Research & Literature

Coagulation factor XIII: a multifunctional transglutaminase with clinical potential in a range of conditions.

Dickneite G, Herwald H, Korte W, et al.

Thrombosis and haemostasis 2015; (113(4)):686-97 doi:10.1160/TH14-07-0625.

Report of a patient with chronic intractable autoimmune hemorrhaphilia due to anti-factor XIII/13 antibodies who died of hemorrhage after sustained clinical remission for 3 years.

Kotake T, Souri M, Takada K, et al.

International journal of hematology 2015; (101(6)):598-602 doi:10.1007/s12185-015-1754-8.

Anti-factor XIII A subunit (FXIII-A) autoantibodies block FXIII-A2 B2 assembly and steal FXIII-A from native FXIII-A2 B2.

Souri M, Osaki T, Ichinose A

Journal of thrombosis and haemostasis : JTH 2015; (13(5)):802-14 doi:10.1111/jth.12877.

The Non-catalytic B Subunit of Coagulation Factor XIII Accelerates Fibrin Cross-linking.

Souri M, Osaki T, Ichinose A

The Journal of biological chemistry 2015; (290(19)):12027-39 doi:10.1074/jbc.M114.608570.

Clinical features of 32 new Japanese cases with autoimmune haemorrha-philia due to anti-factor XIII antibodies.

Ichinose A, Osaki T, Souri M,

Haemophilia : the official journal of the World Federation of Hemophilia 2015; (21(5)):653-8 doi:10.1111/hae.12677.

Measurement of factor XIII (FXIII) activity by an automatic ammonia release assay using iodoacetamide blank-procedure: no more overestimation in the low activity range and better detection of severe FXIII deficiencies.

Cini M, Legnani C, Frascaro M, et al.

Clinical chemistry and laboratory medicine 2016; (54(5)):805-9.

Diagnosis and Management of Congenital and Acquired FXIII Deficiencies.

Muszbek L, Katona É

Seminars in thrombosis and hemostasis 2016; (42(4)):429-39 doi:10.1055/s-0036-1572326.

Diagnosis of factor XIII deficiency.

Dorgalaleh A, Tabibian S, Hosseini MS, et al.

Hematology (Amsterdam, Netherlands) 2016; (21(7)):430-9 doi:10.1080/10245332.2015.1101975.

Compaction of fibrin clots reveals the antifibrinolytic effect of factor XIII.

Rijken DC, Abdul S, Malfliet JJ, et al.

Journal of thrombosis and haemostasis : JTH 2016; (14(7)):1453-61 doi:10.1111/jth.13354.

Acquired Factor XIII Inhibitor in Hospitalized and Perioperative Patients: A Systematic Review of Case Reports and Case Series.

Tone KJ, James TE, Fergusson DA, et al.

Transfusion medicine reviews 2016; (30(3)):123-31.

Laboratory Diagnosis of Factor XIII Deficiency, Routine Coagulation Tests with Quantitative and Qualitative Methods.

Dorgalaleh A, Kazemi A, Zaker F, et al.

Clinical laboratory 2016; (62(4)):491-8 doi:10.7754/clin.lab.2015.150619.

Autoimmune acquired factor XIII deficiency due to anti-factor XIII/13 antibodies: A summary of 93 patients.

Ichinose A,

Blood reviews 2017; (31(1)):37-45 doi:10.1016/j.blre.2016.08.002.

Defective α2 antiplasmin cross-linking and thrombus stability in a case of acquired factor XIII deficiency.

Mitchell JL, Wright S, Kazi S, et al.

British journal of haematology 2017; (178(5)):794-799 doi:10.1111/bjh.14759.

Treatment of an acquired Factor XIII inhibitor in an adolescent with systemic lupus erythematosus and renal failure.

Rabik CA, Atkinson MA, Sule S, Strouse JJ

Transfusion 2017; (57(9)):2159-2163 doi:10.1111/trf.14185.

Lobar Hemorrhage Induced by Acquired Factor XIII Deficiency in a Patient with Cerebral Amyloid Angiopathy.

Arishima H, Neishi H, Kikuta KI, et al.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017; (26(10)):e203-e205 doi:10.1016/j.jstrokecerebrovasdis.2017.07.009.

Intracranial hemorrhage in congenital bleeding disorders.

Tabibian S, Motlagh H, Naderi M, Dorgalaleh A

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2018; (29(1)):1-11 doi:10.1097/MBC.0000000000000660.

Factor XIII deficiency diagnosis: Challenges and tools.

Karimi M, Peyvandi F, Naderi M, Shapiro A

International journal of laboratory hematology 2018; (40(1)):3-11 doi:10.1111/ijlh.12756.

Molecular diagnosis of factor XIII deficiency, data from comprehensive coagulation laboratory in Iran.

Gheidishahran M, Dorgalaleh A, Tabibian S, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2018; (29(1)):87-91 doi:10.1097/MBC.0000000000000679.

State of the art in factor XIII laboratory assessment.

Durda MA, Wolberg AS, Kerlin BA

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2018; (57(6)):700-704 doi:10.1016/j.transci.2018.07.006.

Acquired factor XIII deficiency: A review.

Yan MTS, Rydz N, Goodyear D, Sholzberg M

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2018; (57(6)):724-730 doi:10.1016/j.transci.2018.10.013.

Let's cross-link: diverse functions of the promiscuous cellular transglutaminase factor XIII-A.

Mitchell JL, Mutch NJ

Journal of thrombosis and haemostasis : JTH 2019; (17(1)):19-30 doi:10.1111/jth.14348.

Evaluating the Effects of Fibrinogen αC Mutations on the Ability of Factor XIII to Crosslink the Reactive αC Glutamines (Q237, Q328, Q366).

Mouapi KN, Wagner LJ, Stephens CA, et al.

Thrombosis and haemostasis 2019; (119(7)):1048-1057 doi:10.1055/s-0039-1687875.

Massive recurrent post-tonsillectomy bleedings revealing a transient factor XIII deficiency in a 10-year-old boy. A case report.

Jankovic M, Choucair ML, Hallak B, et al.

International journal of pediatrics & adolescent medicine 2019; (6(2)):55-57 doi:10.1016/j.ijpam.2019.05.006.

The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex.

Singh S, Nazabal A, Kaniyappan S, et al.

Biomolecules 2019; (9(12)) doi:10.3390/biom9120765.

Acquired FXIII inhibitor: Patient characteristics and treatment outcome, a case series in Taiwan.

Chou SC, Lin CY, Yen CT, et al.

Journal of the Formosan Medical Association = Taiwan yi zhi 2021; (120(1 Pt 2)):411-414 doi:10.1016/j.jfma.2020.05.032.

A case of life-threatening small intestinal bleeding accompanied by lower coagulation factor XIII activity.

Murata M, Inatomi O, Ono K, et al.

Clinical journal of gastroenterology 2020; (13(6)):1178-1182 doi:10.1007/s12328-020-01195-4.

[Acquired autoimmune coagulation factor XIII/13 deficiency].

Ogawa Y

[Rinsho ketsueki] The Japanese journal of clinical hematology 2020; (61(7)):799-808 doi:10.11406/rinketsu.61.799.

Nonimmune-acquired factor XIII deficiency: a cause of high volume and delayed postoperative hemorrhage.

Chuliber FA, Schutz NP, Viñuales ES, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2020; (31(8)):511-516 doi:10.1097/MBC.0000000000000953.

Pathological coagulation parameters in as many as 54 patients with autoimmune acquired factor XIII deficiency due to anti-factor XIII autoantibodies.

Ichinose A, Osaki T, Souri M

Haemophilia : the official journal of the World Federation of Hemophilia 2021; (27(3)):454-462 doi:10.1111/hae.14298.

Acquired FXIII Deficiency is Associated with High Morbidity.

Duque P, Chasco-Ganuza M, Ortuzar A, et al.

Thrombosis and haemostasis 2022; (122(1)):48-56 doi:10.1055/a-1481-2733.

Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.

Duval C, Baranauskas A, Feller T, et al.

Proceedings of the National Academy of Sciences of the United States of America 2021; (118(27)) doi:10.1073/pnas.2103226118.

Mild Acquired Factor XIII Deficiency and Clinical Relevance at the ICU-A Retrospective Analysis.

Schmitt FCF, von der Forst M, Miesbach W, et al.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2021; (27()):10760296211024741 doi:10.1177/10760296211024741.

Factor XIII and surgical bleeding.

Guilabert P, Asmis L, Cortina V, et al.

Minerva anestesiologica 2022; (88(3)):156-165 doi:10.23736/S0375-9393.22.15772-X.

Perioperative therapeutic plasma exchange in a patient with rare Factor XIII inhibitor.

Smith J, Bodine JS, Cunningham MT, et al.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2023; (62(3)):103654 doi:10.1016/j.transci.2023.103654.

Factor XIII in the Acute Care Setting and Its Relevance in Obstetric Bleeding.

Duque P, Korte W

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 2023; (50(1)):10-17 doi:10.1159/000526489.

Automation of a Factor XIII Activity Assay Utilizing a Plasma Blank Measurement.

Smock KJ, Moser KA

Methods in molecular biology (Clifton, N.J.) 2023; (2663()):693-706 doi:10.1007/978-1-0716-3175-1_46.

Acquired Factor XIII Deficiency Is Common during ECMO Therapy and Associated with Major Bleeding Events and Transfusion Requirements.

Noitz M, Brooks R, Szasz J, et al.

Journal of clinical medicine 2023; (12(12)) doi:10.3390/jcm12124115.

[A Case of Autoimmune Acquired Factor XIII Deficiency Diagnosed from Recurrent Postoperative Bleeding].

Takashima Y, Kawanishi H, Kotani S, et al.

Hinyokika kiyo. Acta urologica Japonica 2023; (69(6)):169-173 doi:10.14989/ActaUrolJap_69_6_169.

A case of anti-NPX-2 antibody-positive dermatomyositis resulting in massive haemothorax with acquired factor XIII deficiency.

Matsuda T, Haga T, Sakaguchi T, et al.

Modern rheumatology case reports 2023; (8(1)):91-94 doi:10.1093/mrcr/rxad049.

Emicizumab for acquired hemophilia A: Report of two cases and dosing strategies.

Ahmed F, Kasianchyk M, Moreno A, et al.

EJHaem 2024; (5(2)):387-391 doi:10.1002/jha2.878.

MOG Antibody-Associated Disease in the Setting of Metastatic Melanoma Complicated by Immune Checkpoint Inhibitor Use.

Syc-Mazurek SB, Zhao-Fleming H, Guo Y, et al.

Neurology(R) neuroimmunology & neuroinflammation 2024; (11(4)):e200249 doi:10.1212/NXI.0000000000200249.

Factor XIII Deficiency With Repeated Severe Postoperative Bleeding After Laparotomy: A Case Report.

Omoto R, Umemura Y, Watanabe A, et al.

Cureus 2024; (16(5)):e60489 doi:10.7759/cureus.60489.

Factor XIII in major burns coagulation.

Guilabert P, Abarca L, Usúa G, et al.

Burns : journal of the International Society for Burn Injuries 2024; (50(7)):1769-1778 doi:10.1016/j.burns.2024.05.002.

A case of autoimmune factor XIII deficiency due to clearance-accelerating and inhibitory anti-FXIII autoantibodies.

Tsunemine H, Souri M, Kumode W, et al.

International journal of hematology 2025; (121(2)):257-264 doi:10.1007/s12185-024-03874-1.

Acquired factor XIII deficiency: A scoping review.

Duranteau O, Tatar G, Demulder A, Tuna T

European journal of anaesthesiology and intensive care 2023; (2(5)):e0035 doi:10.1097/EA9.0000000000000035.

Measurement of factor XIII for the diagnosis and management of deficiencies: insights from a retrospective review of 10 years of data on consecutive samples and patients.

Al Sharif MA, Mathews N, Tasneem S, et al.

Research and practice in thrombosis and haemostasis 2025; (9(1)):102689 doi:10.1016/j.rpth.2025.102689.

Immune-Related and Non-Immune-Related Acquired Factor XIII Deficiency.

Ichinose A

Seminars in thrombosis and hemostasis 2026; (52(3)):280-303 doi:10.1055/a-2633-0027.

Acquired hemophilia A secondary to cholangiocarcinoma: A case report and literature review.

Han X, Fu L, Li L, et al.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2025; (50(2)):275-280 doi:10.11817/j.issn.1672-7347.2025.240037.

Retroperitoneal fibrosis in presence of autoimmune coagulation factor XIII deficiency result in recurrent critical post-operative hemorrhage: a case report and molecular research with new insights.

Matsushita T, Tachibana M, Nakagawa H, et al.

Frontiers in immunology 2025; (16()):1591847 doi:10.3389/fimmu.2025.1591847.

Comparison of outcomes in autoimmune acquired factor XIII deficiency with and without underlying diseases: a systematic review.

Song J, Liu L, Ding B, et al.

Journal of thrombosis and thrombolysis 2026; (59(1)):116-124 doi:10.1007/s11239-025-03148-5.

Subgaleal Hematoma in a Female With Normal Coagulation Tests.

Ataei-Azimi S, Bos MHA, Rahimi H, Mansouritorghabeh H

Case reports in hematology 2025; (2025()):5481806 doi:10.1155/crh/5481806.

Acquired factor XIII deficiency is associated with mortality and is not linked to hypocalcemia.

Duque P, Esteban ML, Piñeiro P, et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2026; (37(1)):28-37 doi:10.1097/MBC.0000000000001400.

High prevalence of factor XIII deficiency and its association with bleeding in extracorporeal membrane oxygenation patients: an observational study from a prospectively compiled biobank.

Kornfehl A, Brock R, Quehenberger P, et al.

Research and practice in thrombosis and haemostasis 2025; (9(8)):103254 doi:10.1016/j.rpth.2025.103254.

Factor XIII Deficiency: A Review of Biology, Testing, and Treatment.

Jacobs JW, Booth GS, Costa V, et al.

Clinical hematology international 2026; (8(1)):10-25 doi:10.46989/001c.155180.

Factor XIII Deficiency and Measurement.

Hayward CPM, Mathews N

Clinics in laboratory medicine 2026; (46(2)):185-198 doi:10.1016/j.cll.2026.02.012.

Defining a fibrinogen-to-factor XIII replacement ratio in an in-vitro model of dilutional coagulopathy.

Alomar-Dominguez C, Bauer MT, Fries D, et al.

Thrombosis research 2026; (262()):109729 doi:10.1016/j.thromres.2026.109729.

Suspected acquired factor XIII deficiency in a man living with HIV: diagnostic and therapeutic challenges in recurrent spontaneous hemorrhage: a case report.

He W, Chen J, Wu H

Frontiers in medicine 2026; (13()):1768171 doi:10.3389/fmed.2026.1768171.

Unmasking Factor XIII Deficiency: Recurrent Intracranial Hemorrhage Despite Normal Coagulation Studies.

Ramesh K, Hui G, Shodiya M, Palaskas NJ

Cureus 2026; (18(7)):e113621 doi:10.7759/cureus.113621.