Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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Mayo Clinic
Rochester, United States
University of Bergen
Bergen, Norway
Karolinska University Hospital
Stockholm, Sweden
Karolinska Institutet
Stockholm, Sweden
University of Sheffield
Sheffield, United Kingdom
Haukeland University Hospital
Bergen, Norway
NIHR Imperial Biomedical Research Centre
London, United Kingdom
Churchill Hospital
Oxford, United Kingdom
University of Birmingham
Birmingham, United Kingdom
Sapienza University of Rome
Rome, Italy
References
References (78)
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Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison's disease.
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Clinical endocrinology 2016; (85(3)):354-60 doi:10.1111/cen.13059.
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BMJ case reports 2016; (2016()).
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MANAGEMENT OF ENDOCRINE DISEASE: Epidemiology, quality of life and complications of primary adrenal insufficiency: a review.
Bensing S, Hulting AL, Husebye ES, et al.
European journal of endocrinology 2016; (175(3)):R107-16 doi:10.1530/EJE-15-1242.
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Abdominal Distension and Vascular Collapse.
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Adrenal failure due to bilateral adrenal metastasis of rectal cancer: A case report.
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Addison's Disease and Possible Cannabis Withdrawal Syndrome Presenting as an Eating Disorder in a Thirty-Year-Old Female.
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Vertebral fractures assessed with dual-energy X-ray absorptiometry in patients with Addison's disease on glucocorticoid and mineralocorticoid replacement therapy.
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Adrenal crisis and autoimmune polyglandular syndromes.
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Proceedings (Baylor University. Medical Center) 2017; (30(4)):427-428 doi:10.1080/08998280.2017.11930214.
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Group 2: Adrenal insufficiency: screening methods and confirmation of diagnosis.
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Annales d'endocrinologie 2017; (78(6)):495-511 doi:10.1016/j.ando.2017.10.005.
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Group 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality.
Chabre O, Goichot B, Zenaty D, Bertherat J
Annales d'endocrinologie 2017; (78(6)):490-494 doi:10.1016/j.ando.2017.10.010.
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Adrenal crisis after first infusion of zoledronic acid: a case report.
Smrecnik M, Kavcic Trsinar Z, Kocjan T
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2018; (29(7)):1675-1678 doi:10.1007/s00198-018-4508-7.
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Therapeutic patient education in adrenal insufficiency.
Guignat L
Annales d'endocrinologie 2018; (79(3)):167-173 doi:10.1016/j.ando.2018.03.002.
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An overview of inborn errors of metabolism manifesting with primary adrenal insufficiency.
Hannah-Shmouni F, Stratakis CA
Reviews in endocrine & metabolic disorders 2018; (19(1)):53-67 doi:10.1007/s11154-018-9447-2.
PMID: 29956047 - 20
Primary adrenal insufficiency in children: Diagnosis and management.
Kirkgoz T, Guran T
Best practice & research. Clinical endocrinology & metabolism 2018; (32(4)):397-424 doi:10.1016/j.beem.2018.05.010.
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Reversible dilated cardiomyopathy as a complication of adrenal cortex insufficiency: a case report.
Alkhateeb M, Alsakkal M, Alfauri MN, Alasmar D
Journal of medical case reports 2018; (12(1)):345 doi:10.1186/s13256-018-1899-1.
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The Importance of Computed Tomography Findings in Detecting Tuberculous Addison's Disease.
Ferreira S, Freitas-Silva M
European journal of case reports in internal medicine 2017; (4(7)):000622 doi:10.12890/2017_000622.
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Addison's Disease Caused by Tuberculosis: Diagnostic and Therapeutic Difficulties.
van Haren Noman S, Visser H, Muller AF, Limonard GJ
European journal of case reports in internal medicine 2018; (5(8)):000911 doi:10.12890/2018_000911.
PMID: 30756059 - 24
Small Cell Lung Cancer with Pituitary Metastasis Presenting as Secondary Adrenal Insufficiency: A Case Report and Literature Review.
Atallah-Yunes SA, Clark J, Samanani S, Soe M
The American journal of case reports 2019; (20()):207-211 doi:10.12659/AJCR.913388.
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Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis.
Arya P V A, Kumar J, Unnikrishnan D, Raj R
BMJ case reports 2019; (12(2)) doi:10.1136/bcr-2018-227187.
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Hyponatraemia and hyperpigmentation in primary adrenal insufficiency.
Benner BJM, Alsma J, Feelders RA
BMJ case reports 2019; (12(3)) doi:10.1136/bcr-2018-227200.
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Residual endogenous corticosteroid production in patients with adrenal insufficiency.
Vulto A, Bergthorsdottir R, van Faassen M, et al.
Clinical endocrinology 2019; (91(3)):383-390 doi:10.1111/cen.14006.
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Adrenal crisis: prevention and management in adult patients.
Dineen R, Thompson CJ, Sherlock M
Therapeutic advances in endocrinology and metabolism 2019; (10()):2042018819848218 doi:10.1177/2042018819848218.
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Addison Disease: The First Presentation of the Condition May be at Autopsy.
Kemp WL, Koponen MA, Meyers SE
Academic forensic pathology 2016; (6(2)):249-257 doi:10.23907/2016.026.
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Renal involvement in adrenal insufficiency (Addison disease): can we always recognize it?
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Internal and emergency medicine 2020; (15(1)):23-31 doi:10.1007/s11739-019-02209-x.
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Addison's disease in pregnancy: Case report, management, and review of the literature.
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Journal of neonatal-perinatal medicine 2020; (13(2)):275-278 doi:10.3233/NPM-190231.
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A Challenging diagnosis that eventually results in a life-threatening condition: Addison's disease and adrenal crisis.
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BMJ case reports 2019; (12(12)) doi:10.1136/bcr-2019-231858.
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Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK.
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Anaesthesia 2020; (75(5)):654-663 doi:10.1111/anae.14963.
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Autoimmune Addison's disease.
Saverino S, Falorni A
Best practice & research. Clinical endocrinology & metabolism 2020; (34(1)):101379 doi:10.1016/j.beem.2020.101379.
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Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery.
Prete A, Taylor AE, Bancos I, et al.
The Journal of clinical endocrinology and metabolism 2020; (105(7)) doi:10.1210/clinem/dgaa133.
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MANAGEMENT OF ENDOCRINE DISEASE Disease burden and treatment challenges in patients with both Addison's disease and type 1 diabetes mellitus.
Chantzichristos D, Eliasson B, Johannsson G
European journal of endocrinology 2020; (183(1)):R1-R11.
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Adrenal crises in older patients.
Rushworth RL, Torpy DJ, Falhammar H
The lancet. Diabetes & endocrinology 2020; (8(7)):628-639 doi:10.1016/S2213-8587(20)30122-4.
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Guidance for the prevention and emergency management of adult patients with adrenal insufficiency.
Simpson H, Tomlinson J, Wass J, et al.
Clinical medicine (London, England) 2020; (20(4)):371-378 doi:10.7861/clinmed.2019-0324.
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Steroid emergency cards: action needed.
Drug and therapeutics bulletin 2020; (58(11)):163 doi:10.1136/dtb.2020.000063.
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Improved Urinary Cortisol Metabolome in Addison Disease: A Prospective Trial of Dual-Release Hydrocortisone.
Espiard S, McQueen J, Sherlock M, et al.
The Journal of clinical endocrinology and metabolism 2021; (106(3)):814-825 doi:10.1210/clinem/dgaa862.
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Knowledge and attitude of patients with adrenal insufficiency.
Bouziane T, Belmahi N, Salhi H, El Ouahabi H
Annals of African medicine 2020; (19(4)):252-257 doi:10.4103/aam.aam_63_19.
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Primary adrenal insufficiency due to adrenal tuberculosis: a case report.
Yu J, Lu Y, Han B
The Journal of international medical research 2020; (48(12)):300060520980590 doi:10.1177/0300060520980590.
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Hypoparathyroidism as the single major component for decades of autoimmune polyglandular syndrome type 1.
Lima Ferreira J, Simões de Carvalho F, Marques AP, Príncipe RM
Endocrinology, diabetes & metabolism case reports 2020; (2020()).
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Adrenal insufficiency.
Husebye ES, Pearce SH, Krone NP, Kämpe O
Lancet (London, England) 2021; (397(10274)):613-629 doi:10.1016/S0140-6736(21)00136-7.
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Adrenal cortex development and related disorders leading to adrenal insufficiency.
Pignatti E, Flück CE
Molecular and cellular endocrinology 2021; (527()):111206 doi:10.1016/j.mce.2021.111206.
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Addison's Disease: A Diagnosis Easy to Overlook.
Mosca AM, Barbosa M, Araújo R, Santos MJ
Cureus 2021; (13(2)):e13364 doi:10.7759/cureus.13364.
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[X-Linked Adrenoleukodystrophy or the Management of Rare Diseases in the General Practice].
Paunovic S, Koehler W, Knechtle B
Praxis 2021; (110(9)):529-535 doi:10.1024/1661-8157/a003674.
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Corticosteroid-induced sinus bradycardia in a young boy with adrenal insufficiency and sepsis.
Cimbek EA, Kaya G, Öztürk MA, et al.
Archivos argentinos de pediatria 2021; (119(4)):e353-e356 doi:10.5546/aap.2021.eng.e353.
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Latent Adrenal Insufficiency: From Concept to Diagnosis.
Younes N, Bourdeau I, Lacroix A
Frontiers in endocrinology 2021; (12()):720769 doi:10.3389/fendo.2021.720769.
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The natural history of 21-hydroxylase autoantibodies in autoimmune Addison's disease.
Wolff AB, Breivik L, Hufthammer KO, et al.
European journal of endocrinology 2021; (184(4)):607-615 doi:10.1530/EJE-20-1268.
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Challenging Diagnosis of Addison's Disease Presenting with Adrenal Crisis.
Wina Dharmesti NW, Saraswati MR, Suastika K, et al.
Case reports in endocrinology 2021; (2021()):7137950 doi:10.1155/2021/7137950.
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Bilateral adrenal masses due to tuberculosis: how to diagnose without extra-adrenal tuberculosis.
Tran NQ, Phan CC, Doan TTP, Tran TV
Endocrinology, diabetes & metabolism case reports 2021; (2021()).
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Successful Pregnancy Outcome in a Lady with Polyglandular Autoimmune Syndrome Type II.
Rafique M, das D
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2022; (32(1)):102-104 doi:10.29271/jcpsp.2022.01.102.
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X-linked Adrenoleukodystrophy in a 20-Year-Old Male With an ABCD1 Gene Mutation: First Case From Pakistan.
Ghori M, Molani RA, Ibrahim PMN, et al.
Cureus 2022; (14(2)):e21837 doi:10.7759/cureus.21837.
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Adolescent onset of autoimmune polyglandular syndrome type 2.
Murphy SA, Mohd Din FH, O'Grady MJ
BMJ case reports 2022; (15(5)) doi:10.1136/bcr-2022-249839.
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Recurrent episodes of vomiting and diarrhoea in a male child: a rare presentation of X-linked adrenoleukodystrophy.
Gupta P, Keller SR, Patterson B
BMJ case reports 2022; (15(8)) doi:10.1136/bcr-2022-249905.
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Case of Junctional Rhythm in the Setting of Acute Adrenal Insufficiency.
Patel P, Kelschenbach K
Cureus 2022; (14(8)):e27605 doi:10.7759/cureus.27605.
PMID: 36059370 - 58
Trabecular bone score and sclerostin concentrations in patients with primary adrenal insufficiency.
Zdrojowy-Wełna A, Halupczok-Żyła J, Słoka N, et al.
Frontiers in endocrinology 2022; (13()):996157 doi:10.3389/fendo.2022.996157.
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Diagnosis and management of adrenal insufficiency.
Lewis A, Thant AA, Aslam A, et al.
Clinical medicine (London, England) 2023; (23(2)):115-118 doi:10.7861/clinmed.2023-0067.
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Pulsatile Subcutaneous Hydrocortisone Replacement in Primary Adrenal Insufficiency.
Simunkova K, Løvås K, Methlie P, et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2023; (55(7)):471-478 doi:10.1055/a-2092-5228.
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Acute Mania in a Patient With Primary Adrenal Insufficiency Due to Autoimmune Adrenalitis: A Case Report.
Brown NJ, Wang A, Fote G, et al.
Journal of psychiatric practice 2023; (29(3)):260-263 doi:10.1097/PRA.0000000000000711.
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Case Report: Hypercalcemia as a manifestation of acute adrenal crisis precipitated by fluconazole use, and a review of the literature.
Choo KS, Yew J, Tan EJH, Puar THK
Frontiers in endocrinology 2023; (14()):1168797 doi:10.3389/fendo.2023.1168797.
PMID: 37274338 - 63
Adrenal crisis as initial manifestation of bilateral adrenal hemorrhage due to antiphospholipid syndrome: A case report.
Diana H, Diana R, Daniela R, Oscar L
SAGE open medical case reports 2023; (11()):2050313X231181653 doi:10.1177/2050313X231181653.
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An unusual cause of abdominal pain: spontaneous bilateral adrenal hemorrhage.
Rodriguez Tebar A, Panza-Nduli J, Gubin B, et al.
Acta gastro-enterologica Belgica 2023; (86(3)):495-498 doi:10.51821/86.3.11251.
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On Primary Adrenal Insufficiency with Normal Concentrations of Cortisol - Early Manifestation of Addison's Disease.
Wäscher H, Knauerhase A, Klar B, et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2024; (56(1)):16-19 doi:10.1055/a-2180-7108.
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Autoimmune primary adrenal insufficiency -current diagnostic approaches and future perspectives.
Wolff ASB, Kucuka I, Oftedal BE
Frontiers in endocrinology 2023; (14()):1285901 doi:10.3389/fendo.2023.1285901.
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Primary Adrenal Insufficiency (Addison's Disease) Presenting as Sun Tan-Like Skin Pigmentation: A Case Report.
Bondagji MF, Qul H, Nahhas A, et al.
Cureus 2023; (15(12)):e49837 doi:10.7759/cureus.49837.
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Diagnosis and management of secondary adrenal crisis.
Martel-Duguech L, Poirier J, Bourdeau I, Lacroix A
Reviews in endocrine & metabolic disorders 2024; (25(3)):619-637 doi:10.1007/s11154-024-09877-x.
PMID: 38411891 - 69
Glucocorticoid-induced adrenal insufficiency and glucocorticoid withdrawal syndrome: Two sides of the same coin.
Nachawi N, Li D, Lansang MC
Cleveland Clinic journal of medicine 2024; (91(4)):245-255 doi:10.3949/ccjm.91a.23039.
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A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy.
Bindellini D, Michelet R, Aulin LBS, et al.
Journal of pharmacokinetics and pharmacodynamics 2024; (51(6)):809-824 doi:10.1007/s10928-024-09934-7.
PMID: 38977635 - 71
Stokes-Adams Syndrome as a Presenting Feature of Hypoadrenalism: A Rare Presentation.
Kumar K, Kumar R, Pandey M, Verma R
Annals of African medicine 2024; (23(3)):509-511 doi:10.4103/aam.aam_154_22.
PMID: 39034582 - 72
A Rare Presentation of a Common Disease: A Case Report.
Nair P, Sivakumar K
The Journal of the Association of Physicians of India 2024; (72(10)):93-95 doi:10.59556/japi.72.0660.
PMID: 39390870 - 73
Treatment and Prevention of Adrenal Crisis and Family Education
Çamtosun E, Sangün Ö
Journal of clinical research in pediatric endocrinology 2025; (17(Suppl 1)):80-92 doi:10.4274/jcrpe.galenos.2024.2024-6-12-S.
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[Addison's disease: looking to the past and the future].
Valdes-Socin H, Vroonen L, Pétrossians P
Revue medicale de Liege 2025; (80(1)):48-54.
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Patient and caregiver experiences with hydrocortisone injections in adrenal crisis: a mixed-methods cross-sectional study.
Llahana S, Anthony J, Sarafoglou K, et al.
Frontiers in endocrinology 2025; (16()):1544502 doi:10.3389/fendo.2025.1544502.
PMID: 40331138 - 76
Eating Disorder vs Addison's Disease: A Case Report and Review of the Published Case Reports.
Touzon R
Actas espanolas de psiquiatria 2025; (53(3)):632-637 doi:10.62641/aep.v53i3.1840.
PMID: 40356001 - 77
Adrenal Insufficiency in Adults: A Review.
Vaidya A, Findling J, Bancos I
JAMA 2025; (334(8)):714-725 doi:10.1001/jama.2025.5485.
PMID: 40522647 - 78
Unusual Dosing of Long-Acting Hydrocortisone in a Rapid Hydrocortisone Metabolizer With Addison's Disease: A Case Report.
Sungar NR, Srinivasan B
Cureus 2025; (17(8)):e90553 doi:10.7759/cureus.90553.
PMID: 40978990