Research & Literature

Land use and soil type determine the presence of the pathogen Burkholderia pseudomallei in tropical rivers.

Ribolzi O, Rochelle-Newall E, Dittrich S, et al.

Environmental science and pollution research international 2016; (23(8)):7828-39 doi:10.1007/s11356-015-5943-z.

Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India.

Vandana KE, Mukhopadhyay C, Tellapragada C, et al.

PLoS neglected tropical diseases 2016; (10(4)):e0004610 doi:10.1371/journal.pntd.0004610.

Evaluation of the Bruker Biotyper Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry System for Identification of Clinical and Environmental Isolates of Burkholderia pseudomallei.

Wang H, Chen YL, Teng SH, et al.

Frontiers in microbiology 2016; (7()):415 doi:10.3389/fmicb.2016.00415.

Possible misidentification of species in the Pseudomonas fluorescens lineage as Burkholderia pseudomallei and Francisella tularensis, and emended descriptions of Pseudomonas brenneri,Pseudomonas gessardii and Pseudomonas proteolytica.

van den Beld MJC, Reinders E, Notermans DW, Reubsaet FAG

International journal of systematic and evolutionary microbiology 2016; (66(9)):3420-3425 doi:10.1099/ijsem.0.001206.

Loss of Methyltransferase Function and Increased Efflux Activity Leads to Doxycycline Resistance in Burkholderia pseudomallei.

Webb JR, Price EP, Currie BJ, Sarovich DS

Antimicrobial agents and chemotherapy 2017; (61(6)) doi:10.1128/AAC.00268-17.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the identification of Burkholderia pseudomallei from Asia and Australia and differentiation between Burkholderia species.

Suttisunhakul V, Pumpuang A, Ekchariyawat P, et al.

PloS one 2017; (12(4)):e0175294 doi:10.1371/journal.pone.0175294.

Entry, Intracellular Survival, and Multinucleated-Giant-Cell-Forming Activity of Burkholderia pseudomallei in Human Primary Phagocytic and Nonphagocytic Cells.

Whiteley L, Meffert T, Haug M, et al.

Infection and immunity 2017; (85(10)) doi:10.1128/IAI.00468-17.

A simple laboratory algorithm for diagnosis of melioidosis in resource-constrained areas: a study from north-central Vietnam.

Trinh TT, Hoang TS, Tran DA, et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018; (24(1)):84.e1-84.e4 doi:10.1016/j.cmi.2017.07.029.

Melioidosis in lower provincial Cambodia: A case series from a prospective study of sepsis in Takeo Province.

Schully KL, Berjohn CM, Prouty AM, et al.

PLoS neglected tropical diseases 2017; (11(9)):e0005923 doi:10.1371/journal.pntd.0005923.

Presence of Burkholderia pseudomallei in Soil and Paddy Rice Water in a Rice Field in Northeast Thailand, but Not in Air and Rainwater.

Ong CEL, Wongsuvan G, Chew JSW, et al.

The American journal of tropical medicine and hygiene 2017; (97(6)):1702-1705 doi:10.4269/ajtmh.17-0515.

Influence of Biochemical Features of Burkholderia pseudomallei Strains on Identification Reliability by Vitek 2 System.

Zakharova IB, Lopasteyskaya YA, Toporkov AV, Viktorov DV

Journal of global infectious diseases 2018; (10(1)):7-10 doi:10.4103/jgid.jgid_39_17.

Impact of nutritional stress on drug susceptibility and biofilm structures of Burkholderia pseudomallei and Burkholderia thailandensis grown in static and microfluidic systems.

Anutrakunchai C, Bolscher JGM, Krom BP, et al.

PloS one 2018; (13(3)):e0194946 doi:10.1371/journal.pone.0194946.

Burkholderia pseudomallei infection presenting with a lung abscess and osteomyelitis in an adult man: A case report.

Huang L, Yang Z, Zhou XP, Wu JR

Medicine 2018; (97(35)):e12145 doi:10.1097/MD.0000000000012145.

Clinical presentation and treatment of melioidosis in the head and neck region.

Mahawerawat K, Kasemsiri P

The Journal of laryngology and otology 2018; (132(9)):827-831 doi:10.1017/S0022215118001391.

Melioidosis in South Asia (India, Nepal, Pakistan, Bhutan and Afghanistan).

Mukhopadhyay C, Shaw T, Varghese GM, Dance DAB

Tropical medicine and infectious disease 2018; (3(2)) doi:10.3390/tropicalmed3020051.

Evaluation of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for identifying Burkholderia pseudomallei and Burkholderia thailandensis isolates.

Li J, Hu W, Zhang F, et al.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2019; (38(1)):191-196 doi:10.1007/s10096-018-3415-3.

Presence of Burkholderia pseudomallei in the 'Granary of Myanmar'.

Win TT, Su KK, Than AM, et al.

Tropical medicine and infectious disease 2019; (4(1)) doi:10.3390/tropicalmed4010008.

The Tunnel Sign Revisited: A Novel Observation of Cerebral Melioidosis Mimicking Sparganosis.

Peh WM, Hean GG, Clement YHR

Journal of radiology case reports 2018; (12(8)):1-11 doi:10.3941/jrcr.v12i8.3441.

Oral eradication therapy for melioidosis: Important but not without risks.

Sullivan RP, Ward L, Currie BJ

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2019; (80()):111-114 doi:10.1016/j.ijid.2019.01.019.

Clinical Manifestations, Antimicrobial Drug Susceptibility Patterns, and Outcomes in Melioidosis Cases, India.

Koshy M, Jagannati M, Ralph R, et al.

Emerging infectious diseases 2019; (25(2)):316-320 doi:10.3201/eid2502.170745.

Melioidosis with a subdural collection - a case report.

Amarasena HLP, Silva FHDS, Tilakaratna PMYI, et al.

BMC infectious diseases 2019; (19(1)):143 doi:10.1186/s12879-019-3782-0.

Melioidosis: misdiagnosed in Nepal.

Shrestha N, Adhikari M, Pant V, et al.

BMC infectious diseases 2019; (19(1)):176 doi:10.1186/s12879-019-3793-x.

Identification of Burkholderia pseudomallei by Use of the Vitek Mass Spectrometer.

Gassiep I, Armstrong M, Norton RE

Journal of clinical microbiology 2019; (57(5)) doi:10.1128/JCM.00081-19.

Burkholderia pseudomallei Lipopolysaccharide Genotype Does Not Correlate With Severity or Outcome in Melioidosis: Host Risk Factors Remain the Critical Determinant.

Webb JR, Sarovich DS, Price EP, et al.

Open forum infectious diseases 2019; (6(4)):ofz091 doi:10.1093/ofid/ofz091.

Infected aneurysm after returning from Southeast Asia: think Burkholderia pseudomallei!

Auvens C, Neuwirth C, Piroth L, Blot M

BMJ case reports 2019; (12(5)) doi:10.1136/bcr-2018-228856.

Quantitative Proteomics Reveals Differences in the Response of Neutrophils Isolated from Healthy or Diabetic Subjects to Infection with Capsule-Variant Burkholderia thailandensis.

Withatanung P, Kurian D, Tangjittipokin W, et al.

Journal of proteome research 2019; (18(7)):2848-2858 doi:10.1021/acs.jproteome.9b00166.

Fatal deep venous thrombosis and pulmonary embolism secondary to melioidosis in China: case report and literature review.

Wu H, Huang D, Wu B, et al.

BMC infectious diseases 2019; (19(1)):984 doi:10.1186/s12879-019-4627-6.

Hepatic/splenic abscess and/or skin and soft tissue infection as predictors of melioidosis in children.

Chanvitan S, Geater A, Laoprasopwattana K

Journal of infection in developing countries 2019; (13(2)):149-153 doi:10.3855/jidc.10727.

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia.

Virk HS, Mukhopadhyay C, Wiersinga WJ

Seminars in respiratory and critical care medicine 2020; (41(4)):496-508 doi:10.1055/s-0040-1710570.

A Comparison Between 12 Versus 20 Weeks of Trimethoprim-sulfamethoxazole as Oral Eradication Treatment for Melioidosis: An Open-label, Pragmatic, Multicenter, Non-inferiority, Randomized Controlled Trial.

Anunnatsiri S, Chaowagul W, Teparrukkul P, et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021; (73(11)):e3627-e3633 doi:10.1093/cid/ciaa1084.

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System.

Daryabor G, Atashzar MR, Kabelitz D, et al.

Frontiers in immunology 2020; (11()):1582 doi:10.3389/fimmu.2020.01582.

Burkholderia pseudomallei sepsis with osteoarticular melioidosis of the hip in a patient with diabetes mellitus.

Boyer PN, Woods ML

BMJ case reports 2020; (13(12)) doi:10.1136/bcr-2020-238200.

Antimicrobial Susceptibility of Western Hemisphere Isolates of Burkholderia pseudomallei: Phenotypic and Genomic Analyses.

Bugrysheva JV, Lascols C, McLaughlin HP, et al.

Microbial drug resistance (Larchmont, N.Y.) 2021; (27(9)):1176-1185 doi:10.1089/mdr.2020.0362.

Comparative virulence of three different strains of Burkholderia pseudomallei in an aerosol non-human primate model.

Trevino SR, Dankmeyer JL, Fetterer DP, et al.

PLoS neglected tropical diseases 2021; (15(2)):e0009125 doi:10.1371/journal.pntd.0009125.

Antibiotic susceptibility of clinical Burkholderia pseudomallei isolates in northeast Thailand during 2015-2018 and the genomic characterization of β-lactam-resistant isolates.

Fen SHY, Tandhavanant S, Phunpang R, et al.

Antimicrobial agents and chemotherapy 2023; (95(5)) doi:10.1128/AAC.02230-20.

Diagnosis of melioidosis: the role of molecular techniques.

Gassiep I, Burnard D, Bauer MJ, et al.

Future microbiology 2021; (16()):271-288 doi:10.2217/fmb-2020-0202.

Misidentification of Burkholderia pseudomallei, China.

Wu B, Tong X, He H, et al.

Emerging infectious diseases 2021; (27(3)):964-966 doi:10.3201/eid2703.191769.

The regulatory role of insulin in energy metabolism and leukocyte functions.

Cruz-Pineda WD, Parra-Rojas I, Rodríguez-Ruíz HA, et al.

Journal of leukocyte biology 2022; (111(1)):197-208 doi:10.1002/JLB.2RU1220-847R.

Geographical distribution of Burkholderia pseudomallei in soil in Myanmar.

Swe MMM, Win MM, Cohen J, et al.

PLoS neglected tropical diseases 2021; (15(5)):e0009372 doi:10.1371/journal.pntd.0009372.

Melioidosis in Critical Care: A Review.

Sridharan S, Princess IB, Ramakrishnan N

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2021; (25(Suppl 2)):S161-S165 doi:10.5005/jp-journals-10071-23837.

Nocardiosis in Immunocompromised Patients on Alternative Pneumocystis Prophylaxis.

Puing AG, Epstein DJ, Banaei N, et al.

Emerging infectious diseases 2021; (27(10)):2734-2736 doi:10.3201/eid2710.210620.

Generation of Distinct Differentially Culturable Forms of Burkholderia following Starvation at Low Temperature.

Auty JM, Jenkins CH, Hincks J, et al.

Microbiology spectrum 2022; (10(1)):e0211021 doi:10.1128/spectrum.02110-21.

Genomic Epidemiology Links Burkholderia pseudomallei from Individual Human Cases to B. pseudomallei from Targeted Environmental Sampling in Northern Australia.

Webb JR, Mayo M, Rachlin A, et al.

Journal of clinical microbiology 2022; (60(3)):e0164821 doi:10.1128/JCM.01648-21.

Burkholderia pseudomallei pathogenesis in human skin fibroblasts: A Bsa type III secretion system is involved in the invasion, multinucleated giant cell formation, and cellular damage.

Kaewpan A, Duangurai T, Rungruengkitkun A, et al.

PloS one 2022; (17(2)):e0261961 doi:10.1371/journal.pone.0261961.

The Epidemiology of Melioidosis and Its Association with Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Chowdhury S, Barai L, Afroze SR, et al.

Pathogens (Basel, Switzerland) 2022; (11(2)) doi:10.3390/pathogens11020149.

Laboratory Investigations in Patients with Community Acquired Sepsis and/or Pneumonia Caused by Burkholderia pseudomallei.

Behera B, Radhakrishnanan A, Mishra B, et al.

The American journal of tropical medicine and hygiene 2022;.

Analysis of the Clinical Characteristics of Hyponatremia Induced by Trimethoprim/Sulfamethoxazole.

Lei H, Liu X, Zeng J, et al.

Pharmacology 2022; (107(7-8)):351-358 doi:10.1159/000523824.

Comprehensive approaches for the detection of Burkholderia pseudomallei and diagnosis of melioidosis in human and environmental samples.

Oslan SNH, Yusoff AH, Mazlan M, et al.

Microbial pathogenesis 2022; (169()):105637 doi:10.1016/j.micpath.2022.105637.

TLR9 Negatively Regulates Intracellular Bacterial Killing by Pyroptosis in Burkholderia pseudomallei-Infected Mouse Macrophage Cell Line (Raw264.7).

Pudla M, Sanongkiet S, Ekchariyawat P, et al.

Microbiology spectrum 2022; (10(5)):e0348822 doi:10.1128/spectrum.03488-22.

The Risks of Using Trimethoprim/Sulfamethoxazole in Patients with Renal and Cardiac Compromise.

Hoffman AF, Lin TL

Journal of the American Podiatric Medical Association 2022; (112(5)).

Pathogenicity and virulence of Burkholderia pseudomallei.

Bzdyl NM, Moran CL, Bendo J, Sarkar-Tyson M

Virulence 2022; (13(1)):1945-1965 doi:10.1080/21505594.2022.2139063.

Workflow for Identification of Burkholderia pseudomallei Clinical Isolates in Myanmar.

Aung NM, Su KK, Chantratita N, Tribuddharat C

Japanese journal of infectious diseases 2023; (76(2)):106-112 doi:10.7883/yoken.JJID.2022.508.

Burkholderia pseudomallei in soil and natural water bodies in rural Sri Lanka: A hidden threat to public health.

Jayasinghearachchi HS, Muthugama TA, Masakorala J, et al.

Frontiers in veterinary science 2022; (9()):1045088 doi:10.3389/fvets.2022.1045088.

Craniospinal MRI Findings in Neuromelioidosis.

Naik S, Bhoi SK, Jha M, Kumar M

Neurology India 2023; (71(1)):113-118 doi:10.4103/0028-3886.370442.

Travel-associated melioidosis: a narrative review.

Norman FF, Chen LH

Journal of travel medicine 2023; (30(3)) doi:10.1093/jtm/taad039.

The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis.

Currie BJ, Meumann EM, Kaestli M

The American journal of tropical medicine and hygiene 2023; (108(6)):1081-1083 doi:10.4269/ajtmh.23-0223.

Melioidosis as a Mystique Infection: A Study From Central India.

Yadav V, Pawar A, Meena M, et al.

Cureus 2023; (15(8)):e43439 doi:10.7759/cureus.43439.

Burkholderia pseudomallei and melioidosis.

Meumann EM, Limmathurotsakul D, Dunachie SJ, et al.

Nature reviews. Microbiology 2024; (22(3)):155-169 doi:10.1038/s41579-023-00972-5.

Synchronous detection of Burkholderia pseudomallei and its ceftazidime resistance mutation based on RNase-HII hydrolysis combined with lateral flow strip assay.

Yao J, Zhang Z, Tian S, et al.

Microbiology spectrum 2023; (11(6)):e0112523 doi:10.1128/spectrum.01125-23.

Showing the limitations of available phenotypic assays to detect Burkholderia pseudomallei from clinical specimens in Nigeria.

Orababa OQ, Adesida SA, Peters RF, et al.

Access microbiology 2023; (5(10)) doi:10.1099/acmi.0.000604.v5.

The Epidemiological, Clinical, and Microbiological Features of Patients with Burkholderia pseudomallei Bacteraemia-Implications for Clinical Management.

Prinsloo C, Smith S, Law M, Hanson J

Tropical medicine and infectious disease 2023; (8(11)) doi:10.3390/tropicalmed8110481.

Development of neutropenic sepsis during the eradication phase with co-trimoxazole in patients with melioidosis: two case reports.

Jayaweera JAAS, Ranasinghe G

Germs 2023; (13(3)):266-272 doi:10.18683/germs.2023.1393.

Function of Burkholderia pseudomallei RpoS and RpoN2 in bacterial invasion, intracellular survival, and multinucleated giant cell formation in mouse macrophage cell line.

Diep DTH, Vong LB, Tungpradabkul S

Antonie van Leeuwenhoek 2024; (117(1)):39 doi:10.1007/s10482-024-01944-2.

A case of pulmonary melioidosis in Germany: a rare differential diagnosis in returning travelers from South-East Asia.

Gottschalk C, Stojković M, Zange S, et al.

Infection 2024; (52(5)):1671-1676 doi:10.1007/s15010-024-02253-6.

Dysfunctional host cellular immune responses are associated with mortality in melioidosis.

Wright SW, Ekchariyawat P, Sengyee S, et al.

Emerging microbes & infections 2024; (13(1)):2380822 doi:10.1080/22221751.2024.2380822.

Bone and joint infections due to melioidosis; diagnostic and management strategies to optimise outcomes.

Dadwal P, Bonner B, Fraser D, et al.

PLoS neglected tropical diseases 2024; (18(7)):e0012317 doi:10.1371/journal.pntd.0012317.

Phylogenetic and phenotypic characterization of Burkholderia pseudomallei isolates from Ghana reveals a novel sequence type and common phenotypes.

Schully KL, Voegtly LJ, Rice GK, et al.

Frontiers in microbiology 2024; (15()):1401259 doi:10.3389/fmicb.2024.1401259.

Multi-systemic melioidosis.

Nagoba BS, Dhotre SV, Rayate AS, et al.

World journal of clinical cases 2024; (12(28)):6151-6154 doi:10.12998/wjcc.v12.i28.6151.

Burkholderia pseudomallei BopE suppresses the Rab32-dependent defense pathway to promote its intracellular replication and virulence.

Rao C, Zhang Z, Qiao J, et al.

mSphere 2024; (9(11)):e0045324 doi:10.1128/msphere.00453-24.

Adverse reactions to trimethoprim/sulfamethoxazole for melioidosis eradication therapy: An evaluation of frequency and risk factors.

Martin GE, Bramwell J, Gadil E, et al.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2025; (150()):107283 doi:10.1016/j.ijid.2024.107283.

Trimethoprim-Sulfamethoxazole-Induced Pancytopenia: A Case Report.

Chahal J, Junko G

Cureus 2024; (16(12)):e75113 doi:10.7759/cureus.75113.

Drug-induced renal tubular acidosis in a patient receiving trimethoprim-sulfamethoxazole.

Tan HL, Ee SCE, Zhao Y, Lew PS

BMJ case reports 2025; (18(1)) doi:10.1136/bcr-2024-263500.

Hemophagocytic Lymphohistiocytosis Secondary to Melioidosis in Paediatric Patients: A Case Series.

Wan K, Liu Y, Chen Y, et al.

Infection and drug resistance 2025; (18()):1561-1566 doi:10.2147/IDR.S505259.

Melioidosis Presenting as Chronic Pneumonia With Soft Tissue Abscess in a Diabetic Patient Initially Treated for Tuberculosis: A Case Report From Vietnam.

Nguyen HQ, Doan TT, Do TV, et al.

Respirology case reports 2025; (13(6)):e70257 doi:10.1002/rcr2.70257.

Disseminated Melioidosis from a Ruptured Infective Aortic Aneurysm and Pedal Ulcers to Septic Arthritis and Osteomyelitis: A Case Report.

Jagan Sebastian J, Gnana Preethe B, Subramanian S

Vascular specialist international 2025; (41()):20 doi:10.5758/vsi.250025.

Rare Neuromelioidosis Case that Required Long Intensive Phase Therapy.

Ankala S, John T, Varghese B

Oman medical journal 2025; (40(3)):e760 doi:10.5001/omj.2025.14.

Pulmonary Melioidosis Masquerading As Tuberculosis: A Case Report Presenting a Rare Medical Condition From Western India.

Gaikwad N, Makashir PA, Kelkar R, et al.

Cureus 2025; (17(10)):e95272 doi:10.7759/cureus.95272.

Whole Genome Sequencing and Comparative Genomics of the Emerging Pathogen Burkholderia pseudomallei Isolated from Two Travel-Related Infections in Hungary.

Henczkó J, Tóth Á, Knausz M, et al.

Pathogens (Basel, Switzerland) 2025; (14(11)) doi:10.3390/pathogens14111108.

Treatment of Melioidosis.

Meumann EM, Rajahram G, Woolley SD, et al.

Infectious disease clinics of North America 2026; (40(1)):127-147 doi:10.1016/j.idc.2025.12.002.

Burkholderia pseudomallei in Sarawak, Malaysian Borneo, Remains Highly Susceptible to Trimethoprim-Sulfamethoxazole Despite Resistance to Its Individual Components.

Sumbu LL, Sia TL, Ooi MH, et al.

Pathogens (Basel, Switzerland) 2026; (15(1)) doi:10.3390/pathogens15010110.

Tunnel sign on magnetic resonance imaging in neuromelioidosis: A systematic literature review.

Gupta N, Singh S, Kumar TP, et al.

New microbes and new infections 2025; (68()):101639 doi:10.1016/j.nmni.2025.101639.