000000000001271.

Low-molecular-weight heparin for the prevention of preeclampsia in high-risk pregnancies without thrombophilia: a systematic review and meta-analysis.

Chen J, Huai J, Yang H

BMC pregnancy and childbirth 2024; (24(1)):68 doi:10.1186/s12884-023-06218-9.

Pulmonary thromboembolism associated with hereditary antithrombin III deficiency: A case report.

Liu J, Wang Y, Rong C, et al.

Medicine 2024; (103(10)):e37429 doi:10.1097/MD.0000000000037429.

Outcomes of venous thromboembolism in patients with inherited thrombophilia treated with direct oral anticoagulants: insights from the RIETE registry.

Cohen O, Kenet G, Levy-Mendelovich S, et al.

Journal of thrombosis and thrombolysis 2024; (57(4)):710-720 doi:10.1007/s11239-024-02957-4.

Atypical pulmonary thromboembolism caused by the mutation site SERPINC1 of the antithrombin III gene: A case report.

Lin M, Sun X, Wu J

Medicine 2024; (103(31)):e39175 doi:10.1097/MD.0000000000039175.

The Efficacy and Safety of DOACs in Inherited Antithrombin Deficiency: A Cohort Study from a Tertiary Referral Center.

Dix C, Doyle AJ, Breen K, Hunt BJ

Thrombosis and haemostasis 2025; (125(4)):379-384 doi:10.1055/a-2379-7288.

Hereditary antithrombin deficiency pilot project registry from the American Thrombosis and Hemostasis Network.

DeSancho MT, Suvar E, Roberts JC, et al.

Journal of thrombosis and haemostasis : JTH 2024; (22(11)):3183-3190 doi:10.1016/j.jtha.2024.07.026.

Sequelae of Acute Pulmonary Embolism: From Post-Pulmonary Embolism Functional Impairment to Chronic Thromboembolic Disease.

Fountain JH, Peck TJ, Furfaro D

Journal of clinical medicine 2024; (13(21)) doi:10.3390/jcm13216510.

Familial onset of venous thromboembolism due to inherited antithrombin deficiency with a novel gene variant (p.Arg14Gly).

Noiri JI, Tsuji A, Ueda J, et al.

Journal of cardiology cases 2024; (30(5)):139-142 doi:10.1016/j.jccase.2024.06.007.

How we treat severe inherited antithrombin deficiency: lessons from cases homozygous for the Budapest 3 variant.

Bravo-Pérez C, Corral J, Orlando C, et al.

Journal of thrombosis and haemostasis : JTH 2025; (23(5)):1648-1656 doi:10.1016/j.jtha.2025.01.015.

Race against clots: the challenges of managing antithrombin deficiency in the ICU.

Giglio Jimenez A, Aravena P, Ibañez V, Ferre A

BMJ case reports 2024; (17(12)) doi:10.1136/bcr-2024-263287.

Clinical Phenotype and Genetic Analysis of a Family with Hereditary Antithrombin Deficiency Caused by SERPINC1 Gene Mutation.

Zhao Y, Du L, Lin S, et al.

Thrombosis and haemostasis 2026; (126(1)):87-94 doi:10.1055/a-2558-8193.

Diagnostic Performance of Commercial Antithrombin Activity Assays: Do We Get What We Expect?

Orlando C, Drèze C, Evenepoel A, et al.

Thrombosis and haemostasis 2025; doi:10.1055/a-2628-4046.

Cost-effective screening strategy to prevent venous thromboembolism in combined oral contraceptive users.

Douxfils J

Frontiers in endocrinology 2025; (16()):1559162 doi:10.3389/fendo.2025.1559162.

Anti-Xa directed low-molecular-weight heparin dosing to reduce the risk of venous thromboembolism in pregnant women with inherited antithrombin deficiency.

Dix C, Breen K, Robinson S, et al.

Journal of thrombosis and haemostasis : JTH 2026; (24(1)):234-240 doi:10.1016/j.jtha.2025.07.031.

Venous thromboembolism in pregnancy: recent advances.

Kozak M, Cosmi B, Gerotziafas G, et al.

Polish archives of internal medicine 2025; (135(7-8)) doi:10.20452/pamw.17081.

Anticoagulant management in an antithrombin-deficient pregnant woman with a history of venous thromboembolism: a case report.

Kozak M, Vižintin Cuderman T, Božič Mijovski M, et al.

Thrombosis journal 2025; (23(1)):94 doi:10.1186/s12959-025-00775-z.

Transitioning of Patients from Direct-Acting Oral Anticoagulant to Heparin: Impact on Laboratory Testing.

Arachchillage DJ, Vinayagam S, Parsons A, et al.

Seminars in thrombosis and hemostasis 2025; doi:10.1055/a-2734-2293.

Perioperative Management of Hereditary Antithrombin Deficiency in a Patient Undergoing Minimally Invasive Thoracic Surgery: A Case Report.

Domen H, Takakuwa Y, Yamada H

Surgical case reports 2025; (11(1)) doi:10.70352/scrj.cr.25-0166.

Prolonged Neural Block After Lower-Limb Nerve Blocks in a Patient with Inherited Antithrombin III Deficiency: Implications for Regional Anesthesia.

Aizawa T, Sugiura N, Sugita S

Local and regional anesthesia 2025; (18()):151-156 doi:10.2147/LRA.S563087.