Research & Literature

First cases of severe congenital factor XIII deficiency in Southwestern Afghanistan in the vicinity of southeast of Iran.

Hosseini S, Dorgalaleh A, Bamedi T, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2015; (26(8)):908-11 doi:10.1097/MBC.0000000000000358.

Neoplasm-induced bleeding in inherited, heterozygous FXIII-A deficiency.

Ivaškevičius V, Goldmann G, Biswas A, et al.

Hamostaseologie 2015; (35 Suppl 1()):S32-5.

Mild factor XIII deficiency and concurrent hypofibrinogenemia: effect of pregnancy.

Kaveney AD, Philipp CS

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2016; (27(4)):457-60 doi:10.1097/MBC.0000000000000448.

Diagnosis of factor XIII deficiency.

Dorgalaleh A, Tabibian S, Hosseini MS, et al.

Hematology (Amsterdam, Netherlands) 2016; (21(7)):430-9 doi:10.1080/10245332.2015.1101975.

Developing the First Recombinant Factor XIII for Congenital Factor XIII Deficiency: Clinical Challenges and Successes.

Carcao M, Fukutake K, Inbal A, et al.

Seminars in thrombosis and hemostasis 2017; (43(1)):59-68 doi:10.1055/s-0036-1585076.

Medical and Surgical Management of Postpartum Hemorrhage in a Woman with Factor XIII Deficiency.

Cheng M, Nassim J, Angha A, et al.

Case reports in obstetrics and gynecology 2016; (2016()):7963874 doi:10.1155/2016/7963874.

Long Term Follow up Study on a Large Group of Patients with Congenital Factor XIII Deficiency Treated Prophylactically with Fibrogammin P®.

Naderi M, Karimi M, Hosseini MS, et al.

Iranian journal of pharmaceutical research : IJPR 2016; (15(2)):635-40.

Diagnosis, clinical manifestations and management of rare bleeding disorders in Iran.

Dorgalaleh A, Alavi SE, Tabibian S, et al.

Hematology (Amsterdam, Netherlands) 2017; (22(4)):224-230 doi:10.1080/10245332.2016.1263007.

Advances of Coagulation Factor XIII.

Shi DY, Wang SJ

Chinese medical journal 2017; (130(2)):219-223 doi:10.4103/0366-6999.198007.

Treatment with Recombinant Factor XIII (Tretten) in a Pregnant Woman with Factor XIII Deficiency.

Abdel-Samad N

The American journal of case reports 2017; (18()):436-439 doi:10.12659/ajcr.901502.

Comparison of F13A1 gene mutations in 73 patients treated with recombinant FXIII-A2.

Ivaškevičius V, Biswas A, Garly ML, Oldenburg J

Haemophilia : the official journal of the World Federation of Hemophilia 2017; (23(3)):e194-e203 doi:10.1111/hae.13233.

Recombinant factor XIII prophylaxis is safe and effective in young children with congenital factor XIII-A deficiency: international phase 3b trial results.

Kerlin BA, Inbal A, Will A, et al.

Journal of thrombosis and haemostasis : JTH 2017; (15(8)):1601-1606 doi:10.1111/jth.13748.

Minimal factor XIII activity level to prevent major spontaneous bleeds.

Menegatti M, Palla R, Boscarino M, et al.

Journal of thrombosis and haemostasis : JTH 2017; (15(9)):1728-1736 doi:10.1111/jth.13772.

Factor XIII deficiency in south of Tunisia.

Maaloul I, Medhaffer M, Louhichi N, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2017; (28(6)):485-489 doi:10.1097/MBC.0000000000000649.

Factor XIII deficiency diagnosis: Challenges and tools.

Karimi M, Peyvandi F, Naderi M, Shapiro A

International journal of laboratory hematology 2018; (40(1)):3-11 doi:10.1111/ijlh.12756.

A large case series on surgical outcomes in congenital factor XIII deficiency patients in Iran.

Naderi M, Haghpanah S, Miri-Aliabad G, et al.

Journal of thrombosis and haemostasis : JTH 2017; (15(12)):2300-2305 doi:10.1111/jth.13872.

Molecular diagnosis of factor XIII deficiency, data from comprehensive coagulation laboratory in Iran.

Gheidishahran M, Dorgalaleh A, Tabibian S, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2018; (29(1)):87-91 doi:10.1097/MBC.0000000000000679.

Recombinant FXIII (rFXIII-A2) Prophylaxis Prevents Bleeding and Allows for Surgery in Patients with Congenital FXIII A-Subunit Deficiency.

Carcao M, Altisent C, Castaman G, et al.

Thrombosis and haemostasis 2018; (118(3)):451-460 doi:10.1055/s-0038-1624581.

Recombinant factor XIII A-subunit in a patient with factor XIII deficiency and recurrent pregnancy loss.

Al-Khabori M, Pathare A, Menegatti M, Peyvandi F

Journal of thrombosis and haemostasis : JTH 2018; (16(6)):1052-1054 doi:10.1111/jth.14126.

State of the art in factor XIII laboratory assessment.

Durda MA, Wolberg AS, Kerlin BA

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2018; (57(6)):700-704 doi:10.1016/j.transci.2018.07.006.

Choroid Plexus Papilloma and Factor XIII Deficiency: Case Report.

Aydin Ozturk P, Sanri O, Yilmaz A, et al.

Pediatric neurosurgery 2018; (53(6)):413-415 doi:10.1159/000492334.

Recurrent venous thromboembolism patients form clots with lower elastic modulus than those formed by patients with non-recurrent disease.

Baker SR, Zabczyk M, Macrae FL, et al.

Journal of thrombosis and haemostasis : JTH 2019; (17(4)):618-626 doi:10.1111/jth.14402.

Factor XIII topology: organization of B subunits and changes with activation studied with single-molecule atomic force microscopy.

Protopopova AD, Ramirez A, Klinov DV, et al.

Journal of thrombosis and haemostasis : JTH 2019; (17(5)):737-748 doi:10.1111/jth.14412.

Massive recurrent post-tonsillectomy bleedings revealing a transient factor XIII deficiency in a 10-year-old boy. A case report.

Jankovic M, Choucair ML, Hallak B, et al.

International journal of pediatrics & adolescent medicine 2019; (6(2)):55-57 doi:10.1016/j.ijpam.2019.05.006.

Congenital factor XIII deficiency: comprehensive overview of the FranceCoag cohort.

Bouttefroy S, Meunier S, Milien V, et al.

British journal of haematology 2020; (188(2)):317-320 doi:10.1111/bjh.16133.

Factor XIII deficiency with intracranial haemorrhage.

Ejaz M, Saleem A, Ali N, Tariq F

BMJ case reports 2019; (12(8)) doi:10.1136/bcr-2018-228682.

Congenital Factor XIII Deficiency With the Presence of Inhibitor: A Case Study.

Karaman S, Akkaya E, Genc S, et al.

Journal of pediatric hematology/oncology 2021; (43(1)):e99-e102 doi:10.1097/MPH.0000000000001671.

Gynecological and obstetric outcome in the French cohort of women with factor XIII deficiency.

Rugeri L, Martinaud C, Beurrier P, et al.

Thrombosis research 2020; (191()):22-25 doi:10.1016/j.thromres.2020.04.010.

A case of life-threatening small intestinal bleeding accompanied by lower coagulation factor XIII activity.

Murata M, Inatomi O, Ono K, et al.

Clinical journal of gastroenterology 2020; (13(6)):1178-1182 doi:10.1007/s12328-020-01195-4.

Premarital Screening Program for Congenital Factor XIII Deficiency in Iran.

Daneshi M, Dorgalaleh A, Tabibian S, et al.

Clinical laboratory 2020; (66(8)) doi:10.7754/Clin.Lab.2020.191133.

Dental Management of Factor XIII Deficiency Patients: A Case Series.

Pai NG, Mehta LK, Padhye NM, Sayed ZM

International journal of clinical pediatric dentistry 2020; (13(3)):299-302 doi:10.5005/jp-journals-10005-1760.

Prenatal diagnosis of factor 13 deficiency and its recurrence.

Dasari P, Mangolngnbi Chanu S, Gadipudi LP

BMJ case reports 2020; (13(12)) doi:10.1136/bcr-2020-236365.

Management of Neuraxial Analgesia in a Parturient with Factor XIII Deficiency: A Case Report and Proposed Management Algorithm.

Carroll DB, Myler C, Songdej N, et al.

Case reports in anesthesiology 2020; (2020()):8892225 doi:10.1155/2020/8892225.

Clinical Validation of an Automated Fluorogenic Factor XIII Activity Assay Based on Isopeptidase Activity.

Leitner M, Büchold C, Pasternack R, et al.

International journal of molecular sciences 2021; (22(3)) doi:10.3390/ijms22031002.

Factor XIII-A in Diseases: Role Beyond Blood Coagulation.

Dull K, Fazekas F, Törőcsik D

International journal of molecular sciences 2021; (22(3)) doi:10.3390/ijms22031459.

Hemorrhagic Shock after Neonatal Circumcision: Severe Congenital Factor XIII Deficiency.

Cohen EL, Millikan SE, Morocco PC, de Jong JLO

Case reports in pediatrics 2021; (2021()):5550199 doi:10.1155/2021/5550199.

Why fibrin biomechanical properties matter for hemostasis and thrombosis.

Feller T, Connell SDA, Ariёns RAS

Journal of thrombosis and haemostasis : JTH 2022; (20(1)):6-16 doi:10.1111/jth.15531.

Postpartum Hemorrhage in Heterozygote Factor XIII Deficient Women Compared With Healthy Women. A Cross-Sectional Experience From Iran.

Naderi M, Mirzaei I, Yaghoubi S, et al.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2021; (27()):10760296211051714 doi:10.1177/10760296211051714.

Real-Life Population Pharmacokinetics of Recombinant Factor XIII and Dosing Considerations for Preventing the Risk of Bleeding in Patients with FXIII Congenital Deficiency.

Cojutti PG, Zanon E, Pasca S, et al.

Clinical pharmacokinetics 2022; (61(4)):505-513 doi:10.1007/s40262-021-01079-x.

An international collaborative study to assign value for Total Factor XIII-B Subunit Antigen to the WHO 1st International Standard for Factor XIII Plasma, (02/206): Communication from the ISTH SSC Subcommittee on Factor XIII and Fibrinogen.

Raut S, Katona É, Riches-Duit A, et al.

Journal of thrombosis and haemostasis : JTH 2022; (20(2)):525-531 doi:10.1111/jth.15596.

Noninvasive prenatal diagnosis of congenital factor XIII deficiency in Iran.

Motlagh H, Dorgalaleh A, Tabibian S, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2022; (33(3)):167-170 doi:10.1097/MBC.0000000000001121.

Acute Occlusion of the Ventriculoperitoneal Shunt Due to Factor XIII Deficiency-related Postoperative Hemorrhage: A Case Report.

Yamanishi S, Kimura H, Hayashi H, et al.

NMC case report journal 2021; (8(1)):573-577 doi:10.2176/nmccrj.cr.2020-0330.

Abnormally Prolonged Bleeding After an Arthroscopic Knee Reconstruction Because of an Inherited Factor XIII Deficiency: A Case Report.

Wattakavanich N, Boonrod A, Wanitpongpun C, Tharakulphan S

JBJS case connector 2021; (11(4)) doi:10.2106/JBJS.CC.21.00419.

Safety and effectiveness of recombinant factor XIII-A2 in congenital factor XIII deficiency: Real-world evidence.

Poulsen LH, Kerlin BA, Castaman G, et al.

Research and practice in thrombosis and haemostasis 2022; (6(2)):e12628 doi:10.1002/rth2.12628.

The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing.

Kleber C, Sablotzki A, Casu S, et al.

Critical care (London, England) 2022; (26(1)):69 doi:10.1186/s13054-022-03940-2.

Acquired Factor XIII Deficiency in a 19-year-Old Male Following Ballistic Injury.

Rodgers SC, Carter KT, Kutcher ME, Iwuchukwu CO

The American surgeon 2022; (88(9)):2225-2226 doi:10.1177/00031348221091970.

Exploring Diverse Coagulation Factor XIII Subunit Expression Datasets: A Bioinformatic Analysis.

Jamil MA, Singh S, El-Maarri O, et al.

International journal of molecular sciences 2022; (23(9)) doi:10.3390/ijms23094725.

Molecular Detection of Venous Thrombosis in Mouse Models Using SPECT/CT.

Dickhout A, Van de Vijver P, Bitsch N, et al.

Biomolecules 2022; (12(6)) doi:10.3390/biom12060829.

Factor XIII deficiency in a neonate presenting as subpial haemorrhage.

Karthikeyan MG, Ronda P, Sugumaran PC

SA journal of radiology 2022; (26(1)):2344 doi:10.4102/sajr.v26i1.2344.

Hyperfibrinolysis secondary to acquired factor XIII deficiency A case report.

Gao L, Li D, Ding M

Medicine 2022; (101(29)):e29446 doi:10.1097/MD.0000000000029446.

Delayed and prolonged umbilical stump bleeding in a Caucasian newborn as a presenting feature of factor XIII deficiency.

Lim DBN, Mangles S, Goturu A

BMJ case reports 2022; (15(10)) doi:10.1136/bcr-2022-248743.

Genetic landscape in coagulation factor XIII associated defects - Advances in coagulation and beyond.

Javed H, Singh S, Ramaraje Urs SU, et al.

Blood reviews 2023; (59()):101032 doi:10.1016/j.blre.2022.101032.

Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling.

Watanabe H, Mokuda S, Tokunaga T, et al.

Inflammation and regeneration 2023; (43(1)):2 doi:10.1186/s41232-022-00252-4.

The Role of Different Matrixin Gene Expressions on Cerebral Bleeding among Patients with Deficiency of Coagulation Factor XIII.

Mao L, Huang Y, Jia W, et al.

Cellular and molecular biology (Noisy-le-Grand, France) 2022; (68(8)):129-132 doi:10.14715/cmb/2022.68.8.23.

Factor XIII deficiency in the Saudi population, an underestimated bleeding risk. Review article and an illustrative case report with dental complications.

Aljabry M

The Saudi dental journal 2023; (35(4)):305-309 doi:10.1016/j.sdentj.2023.03.015.

Clotting Factor Deficiencies as an Underlying Cause of Abnormal Uterine Bleeding in Women of Reproductive Age: A Literature Review.

Livanou ME, Matsas A, Valsami S, et al.

Life (Basel, Switzerland) 2023; (13(6)) doi:10.3390/life13061321.

[A Case of Autoimmune Acquired Factor XIII Deficiency Diagnosed from Recurrent Postoperative Bleeding].

Takashima Y, Kawanishi H, Kotani S, et al.

Hinyokika kiyo. Acta urologica Japonica 2023; (69(6)):169-173 doi:10.14989/ActaUrolJap_69_6_169.

A case of anti-NPX-2 antibody-positive dermatomyositis resulting in massive haemothorax with acquired factor XIII deficiency.

Matsuda T, Haga T, Sakaguchi T, et al.

Modern rheumatology case reports 2023; (8(1)):91-94 doi:10.1093/mrcr/rxad049.

Heterozygosity in factor XIII genes and the manifestation of mild inherited factor XIII deficiency.

Singh S, Pezeshkpoor B, Jamil MA, et al.

Journal of thrombosis and haemostasis : JTH 2024; (22(2)):379-393 doi:10.1016/j.jtha.2023.09.032.

Successful perinatal management of a woman with congenital factor XIII deficiency using recombinant factor XIII: A case report and literature review.

Ito Y, Tsuji S, Kasahara M, et al.

The journal of obstetrics and gynaecology research 2024; (50(2)):262-265 doi:10.1111/jog.15819.

Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.

Byrnes JR, Lee T, Sharaby S, et al.

Blood 2024; (143(5)):444-455 doi:10.1182/blood.2023022042.

Pyopneumothorax Secondary to Pulmonary Tuberculosis Superadded by Congenital Factor XIII Deficiency: A Case Report.

Bajpai J, Tewari J, Roy S, et al.

Cureus 2023; (15(10)):e47350 doi:10.7759/cureus.47350.

Differential Role of Factor XIII in Acute Myocardial Infarction and Ischemic Stroke.

Traub J, Weber MS, Frey A

Biomedicines 2024; (12(3)) doi:10.3390/biomedicines12030497.

Development and Epitope Mapping of Seven Mouse Anti-Human Coagulation Factor XIII-B Subunit Monoclonal Antibodies.

Osaki T, Magari Y, Souri M, Ichinose A

Monoclonal antibodies in immunodiagnosis and immunotherapy 2024; (43(5)):135-143 doi:10.1089/mab.2024.0016.

Acquired factor XIII deficiency presenting with multiple intracranial hemorrhages and right hip hematoma: A case report.

Wang L, Zhang N, Liang DC, et al.

World journal of radiology 2024; (16(9)):439-445 doi:10.4329/wjr.v16.i9.439.

Bilateral Compartment Syndrome Affecting the Upper Limbs in a Patient With Chronic Myeloid Leukemia.

Varadhan A, Bagavandoss A, Edmunds CT, Oyibo SO

Cureus 2024; (16(11)):e74104 doi:10.7759/cureus.74104.

Factor XIII Deficiency: Laboratory, Molecular, and Clinical Aspects.

Dorgalaleh A, Jozdani S, Zadeh MK

Seminars in thrombosis and hemostasis 2025; (51(2)):155-169 doi:10.1055/s-0044-1796673.

Retroperitoneal fibrosis in presence of autoimmune coagulation factor XIII deficiency result in recurrent critical post-operative hemorrhage: a case report and molecular research with new insights.

Matsushita T, Tachibana M, Nakagawa H, et al.

Frontiers in immunology 2025; (16()):1591847 doi:10.3389/fimmu.2025.1591847.

Subgaleal Hematoma in a Female With Normal Coagulation Tests.

Ataei-Azimi S, Bos MHA, Rahimi H, Mansouritorghabeh H

Case reports in hematology 2025; (2025()):5481806 doi:10.1155/crh/5481806.

Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in patients with trauma.

Boateng NKK, Wimberley R, Rose J, et al.

Blood 2026; (147(1)):87-92 doi:10.1182/blood.2025029458.

Factor XIII Deficiency: A Rare Cause of Hydrocephalus in Infancy.

Alali A, Meshal T, Alali Z, et al.

Clinical case reports 2025; (13(10)):e70962 doi:10.1002/ccr3.70962.

Anovulatory bleeding and the spectrum of bleeding disorders: Understanding heavy menstrual bleeding in adolescents.

Özer E, Akman AÖ, Kurtipek FB, et al.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2025; doi:10.1002/ijgo.70579.

A Targeted LC-MS/MS-Based Quantitative Assay for Detecting Plasma Factor XIII A/B Subunit Deficiency.

Kim J, Venkataraman S, Chavan SN, et al.

The Journal of molecular diagnostics : JMD 2026; (28(1)):64-74 doi:10.1016/j.jmoldx.2025.09.010.

Exploring factor XIII genetic diversity: a familial approach to inheritance and variation.

Naz A, Zameer S, Rind HAP, et al.

Thrombosis journal 2025; (23(1)):109 doi:10.1186/s12959-025-00766-0.

Acquired factor XIII deficiency is associated with mortality and is not linked to hypocalcemia.

Duque P, Esteban ML, Piñeiro P, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2026; (37(1)):28-37 doi:10.1097/MBC.0000000000001400.

Recurrent Intramuscular Hematoma Revealing Moderate Congenital Factor XIII Deficiency.

Ben Halima N, Riahi S, Mazlout I, et al.

Cureus 2025; (17(10)):e95841 doi:10.7759/cureus.95841.

Congenital factor XIII deficiency caused by F13A1 gene mutations presenting with intracranial hemorrhage: a case report.

Wang H, Yang R, Li J

Frontiers in pediatrics 2025; (13()):1732065 doi:10.3389/fped.2025.1732065.

Delayed Postoperative Spinal Epidural Hematoma After Thoracic OPLL Surgery: A Case Report and Literature Review.

Takei H, Ohba T, Tanaka N, et al.

Clinical case reports 2026; (14(1)):e71810 doi:10.1002/ccr3.71810.