Research & Literature

Voltage gated calcium channel antibody-related neurological diseases.

Bekircan-Kurt CE, Derle Çiftçi E, Kurne AT, Anlar B

World journal of clinical cases 2015; (3(3)):293-300 doi:10.12998/wjcc.v3.i3.293.

Lambert-Eaton Myasthenic Syndrome: Ocular Signs and Symptoms.

Young JD, Leavitt JA

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2016; (36(1)):20-2 doi:10.1097/WNO.0000000000000258.

Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults.

Haroldsen PE, Musson DG, Hanson B, et al.

Clinical therapeutics 2015; (37(7)):1555-63.

Pharmacokinetics and safety of 3,4-diaminopyridine base in healthy Japanese volunteers.

Ishida N, Kobayashi E, Kondo Y, et al.

International journal of clinical pharmacology and therapeutics 2015; (53(8)):674-80 doi:10.5414/CP202133.

The European LEMS Registry: Baseline Demographics and Treatment Approaches.

Mantegazza R, Meisel A, Sieb JP, et al.

Neurology and therapy 2015; (4(2)):105-24 doi:10.1007/s40120-015-0034-0.

P/Q- and N-type calcium-channel antibodies: Oncological, neurological, and serological accompaniments.

Zalewski NL, Lennon VA, Lachance DH, et al.

Muscle & nerve 2016; (54(2)):220-7 doi:10.1002/mus.25027.

Amifampridine phosphate (Firdapse(®)) is effective and safe in a phase 3 clinical trial in LEMS.

Oh SJ, Shcherbakova N, Kostera-Pruszczyk A, et al.

Muscle & nerve 2016; (53(5)):717-25 doi:10.1002/mus.25070.

Tubular aggregates in autoimmune Lambert-Eaton myasthenic syndrome.

Cordts I, Funk F, Schulz JB, et al.

Neuromuscular disorders : NMD 2016; (26(12)):880-884 doi:10.1016/j.nmd.2016.09.011.

Lambert-Eaton myasthenic syndrome: Epidemiology and therapeutic response in the national veterans affairs population.

Abenroth DC, Smith AG, Greenlee JE, et al.

Muscle & nerve 2017; (56(3)):421-426 doi:10.1002/mus.25520.

Long-term survival in paraneoplastic Lambert-Eaton myasthenic syndrome.

Maddison P, Gozzard P, Grainge MJ, Lang B

Neurology 2017; (88(14)):1334-1339 doi:10.1212/WNL.0000000000003794.

Lambert-Eaton myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer.

Schoser B, Eymard B, Datt J, Mantegazza R

Journal of neurology 2017; (264(9)):1854-1863 doi:10.1007/s00415-017-8541-9.

[Seronegative nonparaneoplastic Lambert-Eaton myasthenic syndrome].

Sanadze AG, Sidnev DV, Tumurov DA

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2017; (117(5)):77-80 doi:10.17116/jnevro20171175177-80.

Distinguishing Features of the Repetitive Nerve Stimulation Test Between Lambert-Eaton Myasthenic Syndrome and Myasthenia Gravis, 50-Year Reappraisal.

Oh SJ

Journal of clinical neuromuscular disease 2017; (19(2)):66-75 doi:10.1097/CND.0000000000000190.

[P/Q-type Calcium Channel Antibodies in Lambert-Eaton Myasthenic Syndrome].

Kitanosono H, Shiraishi H, Motomura M

Brain and nerve = Shinkei kenkyu no shinpo 2018; (70(4)):341-355 doi:10.11477/mf.1416201007.

Low specificity of voltage-gated calcium channel antibodies in Lambert-Eaton myasthenic syndrome: a call for caution.

Di Lorenzo R, Mente K, Li J, et al.

Journal of neurology 2018; (265(9)):2114-2119 doi:10.1007/s00415-018-8959-8.

Stimulated single-fiber electromyography (sSFEMG) in Lambert-Eaton syndrome.

Todisco V, Cirillo G, Capuano R, et al.

Clinical neurophysiology practice 2018; (3()):148-150 doi:10.1016/j.cnp.2018.07.001.

Amifampridine Phosphate (Firdapse) Is Effective in a Confirmatory Phase 3 Clinical Trial in LEMS.

Shieh P, Sharma K, Kohrman B, Oh SJ

Journal of clinical neuromuscular disease 2019; (20(3)):111-119 doi:10.1097/CND.0000000000000239.

Lambert-Eaton Myasthenic syndrome: early diagnosis is key.

Ivanovski T, Miralles F

Degenerative neurological and neuromuscular disease 2019; (9()):27-37 doi:10.2147/DNND.S192588.

Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia.

Raja SM, Sanders DB, Juel VC, et al.

Muscle & nerve 2019; (60(3)):292-298 doi:10.1002/mus.26625.

Amifampridine for the treatment of Lambert-Eaton myasthenic syndrome.

Oh SJ

Expert review of clinical immunology 2019; (15(10)):991-1007 doi:10.1080/1744666X.2020.1670061.

Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis.

Guidon AC

Continuum (Minneapolis, Minn.) 2019; (25(6)):1785-1806 doi:10.1212/CON.0000000000000807.

Long-term follow-up, quality of life, and survival of patients with Lambert-Eaton myasthenic syndrome.

Lipka AF, Boldingh MI, van Zwet EW, et al.

Neurology 2020; (94(5)):e511-e520 doi:10.1212/WNL.0000000000008747.

Lowering the cutoff value for increment increases the sensitivity for the diagnosis of Lambert-Eaton myasthenic syndrome.

Lipka AF, Titulaer MJ, Tannemaat MR, Verschuuren JJGM

Muscle & nerve 2020; (62(1)):111-114 doi:10.1002/mus.26885.

Lambert-Eaton myasthenia syndrome: specified description of a response pattern to low-frequency repetitive nerve stimulation.

Zhou X, Wang Z, Zhu Y, et al.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology 2020; (53()):102437 doi:10.1016/j.jelekin.2020.102437.

Lung cancer prediction in Lambert-Eaton myasthenic syndrome in a prospective cohort.

Maddison P, Lipka AF, Gozzard P, et al.

Scientific reports 2020; (10(1)):10546 doi:10.1038/s41598-020-67571-9.

Classically Described, Paradoxically Underrecognized: A Case of Proximal Weakness, Hyporeflexia/Areflexia, and Dysautonomia.

Mirian A, Sharma AK, Nicolle MW

American journal of physical medicine & rehabilitation 2021; (100(7)):e98-e100 doi:10.1097/PHM.0000000000001632.

Immunoglobulins to mitigate paraneoplastic Lambert Eaton Myasthenic Syndrome under checkpoint inhibition in Merkel cell carcinoma.

Dohrn MF, Schöne U, Küppers C, et al.

Neurological research and practice 2020; (2()):52 doi:10.1186/s42466-020-00099-5.

Lambert-Eaton Myasthenic Syndrome and Dermatomyositis With Anti-TIF1-gamma Autoantibody: A Unique Association of Autoimmune Neuromuscular Conditions Without Malignancy.

Isfort M, Mnatsakanova D, Oddis C, Lacomis D

Journal of clinical neuromuscular disease 2021; (22(3)):164-168 doi:10.1097/CND.0000000000000318.

Two Lambert-Eaton Myasthenic Syndrome Patients with Ameliorated Activities of Daily Living Due to Cholinesterase Inhibitors.

Yamasaki H, Futamura N, Funakawa I, et al.

Internal medicine (Tokyo, Japan) 2022; (61(7)):1063-1065 doi:10.2169/internalmedicine.7902-21.

Neuromuscular junction disorders beyond myasthenia gravis.

Oh SJ

Current opinion in neurology 2021; (34(5)):648-657 doi:10.1097/WCO.0000000000000972.

Autonomic dysfunction detected by skin sympathetic response in Lambert-Eaton myasthenic syndrome: a case report.

Zhang J, Huang X, Shi Q

BMC neurology 2022; (22(1)):106 doi:10.1186/s12883-022-02625-1.

Lambert-Eaton Myasthenic Syndrome in Lung Cancer.

Wang Y, Xu C, Wang Y, et al.

Contrast media & molecular imaging 2022; (2022()):3912376 doi:10.1155/2022/3912376.

SOX1 antibody-related paraneoplastic neurological syndromes: clinical correlates and assessment of laboratory diagnostic techniques.

Vabanesi M, Pinto AL, Vogrig A, et al.

Journal of neurology 2023; (270(3)):1691-1701 doi:10.1007/s00415-022-11523-y.

Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review.

Seligman C, Chang YM, Luo J, Garden OA

Frontiers in neurology 2022; (13()):1004810 doi:10.3389/fneur.2022.1004810.

Durvalumab for Extensive-Stage of Small-Cell Lung Cancer With Lambert-Eaton Myasthenic Syndrome.

Machiyama H, Minami S

Journal of medical cases 2023; (14(2)):71-75 doi:10.14740/jmc4043.

Simulations of active zone structure and function at mammalian NMJs predict that loss of calcium channels alone is not sufficient to replicate LEMS effects.

Ginebaugh SP, Badawi Y, Laghaei R, et al.

Journal of neurophysiology 2023; (129(5)):1259-1277 doi:10.1152/jn.00404.2022.

Lambert-Eaton myasthenic syndrome with primary thymic marginal zone B-cell lymphoma: A case report.

Soma T, Matsumoto A, Shoji T, Katakura H

Respirology case reports 2023; (11(5)):e01149 doi:10.1002/rcr2.1149.

Cancer detection after a 9-year course of Lambert-Eaton myasthenic syndrome complicated by anti-Hu associated limbic encephalitis.

Falso S, Spagni G, Iorio R, Evoli A

Neuromuscular disorders : NMD 2023; (33(9)):90-92 doi:10.1016/j.nmd.2023.06.011.

Dilated fixed pupils and respiratory failure: a rare clinical course of Lambert-Eaton myasthenic syndrome.

Ten Brinck MF, Verheijen IW, van de Wardt J, et al.

BMJ neurology open 2023; (5(2)):e000426 doi:10.1136/bmjno-2023-000426.

Undiagnosed Lambert-Eaton Myasthenic Syndrome in the Era of Sugammadex: A Case Report.

Yoon JJ, Anderson AL, Niesen AD

Clinical neuropharmacology 2023; (46(6)):205-208 doi:10.1097/WNF.0000000000000569.

Electrophysiological evaluation of the neuromuscular junction: a brief review.

Kouyoumdjian JA, Estephan EP

Arquivos de neuro-psiquiatria 2023; (81(12)):1040-1052 doi:10.1055/s-0043-1777749.

[Diagnosis and Treatment of Lambert-Eaton Myasthenic Syndrome].

Kitanosono H, Yoshimura S, Shiraishi H, Motomura M

Brain and nerve = Shinkei kenkyu no shinpo 2024; (76(1)):33-40 doi:10.11477/mf.1416202555.

Postexercise reflex facilitation in Lambert-Eaton myasthenic syndrome.

Poh M, Ming YC, Yanni PC, et al.

Practical neurology 2024; (24(4)):338-341 doi:10.1136/pn-2023-004032.

Lambert-Eaton myasthenic syndrome.

Lipka AF, Verschuuren JJGM

Handbook of clinical neurology 2024; (200()):307-325 doi:10.1016/B978-0-12-823912-4.00012-8.

SOX-1 antibodies positive Lambert-Eaton myasthenic syndrome with occult small cell lung cancer: A case report.

Zhao L, He H, Han W, et al.

The clinical respiratory journal 2024; (18(3)):e13740 doi:10.1111/crj.13740.

[A case of myasthenia gravis with coexistence of anti-acetylcholine receptor antibodies and anti-P/Q-type VGCC antibodies].

Takeda Y, Noda Y, Seike N, Ishihara H

Rinsho shinkeigaku = Clinical neurology 2024; (64(4)):292-295 doi:10.5692/clinicalneurol.cn-001945.

Amifampridine overdose leading to refractory status epilepticus.

Gooley B, Willenbring B, Wilkinson J

The American journal of emergency medicine 2024; (80()):231.e1-231.e2 doi:10.1016/j.ajem.2024.04.023.

Acute Respiratory Failure Resulting From Lambert-Eaton Myasthenic Syndrome: A Case Report and Literature Review.

Spicer AR, Reyes CZA, Varade PM

Cureus 2024; (16(5)):e59516 doi:10.7759/cureus.59516.

Amifampridines are the Most Effective Drugs for Treating Lambert-Eaton Myasthenic Syndrome With a Focus on Pediatric Lambert-Eaton Myasthenic Syndrome.

Oh SJ

Journal of clinical neurology (Seoul, Korea) 2024; (20(4)):353-361 doi:10.3988/jcn.2024.0018.

Independence in activities of daily living was achieved using aerobic exercise without overwork weakness during rehabilitation: a case report of Lambert-Eaton myasthenic syndrome.

Harayama E, Goto K, Yamauchi K

Journal of physical therapy science 2024; (36(7)):396-401 doi:10.1589/jpts.36.396.

Clinical presentations, electrophysiologic features, and long-term follow-up in Lambert-Eaton myasthenic syndrome: a series of six patients.

Alhammad RM, Alshamlan Y, Alneseyan R, et al.

Frontiers in neurology 2024; (15()):1525155 doi:10.3389/fneur.2024.1525155.

Type 2 Respiratory Failure as an Initial Manifestation of Lambert-Eaton Myasthenic Syndrome Complicated by Paraneoplastic Autoimmune Encephalitis.

Uemura S, Fujiwara S, Sasada T, et al.

Cureus 2025; (17(1)):e78284 doi:10.7759/cureus.78284.

Atypical presentation of Lambert-Eaton myasthenic syndrome associated with oesophageal squamous cell carcinoma.

Bubuioc AM, Gagiu A, Cojocaru L, Lisnic V

BMJ case reports 2025; (18(3)) doi:10.1136/bcr-2024-264472.

Long-term Efficacy and Safety of Amifampridine Phosphate (Firdapse®) in Japanese Patients with Lambert-Eaton Myasthenic Syndrome (LMS-005 Study).

Hatanaka Y, Mori-Yoshimura M, Utsugisawa K, et al.

Internal medicine (Tokyo, Japan) 2025; (64(24)):3493-3501 doi:10.2169/internalmedicine.5363-25.

The recognition, physiology, and treatment of Lambert-Eaton myasthenic syndrome.

Randall DP

Disease-a-month : DM 2025; (71(8)):101967 doi:10.1016/j.disamonth.2025.101967.

A Rare Case of Lambert-Eaton Myasthenia Syndrome With Dysphasia and Dysarthria.

Harimohan H, Yasonova M, Sukkar M, Sabetian K

Cureus 2025; (17(6)):e86700 doi:10.7759/cureus.86700.

N-type voltage-gated calcium channel antibody testing lacks diagnostic value in Lambert-Eaton myasthenic syndrome.

Arlt FA, Majed M, Wu J, et al.

Journal of neuroimmunology 2025; (406()):578681 doi:10.1016/j.jneuroim.2025.578681.

Lambert Eaton Myasthenic Syndrome.

El-Wahsh S, Reddel S

International review of neurobiology 2025; (182()):227-251 doi:10.1016/bs.irn.2025.04.027.

Diaphragmatic Palsy Due to a Paraneoplastic Autoimmune Syndrome Revealed by Checkpoint Inhibitors.

Destival JB, Michot JM, Cauquil C, et al.

Reports (MDPI) 2024; (7(4)) doi:10.3390/reports7040084.

Epidemiological analysis of Lambert-Eaton myasthenic syndrome in Türkiye: insights from a nationwide electronic health database.

Inan B, Ozturk B, Ata N, et al.

Frontiers in neurology 2025; (16()):1667540 doi:10.3389/fneur.2025.1667540.

The management of Lambert Eaton syndrome in the setting of hypertensive disorders of pregnancy: A literature review.

Friedlich N, Slear E, Faszholz A, Bleich A

Pregnancy hypertension 2025; (42()):101255 doi:10.1016/j.preghy.2025.101255.

Lambert-Eaton myasthenic syndrome presenting with occult mediastinal small cell carcinoma and positivity for anti-CV2/CRMP5 and anti-SOX1 antibodies: a case report.

Wang A, Li H, Li D, et al.

BMC neurology 2025; (26(1)):3 doi:10.1186/s12883-025-04541-6.

Paraneoplastic Lambert-Eaton myasthenic syndrome associated with non-small cell lung cancer: data from the European LEMS registry and systematic review.

Preßler H, Haddy I, Daugherty C, et al.

Neurological research and practice 2025; (7(1)):95 doi:10.1186/s42466-025-00453-5.

Lambert-Eaton Myasthenic Syndrome During Immunotherapy in Extensive-Stage Small-Cell Lung Cancer: A Case Report.

Feng Y, Yang Y, Ding L

British journal of hospital medicine (London, England : 2005) 2026; (87(4)):53025 doi:10.31083/BJHM53025.

Early Induction of IVIg Improved the Performance Status and Enabled Chemotherapy Initiation in PCD-LEMS: A Case Report.

Tanaka T, Kitamura A, Tamura R, et al.

Internal medicine (Tokyo, Japan) 2026; doi:10.2169/internalmedicine.7251-26.