Research & Literature

Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part III: neurosurgical intervention in the first postnatal year.

Graf K, Kohl T, Neubauer BA, et al.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2016; (47(2)):158-61 doi:10.1002/uog.14937.

Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain.

Salbaum JM, Kruger C, MacGowan J, et al.

Scientific reports 2015; (5()):16917 doi:10.1038/srep16917.

Prevention of neural tube defects by the fortification of flour with folic acid: a population-based retrospective study in Brazil.

Santos LM, Lecca RC, Cortez-Escalante JJ, et al.

Bulletin of the World Health Organization 2016; (94(1)):22-9 doi:10.2471/BLT.14.151365.

CENTRAL NERVOUS SYSTEM LIGNOCAINE TOXICITY IN AN INFANT FOLLOWING VENTRICULO-PERITONEAL SHUNT AND SPINA BIFIDA REPAIR: A CASE REPORT.

Kituu N, Mugenya WO, Kituyi PW

East African medical journal 2012; (89(2)):71-2.

Fetoscopic versus Open Repair for Spina Bifida Aperta: A Systematic Review of Outcomes.

Joyeux L, Engels AC, Russo FM, et al.

Fetal diagnosis and therapy 2016; (39(3)):161-71 doi:10.1159/000443498.

Myelomeningocele - a single institute analysis of the years 2007 to 2015.

Januschek E, Röhrig A, Kunze S, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2016; (32(7)):1281-7 doi:10.1007/s00381-016-3079-1.

Spina bifida.

Copp AJ, Adzick NS, Chitty LS, et al.

Nature reviews. Disease primers 2015; (1()):15007 doi:10.1038/nrdp.2015.7.

Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: A retrospective study.

Eke CB, Uche EO, Chinawa JM, et al.

Annals of African medicine 2016; (15(3)):126-32 doi:10.4103/1596-3519.188892.

Research: Prevalence of neural tube defects Khartoum, Sudan August 2014-July 2015.

Omer IM, Abdullah OM, Mohammed IN, Abbasher LA

BMC research notes 2016; (9(1)):495 doi:10.1186/s13104-016-2298-6.

The Global Rise of Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization in Pediatric Hydrocephalus.

Dewan MC, Naftel RP

Pediatric neurosurgery 2017; (52(6)):401-408 doi:10.1159/000452809.

Fetoscopic Open Neural Tube Defect Repair: Development and Refinement of a Two-Port, Carbon Dioxide Insufflation Technique.

Belfort MA, Whitehead WE, Shamshirsaz AA, et al.

Obstetrics and gynecology 2017; (129(4)):734-743 doi:10.1097/AOG.0000000000001941.

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.

Sahakyan V, Duelen R, Tam WL, et al.

Scientific reports 2018; (8(1)):2942 doi:10.1038/s41598-018-21103-8.

Ultrasound and magnetic resonance imaging in the prenatal diagnosis of open spina bifida.

Micu R, Chicea AL, Bratu DG, et al.

Medical ultrasonography 2018; (20(2)):221-227 doi:10.11152/mu-1325.

[Spina bifida].

Mühl-Benninghaus R

Der Radiologe 2018; (58(7)):659-663 doi:10.1007/s00117-018-0401-9.

Analysis of Denver Neurodevelopmental Screening Test Results of Myelomeningocele, Hydrocephalus, and Microcephaly Patients.

Alatas I, Canaz G, Arslan G, et al.

Journal of pediatric neurosciences 2018; (13(1)):28-33 doi:10.4103/JPN.JPN_156_17.

Encouraging Results of Bowel and Bladder Management in Spina Bifida Aperta in South India with Quality of Life Scores in a Tertiary Care Institution in South India.

Kurian JJ, Jacob TJK, Mathai J

Journal of Indian Association of Pediatric Surgeons 2019; (24(1)):21-26 doi:10.4103/jiaps.JIAPS_195_17.

Real prevalence of neural tube defects in Japan: How many of such pregnancies have been terminated?

Kondo A, Akada S, Akiyama K, et al.

Congenital anomalies 2019; (59(4)):118-124 doi:10.1111/cga.12333.

MOMS Plus: Single-Institution Review of Outcomes for Extended BMI Criteria for Open Fetal Repair of Myelomeningocele.

Hilton SA, Hodges MM, Dewberry LC, et al.

Fetal diagnosis and therapy 2019; (46(6)):411-414 doi:10.1159/000499484.

Open fetal surgery for neural tube defects.

Moldenhauer JS, Flake AW

Best practice & research. Clinical obstetrics & gynaecology 2019; (58()):121-132 doi:10.1016/j.bpobgyn.2019.03.004.

Benchmarking against the MOMS Trial: Zurich Results of Open Fetal Surgery for Spina Bifida.

Möhrlen U, Ochsenbein-Kölble N, Mazzone L, et al.

Fetal diagnosis and therapy 2020; (47(2)):91-97 doi:10.1159/000500049.

Fetal surgery for spina bifida.

Dewan MC, Wellons JC

Journal of neurosurgery. Pediatrics 2019; (24(2)):105-114.

Ethical and Legal Dilemmas Around Termination of Pregnancy for Severe Fetal Hydrocephalus, Spina Bifida Aperta and Meningomyelocoella.

Cerovac A, Serak A, Zukic H, et al.

Medical archives (Sarajevo, Bosnia and Herzegovina) 2019; (73(2)):126-130 doi:10.5455/medarh.2019.73.126-130.

Detailed Analysis of Hydrocephalus and Hindbrain Herniation After Prenatal and Postnatal Myelomeningocele Closure: Report From a Single Institution.

Flanders TM, Heuer GG, Madsen PJ, et al.

Neurosurgery 2020; (86(5)):637-645 doi:10.1093/neuros/nyz302.

Care management and contemporary challenges in spina bifida: a practice preference survey of the American Society of Pediatric Neurosurgeons.

Alford EN, Hopson BD, Safyanov F, et al.

Journal of neurosurgery. Pediatrics 2019; (24(5)):539-548 doi:10.3171/2019.5.PEDS18738.

Concepts in the neurosurgical care of patients with spinal neural tube defects: An embryologic approach.

Blount JP, George TM, Koueik J, Iskandar BJ

Birth defects research 2019; (111(19)):1564-1576 doi:10.1002/bdr2.1588.

In utero Hepatitis B Immunization during Fetal Surgery for Spina Bifida.

Moehrlen U, Elrod J, Ochsenbein-Kölble N, et al.

Fetal diagnosis and therapy 2020; (47(4)):328-332 doi:10.1159/000503447.

Dynamic acetylation profile during mammalian neurulation.

Massa V, Avagliano L, Grazioli P, et al.

Birth defects research 2020; (112(2)):205-211 doi:10.1002/bdr2.1618.

Fetal surgical intervention for myelomeningocele: lessons learned, outcomes, and future implications.

Danzer E, Joyeux L, Flake AW, Deprest J

Developmental medicine and child neurology 2020; (62(4)):417-425 doi:10.1111/dmcn.14429.

Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes.

Zou J, Wang F, Yang X, et al.

Neural development 2020; (15(1)):8 doi:10.1186/s13064-020-00145-7.

Brain malformations and cognitive performance in spina bifida.

Schneider J, Mohr N, Aliatakis N, et al.

Developmental medicine and child neurology 2021; (63(3)):295-302 doi:10.1111/dmcn.14717.

Intracranial Translucency, Its Use as a Potential First Trimester Ultrasound Marker for Screening of Neural Tube Defects.

Sepúlveda-González G, Arroyo-Lemarroy T, Basurto D, et al.

Diagnostics (Basel, Switzerland) 2020; (10(11)) doi:10.3390/diagnostics10110986.

Neurosurgery guidelines for the care of people with spina bifida.

Blount JP, Bowman R, Dias MS, et al.

Journal of pediatric rehabilitation medicine 2020; (13(4)):467-477 doi:10.3233/PRM-200782.

Rotation flap closure of a giant dorsolumbar myelomeningocele: technical note.

Gomar-Alba M, Vargas-López AJ, Narro-Donate JM, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2021; (37(4)):1323-1326 doi:10.1007/s00381-020-05021-7.

Prenatal ultrasound diagnosis of neural tube defects in the era of intrauterine repair - Eleven years' experiences.

Huang YS, Lussier EC, Olisova K, et al.

Taiwanese journal of obstetrics & gynecology 2021; (60(2)):281-289 doi:10.1016/j.tjog.2021.01.006.

Experience of 300 cases of prenatal fetoscopic open spina bifida repair: report of the International Fetoscopic Neural Tube Defect Repair Consortium.

Sanz Cortes M, Chmait RH, Lapa DA, et al.

American journal of obstetrics and gynecology 2021; (225(6)):678.e1-678.e11 doi:10.1016/j.ajog.2021.05.044.

Fetal myelomeningocele repair: a narrative review of the history, current controversies and future directions.

Yamashiro KJ, Farmer DL

Translational pediatrics 2021; (10(5)):1497-1505 doi:10.21037/tp-20-87.

Correlation of fetal ventricular size and need for postnatal cerebrospinal fluid diversion surgery in open spina bifida.

Agrawal S, Al-Refai A, Abbasi N, et al.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2022; (59(6)):799-803 doi:10.1002/uog.24767.

Early Outcome of Endoscopic Third Ventriculostomy With Choroid Plexus Cauterization Versus Ventriculoperitoneal Shunt as Primary Treatment of Hydrocephalus in Children With Myelomeningocele: A Prospective Cohort Study.

Adebayo BO, Kanu OO, Bankole OB, et al.

Operative neurosurgery (Hagerstown, Md.) 2021; (21(6)):461-466 doi:10.1093/ons/opab314.

Hydrocephalus in Spina Bifida.

Blount JP, Maleknia P, Hopson BD, et al.

Neurology India 2021; (69(Supplement)):S367-S371 doi:10.4103/0028-3886.332247.

Neural tube defects: Different types and brief review of neurulation process and its clinical implication.

Ravi KS, Divasha , Hassan SB, et al.

Journal of family medicine and primary care 2021; (10(12)):4383-4390 doi:10.4103/jfmpc.jfmpc_904_21.

Fetoscopic Myelomeningocele Repair with Complete Release of the Tethered Spinal Cord Using a Three-Port Technique: Twelve-Month Follow-Up-A Case Report.

Pastuszka A, Zamłyński M, Horzelski T, et al.

Diagnostics (Basel, Switzerland) 2022; (12(12)) doi:10.3390/diagnostics12122978.

Advances in Fetal Surgical Repair of Open Spina Bifida.

Chmait RH, Monson MA, Chon AH

Obstetrics and gynecology 2023; (141(3)):505-521 doi:10.1097/AOG.0000000000005074.

Absence of a Hernia Sack in Patients Undergoing Prenatal Repair of Spina Bifida Increases the Risk of Developing Shunt-Dependent Hydrocephalus.

Pastuszka A, Koszutski T, Horzelska E, et al.

Diagnostics (Basel, Switzerland) 2023; (13(3)) doi:10.3390/diagnostics13030343.

Risk factors for shunting at 12 months following open fetal repair of spina bifida by mini-hysterotomy.

Neves da Rocha LS, Bunduki V, Cardeal DD, et al.

Journal of perinatal medicine 2023; (51(6)):792-797 doi:10.1515/jpm-2022-0212.

What has changed in pediatric neurosurgical care in spina bifida? A 30-year UAB/Children's of Alabama observational overview.

Blount JP, Hopson BD, Johnston JM, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2023; (39(7)):1791-1804 doi:10.1007/s00381-023-05938-9.

Motor function outcomes in children with open prenatal repair of Spina Bifida Aperta at 36-month follow-up: The Zurich cohort.

Brun B, Wille DA, Schauer SM, et al.

Journal of pediatric rehabilitation medicine 2023; (16(4)):595-604 doi:10.3233/PRM-220096.

Myelomeningocele: Long-Term Neurosurgical Management.

Marcati E, Meccariello G, Mastino L, et al.

Advances and technical standards in neurosurgery 2024; (49()):95-122 doi:10.1007/978-3-031-42398-7_6.

Antenatally diagnosed myelomeningocele with associated chiari ii malformation in the third trimester. A case report.

Arkorful J, Ackom S, Fiagbedzi E, et al.

Radiology case reports 2024; (19(12)):5990-5994 doi:10.1016/j.radcr.2024.09.045.

Parental Management Choices and Discordant Ultrasound Findings in Referrals for Fetal Spina Bifida.

Van den Eede E, Vergote S, Van der Veeken L, et al.

Prenatal diagnosis 2024; (44(13)):1628-1634 doi:10.1002/pd.6677.

Arnold-Chiari Malformations in Pediatric Patients After Fetal Surgery for Meningomyelocele.

Kohútková M, Horn F

Journal of clinical medicine 2024; (13(22)) doi:10.3390/jcm13226721.

Lumbosacral posterior meningocele in adult patient: a case report.

Wahid ATA, Abdulghani ZM, Al-Fatlawi N, Al-Badri SG

Journal of surgical case reports 2025; (2025(1)):rjaf018 doi:10.1093/jscr/rjaf018.

Initial experience with the anaesthetic management of fetoscopic spina bifida repair at a German University Hospital: A case series of 15 patients.

Schmitt N, Schubert AK, Wulf H, et al.

European journal of anaesthesiology and intensive care 2024; (3(2)):e0047 doi:10.1097/EA9.0000000000000047.

The first experience with 16 open microsurgical fetal surgeries for myelomeningocele in Germany.

El Damaty A, Elsässer M, Pfeifer U, et al.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2025; (55()):79-86 doi:10.1016/j.ejpn.2025.03.009.

Maternal-fetal surgery for myelomeningocele longitudinal follow-up model: Mitigation of care fragmentation through care coordination and outcomes reporting.

Castillo J, Locastro MM, Corroenne R, et al.

Journal of pediatric rehabilitation medicine 2025; (18(2)):146-154 doi:10.1177/18758894251331335.

Fold-and-fuse neurulation in zebrafish requires vangl2.

MacGowan J, Cardenas M, Williams MK

Developmental biology 2025; (524()):55-68 doi:10.1016/j.ydbio.2025.05.001.

Achieving water-tight open spina bifida closure through a novel three-port three-layer fetoscopic repair.

Bowman R, Alhajjat A, Muller R, et al.

American journal of obstetrics & gynecology MFM 2025; (7(7)):101697 doi:10.1016/j.ajogmf.2025.101697.

From Sheffield to the Management of Myelomeningocele Study: The Modern Era of Myelomeningocele Management.

Teasley DE, Adapa AR, Fogel H, et al.

World neurosurgery 2025; (199()):123985 doi:10.1016/j.wneu.2025.123985.

Foundations of Myelomeningocele Management: History, Embryology, Diagnosis, and Treatment of Myelomeningoceles Through the Sheffield Study.

Adapa AR, Teasley DE, Fogel H, Feldstein N

World neurosurgery 2025; (199()):123984 doi:10.1016/j.wneu.2025.123984.

Closing the Gap: Prenatal Repair and the Reimagined Future of Spina Bifida.

Aydin E, Peiro JL, Habli M

Clinical obstetrics and gynecology 2025; (68(3)):383-386 doi:10.1097/GRF.0000000000000960.

Reproductive outcomes following open maternal-fetal surgery for myelomeningocele closure: analysis of MOMS trial participants.

Moldenhauer JS, MacPherson C, Thom EA, et al.

American journal of obstetrics & gynecology MFM 2025; (7(11)):101765 doi:10.1016/j.ajogmf.2025.101765.

Spina bifida as a congenital neurodevelopmental condition: Developing a philosophy of health care transition across the lifespan.

Castillo J, Thibadeau JK, Witt E, et al.

Journal of pediatric rehabilitation medicine 2025; (18(4)):253-255 doi:10.1177/18758894251394504.

Double jeopardy in early infancy: aperta lipomyelomeningocele with Chiari II malformation complicated by infantile hypertrophic pyloric stenosis.

Kattamanchi D, Jayaraman K, Kamalakannan SK, Arun A

BMJ case reports 2025; (18(11)) doi:10.1136/bcr-2025-268860.

Cranial magnetic resonance imaging findings in 167 patients with spina bifida aperta: a retrospective study.

Sezen GB, Alataş İ, Saygı HM, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2025; (41(1)):374 doi:10.1007/s00381-025-07054-2.

Severe myelomeningocele in the fourth pregnancy of a 29-year-old woman: a case report.

Anghelina L, Şerbănescu MS, Gheonea C, et al.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2025; (66(3)):587-592 doi:10.47162/RJME.66.3.16.

Advances in Fetal Repair of Spina Bifida Integrating Prenatal Surgery, Stem Cells, and Biomaterials.

Evangelista A, Ruccolo L, Friuli V, et al.

Biomedicines 2026; (14(1)) doi:10.3390/biomedicines14010136.

Prenatal Closure of Myeloschisis vs Myelomeningocele: Insights From the fMMC Consortium Registry.

Hersh DS, Anuar A, Anadkat J, et al.

Neurosurgery 2026; doi:10.1227/neu.0000000000003954.