Research & Literature

Burden of Illness in Hereditary Angioedema: A Conceptual Model.

Bygum A, Aygören-Pürsün E, Beusterien K, et al.

Acta dermato-venereologica 2015; (95(6)):706-10 doi:10.2340/00015555-2014.

A nationwide survey of hereditary angioedema due to C1 inhibitor deficiency in Italy.

Zanichelli A, Arcoleo F, Barca MP, et al.

Orphanet journal of rare diseases 2015; (10()):11 doi:10.1186/s13023-015-0233-x.

Perioperative management for patients with hereditary angioedema.

Williams AH, Craig TJ

Allergy & rhinology (Providence, R.I.) 2015; (6(1)):50-5 doi:10.2500/ar.2015.6.0112.

The Janus faces of acquired angioedema: C1-inhibitor deficiency, lymphoproliferation and autoimmunity.

Wu MA, Castelli R

Clinical chemistry and laboratory medicine 2016; (54(2)):207-14.

Predictors of Airway Intervention in Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema.

Kieu MC, Bangiyev JN, Thottam PJ, Levy PD

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2015; (153(4)):544-50 doi:10.1177/0194599815588909.

High prevalence of splenic marginal zone lymphoma among patients with acquired C1 inhibitor deficiency.

Castelli R, Wu MA, Arquati M, et al.

British journal of haematology 2016; (172(6)):902-8 doi:10.1111/bjh.13908.

Acquired C1 esterase inhibitor deficiency in lymphomas: prevalence, symptoms, and response to treatment.

Bekos C, Perkmann T, Krauth M, et al.

Leukemia & lymphoma 2016; (57(9)):2033-6 doi:10.3109/10428194.2015.1131273.

Hereditary and acquired C1-inhibitor-dependent angioedema: from pathophysiology to treatment.

Zeerleder S, Levi M

Annals of medicine 2016; (48(4)):256-67 doi:10.3109/07853890.2016.1162909.

Icatibant as acute treatment for hereditary angioedema in adults.

Farkas H

Expert review of clinical pharmacology 2016; (9(6)):779-88 doi:10.1080/17512433.2016.1182425.

"Nuts and Bolts" of Laboratory Evaluation of Angioedema.

Farkas H, Veszeli N, Kajdácsi E, et al.

Clinical reviews in allergy & immunology 2016; (51(2)):140-51 doi:10.1007/s12016-016-8539-6.

Novelties in the Diagnosis and Treatment of Angioedema.

Cicardi M, Suffritti C, Perego F, Caccia S

Journal of investigational allergology & clinical immunology 2016; (26(4)):212-21; quiz two pages after page 221 doi:10.18176/jiaci.0087.

A nationwide study of acquired C1-inhibitor deficiency in France: Characteristics and treatment responses in 92 patients.

Gobert D, Paule R, Ponard D, et al.

Medicine 2016; (95(33)):e4363 doi:10.1097/MD.0000000000004363.

Perioperative course in patients with hereditary or acquired angioedema.

MacBeth LS, Volcheck GW, Sprung J, Weingarten TN

Journal of clinical anesthesia 2016; (34()):385-91.

Comparing acquired angioedema with hereditary angioedema (types I/II): findings from the Icatibant Outcome Survey.

Longhurst HJ, Zanichelli A, Caballero T, et al.

Clinical and experimental immunology 2017; (188(1)):148-153 doi:10.1111/cei.12910.

Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis.

Banerji A, Busse P, Shennak M, et al.

The New England journal of medicine 2017; (376(8)):717-728 doi:10.1056/NEJMoa1605767.

Anabolic androgen use in the management of hereditary angioedema: Not so cheap after all.

Tse KY, Zuraw BL, Chen Q, Christiansen SC

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2017; (118(4)):456-460.e1 doi:10.1016/j.anai.2017.01.015.

Diagnosis, Course, and Management of Angioedema in Patients With Acquired C1-Inhibitor Deficiency.

Zanichelli A, Azin GM, Wu MA, et al.

The journal of allergy and clinical immunology. In practice 2017; (5(5)):1307-1313 doi:10.1016/j.jaip.2016.12.032.

Angioedema.

Hahn J, Hoffmann TK, Bock B, et al.

Deutsches Arzteblatt international 2017; (114(29-30)):489-496.

Refractory Abdominal Pain in a Patient with Chronic Lymphocytic Leukemia: Be Wary of Acquired Angioedema due to C1 Esterase Inhibitor Deficiency.

Abdulkareem A, D'Souza RS, Mundorff J, et al.

Case reports in hematology 2018; (2018()):7809535 doi:10.1155/2018/7809535.

[Acquired C1 esterase inhibitor deficiency via bradykinin-mediated angioedema: Four cases].

Jacquin-Porretaz C, Castelain F, Daguindau E, et al.

Annales de dermatologie et de venereologie 2018; (145(10)):598-602 doi:10.1016/j.annder.2018.02.012.

[Allergic emergencies].

Herr AC, Biedermann T, Brockow K

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 2018; (69(5)):352-363 doi:10.1007/s00105-018-4163-0.

Angioedema and emergency medicine: From pathophysiology to diagnosis and treatment.

Depetri F, Tedeschi A, Cugno M

European journal of internal medicine 2019; (59()):8-13 doi:10.1016/j.ejim.2018.09.004.

Deletions in SERPING1 Lead to Lower C1 Inhibitor Function: Lower C1 Inhibitor Function Can Predict Disease Severity.

Mete Gökmen N, Gülbahar O, Onay H, et al.

International archives of allergy and immunology 2019; (178(1)):50-59 doi:10.1159/000492583.

Nine year follow-up of a rare case of angioedema due to acquired C1-inhibitor deficiency with late onset and good response to attenuated androgen.

Leru PM, Anton VF, Bumbea H

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2018; (14()):69 doi:10.1186/s13223-018-0274-5.

Angioedema due to acquired C1-inhibitor deficiency: spectrum and treatment with C1-inhibitor concentrate.

Bork K, Staubach-Renz P, Hardt J

Orphanet journal of rare diseases 2019; (14(1)):65 doi:10.1186/s13023-019-1043-3.

Acquired C1-inhibitor deficiency presenting with nephrotic syndrome.

Willows J, Wood K, Bourne H, Sayer JA

BMJ case reports 2019; (12(7)) doi:10.1136/bcr-2019-230388.

Evaluation and Management of Angioedema in the Emergency Department.

Long BJ, Koyfman A, Gottlieb M

The western journal of emergency medicine 2019; (20(4)):587-600 doi:10.5811/westjem.2019.5.42650.

Update on bradykinin-mediated angioedema in 2020.

Lepelley M, Bernardeau C, Defendi F, et al.

Therapie 2020; (75(2)):195-205 doi:10.1016/j.therap.2020.02.011.

Acquired C1-inhibitor deficiency due to splenic marginal zone lymhoma: Case Report.

Verschueren J, Schrijvers R, Goffin KE, et al.

Acta clinica Belgica 2021; (76(5)):402-405 doi:10.1080/17843286.2020.1746552.

Patterns of C1-Inhibitor/Plasma Serine Protease Complexes in Healthy Humans and in Hereditary Angioedema Patients.

Kajdácsi E, Jandrasics Z, Veszeli N, et al.

Frontiers in immunology 2020; (11()):794 doi:10.3389/fimmu.2020.00794.

[Acquired angioedema due to C1-inhibitor deficiency: CREAK recommendations for diagnosis and treatment].

Gobert D, Bouillet L, Armengol G, et al.

La Revue de medecine interne 2020; (41(12)):838-842 doi:10.1016/j.revmed.2020.06.010.

A follow-up survey of patients with acquired angioedema due to C1-inhibitor deficiency.

Pólai Z, Balla Z, Andrási N, et al.

Journal of internal medicine 2021; (289(4)):547-558 doi:10.1111/joim.13182.

Acquired Angioedema with C1 Inhibitor Deficiency: Occurrence, Clinical Features, and Management: A Nationwide Retrospective Study in the Czech Republic Patients.

Sobotkova M, Zachova R, Hakl R, et al.

International archives of allergy and immunology 2021; (182(7)):642-649 doi:10.1159/000512933.

Prophylactic Treatment in Hereditary Angioedema Is Associated with Reduced Anxiety in Patients in Leipzig, Germany.

Zarnowski J, Rabe M, Kage P, et al.

International archives of allergy and immunology 2021; (182(9)):819-826 doi:10.1159/000514973.

Where we are with acquired angioedema due to C1 inhibitor deficiency: A systematic literature review.

Shi Y, Wang C

Clinical immunology (Orlando, Fla.) 2021; (230()):108819 doi:10.1016/j.clim.2021.108819.

Acquired angioedema in B cell lymphoproliferative disease: A retrospective case series.

Wonnaparhown A, Stefanovic A, Lugar P, Hostetler HP

Clinical and experimental immunology 2021; (206(3)):378-383 doi:10.1111/cei.13667.

Resolution of Laryngeal Oedema in a Patient with Acquired C1-Inhibitor Deficiency. a Case Report.

Bara NA, Nadasan V

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) 2021; (7(2)):136-140 doi:10.2478/jccm-2021-0003.

Angioedema Due to Acquired Deficiency of C1-Inhibitor: A Cohort Study in Spain and a Comparison With Other Series.

Baeza ML, González-Quevedo T, Caballero T, et al.

The journal of allergy and clinical immunology. In practice 2022; (10(4)):1020-1028 doi:10.1016/j.jaip.2021.11.018.

Anesthetic management of a patient with acquired angioedema submitted to broncofibroscopy: a case report.

Barata M, Marques A, Tiago C, et al.

Brazilian journal of anesthesiology (Elsevier) 2023; (73(4)):500-502 doi:10.1016/j.bjane.2021.11.007.

Longitudinal experience with treatment of acquired angioedema using tranexamic acid.

Kesh S, Singh U, Bernstein JA

Allergy and asthma proceedings 2022; (43(5)):413-418 doi:10.2500/aap.2022.43.220043.

Presentation of an extraordinary colic: abdominal pain as the first and only utterance of an acquired C1-inhibitor deficiency.

Hanevelt J, de Vos Tot Nederveen Cappel WH

BMJ case reports 2022; (15(10)) doi:10.1136/bcr-2022-250710.

A Rare Case Report of Sitagliptin-Induced Angioedema.

Sharma NR, Sharma B, Lamichhane S, et al.

Cureus 2022; (14(10)):e30077 doi:10.7759/cureus.30077.

Long term follow-up of complement parameters to improve the management of acquired angioedema due to C1-inhibitor deficiency.

Polai Z, Balla Z, Varga L, et al.

Heliyon 2022; (8(11)):e11292 doi:10.1016/j.heliyon.2022.e11292.

Content validation and psychometric evaluation of the Angioedema Quality of Life Questionnaire for hereditary angioedema.

Vanya M, Watt M, Shahraz S, et al.

Journal of patient-reported outcomes 2023; (7(1)):33 doi:10.1186/s41687-023-00576-w.

Biochemistry, molecular genetics, and clinical aspects of hereditary angioedema with and without C1 inhibitor deficiency.

Miyata T, Horiuchi T

Allergology international : official journal of the Japanese Society of Allergology 2023; (72(3)):375-384 doi:10.1016/j.alit.2023.04.004.

Efficacy and Safety of Rituximab-Based Treatments in Angioedema With Acquired C1-Inhibitor Deficiency.

Kalmi G, Nguyen Y, Amarger S, et al.

The journal of allergy and clinical immunology. In practice 2024; (12(1)):212-222 doi:10.1016/j.jaip.2023.10.017.

Pseudo-Allergies in the Emergency Department: A Common Misdiagnosis of Hypersensitivity Type 1 Allergic Reaction.

Eraky AM, Wright A, McDonald D

Cureus 2023; (15(10)):e46536 doi:10.7759/cureus.46536.

Comorbidities in Angioedema Due to C1-Inhibitor Deficiency: An Italian Survey.

Zanichelli A, Senter R, Merlo A, et al.

The journal of allergy and clinical immunology. In practice 2024; (12(4)):1029-1036 doi:10.1016/j.jaip.2023.12.046.

Acquired Angioedema and Chronic Lymphocytic Leukemia: Unraveling the Complex Interplay and Addressing Refractory Cases.

Shah D, Rishi R

Cureus 2023; (15(12)):e50238 doi:10.7759/cureus.50238.

Acquired Angioedema Associated with Lymphoproliferative Disorders.

Ng JY, Ooi M, Bennett SK, et al.

Case reports in oncology 2024; (17(1)):329-336 doi:10.1159/000536458.

Isolated Laryngeal Angioedema in a Patient with Long-term ACE Inhibitor Use: A Case Report.

Flinn C, Massaro I

Clinical practice and cases in emergency medicine 2024; (8(1)):18-21 doi:10.5811/cpcem.1565.

Angioedema due to Acquired C1-Inhibitor Deficiency Associated With Monoclonal Gammopathies of Undetermined Significance Characteristics of a French National Cohort.

Lahuna C, Defendi F, Bouillet L, et al.

The journal of allergy and clinical immunology. In practice 2024; (12(12)):3283-3291 doi:10.1016/j.jaip.2024.09.016.

A multi-centre UK-based survey on angioedema secondary to acquired C1 inhibitor deficiency.

Morsi H, Huissoon A, Grammatikos A, et al.

Clinical and experimental immunology 2025; (219(1)) doi:10.1093/cei/uxae121.

Angioedema Due to Acquired C1-Inhibitor Deficiency Without Hematological Condition: A Multicenter French Cohort Study of 34 Patients.

Stammler R, Defendi F, Aubineau M, et al.

The journal of allergy and clinical immunology. In practice 2025; (13(3)):542-550.e2 doi:10.1016/j.jaip.2024.12.027.

Angioedema Shortly After Adding Empagliflozin to Losartan.

Duodu P, Aiad M, Deeb M, et al.

Cureus 2025; (17(1)):e78033 doi:10.7759/cureus.78033.

Acquired Angioedema as the First Sign of Lymphoproliferative Disorder: Case Report and Review of Literature.

Cardenas Rosales JC, Ridwan A, Ruiz-Orasma C, et al.

Journal of primary care & community health 2025; (16()):21501319251360500 doi:10.1177/21501319251360500.

Bradykinin-Mediated Angioedema Induced by Drugs.

Suffritti C, Chan S, Ferrara AL, et al.

Journal of clinical medicine 2025; (14(16)) doi:10.3390/jcm14165712.

A hidden clue behind angioedema in an elderly patient.

Cetin O, Toprak ID, Kemec G, et al.

Oxford medical case reports 2025; (2025(9)):omaf157 doi:10.1093/omcr/omaf157.

Recurrent Airway Swelling in a Patient With Lymphoproliferative Disorder: A Diagnostic Challenge Between Anaphylaxis and Acquired Angioedema.

Nahid MH, Khan B, Munshi R

Cureus 2025; (17(11)):e96070 doi:10.7759/cureus.96070.

Acquired Angioedema Associated With Systemic Lupus Erythematosus Presenting as Acute Abdomen: A Case Report.

Shiota S, Kodama S, Tahara K

Journal of general and family medicine 2026; (27(3)):e70116 doi:10.1002/jgf2.70116.

Acquired angioedema due to C1 inhibitor deficiency: real-world clinical characteristics and treatment outcomes.

Toprak İD, Erdem S, Korkmaz P, et al.

Frontiers in immunology 2026; (17()):1836363 doi:10.3389/fimmu.2026.1836363.

[Clinical presentation and diagnosis of bradykinin-mediated angioedema].

Trainotti S, Lippert U

Dermatologie (Heidelberg, Germany) 2026; (77(9)):584-592 doi:10.1007/s00105-026-05760-9.