Research & Literature

A novel treatment adjunct for aspirin exacerbated respiratory disease: the low-salicylate diet: a multicenter randomized control crossover trial.

Sommer DD, Rotenberg BW, Sowerby LJ, et al.

International forum of allergy & rhinology 2016; (6(4)):385-91 doi:10.1002/alr.21678.

A survey of aspirin desensitization practices among allergists and fellows in training in the United States.

Waldram JD, White AA

The journal of allergy and clinical immunology. In practice 2016; (4(6)):1253-1255 doi:10.1016/j.jaip.2016.06.016.

Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.

Ban GY, Cho K, Kim SH, et al.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2017; (47(1)):37-47 doi:10.1111/cea.12797.

Clinical Characteristics of Aspirin-Exacerbated Respiratory Disease.

Stevenson DD, White AA

Immunology and allergy clinics of North America 2016; (36(4)):643-655 doi:10.1016/j.iac.2016.06.002.

Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis.

Stevens WW, Schleimer RP

Immunology and allergy clinics of North America 2016; (36(4)):669-680 doi:10.1016/j.iac.2016.06.004.

Performing Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease.

Waldram JD, Simon RA

Immunology and allergy clinics of North America 2016; (36(4)):693-703 doi:10.1016/j.iac.2016.06.006.

Lipid Mediators in Aspirin-Exacerbated Respiratory Disease.

Parker AR, Ayars AG, Altman MC, Henderson WR

Immunology and allergy clinics of North America 2016; (36(4)):749-763 doi:10.1016/j.iac.2016.06.009.

Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease.

Cahill KN, Boyce JA

The Journal of allergy and clinical immunology 2017; (139(3)):764-766 doi:10.1016/j.jaci.2016.09.025.

Olfaction and sinonasal symptoms in patients with CRSwNP and AERD and without AERD: a cross-sectional and longitudinal study.

Gudziol V, Michel M, Sonnefeld C, et al.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2017; (274(3)):1487-1493 doi:10.1007/s00405-016-4366-x.

Aspirin-Exacerbated Respiratory Disease.

Walgama ES, Hwang PH

Otolaryngologic clinics of North America 2017; (50(1)):83-94 doi:10.1016/j.otc.2016.08.007.

Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future.

Kennedy JL, Stoner AN, Borish L

American journal of rhinology & allergy 2016; (30(6)):407-413 doi:10.2500/ajra.2016.30.4370.

Diagnostic Accuracy of Urinary LTE4 Measurement to Predict Aspirin-Exacerbated Respiratory Disease in Patients with Asthma.

Bochenek G, Stachura T, Szafraniec K, et al.

The journal of allergy and clinical immunology. In practice 2018; (6(2)):528-535 doi:10.1016/j.jaip.2017.07.001.

Clinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease.

Mortazavi N, Esmaeilzadeh H, Abbasinazari M, et al.

Iranian journal of pharmaceutical research : IJPR 2017; (16(4)):1639-1647.

Factors correlated with repeated aspirin dosing during aspirin desensitization.

Schuler CF, Baldwin JL, Baptist AP

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2018; (121(1)):111-116.e1 doi:10.1016/j.anai.2018.04.005.

Alcohol-induced respiratory symptoms improve after aspirin desensitization in patients with aspirin-exacerbated respiratory disease.

Glicksman JT, Parasher AK, Doghramji L, et al.

International forum of allergy & rhinology 2018; (8(10)):1093-1097 doi:10.1002/alr.22168.

COX-1 mediates IL-33-induced extracellular signal-regulated kinase activation in mast cells: Implications for aspirin sensitivity.

Pan D, Buchheit KM, Samuchiwal SK, et al.

The Journal of allergy and clinical immunology 2019; (143(3)):1047-1057.e8 doi:10.1016/j.jaci.2018.06.033.

Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease.

Trinh HKT, Pham DL, Choi Y, et al.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2018; (48(11)):1464-1473 doi:10.1111/cea.13253.

Aspirin-Exacerbated Respiratory Disease.

White AA, Stevenson DD

The New England journal of medicine 2018; (379(11)):1060-1070 doi:10.1056/NEJMra1712125.

Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease.

Cahill KN, Murphy K, Singer J, et al.

The Journal of allergy and clinical immunology 2019; (143(2)):799-803.e2 doi:10.1016/j.jaci.2018.10.007.

Prostaglandin E2 decrease in induced sputum of hypersensitive asthmatics during oral challenge with aspirin.

Mastalerz L, Tyrak KE, Ignacak M, et al.

Allergy 2019; (74(5)):922-932 doi:10.1111/all.13671.

Sinus surgery improves lower respiratory tract reactivity during aspirin desensitization for AERD.

Huang GX, Palumbo ML, Singer JI, et al.

The journal of allergy and clinical immunology. In practice 2019; (7(5)):1647-1649 doi:10.1016/j.jaip.2019.02.037.

Aspirin Desensitization: Faster Protocols for Busy Patients.

White AA, Stevenson DD

The journal of allergy and clinical immunology. In practice 2019; (7(4)):1181-1183 doi:10.1016/j.jaip.2018.10.019.

Longitudinal progression of aspirin-exacerbated respiratory disease: analysis of a national insurance claims database.

Roland LT, Wang H, Mehta CC, et al.

International forum of allergy & rhinology 2019; (9(12)):1420-1423 doi:10.1002/alr.22412.

Treatment practices for aspirin-exacerbated respiratory disease: analysis of a national insurance claims database.

Roland LT, Nagy C, Wang H, et al.

International forum of allergy & rhinology 2020; (10(2)):190-193 doi:10.1002/alr.22471.

Nasal Polyposis and Aspirin-Exacerbated Respiratory Disease.

Luskin K, Thakrar H, White A

Immunology and allergy clinics of North America 2020; (40(2)):329-343 doi:10.1016/j.iac.2019.12.002.

Aspirin-exacerbated respiratory disease.

Wangberg H, White AA

Current opinion in immunology 2020; (66()):9-13 doi:10.1016/j.coi.2020.02.006.

Surgical outcomes in aspirin-exacerbated respiratory disease without aspirin desensitization.

Grose E, Lee DJ, Yip J, et al.

International forum of allergy & rhinology 2020; (10(10)):1149-1157 doi:10.1002/alr.22626.

Aspirin desensitization for aspirin-exacerbated respiratory disease in the era of biologics: Clinical perspective.

Bosso JV

International forum of allergy & rhinology 2021; (11(4)):822-823 doi:10.1002/alr.22709.

The Effect of Dupilumab on Intractable Chronic Rhinosinusitis with Nasal Polyps in Japan.

Fujieda S, Matsune S, Takeno S, et al.

The Laryngoscope 2021; (131(6)):E1770-E1777 doi:10.1002/lary.29230.

Olfactory outcomes in the management of aspirin exacerbated respiratory disease related chronic rhinosinusitis.

Spielman DB, Overdevest J, Gudis DA

World journal of otorhinolaryngology - head and neck surgery 2020; (6(4)):207-213 doi:10.1016/j.wjorl.2020.07.001.

Lung function and side effects of Aspirin desensitization: a real world study.

Heikki T, Anu LH, Annina L, et al.

European clinical respiratory journal 2021; (8(1)):1869408 doi:10.1080/20018525.2020.1869408.

Biomarkers for predicting response to aspirin therapy in aspirin-exacerbated respiratory disease.

Tyrak KE, Pajdzik K, Jakieła B, et al.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2021; (51(8)):1046-1056 doi:10.1111/cea.13886.

Urine Leukotriene E4: Implications as a Biomarker in Chronic Rhinosinusitis.

Choby G, Low CM, Levy JM, et al.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2022; (166(2)):224-232 doi:10.1177/01945998211011060.

The Effect of Aspirin on Moderate to Severe Asthmatic Patients with Aspirin Hypersensitivity, Chronic Rhinosinusitis, and Nasal Polyposis.

Arshi S, Darougar S, Nabavi M, et al.

Iranian journal of allergy, asthma, and immunology 2021; (20(3)):287-293 doi:10.18502/ijaai.v20i3.6330.

Clinical evaluation and diagnosis of aspirin-exacerbated respiratory disease.

Haque R, White AA, Jackson DJ, Hopkins C

The Journal of allergy and clinical immunology 2021; (148(2)):283-291 doi:10.1016/j.jaci.2021.06.018.

Olfactory Outcomes With Dupilumab in Chronic Rhinosinusitis With Nasal Polyps.

Mullol J, Bachert C, Amin N, et al.

The journal of allergy and clinical immunology. In practice 2022; (10(4)):1086-1095.e5 doi:10.1016/j.jaip.2021.09.037.

Mediator production and severity of aspirin-induced respiratory reactions: Impact of sampling site and body mass index.

Cahill KN, Wu P, Milne GL, et al.

The Journal of allergy and clinical immunology 2022; (150(1)):170-177.e6 doi:10.1016/j.jaci.2021.12.787.

Aspirin desensitization and biologics in aspirin-exacerbated respiratory disease: Efficacy, tolerability, and patient experience.

Mullur J, Steger CM, Gakpo D, et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2022; (128(5)):575-582 doi:10.1016/j.anai.2022.01.043.

Aspirin-Exacerbated Respiratory Disease: A Unique Case of Drug Hypersensitivity.

Corey KB, Cahill KN

Immunology and allergy clinics of North America 2022; (42(2)):421-432 doi:10.1016/j.iac.2021.12.005.

Loss of smell in patients with aspirin-exacerbated respiratory disease impacts mental health and quality of life.

Tchekmedyian R, Lundberg M, Buchheit KM, et al.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2022; (52(12)):1414-1421 doi:10.1111/cea.14157.

The Utility of Nasal Challenges to Phenotype Asthma Patients.

Bentabol-Ramos G, Saenz de Santa Maria-Garcia R, Vidal-Diaz M, et al.

International journal of molecular sciences 2022; (23(9)) doi:10.3390/ijms23094838.

Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis.

Marquette M, Tailor BV, Calder PC, et al.

Current allergy and asthma reports 2022; (22(12)):209-229 doi:10.1007/s11882-022-01049-8.

The role of large cavity sinus surgery in the management of chronic rhinosinusitis in non-steroidal anti-inflammatory drug exacerbated respiratory disease: a single-centre experience and long-term outcomes.

Pendolino AL, Bandino F, Navaratnam A, et al.

The Journal of laryngology and otology 2023; (137(8)):883-889 doi:10.1017/S0022215122002468.

Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease.

Schneider S, Poglitsch K, Morgenstern C, et al.

The European respiratory journal 2023; (61(3)) doi:10.1183/13993003.01335-2022.

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.

Candelo E, McCalla M, Valderrama OA, et al.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023; (169(1)):12-20 doi:10.1002/ohn.248.

Phenotypic associations of medical polypectomy and revision surgery following endoscopic sinus surgery: a retrospective study of a single-centre experience in Scotland.

Misirovs R, Chan R, Stewart K, Lipworth B

The Journal of laryngology and otology 2023; (137(11)):1277-1284 doi:10.1017/S0022215123000853.

One- versus 2-day aspirin desensitization in aspirin exacerbated respiratory disease: A quality improvement project.

Gansert E, Morgenstern-Kaplan D, Donaldson AM, et al.

The journal of allergy and clinical immunology. Global 2023; (2(4)):100158 doi:10.1016/j.jacig.2023.100158.

Management of Aspirin-Exacerbated Respiratory Disease: What Does the Future Hold?

O'Brien EK, Jerschow E, Divekar RD

Otolaryngologic clinics of North America 2024; (57(2)):265-278 doi:10.1016/j.otc.2023.09.006.

Quantifying surgical completeness in patients with aspirin exacerbated respiratory disease.

Levin M, Chan Y, Sommer DD, et al.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 2023; (52(1)):83 doi:10.1186/s40463-023-00682-1.

[Does aspirin therapy after desensitization still have a role in treatment of chronic rhinosinusitis with nasal polyposis in the era of biologics?]

Klimek F, Förster-Ruhrmann U, Hagemann J, et al.

HNO 2024; (72(7)):484-493 doi:10.1007/s00106-024-01431-0.

[Biologic therapy in patients with severe NSAID-exacerbated respiratory disease and previous aspirin desensitization : Results of a multicentric study].

Staufenberg AR, Frankenberger HK, Förster-Ruhrmann U, et al.

HNO 2024; (72(7)):473-483 doi:10.1007/s00106-024-01433-y.

IL-4Rα signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease.

Chen CC, Buchheit KM, Lee PY, et al.

The Journal of allergy and clinical immunology 2024; (154(2)):458-467.e3 doi:10.1016/j.jaci.2024.04.020.

The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma.

Nakagome K, Nagata M

Biomolecules 2024; (14(5)) doi:10.3390/biom14050546.

Cysteinyl Leukotrienes in Allergic Inflammation.

Lee M, Boyce JA, Barrett NA

Annual review of pathology 2025; (20(1)):115-141 doi:10.1146/annurev-pathmechdis-111523-023509.

Update on aspirin exacerbated respiratory disease with chronic rhinosinusitis.

Gandre JR, Ledford DK

Current opinion in allergy and clinical immunology 2025; (25(1)):10-18 doi:10.1097/ACI.0000000000001054.

Nonsteroidal antiinflammatory drug-exacerbated respiratory disease: molecular mechanism, management and treatment.

Ley-Tomas JJ, Xicotencatl-Tellez AM, García-Cruz ML, Jiménez-Chobillon MA

Frontiers in allergy 2024; (5()):1462985 doi:10.3389/falgy.2024.1462985.

Low Prostaglandin E2 but High Prostaglandin D2, a Paradoxical Dissociation in Arachidonic Acid Metabolism in Aspirin-Exacerbated Airway Disease: Role of Airway Epithelium.

Picado C, Machado-Carvalho L, Roca-Ferrer J

Journal of clinical medicine 2024; (13(23)) doi:10.3390/jcm13237416.

What's New in the Diagnosis and Treatment of Aspirin-Exacerbated Respiratory Disease: A Brief Review.

Douglas JE, Bosso JV

American journal of rhinology & allergy 2023; (37(2)):198-206 doi:10.1177/19458924221145254.

Intranasal Aspirin Challenge for Diagnosis of Aspirin-Exacerbated Respiratory Disease: Symptom Score Criteria and Optimal Dosage.

Xiao H, Xu F, Jia Q, et al.

The journal of allergy and clinical immunology. In practice 2025; (13(7)):1732-1738 doi:10.1016/j.jaip.2025.03.038.

Aspirin-exacerbated respiratory disease in the era of biologics.

Laidlaw TM

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2025; (135(4)):366-373 doi:10.1016/j.anai.2025.06.001.

Institutional Experience in Aspirin-Exacerbated Respiratory Disease Yields Favorable Pulmonary and Sinonasal Outcomes.

Douglas JE, Tang SH, Mani A, et al.

Ear, nose, & throat journal 2025; 1455613251356359 doi:10.1177/01455613251356359.

Clinical Efficacy of Biologics and ATAD in NSAID-Exacerbated Respiratory Disease: A Phenotype-Based Comparative Study.

Cihanbeylerden M, Kayıkçı H, Tüccar Ç, et al.

The journal of allergy and clinical immunology. In practice 2025; (13(10)):2700-2710.e2 doi:10.1016/j.jaip.2025.07.038.

Exploring dupilumab for asthma: from mechanistic insights to clinical outcomes, safety, and cost-effectiveness.

Ameer OZ, Mansour GK, Al-Amoudi RS, Abu-Owaimer FM

Frontiers in pharmacology 2025; (16()):1631321 doi:10.3389/fphar.2025.1631321.

Real-World Treatment Patterns in AERD: An Analysis of ATAD, Biologics, and Combination Therapy.

Kumar N, Pace T, Gomes PL, et al.

International forum of allergy & rhinology 2026; (16(1)):99-101 doi:10.1002/alr.70072.

Diagnostic Role of Aspirin Challenge in NSAID-Exacerbated Respiratory Disease: A Prospective Single-Center Study in China.

Xiao H, Xu F, Zhang L, et al.

Allergy, asthma & immunology research 2026; (18(3)):379-390 doi:10.4168/aair.2026.18.3.379.

Real-World Diagnostic Patterns and Symptom Progression in Aspirin-Exacerbated Respiratory Disease.

Weiser O, Melamed G, Confino-Cohen R, Rosman Y

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2026; doi:10.1111/cea.70369.