Research & Literature

Health-related quality of life in youth with Crohn disease: role of disease activity and parenting stress.

Gray WN, Boyle SL, Graef DM, et al.

Journal of pediatric gastroenterology and nutrition 2015; (60(6)):749-53 doi:10.1097/MPG.0000000000000696.

Surgical aspects of inflammatory bowel diseases in pediatric and adolescent age groups.

El-Asmar K, El-Shafei E, Abdel-Latif M, et al.

International journal of colorectal disease 2016; (31(2)):301-5 doi:10.1007/s00384-015-2388-2.

Inflammatory Bowel Disease in Children and Adolescents.

Rosen MJ, Dhawan A, Saeed SA

JAMA pediatrics 2015; (169(11)):1053-60 doi:10.1001/jamapediatrics.2015.1982.

From Genes to Mechanisms: The Expanding Spectrum of Monogenic Disorders Associated with Inflammatory Bowel Disease.

Uhlig HH, Schwerd T

Inflammatory bowel diseases 2016; (22(1)):202-12 doi:10.1097/MIB.0000000000000614.

A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity.

Malo MS

EBioMedicine 2015; (2(12)):2016-23 doi:10.1016/j.ebiom.2015.11.027.

Fecal calprotectin in the prediction of postoperative recurrence of Crohn's disease in children and adolescents.

Hukkinen M, Pakarinen MP, Merras-Salmio L, et al.

Journal of pediatric surgery 2016; (51(9)):1467-72.

Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.

Liu W, Hu D, Huo H, et al.

Journal of the American College of Surgeons 2016; (222(6)):1009-17.

Relationship of clinical symptoms with biomarkers of inflammation in pediatric inflammatory bowel disease.

Hoekman DR, Diederen K, Koot BG, et al.

European journal of pediatrics 2016; (175(10)):1335-42 doi:10.1007/s00431-016-2762-2.

Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells.

Noda S, Yamada A, Tanabe R, et al.

Nutrition research (New York, N.Y.) 2016; (36(11)):1269-1276 doi:10.1016/j.nutres.2016.10.001.

The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract.

Bilski J, Mazur-Bialy A, Wojcik D, et al.

Mediators of inflammation 2017; (2017()):9074601 doi:10.1155/2017/9074601.

IL-10 and IL-10 Receptor Mutations in Very Early Onset Inflammatory Bowel Disease.

Zhu L, Shi T, Zhong C, et al.

Gastroenterology research 2017; (10(2)):65-69 doi:10.14740/gr740w.

Exclusive enteral nutrition for inducing remission in inflammatory bowel disease in paediatric patients.

Assa A, Shamir R

Current opinion in clinical nutrition and metabolic care 2017; (20(5)):384-389 doi:10.1097/MCO.0000000000000402.

Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine.

Fawley J, Koehler S, Cabrera S, et al.

The Journal of surgical research 2017; (218()):35-42 doi:10.1016/j.jss.2017.03.049.

Intestinal alkaline phosphatase ameliorates experimental colitis via toll-like receptor 4-dependent pathway.

Hwang SW, Kim JH, Lee C, et al.

European journal of pharmacology 2018; (820()):156-166 doi:10.1016/j.ejphar.2017.12.026.

Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis.

Parlato M, Charbit-Henrion F, Pan J, et al.

EMBO molecular medicine 2018; (10(4)) doi:10.15252/emmm.201708483.

Perioperative Care of Patients with Inflammatory Bowel Disease: Focus on Nutritional Support.

Stoner PL, Kamel A, Ayoub F, et al.

Gastroenterology research and practice 2018; (2018()):7890161 doi:10.1155/2018/7890161.

Long-term Single-centre Outcomes After Proctocolectomy With Ileoanal Anastomosis for Paediatric Ulcerative Colitis.

Nyholm I, Hukkinen M, Koivusalo A, et al.

Journal of Crohn's & colitis 2019; (13(3)):302-308 doi:10.1093/ecco-jcc/jjy175.

Mechanisms of Disease: Inflammatory Bowel Diseases.

Ramos GP, Papadakis KA

Mayo Clinic proceedings 2019; (94(1)):155-165 doi:10.1016/j.mayocp.2018.09.013.

Endoscopy in Postoperative Patients with Crohn's Disease or Ulcerative Colitis. Does It Translate to Better Outcomes?

Bhattacharya A, Shen B, Regueiro M

Gastrointestinal endoscopy clinics of North America 2019; (29(3)):487-514 doi:10.1016/j.giec.2019.02.013.

Diagnostic Approach to Monogenic Inflammatory Bowel Disease in Clinical Practice: A Ten-Year Multicentric Experience.

Lega S, Pin A, Arrigo S, et al.

Inflammatory bowel diseases 2020; (26(5)):720-727 doi:10.1093/ibd/izz178.

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Evaluation and Management for Patients With Very Early-onset Inflammatory Bowel Disease.

Kelsen JR, Sullivan KE, Rabizadeh S, et al.

Journal of pediatric gastroenterology and nutrition 2020; (70(3)):389-403 doi:10.1097/MPG.0000000000002567.

Intestinal Alkaline Phosphatase Exerts Anti-Inflammatory Effects Against Lipopolysaccharide by Inducing Autophagy.

Singh SB, Carroll-Portillo A, Coffman C, et al.

Scientific reports 2020; (10(1)):3107 doi:10.1038/s41598-020-59474-6.

Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a Single Center.

Crowley E, Warner N, Pan J, et al.

Gastroenterology 2020; (158(8)):2208-2220 doi:10.1053/j.gastro.2020.02.023.

Intestinal alkaline phosphatase targets the gut barrier to prevent aging.

Kühn F, Adiliaghdam F, Cavallaro PM, et al.

JCI insight 2020; (5(6)).

Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study From the Porto Group of ESPGHAN.

Orlanski-Meyer E, Topf-Olivestone C, Ledder O, et al.

Journal of pediatric gastroenterology and nutrition 2020; (71(3)):346-353 doi:10.1097/MPG.0000000000002805.

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.

Stevens TW, Haasnoot ML, D'Haens GR, et al.

The lancet. Gastroenterology & hepatology 2020; (5(10)):900-907 doi:10.1016/S2468-1253(20)30117-5.

Anemia in Children With Inflammatory Bowel Disease: A Position Paper by the IBD Committee of the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition.

Goyal A, Zheng Y, Albenberg LG, et al.

Journal of pediatric gastroenterology and nutrition 2020; (71(4)):563-582 doi:10.1097/MPG.0000000000002885.

Clinical Genomics for the Diagnosis of Monogenic Forms of Inflammatory Bowel Disease: A Position Paper From the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition.

Uhlig HH, Charbit-Henrion F, Kotlarz D, et al.

Journal of pediatric gastroenterology and nutrition 2021; (72(3)):456-473 doi:10.1097/MPG.0000000000003017.

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

Turner D, Ricciuto A, Lewis A, et al.

Gastroenterology 2021; (160(5)):1570-1583 doi:10.1053/j.gastro.2020.12.031.

Determinants of quality of life and psychosocial adjustment to pediatric inflammatory bowel disease: A systematic review focused on Crohn's disease.

Touma N, Varay C, Baeza-Velasco C

Journal of psychosomatic research 2021; (142()):110354 doi:10.1016/j.jpsychores.2020.110354.

Diet and Nutrition in Pediatric Inflammatory Bowel Diseases.

Cucinotta U, Romano C, Dipasquale V

Nutrients 2021; (13(2)) doi:10.3390/nu13020655.

Interleukin 10 and interleukin 10 receptor in paediatric inflammatory bowel disease: from bench to bedside lesson.

Krawiec P, Pawłowska-Kamieniak A, Pac-Kożuchowska E

Journal of inflammation (London, England) 2021; (18(1)):13 doi:10.1186/s12950-021-00279-3.

Failure to thrive: A severe manifestation of interleukin 10 receptor A mutation in adult inflammatory bowel disease.

Ruiz NC, Kamel AY, Liu X, et al.

JPEN. Journal of parenteral and enteral nutrition 2022; (46(1)):238-242 doi:10.1002/jpen.2254.

Impact of developmental and epileptic encephalopathies on caregivers: A literature review.

Gallop K, Lloyd AJ, Olt J, Marshall J

Epilepsy & behavior : E&B 2021; (124()):108324 doi:10.1016/j.yebeh.2021.108324.

Targeting the Intestinal Barrier to Prevent Gut-Derived Inflammation and Disease: A Role for Intestinal Alkaline Phosphatase.

Kühn F, Duan R, Ilmer M, et al.

Visceral medicine 2021; (37(5)):383-393 doi:10.1159/000515910.

Small Bowel Volvulus as Delayed Presentation of Undiagnosed Crohn's Disease: A Case Report.

Nguyen MTT, Ali A, Bodkin RP

Clinical practice and cases in emergency medicine 2021; (5(4)):455-458 doi:10.5811/cpcem.2021.8.53524.

Iron Deficiency Anemia in Inflammatory Bowel Diseases-A Narrative Review.

Mahadea D, Adamczewska E, Ratajczak AE, et al.

Nutrients 2021; (13(11)) doi:10.3390/nu13114008.

Autosomal recessive 333 base pair interleukin 10 receptor alpha subunit deletion in very early-onset inflammatory bowel disease.

Lv JJ, Su W, Chen XY, et al.

World journal of gastroenterology 2021; (27(44)):7705-7715 doi:10.3748/wjg.v27.i44.7705.

Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease.

Collen LV, Kim DY, Field M, et al.

Journal of Crohn's & colitis 2022; (16(9)):1380-1396 doi:10.1093/ecco-jcc/jjac045.

High Impact of Pediatric Inflammatory Bowel Disease on Caregivers' Work Productivity and Daily Activities: An International Prospective Study.

Klomberg RCW, Aardoom MA, Kemos P, et al.

The Journal of pediatrics 2022; (246()):95-102.e4 doi:10.1016/j.jpeds.2022.04.014.

Linking Genetic Diagnosis to Therapeutic Approach in Very Early Onset Inflammatory Bowel Disease: Pharmacologic Considerations.

Levine AE, Zheng HB, Suskind DL

Paediatric drugs 2022; (24(3)):207-216 doi:10.1007/s40272-022-00503-4.

Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene.

Noda S, Yamada A, Asawa Y, et al.

Journal of nutritional science and vitaminology 2022; (68(4)):284-293 doi:10.3177/jnsv.68.284.

Intestinal Ultrasound for the Pediatric Gastroenterologist: A Guide for Inflammatory Bowel Disease Monitoring in Children: Expert Consensus on Behalf of the International Bowel Ultrasound Group (IBUS) Pediatric Committee.

Kellar A, Dolinger M, Novak KL, et al.

Journal of pediatric gastroenterology and nutrition 2023; (76(2)):142-148 doi:10.1097/MPG.0000000000003649.

Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease.

Ateş BB, Talim B, Gülşen HH, et al.

The Turkish journal of pediatrics 2022; (64(6)):1068-1076.

Health Care Maintenance in Pediatric Inflammatory Bowel Disease.

Mitchel EB, Grossman A

Gastroenterology clinics of North America 2023; (52(3)):609-627 doi:10.1016/j.gtc.2023.05.009.

Application of a pattern-based approach to histological diagnosis in very early onset IBD (VEO-IBD) in a multicentric cohort of children with emphasis on monogenic disease with IBD-like morphology.

Parente P, Macciomei MC, Buccoliero AM, et al.

Histopathology 2024; (84(3)):440-450 doi:10.1111/his.15084.

Understanding very early onset inflammatory bowel disease (VEOIBD) in relation to inborn errors of immunity.

Hall CHT, de Zoeten EF

Immunological reviews 2024; (322(1)):329-338 doi:10.1111/imr.13302.

AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review.

Hashash JG, Elkins J, Lewis JD, Binion DG

Gastroenterology 2024; (166(3)):521-532 doi:10.1053/j.gastro.2023.11.303.

Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis.

Ouahed JD, Griffith A, Collen LV, Snapper SB

Inflammatory bowel diseases 2024; (30(7)):1189-1206 doi:10.1093/ibd/izad319.

Effectiveness of family centred interventions for family caregivers: A systematic review and meta-analysis of randomized controlled trials.

Wang Z, Yu S, Liu Y, et al.

Journal of clinical nursing 2024; (33(5)):1958-1975 doi:10.1111/jocn.17091.

Caregiver burden among parents of children with type 1 diabetes: A qualitative scoping review.

Azimi T, Johnson J, Campbell SM, Montesanti S

Heliyon 2024; (10(6)):e27539 doi:10.1016/j.heliyon.2024.e27539.

Very Early Onset Inflammatory Bowel Disease: Diagnostic and Therapeutic Challenges for Pediatric Gastroenterologists.

Nahid KL, Rukunuzzaman M, Fathema K

Mymensingh medical journal : MMJ 2024; (33(3)):944-951.

Assessing the correlation between fecal calprotectin, blood markers and disease activity in pediatric inflammatory bowel disease.

Plume JL, De A, Mutalib M

Annals of gastroenterology 2024; (37(4)):436-441 doi:10.20524/aog.2024.0892.

Role of ileal diversion in pediatric inflammatory bowel disease.

Simard AA, Kotamraju S, DeFazio JR, Picoraro JA

Journal of pediatric gastroenterology and nutrition 2024; (79(4)):800-806 doi:10.1002/jpn3.12331.

Multidisciplinary Perspectives on Medical Decision-Making for Ostomy Surgery in Pediatric IBD: Themes from Focus Groups.

David JG, Dotson JL, Mackner L

Journal of clinical psychology in medical settings 2025; (32(2)):278-285 doi:10.1007/s10880-024-10036-2.

The mediating role of resilience between caregiver burden and hope among patients with inflammatory bowel disease.

Zhou M, Wang M, Luo D, et al.

Nursing open 2024; (11(8)):e70001 doi:10.1002/nop2.70001.

Deficiency of intestinal alkaline phosphatase affects behavior and microglia activity in mice.

Dai J, Yang J, Han S, et al.

Brain, behavior, and immunity 2025; (126()):297-310 doi:10.1016/j.bbi.2025.02.006.

Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial.

O'Donnell JEM, Leach ST, Bowcock NL, et al.

Digestive diseases and sciences 2025; (70(5)):1844-1853 doi:10.1007/s10620-025-08913-3.

Histologic alterations are common in Monogenic Disease patients with 'healthy' endoscopy: Results from a GIPAD-GIPPI multicenter study.

Ferro J, Francalanci P, Angerilli V, et al.

Human pathology 2025; (157()):105763 doi:10.1016/j.humpath.2025.105763.

Genetic and Clinical Characteristics of Difficult-To-Treat Crohn's Disease: Trio-Based Exome Sequencing in 24 Families.

Wu HB, Xu ZY, Wang W, et al.

Journal of digestive diseases 2025; (26(5-6)):230-240 doi:10.1111/1751-2980.13358.

RANKL/OPG Axis and Bone Mineral Density in Pediatric Inflammatory Bowel Disease.

Olczyk M, Frankowska A, Tkaczyk M, et al.

Journal of clinical medicine 2025; (14(15)) doi:10.3390/jcm14155440.

Challenges in the Management of Inflammatory Bowel Disease in Children: A Narrative Review.

Hathagoda W, Rajindrajith S, Niriella MA

Clinical and experimental gastroenterology 2025; (18()):259-275 doi:10.2147/CEG.S557464.

Systematic review of indirect costs to families of children with developmental epileptic encephalopathies.

Abdelmageed S, Du RY, Carroll M, et al.

Orphanet journal of rare diseases 2025; (20(1)):579 doi:10.1186/s13023-025-04081-9.

Nutritional Approach in Pediatric Patients with Inflammatory Bowel Disease: Treatment, Risk and Challenges.

Capra ME, Bellani AM, Berzieri M, et al.

Nutrients 2025; (17(22)) doi:10.3390/nu17223545.

Targeted therapies and their outcomes in monogenic very early onset inflammatory bowel disease: a systematic review.

Abhari AP, Rezvanian P, Sohrabi E, et al.

BMC gastroenterology 2026; (26(1)):113 doi:10.1186/s12876-025-04592-6.

Real-world data on STRIDE-II treatment targets in a pediatric cohort with inflammatory bowel disease.

Frank ML, Thi TGL, Schacker I, et al.

Journal of pediatric gastroenterology and nutrition 2026; (82(4)):1006-1018 doi:10.1002/jpn3.70345.

Incidence and prevalence of immune-mediated extraintestinal manifestations in pediatric inflammatory bowel disease: a systematic review and meta-analysis.

Colman RJ, Vuyyuru SK, Solitano V, et al.

Crohn's & colitis 360 2026; (8(2)):otag024 doi:10.1093/crocol/otag024.

[Beyond the gut: articular involvement in inflammatory bowel disease].

Parra Izquierdo V, Frías-Ordoñez JS, Romero MC

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 2026; (46(1)):51-57.

Issues navigating the healthcare delivery system among caregivers of children and youth with special healthcare needs: a qualitative study.

Meyer CM, Campbell RK, Kelleher MR, et al.

BMC health services research 2026; (26(1)).

Alleviating effect of intestinal alkaline phosphatase on Enterotoxigenic Escherichia coli K99-induced diarrhea.

Wang S, Zhang Y, Zhang X, et al.

Microbial pathogenesis 2026; (218()):108645 doi:10.1016/j.micpath.2026.108645.

Tricho-Hepato-Enteric Syndromic Immunodeficiency: Clinical Spectrum, Pathobiology, and Emerging Therapies.

Mandola AB, Frizinsky S, Somekh I, et al.

The Israel Medical Association journal : IMAJ 2026; (28(8)):487-493.

Proxy-reported quality of life of children with intestinal pseudo-obstruction and caregivers' self-reported health outcomes in China.

Cai C, Wang Y, You Y, et al.

Journal of pediatric gastroenterology and nutrition 2026; doi:10.1002/jpn3.70586.