Research & Literature

Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.

Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, et al.

Annals of neurology 2015; (78(2)):193-210 doi:10.1002/ana.24449.

Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report.

LaBianca S, Jensen R, van den Maagdenberg AM, et al.

Headache 2015; (55(7)):1004-7 doi:10.1111/head.12595.

A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging.

Kim S, Kang M, Choi S

European journal of pediatrics 2016; (175(2)):295-8 doi:10.1007/s00431-015-2609-2.

Cerebellar function and ischemic brain lesions in migraine patients from the general population.

Koppen H, Boele HJ, Palm-Meinders IH, et al.

Cephalalgia : an international journal of headache 2017; (37(2)):177-190 doi:10.1177/0333102416643527.

Migraine in the era of precision medicine.

Zhang LM, Dong Z, Yu SY

Annals of translational medicine 2016; (4(6)):105 doi:10.21037/atm.2016.03.13.

Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack.

Chastan N, Lebas A, Legoff F, et al.

Neurophysiologie clinique = Clinical neurophysiology 2016; (46(4-5)):307-311 doi:10.1016/j.neucli.2016.03.004.

Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation.

Pelzer N, Blom DE, Stam AH, et al.

Cephalalgia : an international journal of headache 2017; (37(8)):737-755 doi:10.1177/0333102416651284.

ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of Disease.

Friedrich T, Tavraz NN, Junghans C

Frontiers in physiology 2016; (7()):239 doi:10.3389/fphys.2016.00239.

Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation.

Martínez E, Moreno R, López-Mesonero L, et al.

Case reports in neurological medicine 2016; (2016()):3464285 doi:10.1155/2016/3464285.

Familial Hemiplegic Migraine With Asymmetric Encephalopathy Secondary to ATP1A2 Mutation: A Case Series.

Murphy OC, Merwick A, OʼMahony O, et al.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2018; (35(1)):e3-e7 doi:10.1097/WNP.0000000000000387.

De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report.

Gagliardi S, Grieco GS, Gualandi F, et al.

The journal of headache and pain 2017; (18(1)):63 doi:10.1186/s10194-017-0770-x.

Ten years of follow-up in a large family with familial hemiplegic migraine type 1: Clinical course and implications for treatment.

Indelicato E, Nachbauer W, Eigentler A, et al.

Cephalalgia : an international journal of headache 2018; (38(6)):1167-1176 doi:10.1177/0333102417715229.

Flunarizine in migraine-related headache prevention: results from 200 patients treated in the UK.

Karsan N, Palethorpe D, Rattanawong W, et al.

European journal of neurology 2018; (25(6)):811-817 doi:10.1111/ene.13621.

Caffeine does not affect susceptibility to cortical spreading depolarization in mice.

Yalcin N, Chen SP, Yu ES, et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2019; (39(4)):740-750 doi:10.1177/0271678X18768955.

Time Course of Cerebral Perfusion Changes in Children with Migraine with Aura Mimicking Stroke.

Cobb-Pitstick KM, Munjal N, Safier R, et al.

AJNR. American journal of neuroradiology 2018; (39(9)):1751-1755 doi:10.3174/ajnr.A5693.

Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine.

Dhifallah S, Lancaster E, Merrill S, et al.

Frontiers in molecular neuroscience 2018; (11()):232 doi:10.3389/fnmol.2018.00232.

Familial Hemiplegic Migraine Type 3 (FHM3) With an SCN1A Mutation in a Chinese Family: A Case Report.

Shao N, Zhang H, Wang X, et al.

Frontiers in neurology 2018; (9()):976 doi:10.3389/fneur.2018.00976.

A Chinese family with familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2.

Tang W, Zhang M, Qiu E, et al.

Cephalalgia : an international journal of headache 2019; (39(11)):1382-1395 doi:10.1177/0333102419847738.

Upregulation of IL-1 Receptor Antagonist in a Mouse Model of Migraine.

Lombardo SD, Mazzon E, Basile MS, et al.

Brain sciences 2019; (9(7)) doi:10.3390/brainsci9070172.

First FHM3 mouse model shows spontaneous cortical spreading depolarizations.

Jansen NA, Dehghani A, Linssen MML, et al.

Annals of clinical and translational neurology 2020; (7(1)):132-138 doi:10.1002/acn3.50971.

Familial "Diplegic" Migraine - Description of a Family With a Novel CACNA1A Mutation.

Sprouse Blum AS, Couperus CJ, Rosen BJ, et al.

Headache 2020; (60(3)):600-606 doi:10.1111/head.13741.

Novel Therapies in Acute Migraine Management: Small-Molecule Calcitonin Gene-Receptor Antagonists and Serotonin 1F Receptor Agonist.

Joyner KR, Morgan KW

The Annals of pharmacotherapy 2021; (55(6)):745-759 doi:10.1177/1060028020963574.

New Nonsense Variant c.2983G>T; p.Glu995* in the CACNA1A Gene Causes Progressive Autosomal Dominant Ataxia.

Saathoff Y, Biskup S, Funke C, Roth C

Journal of movement disorders 2021; (14(1)):70-74 doi:10.14802/jmd.20082.

R1352Q CACNA1A Variant in a Patient with Sporadic Hemiplegic Migraine, Ataxia, Seizures and Cerebral Oedema: A Case Report.

Stubberud A, O'Connor E, Tronvik E, et al.

Case reports in neurology 2021; (13(1)):123-130 doi:10.1159/000512275.

Migraine: Calcium Channels and Glia.

Kowalska M, Prendecki M, Piekut T, et al.

International journal of molecular sciences 2021; (22(5)) doi:10.3390/ijms22052688.

Epilepsy in patients with familial hemiplegic migraine.

Hasırcı Bayır BR, Tutkavul K, Eser M, Baykan B

Seizure 2021; (88()):87-94 doi:10.1016/j.seizure.2021.03.028.

Serial magnetic resonance imaging findings during severe attacks of familial hemiplegic migraine type 2: a case report.

Fear D, Patel M, Zand R

BMC neurology 2021; (21(1)):173 doi:10.1186/s12883-021-02201-z.

Acute Treatment of Migraine: What has Changed in Pharmacotherapies?

Yang CP, Huang KT, Chang CM, et al.

Neurology India 2021; (69(Supplement)):S25-S42 doi:10.4103/0028-3886.315995.

Hemiplegic migraine type 2 caused by a novel variant within the P-type ATPase motif in ATP1A2 concomitant with a CACNA1A variant.

Kubota T, Nabatame S, Sato R, et al.

Brain & development 2021; (43(9)):952-957 doi:10.1016/j.braindev.2021.05.011.

Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance.

Crivellaro G, Tottene A, Vitale M, et al.

Neurobiology of disease 2021; (156()):105419 doi:10.1016/j.nbd.2021.105419.

Widespread brain parenchymal HMGB1 and NF-κB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice.

Dehghani A, Phisonkunkasem T, Yilmaz Ozcan S, et al.

Neurobiology of disease 2021; (156()):105424 doi:10.1016/j.nbd.2021.105424.

A case report of atypical hemiplegic migraine with nonheadache onset in a Chinese child.

Chen H, Sun X, Wang R, et al.

BMC neurology 2021; (21(1)):267 doi:10.1186/s12883-021-02302-9.

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.

Lemaire L, Desroches M, Krupa M, et al.

PLoS computational biology 2021; (17(7)):e1009239 doi:10.1371/journal.pcbi.1009239.

CACNA1A-p.Thr501Met mutation associated with familial hemiplegic migraine: a family report.

Romozzi M, Primiano G, Rollo E, et al.

The journal of headache and pain 2021; (22(1)):85 doi:10.1186/s10194-021-01297-5.

Relationships between migraine and epilepsy: Pathophysiological mechanisms and clinical implications.

Demarquay G, Rheims S

Revue neurologique 2021; (177(7)):791-800 doi:10.1016/j.neurol.2021.06.004.

[Familial hemiplegic migraine].

Starikova NL, Kulesh AA

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2021; (121(7)):114-117 doi:10.17116/jnevro2021121071114.

Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.

Auffenberg E, Hedrich UB, Barbieri R, et al.

The Journal of clinical investigation 2021; (131(21)).

[Diversity of CACNA1A-related disorders].

Rudenskaya GE, Sermyagina IG, Chukhrova AL, et al.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2021; (121(12)):106-111 doi:10.17116/jnevro2021121121106.

CaV2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury.

Terpolilli NA, Dolp R, Waehner K, et al.

eLife 2022; (11()).

Haploinsufficiency of PRRT2 Leading to Familial Hemiplegic Migraine in Chromosome 16p11.2 Deletion Syndrome.

Sen K, Genser I, DiFazio M, DiSabella M

Neuropediatrics 2022; (53(4)):279-282 doi:10.1055/a-1863-1798.

Case Report: A Novel CACNA1A Mutation Caused Flunarizine-Responsive Type 2 Episodic Ataxia and Hemiplegic Migraine With Abnormal MRI of Cerebral White Matter.

Yuan X, Zheng Y, Gao F, et al.

Frontiers in neurology 2022; (13()):899813 doi:10.3389/fneur.2022.899813.

The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications.

Brunklaus A, Brünger T, Feng T, et al.

Brain : a journal of neurology 2022; (145(11)):3816-3831 doi:10.1093/brain/awac210.

Sporadic Hemiplegic Migraine.

Kana T, Mehjabeen S, Patel N, et al.

Cureus 2023; (15(5)):e38930 doi:10.7759/cureus.38930.

Familial hemiplegic migraine in pediatric patients: A genetic, clinical, and follow-up study.

Mangano GD, Capizzi MR, Mantuano E, et al.

Headache 2023; (63(7)):889-898 doi:10.1111/head.14582.

Migraine with prolonged aphasic aura associated with a CACNA1A mutation: A case report and narrative review.

Jicha CJ, Alex A, Herskovitz S, et al.

Headache 2023; (63(7)):975-980 doi:10.1111/head.14594.

Migraine Aura-Catch Me If You Can with EEG and MRI-A Narrative Review.

Riederer F, Beiersdorf J, Scutelnic A, Schankin CJ

Diagnostics (Basel, Switzerland) 2023; (13(17)) doi:10.3390/diagnostics13172844.

Pathophysiology of migraine aura.

Sanchez Del Rio M, Cutrer FM

Handbook of clinical neurology 2023; (198()):71-83 doi:10.1016/B978-0-12-823356-6.00016-0.

Hemiplegic migraine.

de Boer I, Hansen JM, Terwindt GM

Handbook of clinical neurology 2024; (199()):353-365 doi:10.1016/B978-0-12-823357-3.00015-X.

Familial hemiplegic migraine type 2: a case report of an adolescent with ATP1A2 mutation.

Zhang H, Jiang L, Xian Y, Yang S

Frontiers in neurology 2024; (15()):1339642 doi:10.3389/fneur.2024.1339642.

Familial hemiplegic migraine in Indian children-a tertiary center experience.

Saini L, Gunasekaran PK, Tiwari S, et al.

Journal of tropical pediatrics 2024; (70(3)) doi:10.1093/tropej/fmae008.

Treatment of CACNA1A Encephalopathy and Cerebral Edema with Magnesium and Dexamethasone.

Turner C, Campbell L, Fung R, et al.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2024; 1-4 doi:10.1017/cjn.2024.52.

Familial hemiplegic migraine.

Villar-Martinez MD, Moreno-Ajona D, Goadsby PJ

Handbook of clinical neurology 2024; (203()):135-144 doi:10.1016/B978-0-323-90820-7.00007-0.

Expanding the Genetic and Clinical Spectrum of SCN1A-Related Hemiplegic Migraine: Analysis of Mutations in Japanese.

Danno D, Tada H, Oda I, et al.

International journal of molecular sciences 2025; (26(4)) doi:10.3390/ijms26041426.

Efficacy of anti-calcitonin gene-related peptide monoclonal antibodies in hemiplegic migraine: a case report and review of literature.

Héja M, Oláh L

Frontiers in neurology 2025; (16()):1579203 doi:10.3389/fneur.2025.1579203.

Familial Hemiplegic Migraine (FHM) with Transient Psychotic Symptoms: A Case Report and Literature Review.

Öz T, Gürel ŞC

Turk psikiyatri dergisi = Turkish journal of psychiatry 2025; (36()):50 doi:10.5080/u27678.

Reduced Frequency of Prolonged Sporadic Hemiplegic Migraine Attacks Following Fremanezumab Treatment-A Case Report.

Hotz JF, Kaindl L, Krebs S, et al.

European journal of neurology 2026; (33(2)):e70514 doi:10.1111/ene.70514.