Research & Literature

Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative.

Matoba AY, Peterson JR, Wilhelmus KR

Ophthalmology 2016; (123(3)):451-6.

Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis.

Füst Á, Tóth J, Simon G, et al.

European journal of ophthalmology 2017; (27(1)):10-15 doi:10.5301/ejo.5000817.

Assessment of Confocal Microscopy for the Diagnosis of Polymerase Chain Reaction-Positive Acanthamoeba Keratitis: A Case-Control Study.

De Craene S, Knoeri J, Georgeon C, et al.

Ophthalmology 2018; (125(2)):161-168 doi:10.1016/j.ophtha.2017.08.037.

Reduction of Acanthamoeba Cyst Density Associated With Treatment Detected by In Vivo Confocal Microscopy in Acanthamoeba Keratitis.

Wang YE, Tepelus TC, Gui W, et al.

Cornea 2019; (38(4)):463-468 doi:10.1097/ICO.0000000000001857.

Polyquaternium-1-Associated Dendritiform Keratopathy.

Verkade A, Matoba AY

Cornea 2019; (38(4)):502-503 doi:10.1097/ICO.0000000000001885.

Acanthamoeba keratitis - Clinical signs, differential diagnosis and treatment.

Szentmáry N, Daas L, Shi L, et al.

Journal of current ophthalmology 2019; (31(1)):16-23 doi:10.1016/j.joco.2018.09.008.

Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis.

Dewan N, Ming W, Holland SP, et al.

Cornea 2019; (38(7)):914-917 doi:10.1097/ICO.0000000000001968.

Early Penetrating Keratoplasty À Chaud May Improve Outcome in Therapy-Resistant Acanthamoeba Keratitis.

Laurik KL, Szentmáry N, Daas L, et al.

Advances in therapy 2019; (36(9)):2528-2540 doi:10.1007/s12325-019-01031-3.

Acanthamoeba keratitis therapy: time to cure and visual outcome analysis for different antiamoebic therapies in 227 cases.

Papa V, Rama P, Radford C, et al.

The British journal of ophthalmology 2020; (104(4)):575-581 doi:10.1136/bjophthalmol-2019-314485.

The rising incidence of Acanthamoeba keratitis: A 7-year nationwide survey and clinical assessment of risk factors and functional outcomes.

Randag AC, van Rooij J, van Goor AT, et al.

PloS one 2019; (14(9)):e0222092 doi:10.1371/journal.pone.0222092.

Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review.

Höllhumer R, Keay L, Watson SL

Eye (London, England) 2020; (34(4)):725-732 doi:10.1038/s41433-019-0589-6.

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability.

Heaselgrave W, Hamad A, Coles S, Hau S

Translational vision science & technology 2019; (8(5)):17 doi:10.1167/tvst.8.5.17.

Oral miltefosine for refractory Acanthamoeba keratitis.

Hirabayashi KE, Lin CC, Ta CN

American journal of ophthalmology case reports 2019; (16()):100555 doi:10.1016/j.ajoc.2019.100555.

Natural Honey-Induced Acanthamoeba keratitis.

Peyman A, Pourazizi M, Peyman M, Kianersi F

Middle East African journal of ophthalmology 2019; (26(4)):243-245 doi:10.4103/meajo.MEAJO_56_18.

Topical Voriconazole as Supplemental Treatment for Acanthamoeba Keratitis.

Musayeva A, Riedl JC, Schuster AK, et al.

Cornea 2020; (39(8)):986-990 doi:10.1097/ICO.0000000000002315.

In Vivo Confocal Microscopy Morphologic Features and Cyst Density in Acanthamoeba Keratitis.

Chopra R, Mulholland PJ, Hau SC

American journal of ophthalmology 2020; (217()):38-48 doi:10.1016/j.ajo.2020.03.048.

A 5-Year Review of Acanthamoeba Keratitis Related to Wearing Contact Lenses in Korea.

Jo YJ, Jang SK, Lee J, Lee JS

Eye & contact lens 2020; (46(4)):223-227 doi:10.1097/ICL.0000000000000669.

An Optimized Most Probable Number (MPN) Method to Assess the Number of Thermophilic Free-Living Amoebae (FLA) in Water Samples.

Moussa M, Marcelino I, Richard V, et al.

Pathogens (Basel, Switzerland) 2020; (9(5)) doi:10.3390/pathogens9050409.

Investigation of the in vitro cysticidal activity of miltefosine against Acanthamoeba spp.

Chao M, Thongseesuksai T, Boonmars T, Laummaunwai P

Journal of parasitic diseases : official organ of the Indian Society for Parasitology 2020; (44(2)):491-495 doi:10.1007/s12639-020-01204-w.

Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis.

Thulasi P, Saeed HN, Rapuano CJ, et al.

American journal of ophthalmology 2021; (223()):75-82 doi:10.1016/j.ajo.2020.09.048.

Acanthamoeba keratitis: a review of biology, pathophysiology and epidemiology.

de Lacerda AG, Lira M

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 2021; (41(1)):116-135 doi:10.1111/opo.12752.

Acanthamoeba Keratitis: Perspectives for Patients.

Bonini S, Di Zazzo A, Varacalli G, Coassin M

Current eye research 2021; (46(6)):771-776 doi:10.1080/02713683.2020.1846753.

Topical corticosteroids in Acanthamoeba keratitis: Friend or foe?

Wouters KA, Verhoekx JS, van Rooij J, et al.

European journal of ophthalmology 2022; (32(1)):170-175 doi:10.1177/1120672120973606.

Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery.

Paik DW, Lim DH, Chung TY

The British journal of ophthalmology 2022; (106(4)):474-479 doi:10.1136/bjophthalmol-2020-317570.

Management of refractory Acanthamoeba keratitis, two cases.

Soleimani M, Latifi A, Momenaei B, et al.

Parasitology research 2021; (120(3)):1121-1124 doi:10.1007/s00436-020-06997-6.

Microbiological diagnosis of Acanthamoebic keratitis: experience from tertiary care center of North India.

Megha K, Sharma M, Gupta A, et al.

Diagnostic microbiology and infectious disease 2021; (100(2)):115339 doi:10.1016/j.diagmicrobio.2021.115339.

Topical Corticosteroids for Infectious Keratitis Before Culture-Proven Diagnosis.

Hirano K, Tanaka H, Kato K, Araki-Sasaki K

Clinical ophthalmology (Auckland, N.Z.) 2021; (15()):609-616 doi:10.2147/OPTH.S297202.

Bilateral Acanthamoeba keratitis with radial keratoneuritis - utility of AS-OCT in management and treatment.

Agarwal M, Asokan R, Therese KL, Lakshmipathy M

Clinical & experimental optometry 2021; (104(8)):871-873 doi:10.1080/08164622.2021.1878857.

Diagnosis of Acanthamoeba keratitis in Mashhad, Northeastern Iran: A Gene-Based PCR Assay.

Khosravinia N, Fata A, Moghaddas E, et al.

Iranian journal of parasitology 2021; (16(1)):111-121 doi:10.18502/ijpa.v16i1.5530.

Early therapeutic lamellar keratoplasty for acanthamoeba keratitis followed by implantable Collamer lens for visual rehabilitation.

Al-Motowa S, AlMutawa S, Al-Kadi T

Middle East African journal of ophthalmology 2020; (27(4)):244-246 doi:10.4103/meajo.meajo_557_20.

Acanthamoeba Keratitis - A Case Report.

Joshi LS, Gurung R

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH 2021; (13(25)):133-136 doi:10.3126/nepjoph.v13i1.29912.

[Confocal microscopy in the diagnosis of acanthamoeba keratitis].

Kasparova EA, Marchenko NR, Surnina ZV, Mitichkina TS

Vestnik oftalmologii 2021; (137(5. Vyp. 2)):201-208 doi:10.17116/oftalma2021137052201.

Impact of Acanthamoeba Keratitis on the Vision-Related Quality of Life of Contact Lens Wearers.

Carnt NA, Man REK, Fenwick EK, et al.

Cornea 2022; (41(2)):206-210 doi:10.1097/ICO.0000000000002901.

Outcomes of amoebic, fungal, and bacterial keratitis: A retrospective cohort study.

Moe CA, Lalitha P, Prajna NV, et al.

PloS one 2022; (17(2)):e0264021 doi:10.1371/journal.pone.0264021.

Risk factors, management, and outcomes of Acanthamoeba keratitis: A retrospective analysis of 110 cases.

Scruggs BA, Quist TS, Zimmerman MB, et al.

American journal of ophthalmology case reports 2022; (25()):101372 doi:10.1016/j.ajoc.2022.101372.

Acanthamoeba epitheliopathy: Importance of early diagnosis.

Li G, Shekhawat N

American journal of ophthalmology case reports 2022; (26()):101499 doi:10.1016/j.ajoc.2022.101499.

New Insights in Acanthamoeba.

Reyes-Batlle M, Sifaoui I, Rodríguez-Expósito RL, et al.

Pathogens (Basel, Switzerland) 2022; (11(5)) doi:10.3390/pathogens11050609.

Sandpaper curettage: A simple method to improve PDT outcomes for actinic keratosis.

Heusinkveld LE, Bullock TA, Negrey J, et al.

Photodiagnosis and photodynamic therapy 2022; (40()):103050 doi:10.1016/j.pdpdt.2022.103050.

The global epidemiology and clinical diagnosis of Acanthamoeba keratitis.

Zhang Y, Xu X, Wei Z, et al.

Journal of infection and public health 2023; (16(6)):841-852 doi:10.1016/j.jiph.2023.03.020.

The role of the calcofluor white staining in the diagnosis of Acanthamoeba keratitis.

Elhardt C, Schweikert R, Hartmann LM, et al.

Journal of ophthalmic inflammation and infection 2023; (13(1)):23 doi:10.1186/s12348-023-00345-2.

Diagnosis of Acanthamoeba Keratitis: Past, Present and Future.

Azzopardi M, Chong YJ, Ng B, et al.

Diagnostics (Basel, Switzerland) 2023; (13(16)) doi:10.3390/diagnostics13162655.

Diagnosing and monitoring the characteristics of Acanthamoeba keratitis using slit scanning and laser scanning in vivo confocal microscopy.

Curro-Tafili K, Verbraak FD, de Vries R, et al.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 2024; (44(1)):131-152 doi:10.1111/opo.13238.

Different Outcomes of Acanthamoeba Keratitis: A Case Series.

Lin H, Khaliddin N

Cureus 2023; (15(11)):e48129 doi:10.7759/cureus.48129.

Lactase can target cellular differentiation of Acanthamoeba castellanii belonging to the T4 genotype.

Simau FA, Ahmed U, Khan KM, et al.

Parasitology research 2024; (123(2)):117 doi:10.1007/s00436-024-08131-2.

Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection.

Petrillo F, Tortori A, Vallino V, et al.

Microorganisms 2024; (12(4)) doi:10.3390/microorganisms12040758.

Diagnostic utility of in vivo confocal microscopy in Acanthamoeba keratitis following corneal crosslinking.

Kong CF, Go C, Goolam S, Yeung S

BMJ case reports 2024; (17(5)) doi:10.1136/bcr-2023-257279.

The incidence of severe complications in acanthamoeba keratitis: Qualitative and quantitative systematic assessment.

Posarelli M, Passaro ML, Avolio FC, et al.

Survey of ophthalmology 2024; (69(5)):769-778 doi:10.1016/j.survophthal.2024.06.001.

Assessing PCR-Positive Acanthamoeba Keratitis-A Retrospective Chart Review.

Blaser F, Bajka A, Grimm F, et al.

Microorganisms 2024; (12(6)) doi:10.3390/microorganisms12061214.

Ophthalmic adverse effects of miltefosine in the treatment of leishmaniasis: a systematic review.

Pal B, Atem TD, Kumari S, et al.

Cutaneous and ocular toxicology 2024; (43(3)):190-197 doi:10.1080/15569527.2024.2380311.

Use of in vivo confocal microscopy in suspected Acanthamoeba keratitis: a 12-year real-world data study at a Swedish regional referral center.

Toba B, Lagali N

Journal of ophthalmic inflammation and infection 2024; (14(1)):43 doi:10.1186/s12348-024-00424-y.

Rethinking Keratoplasty for Patients with Acanthamoeba Keratitis: Early "Low Load Keratoplasty" in Contrast to Late Optical and Therapeutic Keratoplasty.

Abu Dail Y, Flockerzi E, Munteanu C, et al.

Microorganisms 2024; (12(9)) doi:10.3390/microorganisms12091801.

Fungal keratitis complicating the diagnosis of Acanthamoeba keratitis.

Atighehchian M, Latifi A, Nozarian Z, et al.

Medical mycology case reports 2025; (47()):100687 doi:10.1016/j.mmcr.2024.100687.

In Vitro Efficacy of Miltefosine Against Clinical Isolates of Acanthamoeba spp. from Patients with Keratitis.

Gowtham L, Sharma S, Bagga B

Seminars in ophthalmology 2025; (40(8)):767-774 doi:10.1080/08820538.2025.2467272.

Photodynamic therapy combined with curettage for actinic keratosis on the face and scalp: An efficient treatment for field cancerization of the skin.

Zhang C, Wang T, Lu W, et al.

Photodiagnosis and photodynamic therapy 2025; (53()):104553 doi:10.1016/j.pdpdt.2025.104553.

Acanthamoeba Keratitis Management and Prognostic Factors: A Systematic Review.

Marques-Couto P, Monteiro M, Ferreira AM, et al.

Journal of clinical medicine 2025; (14(7)) doi:10.3390/jcm14072528.

Combined Trans-Epithelial PRK and PTK for Treatment of Corneal Opacity Following Acanthamoeba Keratitis: A Case Report.

Buonamassa R, Addabbo G, Pignatelli F, et al.

International medical case reports journal 2025; (18()):629-635 doi:10.2147/IMCRJ.S495729.

Polihexanide (PHMB) 0.08% versus currently used treatments for Acanthamoeba keratitis: indirect treatment comparisons.

Papa V, Galeone C, De Francesco M, et al.

BMJ open ophthalmology 2025; (10(1)) doi:10.1136/bmjophth-2024-002082.

Diagnostic Accuracy of Clinic-Based Loop-Mediated Isothermal Amplification and Quantitative PCR for Fungal and Acanthamoeba Keratitis.

Cao B, Vu CHV, Le CX, et al.

Cornea 2025; doi:10.1097/ICO.0000000000003944.

Optimizing early diagnosis and treatment of acanthamoeba keratitis through corneal scraping.

Chang WH, Kuo YW, Hou YC

Journal of optometry 2026; (19(1)):100566 doi:10.1016/j.optom.2025.100566.

Retrospective study of Acanthamoeba keratitis: Three-year experience with an integrated clinical and diagnostic workflow.

Ortalli M, Moramarco A, Versura P, et al.

Diagnostic microbiology and infectious disease 2026; (114(4)):117247 doi:10.1016/j.diagmicrobio.2025.117247.

Nested PCR as a superior diagnostic method for Acanthamoeba keratitis compared to conventional techniques.

Khaksar S, Latifi A, Mohebali M, et al.

Scientific reports 2026; (16(1)):3502 doi:10.1038/s41598-025-32716-1.