Research & Literature

Interferon-free regimens for chronic hepatitis C overcome the effects of portal hypertension on virological responses.

Mandorfer M, Kozbial K, Freissmuth C, et al.

Alimentary pharmacology & therapeutics 2015; (42(6)):707-18 doi:10.1111/apt.13315.

Hepatocellular Carcinoma Surveillance Among Cirrhotic Patients With Commercial Health Insurance.

Goldberg DS, Valderrama A, Kamalakar R, et al.

Journal of clinical gastroenterology 2016; (50(3)):258-65 doi:10.1097/MCG.0000000000000411.

Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis.

Nishikawa H, Osaki Y

Mediators of inflammation 2015; (2015()):872152 doi:10.1155/2015/872152.

Assessment of adult patients with chronic liver failure for liver transplantation in 2015: who and when?

McCaughan GW, Crawford M, Sandroussi C, et al.

Internal medicine journal 2016; (46(4)):404-12 doi:10.1111/imj.13025.

Liver Cirrhosis and Kidney.

Gerbes AL

Digestive diseases (Basel, Switzerland) 2016; (34(4)):387-90 doi:10.1159/000444553.

Predictors of adequate ultrasound quality for hepatocellular carcinoma surveillance in patients with cirrhosis.

Simmons O, Fetzer DT, Yokoo T, et al.

Alimentary pharmacology & therapeutics 2017; (45(1)):169-177 doi:10.1111/apt.13841.

[Advances in basic and clinical research on liver cirrhosis in 2016].

Gu C, Song MY, Sun WJ, et al.

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2017; (25(1)):5-8 doi:10.3760/cma.j.issn.1007-3418.2017.01.003.

Mechanisms of hepatic stellate cell activation.

Tsuchida T, Friedman SL

Nature reviews. Gastroenterology & hepatology 2017; (14(7)):397-411 doi:10.1038/nrgastro.2017.38.

[New therapeutic paradigm and concepts for patients with cirrhotic refractory ascites].

Wang SZ, Ding HG

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2017; (25(4)):249-253 doi:10.3760/cma.j.issn.1007-3418.2017.04.003.

Intestinal fungi contribute to development of alcoholic liver disease.

Yang AM, Inamine T, Hochrath K, et al.

The Journal of clinical investigation 2017; (127(7)):2829-2841.

ACG Clinical Guideline: Alcoholic Liver Disease.

Singal AK, Bataller R, Ahn J, et al.

The American journal of gastroenterology 2018; (113(2)):175-194 doi:10.1038/ajg.2017.469.

Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis.

Tzartzeva K, Obi J, Rich NE, et al.

Gastroenterology 2018; (154(6)):1706-1718.e1 doi:10.1053/j.gastro.2018.01.064.

Spontaneous bacterial and fungal peritonitis in patients with liver cirrhosis: A literature review.

Shizuma T

World journal of hepatology 2018; (10(2)):254-266 doi:10.4254/wjh.v10.i2.254.

Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis.

Lee BP, Mehta N, Platt L, et al.

Gastroenterology 2018; (155(2)):422-430.e1 doi:10.1053/j.gastro.2018.04.009.

[Nutritional Assessment and Management for Patients with Chronic Liver Disease].

Lee TH

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2018; (71(4)):185-191 doi:10.4166/kjg.2018.71.4.185.

Dietary Interventions in Liver Cirrhosis.

Yao CK, Fung J, Chu NHS, Tan VPY

Journal of clinical gastroenterology 2018; (52(8)):663-673 doi:10.1097/MCG.0000000000001071.

Hepatocellular Carcinoma Surveillance: Benefit of Serum Alfa-fetoprotein in Real-world Practice.

Lersritwimanmaen P, Nimanong S

Euroasian journal of hepato-gastroenterology 2018; (8(1)):83-87 doi:10.5005/jp-journals-10018-1268.

Predicting Low Risk for Sustained Alcohol Use After Early Liver Transplant for Acute Alcoholic Hepatitis: The Sustained Alcohol Use Post-Liver Transplant Score.

Lee BP, Vittinghoff E, Hsu C, et al.

Hepatology (Baltimore, Md.) 2019; (69(4)):1477-1487 doi:10.1002/hep.30478.

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study.

Szabo G, Kamath PS, Shah VH, et al.

Hepatology (Baltimore, Md.) 2019; (69(5)):2271-2283 doi:10.1002/hep.30369.

Microbiome as a therapeutic target in alcohol-related liver disease.

Sarin SK, Pande A, Schnabl B

Journal of hepatology 2019; (70(2)):260-272 doi:10.1016/j.jhep.2018.10.019.

Non-invasive diagnosis and biomarkers in alcohol-related liver disease.

Moreno C, Mueller S, Szabo G

Journal of hepatology 2019; (70(2)):273-283 doi:10.1016/j.jhep.2018.11.025.

Role of endoscopy in acute gastrointestinal bleeding in real clinical practice: An evidence-based review.

Jung K, Moon W

World journal of gastrointestinal endoscopy 2019; (11(2)):68-83 doi:10.4253/wjge.v11.i2.68.

Natural history of histologically proven alcohol-related liver disease: A systematic review.

Parker R, Aithal GP, Becker U, et al.

Journal of hepatology 2019; (71(3)):586-593 doi:10.1016/j.jhep.2019.05.020.

Primary and secondary prophylaxis of spontaneous bacterial peritonitis: current state of the art.

Facciorusso A, Antonino M, Orsitto E, Sacco R

Expert review of gastroenterology & hepatology 2019; (13(8)):751-759 doi:10.1080/17474124.2019.1644167.

Hepatorenal Syndrome Type 1: Current Challenges And Future Prospects.

Facciorusso A

Therapeutics and clinical risk management 2019; (15()):1383-1391 doi:10.2147/TCRM.S205328.

Serum Zinc Level Is Associated with Frailty in Chronic Liver Diseases.

Nishikawa H, Yoh K, Enomoto H, et al.

Journal of clinical medicine 2020; (9(5)) doi:10.3390/jcm9051570.

Oxidative stress in alcohol-related liver disease.

Tan HK, Yates E, Lilly K, Dhanda AD

World journal of hepatology 2020; (12(7)):332-349 doi:10.4254/wjh.v12.i7.332.

Complications and Mortality in Hospitalised Patients With Decompensated Cirrhosis of Liver in a Tertiary Care Centre in Nepal.

Bhattarai S

Cureus 2020; (12(8)):e9996 doi:10.7759/cureus.9996.

Malnutrition in Patients with Liver Cirrhosis.

Traub J, Reiss L, Aliwa B, Stadlbauer V

Nutrients 2021; (13(2)) doi:10.3390/nu13020540.

Gut dysbiosis as a driver in alcohol-induced liver injury.

Fairfield B, Schnabl B

JHEP reports : innovation in hepatology 2021; (3(2)):100220 doi:10.1016/j.jhepr.2020.100220.

Feasibility and early experience of a novel multidisciplinary alcohol-associated liver disease clinic.

Mellinger JL, Winder GS, Fernandez AC, et al.

Journal of substance abuse treatment 2021; (130()):108396 doi:10.1016/j.jsat.2021.108396.

Non-invasive diagnosis and follow-up of portal hypertension.

Thabut D, Weil D, Bouzbib C, et al.

Clinics and research in hepatology and gastroenterology 2022; (46(8)):101767 doi:10.1016/j.clinre.2021.101767.

Results of Early Transplantation for Alcohol-Related Cirrhosis: Integrated Addiction Treatment With Low Rate of Relapse.

Carrique L, Quance J, Tan A, et al.

Gastroenterology 2021; (161(6)):1896-1906.e2 doi:10.1053/j.gastro.2021.08.004.

MELD 3.0: The Model for End-Stage Liver Disease Updated for the Modern Era.

Kim WR, Mannalithara A, Heimbach JK, et al.

Gastroenterology 2021; (161(6)):1887-1895.e4 doi:10.1053/j.gastro.2021.08.050.

Research methodologies to address clinical unmet needs and challenges in alcohol-associated liver disease.

Singal AK, Kwo P, Kwong A, et al.

Hepatology (Baltimore, Md.) 2022; (75(4)):1026-1037 doi:10.1002/hep.32143.

Liver cirrhosis.

Ginès P, Krag A, Abraldes JG, et al.

Lancet (London, England) 2021; (398(10308)):1359-1376 doi:10.1016/S0140-6736(21)01374-X.

Clinical relevance of shear wave elastography compared with transient elastography and other markers of liver fibrosis.

Ayonrinde OT, Zelesco M, Welman CJ, et al.

Internal medicine journal 2022; (52(4)):640-650 doi:10.1111/imj.15603.

Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography.

Podrug K, Trkulja V, Zelenika M, et al.

Digestive diseases and sciences 2022; (67(7)):3327-3332 doi:10.1007/s10620-021-07277-8.

Osteosarcopenia in autoimmune cholestatic liver diseases: Causes, management, and challenges.

Pugliese N, Arcari I, Aghemo A, et al.

World journal of gastroenterology 2022; (28(14)):1430-1443 doi:10.3748/wjg.v28.i14.1430.

Noninvasive assessment oesophageal varices: impact of the Baveno VI criteria.

Bai W, Abraldes JG

Current opinion in gastroenterology 2022; (38(3)):206-215 doi:10.1097/MOG.0000000000000824.

Current Medical Treatment for Alcohol-Associated Liver Disease.

Ayares G, Idalsoaga F, Díaz LA, et al.

Journal of clinical and experimental hepatology 2022; (12(5)):1333-1348 doi:10.1016/j.jceh.2022.02.001.

Endoscopic diagnosis and management of esophagogastric variceal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Gralnek IM, Camus Duboc M, Garcia-Pagan JC, et al.

Endoscopy 2022; (54(11)):1094-1120 doi:10.1055/a-1939-4887.

Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance.

Wan Q, Anugwom C, Desalegn H, Debes JD

Hepatoma research 2022; (8()) doi:10.20517/2394-5079.2022.32.

Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions.

Liu YB, Chen MK

World journal of gastroenterology 2022; (28(41)):5910-5930 doi:10.3748/wjg.v28.i41.5910.

Recent Progress of Nutritional Management for Liver Cirrhosis.

Kawaguchi T, Kato A

Journal of nutritional science and vitaminology 2022; (68(Supplement)):S73-S75 doi:10.3177/jnsv.68.S73.

Therapeutic Pipeline in Alcohol-Associated Liver Disease.

Thakral N, Deutsch-Link S, Singal AK

Seminars in liver disease 2023; (43(1)):60-76 doi:10.1055/s-0042-1759614.

Carvedilol as the new non-selective beta-blocker of choice in patients with cirrhosis and portal hypertension.

Turco L, Reiberger T, Vitale G, La Mura V

Liver international : official journal of the International Association for the Study of the Liver 2023; (43(6)):1183-1194 doi:10.1111/liv.15559.

Serum and plasma protein biomarkers associated with frailty in patients with cirrhosis.

Ha NB, Seetharaman S, Kent DS, et al.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2023; (29(10)):1089-1099 doi:10.1097/LVT.0000000000000128.

Global burden of liver disease: 2023 update.

Devarbhavi H, Asrani SK, Arab JP, et al.

Journal of hepatology 2023; (79(2)):516-537 doi:10.1016/j.jhep.2023.03.017.

Diagnosis and Management of Cirrhosis and Its Complications: A Review.

Tapper EB, Parikh ND

JAMA 2023; (329(18)):1589-1602 doi:10.1001/jama.2023.5997.

Imaging Modalities for Hepatocellular Carcinoma Surveillance: Expanding Horizons beyond Ultrasound.

Park HJ, Kim SY

Journal of liver cancer 2020; (20(2)):99-105 doi:10.17998/jlc.20.2.99.

Accuracy of spleen stiffness measurement for the diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a systematic review and individual patient data meta-analysis.

Dajti E, Ravaioli F, Zykus R, et al.

The lancet. Gastroenterology & hepatology 2023; (8(9)):816-828 doi:10.1016/S2468-1253(23)00150-4.

Overview of Alcohol Use Disorder.

Kranzler HR

The American journal of psychiatry 2023; (180(8)):565-572 doi:10.1176/appi.ajp.20230488.

Evaluation and Management of Nutritional Consequences of Chronic Liver Diseases.

Espina S, Casas-Deza D, Bernal-Monterde V, et al.

Nutrients 2023; (15(15)) doi:10.3390/nu15153487.

Medications for alcohol use disorder promote abstinence in alcohol-associated cirrhosis: Results from a systematic review and meta-analysis.

Gratacós-Ginès J, Bruguera P, Pérez-Guasch M, et al.

Hepatology (Baltimore, Md.) 2024; (79(2)):368-379 doi:10.1097/HEP.0000000000000570.

Alcohol-Related Liver Disease: Is There a Safe Alcohol Consumption Limit for Liver Disease?

Pekarska K, Parker R

Seminars in liver disease 2023; (43(3)):305-310 doi:10.1055/s-0043-1772836.

Nutritional Management of a Liver Transplant Candidate.

Mishra S, Premkumar M

Journal of clinical and experimental hepatology 2023; (13(5)):878-894 doi:10.1016/j.jceh.2023.03.012.

Imaging of Alcohol-Associated Liver Disease.

Maheshwari S, Gu CN, Caserta MP, et al.

AJR. American journal of roentgenology 2024; (222(1)):e2329917 doi:10.2214/AJR.23.29917.

Alcohol use disorder in alcohol-associated liver disease: Two sides of the same coin.

Singal AK, Leggio L, DiMartini A

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2024; (30(2)):200-212 doi:10.1097/LVT.0000000000000296.

Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction.

LeFort KR, Rungratanawanich W, Song BJ

Cellular and molecular life sciences : CMLS 2024; (81(1)):34 doi:10.1007/s00018-023-05061-7.

Evolution of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis.

Vidal-González J, Martínez J, Mulay A, et al.

JHEP reports : innovation in hepatology 2024; (6(2)):100977 doi:10.1016/j.jhepr.2023.100977.

The Role of Endoscopy for Primary and Secondary Prophylaxis of Variceal Bleeding.

Ma AS, Thuluvath PJ

Gastrointestinal endoscopy clinics of North America 2024; (34(2)):231-248 doi:10.1016/j.giec.2023.09.012.

Review article: Current indications and selection criteria for early liver transplantation in severe alcohol-associated hepatitis.

Ramirez-Cadiz C, Blaney H, Kubanek N, et al.

Alimentary pharmacology & therapeutics 2024; (59(9)):1049-1061 doi:10.1111/apt.17948.

Is There a Safe Alcohol Consumption Limit for the General Population and in Patients with Liver Disease?

Romero-Gómez M, Arab JP, Oliveira CP, et al.

Seminars in liver disease 2024; (44(1)):69-78 doi:10.1055/s-0044-1785228.

The Role of Transjugular Intrahepatic Portosystemic Shunt for the Management of Ascites in Patients with Decompensated Cirrhosis.

Iannone G, Pompili E, De Venuto C, et al.

Journal of clinical medicine 2024; (13(5)) doi:10.3390/jcm13051349.

Emergency medicine updates: Upper gastrointestinal bleeding.

Long B, Gottlieb M

The American journal of emergency medicine 2024; (81()):116-123 doi:10.1016/j.ajem.2024.04.052.

Safety of naltrexone in patients with cirrhosis.

Thompson R, Taddei T, Kaplan D, Rabiee A

JHEP reports : innovation in hepatology 2024; (6(7)):101095 doi:10.1016/j.jhepr.2024.101095.

Population screening for cirrhosis.

Thiele M, Pose E, Juanola A, et al.

Hepatology communications 2024; (8(9)) doi:10.1097/HC9.0000000000000512.

Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies.

Jensen MD, West J, Crooks C, et al.

The American journal of gastroenterology 2025; (120(3)):593-602 doi:10.14309/ajg.0000000000003077.

Exploring algorithms to select candidates for non-selective beta-blockers in cirrhosis: A post hoc analysis of the PREDESCI trial.

Dajti E, Villanueva C, Berzigotti A, et al.

Journal of hepatology 2025; (82(3)):490-498 doi:10.1016/j.jhep.2024.09.014.

Advances in the management of alcohol-associated liver disease.

Anouti A, Kerr TA, Mitchell MC, Cotter TG

Gastroenterology report 2024; (12()):goae097 doi:10.1093/gastro/goae097.

A comprehensive review of diagnosis and management of alcohol-associated hepatitis.

Philips CA

SAGE open medicine 2024; (12()):20503121241297000 doi:10.1177/20503121241297000.

Inflammation remains a dynamic component of portal hypertension in regressive alcohol-related cirrhosis.

Hofer BS, Simbrunner B, Königshofer P, et al.

United European gastroenterology journal 2025; (13(3)):317-329 doi:10.1002/ueg2.12643.

Acute Kidney Injury in Patients with Chronic Liver Disease: A Review.

Elom HA, Hegazy Y, Lerma EV, Hassanein M

Indian journal of nephrology 2025; (35(1)):21-28 doi:10.25259/ijn_333_23.

Prevalence and predictors of cirrhosis and portal hypertension in the United States.

Younossi ZM, de Avila L, Racila A, et al.

Hepatology (Baltimore, Md.) 2025; (82(5)):1229-1240 doi:10.1097/HEP.0000000000001243.

Metabolic Dysfunction and Alcohol-Associated Liver Disease: A Narrative Review.

Dunn N, Al-Khouri N, Abdellatif I, Singal AK

Clinical and translational gastroenterology 2025; (16(5)):e00828 doi:10.14309/ctg.0000000000000828.

Association of Social Isolation From Living Alone and Psychological Distress Among Adults With Chronic Liver Disease in the United States.

Walker T, Alejandro-Soto A, Nephew L, et al.

The American journal of gastroenterology 2025; (120(8)):1860-1864 doi:10.14309/ajg.0000000000003504.

Transforming Growth Factor-β Signaling in Alcohol-Associated Liver Disease: A Multicellular Perspective.

Zou H, Wang S, Huang C, et al.

The American journal of pathology 2026; (196(1)):50-67 doi:10.1016/j.ajpath.2025.09.017.

AGA Clinical Practice Update on the Management of Ascites, Volume Overload, and Hyponatremia in Cirrhosis: Expert Review.

Orman ES, Fortune BE, John BV, Asrani SK

Gastroenterology 2025; (169(7)):1547-1557 doi:10.1053/j.gastro.2025.08.029.

Predicting hepatic decompensation using non-invasive tests in a contemporary multicentre cohort of patients with cACLD.

Jachs M, Thöne P, Odriozola A, et al.

Journal of hepatology 2026; (84(4)):738-748 doi:10.1016/j.jhep.2025.10.019.

Integrated approaches to reduce alcohol use in people with liver disease: a scoping review and quantitative analysis.

Weber AN, Osman M, Smeins L, et al.

Alcohol and alcoholism (Oxford, Oxfordshire) 2025; (60(6)) doi:10.1093/alcalc/agaf066.

Pharmacotherapy to Prevent Alcohol Relapse in Alcohol-Associated Liver Disease.

Zhang W, Hwang SY, Luther J

Current gastroenterology reports 2025; (27(1)):74.

Disparities in Alcohol-Related Liver Disease.

Lushniak L, Jowell A, Garbarino S, Wilder J

Clinics in liver disease 2026; (30(1)):185-193 doi:10.1016/j.cld.2025.09.006.

Transplant Selection: Disease Severity and Psychosocial Evaluation.

Fomin V, Rutledge S, Brown RS

Clinics in liver disease 2026; (30(1)):195-220 doi:10.1016/j.cld.2025.08.005.

Incidence and implications of abstinence-induced recompensation in alcohol-related cirrhosis.

Hofer BS, Tonon M, Buttler L, et al.

Journal of hepatology 2026; (84(6)):1077-1088 doi:10.1016/j.jhep.2026.01.007.

Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy.

Goyal MK, Chowdhary R, Vohra C, et al.

World journal of hepatology 2026; (18(1)):115048 doi:10.4254/wjh.v18.i1.115048.

Assessing Major Adverse Liver Outcomes With Baclofen Compared to Acamprosate in Compensated Alcohol-Associated Cirrhosis.

Yeo YH, Mehravar S, Choi E, et al.

Alimentary pharmacology & therapeutics 2026; (63(12)):1673-1684 doi:10.1111/apt.70619.

Alcohol Abstinence Is Associated with Regression of Non-Invasive Fibrosis Markers in Patients with Metabolic Syndrome: A 12-Month Prospective Study.

Mihăilă D, Domnariu HP, Moga DF, Domnariu CD

Journal of clinical medicine 2026; (15(6)) doi:10.3390/jcm15062257.

Spontaneous Recovery and Mortality in Patients With ALD Referred for Early Liver Transplantation.

Hasjim BJ, Kwong AJ, Cheung A, et al.

The American journal of gastroenterology 2026; doi:10.14309/ajg.0000000000004032.

AGA Clinical Practice Update on Risk Stratification and Emerging Surveillance Strategies for Hepatocellular Carcinoma: Expert Review.

Rich NE, Villanueva A, Marrero JA, Kanwal F

Gastroenterology 2026; (170(7)):1606-1615 doi:10.1053/j.gastro.2026.03.006.

Development and validation of a disease-specific health-related quality of life questionnaire for alcohol-associated liver disease: The CLDQ-ALD.

Younossi ZM, Stepanova M, Younossi I, deAvila L

Hepatology communications 2026; (10(6)) doi:10.1097/HC9.0000000000000963.

Clinical practice patterns in the pre-endoscopic management of individuals presenting with acute upper gastrointestinal bleeding: results of an international survey.

Obeidat M, Floria DE, Teutsch B, et al.

Therapeutic advances in gastroenterology 2026; (19()):17562848261455285 doi:10.1177/17562848261455285.

Global epidemiology of metabolic and alcohol-associated liver disease: risk factors, natural history and clinical implications.

Díaz LA, Pose E, Israelsen M, Loomba R

Nature reviews. Gastroenterology & hepatology 2026; doi:10.1038/s41575-026-01240-6.

Naltrexone Is Superior to Placebo for Abstinence and Craving Reduction in Alcohol-Associated Cirrhosis: NAL-CI Trial.

Alla M, Varshney M, Bhardwaj A, et al.

Liver international : official journal of the International Association for the Study of the Liver 2026; (46(9)):e70845 doi:10.1111/liv.70845.