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PubMed This is a summary of 15 peer-reviewed journal articles Updated

Why Did I Develop a Breast Fibroadenoma? Hormones Explained

At a Glance

Most breast fibroadenomas have no known cause and are not caused by diet, exercise, stress, trauma, or lifestyle choices. They are benign growths of glandular and connective tissue that may swell with menstrual hormones, enlarge during pregnancy, and shrink after menopause.

It is completely natural to wonder if something you did caused your breast lump. The most important thing to know is that you did not cause your fibroadenoma. While the exact cause of most fibroadenomas remains unknown, there is no medical evidence that diet, exercise, stress, physical trauma, or lifestyle choices create these lumps [1][2]. Instead, a confirmed fibroadenoma is a benign (non-cancerous) overgrowth of normal breast tissue that often develops alongside the body’s natural hormonal signals [3][4].

(Note: A new or changing breast lump should always be properly evaluated by a doctor using a clinical exam, imaging, and sometimes a tissue biopsy. This confirms whether it is a fibroadenoma and rules out other conditions [5].)

What is a Fibroadenoma Made Of?

To understand why fibroadenomas form, it helps to know what they are made of. Medical professionals describe fibroadenomas as biphasic lesions, meaning they contain two different types of normal breast tissue [1][6]:

  • Epithelial (glandular) tissue: The functional parts of the breast, including the lobules that produce milk and the ducts that transport it.
  • Stromal tissue: The fibrous connective tissue that provides shape and support to the breast.

During normal breast development, these tissues grow together in a coordinated way. In a fibroadenoma, a cluster of these tissues grows slightly out of step with the surrounding area, forming a solid, benign lump [3].

The Role of Reproductive Hormones

Normal breast tissue is highly sensitive to reproductive hormones, particularly estrogen and progesterone. Because fibroadenomas are made of breast tissue, many of them are also hormone-responsive and contain receptors for these hormones [7][4]. While not every fibroadenoma will react the exact same way, they may change during different life stages [8]:

  • Puberty: Fibroadenomas most commonly appear during adolescence and early adulthood [9][10]. As hormone levels rise and the breasts develop, these signals can stimulate the glandular tissue to overgrow, causing a lump to become noticeable [10].
  • Menstrual Cycles: Because many are hormone-dependent, your fibroadenoma may swell, feel firmer, or become tender in the days leading up to your period. It will often soften or shrink slightly once your period begins [7][4].
  • Pregnancy and Breastfeeding (Lactation): The high hormone levels during pregnancy and lactation often cause existing fibroadenomas to grow larger [8][11]. Rarely, rapid growth during these times can cause the lump to temporarily outgrow its blood supply (a process called infarction). This complication is benign but can cause sudden tenderness, pain, or swelling [9][12]. Because sudden pain or swelling can also mimic other serious issues like an infection, it should always be evaluated by a doctor.
  • Hormonal Contraceptives: Some studies have noted an association between taking hormonal birth control and having fibroadenomas. However, this evidence is considered low-quality and does not definitively prove that contraceptives cause the lumps [13]. You should not stop taking prescribed birth control or hormone therapy solely because of a fibroadenoma; always discuss it with your doctor first.
  • Perimenopause and Menopause: When estrogen and progesterone levels naturally drop during the transition into menopause, fibroadenomas lose their primary hormonal signals. They often stop growing and may shrink or disappear completely on their own, a process known as spontaneous regression [14]. In some cases, they can persist into postmenopause, or hormone replacement therapy may affect them [15].

When to Contact Your Doctor

While a confirmed fibroadenoma is benign and hormone-related changes are common, you should not assume every change is harmless. Contact your doctor for a reassessment if you experience:

  • A new breast lump, especially if you are past menopause
  • Rapid enlargement of an existing lump
  • Persistent or severe breast pain
  • Skin changes (like dimpling or redness), unusual nipple discharge, or an enlarged underarm node

Common questions in this guide

What causes a breast fibroadenoma?
The exact cause of most breast fibroadenomas is unknown. They are benign overgrowths of normal glandular and connective breast tissue, and there is no evidence that diet, exercise, stress, physical trauma, or lifestyle choices create them.
Can hormones make a fibroadenoma grow or hurt?
Yes. Many fibroadenomas respond to estrogen and progesterone, so they may become larger, firmer, or more tender around a menstrual period. Pregnancy and breastfeeding can also make an existing fibroadenoma grow.
Does hormonal birth control cause fibroadenomas?
Some studies have found an association between hormonal birth control and fibroadenomas, but the evidence is limited and does not prove that birth control causes them. Do not stop prescribed birth control or hormone treatment without discussing it with your clinician.
Why does my fibroadenoma feel different before my period?
Hormone levels change throughout the menstrual cycle, and a hormone-responsive fibroadenoma may swell, feel firmer, or become tender before a period. It may soften or become slightly smaller once the period begins.
Should a new or rapidly growing breast lump be checked?
Yes. Even though a confirmed fibroadenoma is benign, a new, rapidly enlarging, persistently painful, or otherwise changing lump should be reassessed with a clinical examination and appropriate imaging, and sometimes a biopsy. Skin changes, unusual nipple discharge, or an enlarged underarm node also warrant medical review.

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References

References (15)
  1. 1

    Fibroepithelial lesions revisited: implications for diagnosis and management.

    Tan PH

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2021; (34(Suppl 1)):15-37 doi:10.1038/s41379-020-0583-3.

    PMID: 32461622
  2. 2

    Spontaneous infarction of fibroadenoma of breast-A case report with literature review.

    Salih AM, Kakamad FH

    International journal of surgery case reports 2016; (24()):1-3.

    PMID: 27163627
  3. 3

    Ductal carcinoma in situ arising from fibroadenoma; a rare case with review of literature.

    Hammood ZD, Mohammed SH, Abdulla BA, et al.

    Annals of medicine and surgery (2012) 2022; (75()):103449 doi:10.1016/j.amsu.2022.103449.

    PMID: 35386780
  4. 4

    Metformin as a new option in the medical management of breast fibroadenoma; a randomized clinical trial.

    Alipour S, Abedi M, Saberi A, et al.

    BMC endocrine disorders 2021; (21(1)):169 doi:10.1186/s12902-021-00824-4.

    PMID: 34416879
  5. 5

    Association of Paraoxonase 1 Gene Polymorphisms with the Risk of Breast Fibroadenoma and Breast Cancer in the Females of Guangxi, China.

    Chen K, Wang X, Li D, et al.

    Journal of healthcare engineering 2022; (2022()):3642799 doi:10.1155/2022/3642799.

    PMID: 35299679
  6. 6

    Fine needle aspiration biopsy cytology of phyllodes tumour and fibroadenoma: A cytomorphological study of 104 cases.

    Wang XY, Mahajan H, Dickinson N, et al.

    Diagnostic cytopathology 2018; (46(11)):927-935 doi:10.1002/dc.24021.

    PMID: 30284391
  7. 7

    Emerging biomarkers in breast fibroadenoma: implications for differential diagnosis, malignant transformation, and precision medicine.

    Ravi N, Sankar R, Mathavan A, et al.

    Molecular biology reports 2026; (53(1)).

    PMID: 42530698
  8. 8

    Fibroadenomas: a multidisciplinary review of the variants.

    Basara Akin I, Balci P

    Clinical imaging 2021; (71()):83-100 doi:10.1016/j.clinimag.2020.10.058.

    PMID: 33186871
  9. 9

    Spontaneous infarction of breast fibroadenoma unrelated to any known risk factor: A case report.

    Shrateh ON, Doudin DRA, Torman Y, Abulihya M

    International journal of surgery case reports 2023; (105()):108031 doi:10.1016/j.ijscr.2023.108031.

    PMID: 36965440
  10. 10

    Breast fibroadenomas: a review in the light of current literature.

    Salati SA

    Polski przeglad chirurgiczny 2020; (93(1)):40-48 doi:10.5604/01.3001.0014.5676.

    PMID: 33729177
  11. 11

    Giant breast fibroadenoma in pregnancy.

    Krhovský Miroslav, Pilka Radovan, Fait Vuk, Eim Josef

    Ceska gynekologie 2021; (86(2)):114-117 doi:10.48095/cccg2021114.

    PMID: 34020558
  12. 12

    Giant fibroadenoma with massive infarction masquerading as malignancy: a case report.

    Singh SK, Gupta P, Arora R, et al.

    International cancer conference journal 2017; (6(4)):167-170 doi:10.1007/s13691-017-0299-5.

    PMID: 31149495
  13. 13

    Defining Multiple Fibroadenomas: A Systematic Review of Clinical Characteristics and Management.

    Math P, Sajith G, Mahadevappa K, Hegde SG

    The breast journal 2026; (2026(1)):e5572826 doi:10.1155/tbj/5572826.

    PMID: 41919577
  14. 14

    Efficacy and Safety of Centchroman in the Treatment of Breast Fibroadenoma: A Systematic Review and Meta-Analysis.

    Kumar K, Pallavi K, Martand K, et al.

    Cureus 2025; (17(6)):e87046 doi:10.7759/cureus.87046.

    PMID: 40741574
  15. 15

    Fibroadenoma With Multiple Epidermal Inclusion Cysts Masquerading as Malignancy: An Underreported Entity With Review of Literature.

    Spoorthy Rekha YC, Ramachandra Rao RK, Sandeep S, Vivek TG

    International journal of surgical pathology 2025; (33(3)):753-756 doi:10.1177/10668969241283487.

    PMID: 39350750

This page is for informational purposes only and does not constitute medical advice. It explains hormonal changes in breast fibroadenomas, but any new, growing, painful, or changing breast lump should be assessed by a healthcare professional.