Research & Literature

Outcomes of Descemet membrane endothelial keratoplasty, Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty from a single centre study.

Heinzelmann S, Böhringer D, Eberwein P, et al.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2016; (254(3)):515-22 doi:10.1007/s00417-015-3248-z.

LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).

Poulsen ET, Nielsen NS, Jensen MM, et al.

Proteomics 2016; (16(3)):539-43 doi:10.1002/pmic.201500287.

Acute Corneal Hydrops Complicated by Microbial Keratitis: Case Series Reveals Poor Immediate and Long-Term Prognosis.

Meyer JJ, McGhee CN

Cornea 2016; (35(7)):1019-22 doi:10.1097/ICO.0000000000000883.

TGFBI Gene Mutation Analysis in Chinese Families with Corneal Dystrophies.

Cai J, Zhu L, Zha Y, Kang Q

Genetic testing and molecular biomarkers 2016; (20(7)):388-92 doi:10.1089/gtmb.2015.0315.

Evaluation of Visual Quality in Patients With Fuchs Endothelial Corneal Dystrophy.

Oie Y, Watanabe S, Nishida K

Cornea 2016; (35 Suppl 1()):S55-S58 doi:10.1097/ICO.0000000000000994.

Microbial Keratitis After Penetrating Keratoplasty.

Sun JP, Chen WL, Huang JY, et al.

American journal of ophthalmology 2017; (178()):150-156 doi:10.1016/j.ajo.2017.03.022.

[Paraproteinemic Keratopathy as a Clinical Sign of Monoclonal Gammopathy].

Wasielica-Poslednik J, Gericke A, Pfeiffer N, Lisch W

Klinische Monatsblatter fur Augenheilkunde 2019; (236(3)):289-294 doi:10.1055/s-0043-102493.

Corneal dystrophies.

Bourges JL

Journal francais d'ophtalmologie 2017; (40(6)):e177-e192 doi:10.1016/j.jfo.2017.05.003.

Recurrence of Granular Corneal Dystrophy Type 1 After Phototherapeutic Keratectomy, Lamellar Keratoplasty, and Penetrating Keratoplasty in a Single Population.

Lewis DR, Price MO, Feng MT, Price FW

Cornea 2017; (36(10)):1227-1232 doi:10.1097/ICO.0000000000001303.

Anterior segment optical coherence tomography for the diagnosis of corneal dystrophies according to the IC3D classification.

Siebelmann S, Scholz P, Sonnenschein S, et al.

Survey of ophthalmology 2018; (63(3)):365-380 doi:10.1016/j.survophthal.2017.08.001.

Prevalence of transforming growth factor β-induced gene corneal dystrophies in Chinese refractive surgery candidates.

Song Y, Sun M, Wang N, et al.

Journal of cataract and refractive surgery 2017; (43(12)):1489-1494 doi:10.1016/j.jcrs.2017.07.038.

Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy.

Kobashi H, Kamiya K, Shimizu K

Optometry and vision science : official publication of the American Academy of Optometry 2018; (95(1)):21-26 doi:10.1097/OPX.0000000000001157.

Association Between Visual Acuity and the Corneal Area Occupied by Granular Lesions, Linear Lesions, or Diffuse Haze in Patients With Granular Corneal Dystrophy Type 2.

Kim HS, Rim TH, Kim TI, Kim EK

Cornea 2018; (37(5)):542-547 doi:10.1097/ICO.0000000000001540.

Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity.

Zarouchlioti C, Sanchez-Pintado B, Hafford Tear NJ, et al.

American journal of human genetics 2018; (102(4)):528-539 doi:10.1016/j.ajhg.2018.02.010.

Persistence of granular corneal dystrophy type-1 deposits in the predescemetic layer after big-bubble deep anterior lamellar keratoplasty.

Müller EG, Gomes JÁP, Nosé W, Nosé RM

Arquivos brasileiros de oftalmologia 2018; (81(1)):66-69 doi:10.5935/0004-2749.20180015.

Outcomes of keratoplasty in lattice corneal dystrophy in a large cohort of Indian eyes.

Mohamed A, Chaurasia S, Ramappa M, et al.

Indian journal of ophthalmology 2018; (66(5)):666-672 doi:10.4103/ijo.IJO_1150_17.

The successful treatment of a multidrug-resistant Achromobacter xylosoxidans corneal ulcer with topical meropenem.

Tavassoli S, Gunn D, Williams OM, Darcy K

BMJ case reports 2018; (2018()) doi:10.1136/bcr-2018-225163.

[Analysis of TGFBI gene mutation in a Chinese pedigree affected with lattice corneal dystrophy].

Duan H, Zheng L, Wu H, et al.

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2018; (35(4)):518-521 doi:10.3760/cma.j.issn.1003-9406.2018.04.013.

[Corneal dystrophies in optical coherence tomography].

Elhardt C, Priglinger SG, Karakolova Y, et al.

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 2019; (116(9)):857-864 doi:10.1007/s00347-018-0832-8.

[Epithelial Dystrophies of the Cornea].

Finis D, Stammen J, Lisch W, Geerling G

Klinische Monatsblatter fur Augenheilkunde 2019; doi:10.1055/a-0849-0228.

Analysis of TGFBI Gene Mutations in Three Chinese Families with Corneal Dystrophy.

Zhao F, Liu Y, Guan T

Journal of ophthalmology 2019; (2019()):6769013 doi:10.1155/2019/6769013.

Identification of a Heterozygous Mutation in the TGFBI Gene in a Hui-Chinese Family with Corneal Dystrophy.

Xiang Q, Yuan L, Cao Y, et al.

Journal of ophthalmology 2019; (2019()):2824179 doi:10.1155/2019/2824179.

Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty.

Skalicka P, Dudakova L, Palos M, et al.

Acta ophthalmologica 2019; (97(7)):e987-e992 doi:10.1111/aos.14123.

Efficacy of a Topical Heparan Sulfate Mimetic Polymer on Ocular Surface Discomfort in Patients with Cogan's Epithelial Basement Membrane Dystrophy.

Labetoulle M, Rousseau A, M'Garrech M, et al.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2019; (35(6)):359-365 doi:10.1089/jop.2019.0015.

Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty.

Woo JH, Ang M, Htoon HM, Tan D

American journal of ophthalmology 2019; (207()):288-303 doi:10.1016/j.ajo.2019.06.012.

Clinical and genetic update of corneal dystrophies.

Lisch W, Weiss JS

Experimental eye research 2019; (186()):107715 doi:10.1016/j.exer.2019.107715.

Systematic Review and Meta-Analysis of Clinical Outcomes of Penetrating Keratoplasty Versus Deep Anterior Lamellar Keratoplasty for Keratoconus.

Song Y, Zhang J, Pan Z

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2020; (18(4)):417-428 doi:10.6002/ect.2019.0123.

Morphological and Optical Determinants of Visual Disability in Fuchs Endothelial Corneal Dystrophy.

Wacker K, Grewing V, Fritz M, et al.

Cornea 2020; (39(6)):726-731 doi:10.1097/ICO.0000000000002236.

Morning Myopic Shift and Glare in Advanced Fuchs Endothelial Corneal Dystrophy.

Loreck N, Adler W, Siebelmann S, et al.

American journal of ophthalmology 2020; (213()):69-75 doi:10.1016/j.ajo.2020.01.011.

Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies.

Nielsen NS, Poulsen ET, Lukassen MV, et al.

Progress in retinal and eye research 2020; (77()):100843 doi:10.1016/j.preteyeres.2020.100843.

Evolution of therapies for the corneal endothelium: past, present and future approaches.

Ong HS, Ang M, Mehta JS

The British journal of ophthalmology 2021; (105(4)):454-467 doi:10.1136/bjophthalmol-2020-316149.

Molecular Mechanisms of Fuchs and Congenital Hereditary Endothelial Corneal Dystrophies.

Malhotra D, Casey JR

Reviews of physiology, biochemistry and pharmacology 2020; (178()):41-81 doi:10.1007/112_2020_39.

Rare stromal corneal dystrophic diseases in Oman: A clinical and histopathological analysis for accurate diagnosis.

Reda AM, Saad El-Din SA

Oman journal of ophthalmology 2020; (13(2)):70-75 doi:10.4103/ojo.OJO_283_2019.

Schnyder Corneal Dystrophy: A Rare Case Report.

Kurtul BE, Elbeyli A, Ozcan DO, et al.

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH 2020; (12(23)):110-113 doi:10.3126/nepjoph.v12i1.26185.

The morphogenesis of granular and lattice corneal dystrophy - A mutation combination hypothesis.

Sabir M

Medical hypotheses 2020; (145()):110291 doi:10.1016/j.mehy.2020.110291.

Granular corneal dystrophy recurrence at the posterior graft-host interface after type 1 big bubble deep anterior lamellar keratoplasty.

Oke I, Haddad N, Lee HJ

American journal of ophthalmology case reports 2020; (20()):100960 doi:10.1016/j.ajoc.2020.100960.

Contact lens induced bacterial keratitis in LCD II: Management and multimodal imaging: a case report and review of literature.

Alafaleq M, Knoeri J, Boutboul S, Borderie V

European journal of ophthalmology 2021; (31(5)):2313-2318 doi:10.1177/1120672120968724.

Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema.

Chow SC, Chan JC

Cornea 2021; (40(4)):533-539 doi:10.1097/ICO.0000000000002652.

Practice patterns of corneal transplantation in Europe: first report by the European Cornea and Cell Transplantation Registry.

Dunker SL, Armitage WJ, Armitage M, et al.

Journal of cataract and refractive surgery 2021; (47(7)):865-869 doi:10.1097/j.jcrs.0000000000000574.

Hyperosmolar Eye Drops for Diurnal Corneal Edema in Fuchs' Endothelial Dystrophy: A Double-Masked, Randomized Controlled Trial.

Zander DB, Böhringer D, Fritz M, et al.

Ophthalmology 2021; (128(11)):1527-1533 doi:10.1016/j.ophtha.2021.04.015.

Novel compound heterozygous mutations in the CHST6 gene cause macular corneal dystrophy in a Han Chinese family.

Huang Y, Yuan L, Cao Y, et al.

Annals of translational medicine 2021; (9(8)):622 doi:10.21037/atm-20-7178.

Detailed corneal and genetic characteristics of a pediatric patient with macular corneal dystrophy - case report.

Nowińska A, Chlasta-Twardzik E, Dembski M, et al.

BMC ophthalmology 2021; (21(1)):285 doi:10.1186/s12886-021-02041-y.

Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy.

AlAraj A, AlAmeer A, Al-Swailem S

Clinical ophthalmology (Auckland, N.Z.) 2021; (15()):3139-3145 doi:10.2147/OPTH.S317971.

Long-Term Observation of Deep Anterior Lamellar Keratoplasty in Patients with Post-LASIK Granular Corneal Dystrophy Type 2: Two Case Reports.

Shinji K, Chikama T, Maruoka S, Kiuchi Y

Ophthalmology and therapy 2021; (10(4)):1163-1169 doi:10.1007/s40123-021-00399-2.

Descemet Stripping Only for Fuchs Endothelial Corneal Dystrophy: Will It Become the Gold Standard?

Colby K

Cornea 2022; (41(3)):269-271 doi:10.1097/ICO.0000000000002796.

Influence of graft vascularization on graft survival following homologous limbo-keratoplasty.

Lang SJ, Werner N, Böhringer D, et al.

International ophthalmology 2022; (42(10)):3053-3059 doi:10.1007/s10792-022-02291-9.

Atypical Presentation of Salzmann Nodular Corneal Degeneration as a Subepithelial Corneal Dystrophy: A Case Report.

Santhiran P, Wan Abdul Halim WH, Yong MH

Cureus 2022; (14(4)):e24328 doi:10.7759/cureus.24328.

New Frontier in the Management of Corneal Dystrophies: Basics, Development, and Challenges in Corneal Gene Therapy and Gene Editing.

Salman M, Verma A, Singh VK, et al.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2022; (11(4)):346-359 doi:10.1097/APO.0000000000000443.

Fuchs Dystrophy and Cataract: Diagnosis, Evaluation and Treatment.

Ali M, Cho K, Srikumaran D

Ophthalmology and therapy 2023; (12(2)):691-704 doi:10.1007/s40123-022-00637-1.

Management of Stromal Corneal Dystrophies; Review of the Literature with a Focus on Phototherapeutic Keratectomy and Keratoplasty.

Ashena Z, Niestrata M, Tavassoli S

Vision (Basel, Switzerland) 2023; (7(1)) doi:10.3390/vision7010022.

Diurnal Variation of Visual Acuity and Refraction in Fuchs Endothelial Corneal Dystrophy.

Brandi-Dohrn F, Jiang J, Grewing V, et al.

Cornea 2024; (43(1)):83-87 doi:10.1097/ICO.0000000000003291.

Role of descemet's stripping without keratoplasty in management of endothelial disease.

Northey LC, Moloney G

Current opinion in ophthalmology 2023; (34(4)):348-353 doi:10.1097/ICU.0000000000000963.

Mini-Review: Clinical Features and Management of Granular Corneal Dystrophy Type 2.

Chang MS, Jun I, Kim EK

Korean journal of ophthalmology : KJO 2023; (37(4)):340-347 doi:10.3341/kjo.2023.0032.

The role of corneal endothelium in macular corneal dystrophy development and recurrence.

Zhang BN, Qi B, Dong C, et al.

Science China. Life sciences 2024; (67(2)):332-344 doi:10.1007/s11427-023-2364-3.

Unilateral Granular Type 2 Corneal Dystrophy With Exacerbation After LASIK.

Bostan C, Randleman JB

Cornea 2024; (43(5)):648-651 doi:10.1097/ICO.0000000000003490.

Fuchs endothelial corneal dystrophy: an updated review.

Altamirano F, Ortiz-Morales G, O'Connor-Cordova MA, et al.

International ophthalmology 2024; (44(1)):61 doi:10.1007/s10792-024-02994-1.

IC3D Classification of Corneal Dystrophies-Edition 3.

Weiss JS, Rapuano CJ, Seitz B, et al.

Cornea 2024; (43(4)):466-527 doi:10.1097/ICO.0000000000003420.

Deep anterior lamellar keratoplasty and penetrating keratoplasty in macular corneal dystrophy: comparison of visual and topographic outcomes and complications.

Balıkçı AT, Burcu A, Akkaya ZY, et al.

Arquivos brasileiros de oftalmologia 2024; (87(3)):e20230109 doi:10.5935/0004-2749.2023-0109.

Therapeutic future of Fuchs endothelial corneal dystrophy: An ongoing way to explore.

Liu JX, Chiang TL, Hung KF, Sun YC

Taiwan journal of ophthalmology 2024; (14(1)):15-26 doi:10.4103/tjo.TJO-D-23-00115.

[The latest IC3D classification of corneal dystrophies-Overview and changes of the 3rd edition].

Berger T, Weiss JS, Lisch W, Seitz B

Die Ophthalmologie 2024; (121(9)):714-725 doi:10.1007/s00347-024-02066-w.

Loss of carbohydrate sulfotransferase 6 function leads to macular corneal dystrophy phenotypes and skeletal defects in zebrafish.

Basol M, Ersoz-Gulseven E, Ozaktas H, et al.

The FEBS journal 2025; (292(2)):373-390 doi:10.1111/febs.17337.

Penetrating keratoplasty versus deep anteriror lamellar keratoplasty for macular corneal dystrophy: A meta-analysis.

Le NVA, Nguyen NC, Kasetsuwan N, Reinprayoon U

Survey of ophthalmology 2025; (70(3)):480-488 doi:10.1016/j.survophthal.2024.12.005.

Ten-year outcomes after DMEK, DSAEK, and PK: insights on graft survival, endothelial cell density loss, rejection and visual acuity.

Wilhelm TI, Gauché L, Böhringer D, et al.

Scientific reports 2025; (15(1)):1249 doi:10.1038/s41598-025-85138-4.

In Vivo Confocal Microscopy Findings in Corneal Stromal Dystrophies.

Okudan S, Tınkır Kayıtmazbatır E, Bozkurt Oflaz A, Bozkurt B

Diagnostics (Basel, Switzerland) 2025; (15(2)) doi:10.3390/diagnostics15020182.

Genotype-Phenotype Correlations in Corneal Dystrophies: Advances in Molecular Genetics and Therapeutic Insights.

Liskova P, Skalicka P, Dudakova L, Vincent AL

Clinical & experimental ophthalmology 2025; (53(3)):232-245 doi:10.1111/ceo.14516.

TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery.

McLain A, Kowalczyk A, Baran-Rachwalska P, et al.

Journal of controlled release : official journal of the Controlled Release Society 2025; (382()):113681 doi:10.1016/j.jconrel.2025.113681.

A Case Report of Successful Cataract Surgery in Theil-Behnke Corneal Dystrophy: A Visual Rehabilitation for the Patient.

Paranjpe R, Manade V, Abraham P, et al.

Case reports in ophthalmology 2025; (16(1)):308-312 doi:10.1159/000544846.

Rho-Kinase Inhibitors in the Management of Fuchs Endothelial Corneal Dystrophy: A Review.

Jukić A, Pupić Bakrač A, Đapic Ivančić B, et al.

Medicina (Kaunas, Lithuania) 2025; (61(5)) doi:10.3390/medicina61050772.

Rare TGFBI Mutation c.1553T>G p.(L518R) in Lattice Corneal Dystrophy: Comprehensive Clinical and Genetic Analysis in a Chinese Family.

Cui X, Shu L, Liu B, et al.

American journal of ophthalmology 2025; (279()):127-136 doi:10.1016/j.ajo.2025.07.012.

Investigating the Relationship Between Corneal Dystrophy and Mental Health Conditions Using the All of Us Research Program Database.

Nishihara TW, Afshari NA

American journal of ophthalmology 2025; (279()):205-212 doi:10.1016/j.ajo.2025.07.032.

Efficacy and Safety of Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty in Corneal Macular Dystrophy: A Systematic Review and Meta-Analysis.

Awad AA, Elettreby AM, Abo Elnaga AA, et al.

Journal of ophthalmology 2025; (2025()):8867750 doi:10.1155/joph/8867750.

Distribution and Surgical Treatment of Corneal Dystrophies Over Eight Decades (1945-2024): An Analysis of Histopathologically Confirmed Cases from a German Center.

Touirssa O, Maier P, Boehringer D, et al.

Journal of epidemiology and global health 2025; (15(1)):112 doi:10.1007/s44197-025-00458-y.

Schnyder Corneal Dystrophy in an Adolescent: A Case Report With Multimodal Imaging.

Bombuy Gimenez J, Izdebska J, Szaflik JP

Cureus 2025; (17(8)):e89786 doi:10.7759/cureus.89786.

Concordance Between Clinical and Pathological Diagnosis of Stromal Corneal Dystrophies in a Large Case Series.

Fajardo A, Jara Noel K, Azevedo A, et al.

Cornea 2025; (44(12)):1528-1531 doi:10.1097/ICO.0000000000003980.

Biallelic excision of the CTG18.1 expansion in two Fuchs endothelial corneal dystrophy-derived iPSC lines and one control (SCTCi046-A-1, SCTCi047-A-1 and SCTCi041-A-1) using an episomal vector-based CRISPR/Cas9 approach.

Landi E, Zondag R, Dehnen JA, et al.

Stem cell research 2025; (89()):103881 doi:10.1016/j.scr.2025.103881.

Objective assessment of graft clarity and recurrence after penetrating keratoplasty for granular, lattice and macular corneal dystrophy using scheimpflug densitometry.

Berger T, Seitz B, Flockerzi E, et al.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2025; doi:10.1007/s00417-025-07050-x.

Anterior Segment Optical Coherence Tomography in the Diagnosis of Corneal Stromal Dystrophies in Romania.

Gheorghe AG, Arghirescu AM, Voinea LM, et al.

Maedica 2025; (20(4)):833-839 doi:10.26574/maedica.2025.20.4.833.

Advances and challenges of CRISPR/Cas gene editing for corneal diseases.

Han Y, Chen R, Shentu X

Advances in ophthalmology practice and research 2026; (6(1)):68-79 doi:10.1016/j.aopr.2025.11.002.