Research & Literature

Natural history of multiple system atrophy in the USA: a prospective cohort study.

Low PA, Reich SG, Jankovic J, et al.

The Lancet. Neurology 2015; (14(7)):710-9.

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.

Bernis ME, Babila JT, Breid S, et al.

Acta neuropathologica communications 2015; (3()):75 doi:10.1186/s40478-015-0254-7.

Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine.

Okamoto LE, Diedrich A, Baudenbacher FJ, et al.

Hypertension (Dallas, Tex. : 1979) 2016; (68(2)):418-26 doi:10.1161/HYPERTENSIONAHA.116.07199.

Vasomotor regulation in patients with multiple system atrophy.

Shindo K, Tsuchiya M, Ichinose Y, et al.

Journal of neural transmission (Vienna, Austria : 1996) 2017; (124(4)):477-481 doi:10.1007/s00702-016-1644-0.

Multiple System Atrophy - State of the Art.

Laurens B, Vergnet S, Lopez MC, et al.

Current neurology and neuroscience reports 2017; (17(5)):41 doi:10.1007/s11910-017-0751-0.

Pathologic confirmation of retinal ganglion cell loss in multiple system atrophy.

Mendoza-Santiesteban CE, Palma JA, Ortuño-Lizarán I, et al.

Neurology 2017; (88(23)):2233-2235 doi:10.1212/WNL.0000000000004020.

Multiple system atrophy: clinicopathological characteristics in Japanese patients.

Ozawa T, Onodera O

Proceedings of the Japan Academy. Series B, Physical and biological sciences 2017; (93(5)):251-258 doi:10.2183/pjab.93.016.

REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies.

St Louis EK, Boeve AR, Boeve BF

Movement disorders : official journal of the Movement Disorder Society 2017; (32(5)):645-658 doi:10.1002/mds.27018.

Relevance of non-specific MRI features in multiple system atrophy.

Pradhan S, Tandon R

Clinical neurology and neurosurgery 2017; (159()):29-33 doi:10.1016/j.clineuro.2017.05.008.

Adding droxidopa to fludrocortisone or midodrine in a patient with neurogenic orthostatic hypotension and Parkinson disease.

Kremens D, Lew M, Claassen D, Goodman BP

Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2017; (27(Suppl 1)):29-31 doi:10.1007/s10286-017-0434-6.

Anesthetic considerations in a patient with multiple system atrophy-cerebellar for lower limb surgery.

Agarwal S, Aggarwal R

Saudi journal of anaesthesia 2017; (11(3)):365-366 doi:10.4103/sja.SJA_57_17.

Effect and Efficiency of an Embedded Palliative Care Nurse Practitioner in an Oncology Clinic.

Walling AM, D'Ambruoso SF, Malin JL, et al.

Journal of oncology practice 2017; (13(9)):e792-e799 doi:10.1200/JOP.2017.020990.

Symptomatic therapy of multiple system atrophy.

Rohrer G, Höglinger GU, Levin J

Autonomic neuroscience : basic & clinical 2018; (211()):26-30 doi:10.1016/j.autneu.2017.10.006.

Sporadic adult-onset ataxia.

Klockgether T

Handbook of clinical neurology 2018; (155()):217-225 doi:10.1016/B978-0-444-64189-2.00014-7.

Standing and Supine Blood Pressure Outcomes Associated With Droxidopa and Midodrine in Patients With Neurogenic Orthostatic Hypotension: A Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials.

Chen JJ, Han Y, Tang J, et al.

The Annals of pharmacotherapy 2018; (52(12)):1182-1194 doi:10.1177/1060028018786954.

Therapeutic Management of the Overlapping Syndromes of Atypical Parkinsonism.

Giagkou N, Stamelou M

CNS drugs 2018; (32(9)):827-837 doi:10.1007/s40263-018-0551-3.

An update on advances in magnetic resonance imaging of multiple system atrophy.

Chelban V, Bocchetta M, Hassanein S, et al.

Journal of neurology 2019; (266(4)):1036-1045 doi:10.1007/s00415-018-9121-3.

The 'Hot Cross Bun' Sign Is Not Always Multiple System Atrophy: Etiologies of 11 Cases.

Way C, Pettersson D, Hiller A

Journal of movement disorders 2019; (12(1)):27-30 doi:10.14802/jmd.18031.

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Mavroeidi P, Arvanitaki F, Karakitsou AK, et al.

Acta neuropathologica 2019; (138(3)):415-441 doi:10.1007/s00401-019-02014-y.

Autonomic Dysfunction in α-Synucleinopathies.

Mendoza-Velásquez JJ, Flores-Vázquez JF, Barrón-Velázquez E, et al.

Frontiers in neurology 2019; (10()):363 doi:10.3389/fneur.2019.00363.

Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features.

Lieto M, Roca A, Bruzzese D, et al.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2019; (40(10)):2105-2109 doi:10.1007/s10072-019-03948-7.

Management of coexistent neurogenic orthostatic hypotension and supine hypertension.

Cannom DS

Journal of clinical hypertension (Greenwich, Conn.) 2019; (21(11)):1732-1734 doi:10.1111/jch.13699.

Differential Diagnosis Of Multiple-System Atrophy With Parkinson's Disease By External Anal- And Urethral-Sphincter Electromyography.

Qiu F, Wang K, Li T, et al.

Neuropsychiatric disease and treatment 2019; (15()):3061-3067 doi:10.2147/NDT.S218073.

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb.

Rey NL, Bousset L, George S, et al.

Acta neuropathologica communications 2019; (7(1)):221 doi:10.1186/s40478-019-0859-3.

Epigallocatechin gallate in multiple system atrophy (PROMESA).

Jellinger KA

Annals of translational medicine 2019; (7(Suppl 8)):S278 doi:10.21037/atm.2019.11.141.

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.

Shahnawaz M, Mukherjee A, Pritzkow S, et al.

Nature 2020; (578(7794)):273-277 doi:10.1038/s41586-020-1984-7.

Disease progression and prognostic factors in multiple system atrophy: A prospective cohort study.

Foubert-Samier A, Pavy-Le Traon A, Guillet F, et al.

Neurobiology of disease 2020; (139()):104813 doi:10.1016/j.nbd.2020.104813.

Cardiovascular Safety Considerations in the Treatment of Neurogenic Orthostatic Hypotension.

Olshansky B, Muldowney J

The American journal of cardiology 2020; (125(10)):1582-1593 doi:10.1016/j.amjcard.2020.01.037.

Diagnosing multiple system atrophy at the prodromal stage.

Xia C, Postuma RB

Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2020; (30(3)):197-205 doi:10.1007/s10286-020-00682-5.

Vertical pons hyperintensity and hot cross bun sign in cerebellar-type multiple system atrophy and spinocerebellar ataxia type 3.

Sugiyama A, Yokota H, Yamanaka Y, et al.

BMC neurology 2020; (20(1)):157 doi:10.1186/s12883-020-01738-9.

Structures of α-synuclein filaments from multiple system atrophy.

Schweighauser M, Shi Y, Tarutani A, et al.

Nature 2020; (585(7825)):464-469 doi:10.1038/s41586-020-2317-6.

Difference in cardiovascular response during orthostatic stress in Parkinson's disease and multiple system atrophy.

Nakamura T, Suzuki M, Ueda M, et al.

Journal of neural transmission (Vienna, Austria : 1996) 2020; (127(10)):1377-1386 doi:10.1007/s00702-020-02241-8.

Effect of Short-term Integrated Palliative Care on Patient-Reported Outcomes Among Patients Severely Affected With Long-term Neurological Conditions: A Randomized Clinical Trial.

Gao W, Wilson R, Hepgul N, et al.

JAMA network open 2020; (3(8)):e2015061 doi:10.1001/jamanetworkopen.2020.15061.

Automated Analysis of Diffusion-Weighted Magnetic Resonance Imaging for the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease.

Krismer F, Beliveau V, Seppi K, et al.

Movement disorders : official journal of the Movement Disorder Society 2021; (36(1)):241-245 doi:10.1002/mds.28281.

Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group.

Pellecchia MT, Stankovic I, Fanciulli A, et al.

Movement disorders clinical practice 2020; (7(7)):750-762 doi:10.1002/mdc3.13052.

Differential value of external anal- and urethral-sphincter electromyography in multiple system atrophy cerebellar type and spinocerebellar ataxias.

Miao Y, Wang K, Han J, et al.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020; (80()):16-22 doi:10.1016/j.jocn.2020.07.067.

Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy.

Lin J, Xu X, Hou Y, et al.

Frontiers in aging neuroscience 2020; (12()):591666 doi:10.3389/fnagi.2020.591666.

Amelioration of motor and nonmotor symptoms in cortical cerebellar atrophy and multiple system atrophy-cerebellar type by inpatient rehabilitation: a retrospective study.

Sonoda Y, Yamanaka Y, Sawano S, et al.

International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation 2021; (44(2)):104-109 doi:10.1097/MRR.0000000000000455.

Management Strategies for Comorbid Supine Hypertension in Patients with Neurogenic Orthostatic Hypotension.

Isaacson SH, Dashtipour K, Mehdirad AA, Peltier AC

Current neurology and neuroscience reports 2021; (21(4)):18 doi:10.1007/s11910-021-01104-3.

Fluoxetine for the Symptomatic Treatment of Multiple System Atrophy: The MSA-FLUO Trial.

Rascol O, Cochen de Cock V, Pavy-Le Traon A, et al.

Movement disorders : official journal of the Movement Disorder Society 2021; (36(7)):1704-1711 doi:10.1002/mds.28569.

Heightened risk of early vocal fold motion impairment onset and dysphagia in the parkinsonian variant of multiple system atrophy: a comparative study.

Tsuchiya K, Ueha R, Suzuki S, et al.

Clinical parkinsonism & related disorders 2020; (3()):100037 doi:10.1016/j.prdoa.2020.100037.

A historical review of multiple system atrophy with a critical appraisal of cellular and animal models.

Marmion DJ, Peelaerts W, Kordower JH

Journal of neural transmission (Vienna, Austria : 1996) 2021; (128(10)):1507-1527 doi:10.1007/s00702-021-02419-8.

Endoscopic Characteristics of Dysphagia in Multiple System Atrophy Compared to Parkinson's Disease.

Vogel A, Claus I, Ahring S, et al.

Movement disorders : official journal of the Movement Disorder Society 2022; (37(3)):535-544 doi:10.1002/mds.28854.

An Item Response Theory analysis of the Unified Multiple System Atrophy Rating Scale.

Foubert-Samier A, Pavy-Le Traon A, Saulnier T, et al.

Parkinsonism & related disorders 2022; (94()):40-44 doi:10.1016/j.parkreldis.2021.11.024.

Sensitivity to Change and Patient-Centricity of the Unified Multiple System Atrophy Rating Scale Items: A Data-Driven Analysis.

Krismer F, Seppi K, Jönsson L, et al.

Movement disorders : official journal of the Movement Disorder Society 2022; (37(7)):1425-1431 doi:10.1002/mds.28993.

The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy.

Wenning GK, Stankovic I, Vignatelli L, et al.

Movement disorders : official journal of the Movement Disorder Society 2022; (37(6)):1131-1148 doi:10.1002/mds.29005.

Female Urinary Retention Progressing to Possible Multiple System Atrophy-cerebellar Form after 12 Years.

Sakakibara R, Sekiguchi Y, N Panicker J, et al.

Internal medicine (Tokyo, Japan) 2022; (61(23)):3599-3604 doi:10.2169/internalmedicine.8724-21.

Screening for RFC-1 pathological expansion in late-onset ataxias: a contribution to the differential diagnosis.

Barghigiani M, De Michele G, Tessa A, et al.

Journal of neurology 2022; (269(10)):5431-5435 doi:10.1007/s00415-022-11192-x.

Radiological hints for differentiation of cerebellar multiple system atrophy from spinocerebellar ataxia.

Chen HC, Lee LH, Lirng JF, Soong BW

Scientific reports 2022; (12(1)):10499 doi:10.1038/s41598-022-14531-0.

A Review on the Clinical Diagnosis of Multiple System Atrophy.

Stankovic I, Fanciulli A, Sidoroff V, Wenning GK

Cerebellum (London, England) 2023; (22(5)):825-839 doi:10.1007/s12311-022-01453-w.

Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.

Hopfner F, Tietz AK, Ruf VC, et al.

Movement disorders : official journal of the Movement Disorder Society 2022; (37(10)):2110-2121 doi:10.1002/mds.29164.

Multiple system atrophy.

Poewe W, Stankovic I, Halliday G, et al.

Nature reviews. Disease primers 2022; (8(1)):56 doi:10.1038/s41572-022-00382-6.

Responsiveness of UMSARS and other clinical measures in a longitudinal structured care clinic for multiple system atrophy.

Golden EP, McCreary M, Vernino S

Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2022; (32(6)):477-484 doi:10.1007/s10286-022-00898-7.

Patient-Reported Symptoms in the Global Multiple System Atrophy Registry.

Palma JA, Krismer F, Meissner WG, et al.

Movement disorders clinical practice 2022; (9(7)):967-971 doi:10.1002/mdc3.13544.

Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study.

Zhang L, Hou Y, Cao B, et al.

BMC medicine 2022; (20(1)):446 doi:10.1186/s12916-022-02645-1.

Chemical disaggregation of alpha-synuclein fibrils as a therapy for synucleinopathies.

Wu S, Hernandez Villegas NC, Schekman R

Proceedings of the National Academy of Sciences of the United States of America 2023; (120(11)):e2300965120 doi:10.1073/pnas.2300965120.

Swallowing Characteristics in Patients with Multiple System Atrophy Analyzed Using FEES Examination.

Mozzanica F, Pizzorni N, Eplite A, et al.

Dysphagia 2024; (39(3)):387-397 doi:10.1007/s00455-023-10619-5.

In vivo cerebral metabolic and dopaminergic characteristics in multiple system atrophy with orthostatic hypotension.

Xue C, Dou X, Yu C, et al.

European journal of nuclear medicine and molecular imaging 2024; (51(2)):468-480 doi:10.1007/s00259-023-06443-6.

Validation Study of the MDS Criteria for the Diagnosis of Multiple System Atrophy in the Mayo Clinic Brain Bank.

Sekiya H, Koga S, Murakami A, et al.

Neurology 2023; (101(24)):e2460-e2471 doi:10.1212/WNL.0000000000207905.

Feasibility and effectiveness of a two-tiered intervention involving training and a new consultation model for patients with palliative care needs in primary care: A before-after study.

Seiça Cardoso C, Prazeres F, Oliveiros B, et al.

Palliative medicine 2024; (38(8)):842-852 doi:10.1177/02692163231219682.

Nature of Parkinsonian features in multiple system atrophy.

Pradhan S, Tandon R

Journal of neurosciences in rural practice 2024; (15(2)):211-216 doi:10.25259/JNRP_445_2023.

Clinical Application of 18 F-THK5351 PET to Image Ongoing Astrogliosis in MSA-P and MSA-C.

Kondo S, Ishibashi K, Ishii K, et al.

Clinical nuclear medicine 2024; (49(10)):e503-e505 doi:10.1097/RLU.0000000000005347.

Early-onset dysphagia predicts short survival in multiple system atrophy.

Wada T, Shimizu T, Asano Y, et al.

Journal of neurology 2024; (271(10)):6715-6723 doi:10.1007/s00415-024-12623-7.

Cryo-EM structure of a novel α-synuclein filament subtype from multiple system atrophy.

Yan NL, Candido F, Tse E, et al.

FEBS letters 2025; (599(1)):33-40 doi:10.1002/1873-3468.15048.

Bright middle cerebellar peduncle sign in multiple system atrophy with predominant cerebellar ataxia is more apparent in double-inversion recovery imaging than in conventional imaging.

Shiraishi W, Matsuyoshi A, Nakazawa Y, et al.

PloS one 2024; (19(11)):e0313651 doi:10.1371/journal.pone.0313651.

A strategic approach of the management of sleep-disordered breathing in multiple system atrophy.

Laga A, Bauters F, Hertegonne K, et al.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2025; (21(4)):703-711 doi:10.5664/jcsm.11472.

Multiple system atrophy related neurogenic bladder: mechanism and treatment.

Ren G, Wang Y, Tian H, et al.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2025; (46(5)):1965-1976 doi:10.1007/s10072-025-08002-3.

Palliative Care Need and Quality of Life Mediated by Psychological Distress in Neurologic Diseases.

Chan LML, Choi EPH, Lam WWT, et al.

Journal of pain and symptom management 2025; (69(6)):641-653.e3 doi:10.1016/j.jpainsymman.2025.03.004.

Prevalence of Supine Hypertension in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis.

Moss Lopes PR, Westphal Filho FL, Mendes Filho FSM, et al.

Movement disorders clinical practice 2025; (12(11)):1703-1713 doi:10.1002/mdc3.70142.

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes.

Wihan J, Battis K, Hoffmann A, et al.

Acta neuropathologica 2025; (150(1)):33 doi:10.1007/s00401-025-02933-z.