Research & Literature

Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation.

De Ferrari GM, Dusi V, Spazzolini C, et al.

Circulation 2015; (131(25)):2185-93 doi:10.1161/CIRCULATIONAHA.115.015731.

Thoracoscopic Left Cardiac Sympathetic Denervation for a Patient with Catecholaminergic Polymorphic Ventricular Tachycardia and Recurrent Implantable Cardioverter-Defibrillator Shocks.

Yu WS, Kim TH, Suh JW, et al.

The Korean journal of thoracic and cardiovascular surgery 2015; (48(3)):220-4 doi:10.5090/kjtcs.2015.48.3.220.

New Family With Catecholaminergic Polymorphic Ventricular Tachycardia Linked to the Triadin Gene.

Rooryck C, Kyndt F, Bozon D, et al.

Journal of cardiovascular electrophysiology 2015; (26(10)):1146-50 doi:10.1111/jce.12763.

Quality of life after videoscopic left cardiac sympathetic denervation in patients with potentially life-threatening cardiac channelopathies/cardiomyopathies.

Antiel RM, Bos JM, Joyce DD, et al.

Heart rhythm 2016; (13(1)):62-9.

Exercise and β-blocker therapy recommendations for inherited arrhythmogenic conditions.

Christian S, Somerville M, Taylor S, Atallah J

Cardiology in the young 2016; (26(6)):1123-9 doi:10.1017/S1047951115001894.

Early repolarization pattern: a marker of increased risk in patients with catecholaminergic polymorphic ventricular tachycardia.

Tülümen E, Schulze-Bahr E, Zumhagen S, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2016; (18(10)):1587-1592 doi:10.1093/europace/euv357.

Clinical Challenges in Catecholaminergic Polymorphic Ventricular Tachycardia.

Imberti JF, Underwood K, Mazzanti A, Priori SG

Heart, lung & circulation 2016; (25(8)):777-83.

Efficacy of bilateral thoracoscopic sympathectomy in a patient with catecholaminergic polymorphic ventricular tachycardia.

Okajima K, Kiuchi K, Yokoi K, et al.

Journal of arrhythmia 2016; (32(1)):62-6 doi:10.1016/j.joa.2015.07.002.

Inherited catecholaminergic polymorphic ventricular tachycardia due to RYR2 mutation.

Watanabe T, Ohno S, Shirai M, et al.

Pediatrics international : official journal of the Japan Pediatric Society 2016; (58(6)):512-515 doi:10.1111/ped.12910.

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses.

Preininger MK, Jha R, Maxwell JT, et al.

Disease models & mechanisms 2016; (9(9)):927-39 doi:10.1242/dmm.026823.

A guide to the 3D structure of the ryanodine receptor type 1 by cryoEM.

Samsó M

Protein science : a publication of the Protein Society 2017; (26(1)):52-68 doi:10.1002/pro.3052.

Canadian Cardiovascular Society and Canadian Pediatric Cardiology Association Position Statement on the Approach to Syncope in the Pediatric Patient.

Sanatani S, Chau V, Fournier A, et al.

The Canadian journal of cardiology 2017; (33(2)):189-198 doi:10.1016/j.cjca.2016.09.006.

Avoiding sports-related sudden cardiac death in children with congenital channelopathy : Recommendations for sports activities.

Lang CN, Steinfurt J, Odening KE

Herz 2017; (42(2)):162-170 doi:10.1007/s00059-017-4549-2.

State Requirements for Automated External Defibrillators in American Schools: Framing the Debate About Legislative Action.

Sherrid MV, Aagaard P, Serrato S, et al.

Journal of the American College of Cardiology 2017; (69(13)):1735-1743 doi:10.1016/j.jacc.2017.01.033.

Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.

Salvage SC, Chandrasekharan KH, Jeevaratnam K, et al.

British journal of pharmacology 2018; (175(8)):1260-1278 doi:10.1111/bph.13807.

Choking-induced cardiac arrest unmasks a diagnosis of catecholaminergic polymorphic ventricular tachycardia.

Roston TM, AlAhmari L, Krahn AD, et al.

HeartRhythm case reports 2015; (1(6)):494-497 doi:10.1016/j.hrcr.2015.08.007.

[Ventricular arrhythmias in ion channel diseases].

Wolpert C, Vogel M, Nagel C, et al.

Herzschrittmachertherapie & Elektrophysiologie 2017; (28(2)):169-176 doi:10.1007/s00399-017-0510-6.

Catecholaminergic Polymorphic Ventricular Tachycardia.

Wall JJ, Iyer RV

Pediatric emergency care 2017; (33(6)):427-431 doi:10.1097/PEC.0000000000001156.

The evolving role of ankyrin-B in cardiovascular disease.

Koenig SN, Mohler PJ

Heart rhythm 2017; (14(12)):1884-1889 doi:10.1016/j.hrthm.2017.07.032.

Flecainide Reduces Ventricular Arrhythmias in Patients With Genotype RyR2-positive Catecholaminergic Polymorphic Ventricular Tachycardia.

Wangüemert Pérez F, Hernández Afonso JS, Groba Marco MDV, et al.

Revista espanola de cardiologia (English ed.) 2018; (71(3)):185-191 doi:10.1016/j.rec.2017.04.032.

CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca2+ release termination and diminishes protein expression.

Liu Y, Wei J, Wong King Yuen SM, et al.

PloS one 2017; (12(9)):e0184177 doi:10.1371/journal.pone.0184177.

[Clinical challenges in the management of catecholaminergic polymorphic ventricular tachycardia in children].

Ge HY, Li XM, Jiang H, et al.

Zhonghua er ke za zhi = Chinese journal of pediatrics 2017; (55(12)):926-931 doi:10.3760/cma.j.issn.0578-1310.2017.12.012.

Catecholaminergic Polymorphic Ventricular Tachycardia - Looking to the Future.

Velcea AE, Siliste C, Vinereanu D

Maedica 2017; (12(4)):306-310.

Effects of Catheter Ablation Targeting the Trigger Beats in Inherited Catecholaminergic Polymorphic Ventricular Tachycardia.

Kaneshiro T, Nogami A, Kato Y, et al.

JACC. Clinical electrophysiology 2017; (3(9)):1062-1063 doi:10.1016/j.jacep.2017.04.017.

Competitive Sports Participation in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia: A Single Center's Early Experience.

Ostby SA, Bos JM, Owen HJ, et al.

JACC. Clinical electrophysiology 2016; (2(3)):253-262 doi:10.1016/j.jacep.2016.01.020.

Catecholaminergic Polymorphic Ventricular Tachycardia: Activity as Tolerated?

Krahn AD, Sanatani S

JACC. Clinical electrophysiology 2016; (2(3)):263-265 doi:10.1016/j.jacep.2016.04.002.

Efficacy of ivabradine to control ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia.

Vaksmann G, Klug D

Pacing and clinical electrophysiology : PACE 2018; (41(10)):1378-1380 doi:10.1111/pace.13446.

Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review.

Roston TM, Jones K, Hawkins NM, et al.

Heart rhythm 2018; (15(12)):1791-1799 doi:10.1016/j.hrthm.2018.06.046.

Description of a novel RyR2 mutation in a juvenile patient with symptomatic catecholaminergic polymorphic ventricular tachycardia in sleep and during exercise: a case report.

Seidlmayer LK, Riediger F, Pagonas N, et al.

Journal of medical case reports 2018; (12(1)):298 doi:10.1186/s13256-018-1825-6.

Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia.

Dharmawan T, Nakajima T, Ohno S, et al.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2019; (24(3)):e12623 doi:10.1111/anec.12623.

Catecholaminergic Polymorphic Ventricular Tachycardia: The Cardiac Arrest Where Epinephrine Is Contraindicated.

Bellamy D, Nuthall G, Dalziel S, Skinner JR

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2019; (20(3)):262-268 doi:10.1097/PCC.0000000000001847.

Radiofrequency catheter ablation for drug-refractory atrial tachyarrhythmias in a patient with catecholaminergic polymorphic ventricular tachycardia: A case report.

Kawada S, Morita H, Watanabe A, Ito H

Journal of cardiology cases 2019; (19(1)):36-39 doi:10.1016/j.jccase.2018.09.004.

A compound heterozygosity of Tecrl gene confirmed in a catecholaminergic polymorphic ventricular tachycardia family.

Xie L, Hou C, Jiang X, et al.

European journal of medical genetics 2019; (62(7)):103631 doi:10.1016/j.ejmg.2019.01.018.

Ryanodine receptor 2 (RYR2) mutation: A potentially novel neurocardiac calcium channelopathy manifesting as primary generalised epilepsy.

Yap SM, Smyth S

Seizure 2019; (67()):11-14 doi:10.1016/j.seizure.2019.02.017.

A large deletion in RYR2 exon 3 is associated with nadolol and flecainide refractory catecholaminergic polymorphic ventricular tachycardia.

Kohli U, Aziz Z, Beaser AD, Nayak HM

Pacing and clinical electrophysiology : PACE 2019; (42(8)):1146-1154 doi:10.1111/pace.13668.

Sudden cardiac death in Long QT syndrome (LQTS), Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT).

Singh M, Morin DP, Link MS

Progress in cardiovascular diseases 2019; (62(3)):227-234 doi:10.1016/j.pcad.2019.05.006.

Bilateral cardiac sympathetic denervation in catecholaminergic polymorphic ventricular tachycardia.

Stec S, Zamorski P, Wołek W, et al.

Kardiologia polska 2019; (77(6)):653-654 doi:10.33963/KP.14834.

Assessment and Validation of a Phenotype-Enhanced Variant Classification Framework to Promote or Demote RYR2 Missense Variants of Uncertain Significance.

Giudicessi JR, Lieve KVV, Rohatgi RK, et al.

Circulation. Genomic and precision medicine 2019; (12(5)):e002510 doi:10.1161/CIRCGEN.119.002510.

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest.

van der Werf C, Lieve KV, Bos JM, et al.

European heart journal 2019; (40(35)):2953-2961 doi:10.1093/eurheartj/ehz309.

Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue.

Park SJ, Zhang D, Qi Y, et al.

Circulation 2019; (140(5)):390-404 doi:10.1161/CIRCULATIONAHA.119.039711.

BASIC AND CLINICAL INSIGHTS IN CATECHOLAMINERGIC (FAMILIAL) POLYMORPHIC VENTRICULAR TACHYCARDIA.

Márquez MF, Totomoch-Serra A, Rueda A, et al.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 2019; (71(4)):226-236 doi:10.24875/RIC.19002939.

The Effect of Left Cardiac Sympathetic Denervation on Exercise in Patients With Long QT Syndrome.

Anderson HN, Bos JM, Rohatgi RK, Ackerman MJ

JACC. Clinical electrophysiology 2019; (5(9)):1084-1090 doi:10.1016/j.jacep.2019.06.008.

Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia.

Wleklinski MJ, Kannankeril PJ, Knollmann BC

The Journal of physiology 2020; (598(14)):2817-2834 doi:10.1113/JP276757.

Catecholaminergic Polymorphic Ventricular Tachycardia: Challenges During Resuscitation and Post-Cardiac Arrest Care.

Carinci V, Gamberini L, Coniglio C, et al.

The Journal of emergency medicine 2020; (58(4)):677-681 doi:10.1016/j.jemermed.2020.01.008.

Fathers of Children With Congenital Heart Disease: Sources of Stress and Opportunities for Intervention.

Hoffman MF, Karpyn A, Christofferson J, et al.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2020; (21(11)):e1002-e1009 doi:10.1097/PCC.0000000000002388.

Catecholaminergic polymorphic ventricular tachycardia in pregnancy: a case report.

Schumer A, Contag S

Journal of medical case reports 2020; (14(1)):238 doi:10.1186/s13256-020-02569-5.

The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes.

Hamilton S, Veress R, Belevych A, Terentyev D

Pflugers Archiv : European journal of physiology 2021; (473(3)):377-387 doi:10.1007/s00424-020-02505-y.

A Rare Case of RYR2 Mutation Causing Sudden Cardiac Arrest Due to Catecholaminergic Polymorphic Ventricular Tachycardia.

Vemireddy LP, Aqeel A, Ying GW, et al.

Cureus 2021; (13(2)):e13417 doi:10.7759/cureus.13417.

Role alteration predicts anxiety and depressive symptoms in parents of infants with congenital heart disease: a pilot study.

Lisanti AJ, Kumar A, Quinn R, et al.

Cardiology in the young 2021; (31(11)):1842-1849 doi:10.1017/S1047951121001037.

Burst Exercise Testing Can Unmask Arrhythmias in Patients With Incompletely Penetrant Catecholaminergic Polymorphic Ventricular Tachycardia.

Roston TM, Kallas D, Davies B, et al.

JACC. Clinical electrophysiology 2021; (7(4)):437-441 doi:10.1016/j.jacep.2021.02.013.

Mechanisms of flecainide induced negative inotropy: An in silico study.

Yang PC, Giles WR, Belardinelli L, Clancy CE

Journal of molecular and cellular cardiology 2021; (158()):26-37 doi:10.1016/j.yjmcc.2021.05.007.

Advances in the Molecular Genetics of Catecholaminergic Polymorphic Ventricular Tachycardia.

Song J, Luo Y, Jiang Y, He J

Frontiers in pharmacology 2021; (12()):718208 doi:10.3389/fphar.2021.718208.

Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic death.

Walsh R, Adler A, Amin AS, et al.

European heart journal 2022; (43(15)):1500-1510 doi:10.1093/eurheartj/ehab687.

Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation.

Itoh H, Murayama T, Kurebayashi N, et al.

Journal of electrocardiology 2021; (69()):111-118 doi:10.1016/j.jelectrocard.2021.09.015.

An International Multicenter Cohort Study on β-Blockers for the Treatment of Symptomatic Children With Catecholaminergic Polymorphic Ventricular Tachycardia.

Peltenburg PJ, Kallas D, Bos JM, et al.

Circulation 2022; (145(5)):333-344 doi:10.1161/CIRCULATIONAHA.121.056018.

The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.

Blackwell DJ, Faggioni M, Wleklinski MJ, et al.

JCI insight 2022; (7(3)).

The Year in Pediatric Electrophysiology: 2021.

von Alvensleben JC, Collins KK

The Journal of innovations in cardiac rhythm management 2022; (13(1)):4825-4828 doi:10.19102/icrm.2022.130111.

Impact of cascade screening for catecholaminergic polymorphic ventricular tachycardia type 1.

Shimamoto K, Ohno S, Kato K, et al.

Heart (British Cardiac Society) 2022; (108(11)):840-847 doi:10.1136/heartjnl-2021-320220.

The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia.

Li Y, Peng X, Lin R, et al.

Frontiers in physiology 2022; (13()):850117 doi:10.3389/fphys.2022.850117.

Clinical Characteristics, Genetic Findings and Arrhythmic Outcomes of Patients with Catecholaminergic Polymorphic Ventricular Tachycardia from China: A Systematic Review.

Leung J, Lee S, Zhou J, et al.

Life (Basel, Switzerland) 2022; (12(8)) doi:10.3390/life12081104.

Repeatability of ventricular arrhythmia characteristics on the exercise-stress test in RYR2-mediated catecholaminergic polymorphic ventricular tachycardia.

Peltenburg PJ, Pultoo SNJ, Tobert KE, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023; (25(2)):619-626 doi:10.1093/europace/euac177.

The role of parenting stress in anxiety and sleep outcomes in toddlers with congenital heart disease.

Lepage C, Gaudet I, Doussau A, et al.

Frontiers in pediatrics 2022; (10()):1055526 doi:10.3389/fped.2022.1055526.

Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Gao J, Makiyama T, Yamamoto Y, et al.

Circulation. Arrhythmia and electrophysiology 2023; (16(3)):e011387 doi:10.1161/CIRCEP.122.011387.

Current management of inherited arrhythmia syndromes associated with the cardiac ryanodine receptor.

Przybylski R, Abrams DJ

Current opinion in cardiology 2023; (38(4)):390-395 doi:10.1097/HCO.0000000000001051.

Athletes and suspected catecholaminergic polymorphic ventricular tachycardia: Awareness and current knowledge.

Mascia G, Brugada J, Arbelo E, Porto I

Journal of cardiovascular electrophysiology 2023; (34(10)):2095-2101 doi:10.1111/jce.16045.

Broad and narrow complex tachycardia resulting in cardiorespiratory arrest in a child: what is the optimal treatment strategy?

Sadagopan SN, Yue AM

European heart journal. Case reports 2023; (7(10)):ytad490 doi:10.1093/ehjcr/ytad490.

Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia.

Bergeman AT, Lieve KVV, Kallas D, et al.

Circulation 2023; (148(25)):2029-2037 doi:10.1161/CIRCULATIONAHA.123.064786.

Catecholaminergic Polymorphic Ventricular Tachycardia and Gene Therapy: A Comprehensive Review of the Literature.

Henriquez E, Hernandez EA, Mundla SR, et al.

Cureus 2023; (15(10)):e47974 doi:10.7759/cureus.47974.

Clinical and genetic profiles of chinese pediatric patients with catecholaminergic polymorphic ventricular tachycardia.

Yan Y, Tang L, Wang X, et al.

Orphanet journal of rare diseases 2023; (18(1)):380 doi:10.1186/s13023-023-02991-0.

Toxic Stress as a Potential Factor Inducing Negative Emotions in Parents of Newborns and Infants with Cyanotic Congenital Heart Disease.

Cepuch G, Kruszecka-Krówka A, Lalik A, Micek A

Children (Basel, Switzerland) 2023; (10(12)) doi:10.3390/children10121893.

Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with catecholaminergic polymorphic ventricular tachycardia.

Peltenburg PJ, van den Heuvel LM, Kallas D, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2024; (26(2)) doi:10.1093/europace/euae044.

A contemporary review of sudden cardiac arrest and death in competitive and recreational athletes.

Kim JH, Martinez MW, Guseh JS, et al.

Lancet (London, England) 2024; (404(10468)):2209-2222 doi:10.1016/S0140-6736(24)02086-5.

Emotion-related syncope in a young female patient.

Abbas E, Abdelshafi K

European heart journal. Case reports 2024; (8(12)):ytae614 doi:10.1093/ehjcr/ytae614.

Flecainide Specifically Targets the Monovalent Countercurrent Through the Cardiac Ryanodine Receptor, While a Dominant Opposing Ca2+/Ba2+ Current Is Present.

Gaburjakova J, Domsicova M, Poturnayova A, Gaburjakova M

International journal of molecular sciences 2024; (26(1)) doi:10.3390/ijms26010203.

Prehospital care of suspected spine-injured lacrosse athletes: a systematic search, evidence review, and consensus recommendations.

Bowman TG, Boergers RJ, Caswell SV, et al.

British journal of sports medicine 2025; (59(9)):630-639 doi:10.1136/bjsports-2024-108951.

Compromised repolarization reserve in a murine model of catecholaminergic polymorphic ventricular tachycardia caused by RyR2-R420Q mutation.

Zissimopoulos S, Kirilenko P, Braza-Boïls A, et al.

Journal of molecular and cellular cardiology 2025; (206()):127-140 doi:10.1016/j.yjmcc.2025.07.014.

Optimizing Peri-Operative Pain Management in Children With Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia Undergoing Left Cardiac Sympathetic Denervation: A Case Series on Continuous Erector Spinae Plane Block and Serratus Plane Block.

Mossetti V, Di Corrado R, HaxhiNasto H, et al.

Paediatric anaesthesia 2026; (36(2)):173-180 doi:10.1111/pan.70075.