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Dermatology

What Autoimmune Diseases Are Linked to DH?

At a Glance

Dermatitis Herpetiformis (DH) increases your risk of developing other autoimmune conditions, most commonly Hashimoto's thyroiditis and Type 1 diabetes, due to shared genetics. Regular screenings, such as annual thyroid and blood sugar tests, are critical for early detection.

If you have Dermatitis Herpetiformis (DH), you have a higher likelihood of developing other autoimmune conditions. Because DH is the skin manifestation of celiac disease, it shares genetic roots and underlying immune system behaviors with several other autoimmune disorders [1][2]. The most common conditions associated with DH are autoimmune thyroid disease—specifically Hashimoto’s thyroiditis—and Type 1 diabetes [3].

Learning that you have an increased risk for other diseases can be stressful, but remember that these are just possibilities, not guarantees. Routine screening allows you to take charge of your health and catch any issues early.

The Connection Between DH and Other Autoimmune Diseases

When you have one autoimmune condition, your immune system is already predisposed to mistakenly attack healthy tissue [2]. Since DH and celiac disease are driven by a reaction to gluten, this immune system dysregulation slightly increases the chances of other organs being targeted [4].

The most frequently seen overlapping conditions include:

  • Autoimmune Thyroid Disease (Hashimoto’s): This condition causes your immune system to attack the thyroid gland, typically leading to hypothyroidism (an underactive thyroid that slows down your metabolism) [5]. Symptoms can include unexplained fatigue, feeling cold, weight gain, and dry skin. It is highly prevalent among individuals with celiac-related conditions [6].
  • Type 1 Diabetes: Unlike the more common Type 2 diabetes, Type 1 is an autoimmune disease where the body attacks the cells in the pancreas that produce insulin [3]. It shares a strong genetic link with celiac disease and DH [7]. Warning signs include excessive thirst, frequent urination, blurred vision, and unexplained weight loss.
  • Other Conditions: While less common, individuals may also have a slightly increased risk for Addison’s disease (which affects the adrenal glands and can cause extreme fatigue, dizziness, and darkening of the skin), vitiligo (loss of skin pigment), and psoriasis [7][8].

Routine Screening Recommendations

Because of these associations, long-term follow-up care for DH shouldn’t just focus on your skin and your gut. Preventative screening is an important part of your ongoing health plan, allowing doctors to detect new autoimmune issues before they cause significant symptoms [7].

As part of your routine monitoring, you should discuss establishing routine screening intervals with your care team, such as:

  • Annual TSH (Thyroid Stimulating Hormone) Test: A simple blood test that checks how well your thyroid is working [7].
  • Annual Blood Glucose Testing: A fasting blood sugar or A1C test to monitor your blood sugar levels and screen for diabetes [7].

(Note: Conditions like Addison’s disease are typically not part of standard annual blood panels; doctors usually only test for them if you develop specific physical symptoms.)

Remaining strictly on a gluten-free diet is essential for managing DH and healing your body [9]. However, research is mixed on whether a strict diet fully prevents the onset of other genetically linked autoimmune conditions. This is why staying vigilant through regular check-ups remains the best way to protect your long-term health.

Common questions in this guide

What other autoimmune diseases are associated with Dermatitis Herpetiformis?
The most common autoimmune diseases linked to Dermatitis Herpetiformis are autoimmune thyroid disease (Hashimoto's) and Type 1 diabetes. Less commonly, individuals may have an increased risk for Addison's disease, vitiligo, and psoriasis.
Why do people with DH get other autoimmune diseases?
When you have one autoimmune condition like DH, your immune system is already prone to mistakenly attacking healthy tissue. DH shares strong genetic roots and immune behaviors with celiac disease, making other organs more likely to be targeted.
What routine tests should I get if I have Dermatitis Herpetiformis?
Your doctor will likely recommend an annual TSH test to check your thyroid function and an annual A1C or fasting blood sugar test to monitor for diabetes. Discuss establishing a routine screening schedule with your care team.
Can a gluten-free diet prevent other autoimmune diseases if I have DH?
While a strict gluten-free diet is essential for managing DH and healing your body, research is mixed on whether it fully prevents other genetically linked autoimmune conditions. This is why regular check-ups remain critical.
What symptoms might indicate I have developed another autoimmune condition?
Symptoms such as unusual fatigue, feeling cold, sudden weight changes, excessive thirst, frequent urination, or blurred vision could indicate a new condition like thyroid disease or diabetes. Inform your doctor if you experience any of these signs.

Questions to Ask Your Doctor

Curated prompts to bring to your next appointment.

  1. 1.Given my DH diagnosis, do you recommend we set up a schedule for an annual TSH and A1C test, or would you suggest a different interval?
  2. 2.Should I be monitored by an endocrinologist for these autoimmune risks, or will you handle the screening as my primary care doctor?
  3. 3.Could any of the fatigue or skin issues I am currently experiencing be related to my thyroid rather than my DH?
  4. 4.Are there specific warning signs of Type 1 diabetes or Addison's disease that I should look out for between our appointments?

Questions For You

Tap a prompt to share your answer — we'll use it plus this page's context to start a tailored conversation.

References

References (9)
  1. 1

    Dermatitis herpetiformis: a cutaneous manifestation of coeliac disease.

    Collin P, Salmi TT, Hervonen K, et al.

    Annals of medicine 2017; (49(1)):23-31 doi:10.1080/07853890.2016.1222450.

    PMID: 27499257
  2. 2

    Genetic risk factors for type 1 diabetes.

    Pociot F, Lernmark Å

    Lancet (London, England) 2016; (387(10035)):2331-2339 doi:10.1016/S0140-6736(16)30582-7.

    PMID: 27302272
  3. 3

    Adrenal crisis in a 14-year-old boy 12 years after hematopoietic stem cell transplantation.

    Penger T, Albrecht A, Marx M, et al.

    Endocrinology, diabetes & metabolism case reports 2018; (2018()).

    PMID: 29899990
  4. 4

    S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV).

    Görög A, Antiga E, Caproni M, et al.

    Journal of the European Academy of Dermatology and Venereology : JEADV 2021; (35(6)):1251-1277 doi:10.1111/jdv.17183.

    PMID: 34004067
  5. 5

    Co-existence of type 1 diabetes and other autoimmune ailments in subjects with autoimmune thyroid disorders.

    Sharma H, Sahlot R, Purwar N, et al.

    Diabetes & metabolic syndrome 2022; (16(2)):102405 doi:10.1016/j.dsx.2022.102405.

    PMID: 35093687
  6. 6

    Coeliac disease is a risk factor for the development of seronegative arthritis in patients with autoimmune thyroid disease.

    Lupoli GA, Tasso M, Costa L, et al.

    Rheumatology (Oxford, England) 2021; (60(5)):2440-2447 doi:10.1093/rheumatology/keaa640.

    PMID: 33197262
  7. 7

    A patient diagnosed with new-onset type 1 diabetes and Addison's disease at initial presentation.

    Towslee E, Macdonald A, Shoar Z

    Endocrinology, diabetes & metabolism case reports 2024; (2024(2)).

    PMID: 38744309
  8. 8

    Sulfasalazine-induced generalized vitiligo in a patient with dermatitis herpetiformis and celiac disease.

    Turkowski Y, Konnikov N

    Dermatologic therapy 2019; (32(5)):e13007 doi:10.1111/dth.13007.

    PMID: 31237078
  9. 9

    Dermatitis herpetiformis.

    Salmi TT

    Clinical and experimental dermatology 2019; (44(7)):728-731 doi:10.1111/ced.13992.

    PMID: 31093998

This page provides educational information about conditions associated with Dermatitis Herpetiformis. It does not replace professional medical advice; always consult your healthcare provider to discuss routine screening and specific symptoms.

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