Research & Literature

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

Richards S, Aziz N, Bale S, et al.

Genetics in medicine : official journal of the American College of Medical Genetics 2015; (17(5)):405-24 doi:10.1038/gim.2015.30.

Gastrostomy in patients with amyotrophic lateral sclerosis (ProGas): a prospective cohort study.

The Lancet. Neurology 2015; (14(7)):702-9.

Effects of non-invasive ventilation on objective sleep and nocturnal respiration in patients with amyotrophic lateral sclerosis.

Boentert M, Brenscheidt I, Glatz C, Young P

Journal of neurology 2015; (262(9)):2073-82 doi:10.1007/s00415-015-7822-4.

Amyotrophic Lateral Sclerosis Regional Variants (Brachial Amyotrophic Diplegia, Leg Amyotrophic Diplegia, and Isolated Bulbar Amyotrophic Lateral Sclerosis).

Jawdat O, Statland JM, Barohn RJ, et al.

Neurologic clinics 2015; (33(4)):775-85.

Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.

Spies J, Waizenegger A, Barton O, et al.

Molecular cell 2016; (62(6)):903-917 doi:10.1016/j.molcel.2016.04.032.

Assessment of the upper motor neuron in amyotrophic lateral sclerosis.

Huynh W, Simon NG, Grosskreutz J, et al.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2016; (127(7)):2643-60.

Pathogenesis of amyotrophic lateral sclerosis.

Morgan S, Orrell RW

British medical bulletin 2016; (119(1)):87-98 doi:10.1093/bmb/ldw026.

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Kenna KP, van Doormaal PT, Dekker AM, et al.

Nature genetics 2016; (48(9)):1037-42 doi:10.1038/ng.3626.

Genetic testing and genetic counseling for amyotrophic lateral sclerosis: an update for clinicians.

Roggenbuck J, Quick A, Kolb SJ

Genetics in medicine : official journal of the American College of Medical Genetics 2017; (19(3)):267-274 doi:10.1038/gim.2016.107.

The epidemiology of amyotrophic lateral sclerosis.

Talbott EO, Malek AM, Lacomis D

Handbook of clinical neurology 2016; (138()):225-38.

Identification and outcomes of clinical phenotypes in amyotrophic lateral sclerosis/motor neuron disease: Australian National Motor Neuron Disease observational cohort.

Talman P, Duong T, Vucic S, et al.

BMJ open 2016; (6(9)):e012054 doi:10.1136/bmjopen-2016-012054.

[Ventilatory Support and Management of Secretions in Amyotrophic Lateral Sclerosis].

Boentert M, Young P

Fortschritte der Neurologie-Psychiatrie 2016; (84(10)):640-650 doi:10.1055/s-0042-117284.

Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).

Grad LI, Rouleau GA, Ravits J, Cashman NR

Cold Spring Harbor perspectives in medicine 2017; (7(8)) doi:10.1101/cshperspect.a024117.

Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity.

Singh V, Connelly ZM, Shen X, De Benedetti A

Cell cycle (Georgetown, Tex.) 2017; (16(10)):915-926 doi:10.1080/15384101.2017.1314421.

Care management in amyotrophic lateral sclerosis.

Soriani MH, Desnuelle C

Revue neurologique 2017; (173(5)):288-299 doi:10.1016/j.neurol.2017.03.031.

Amyotrophic lateral sclerosis or not: Keys for the diagnosis.

Lenglet T, Camdessanché JP

Revue neurologique 2017; (173(5)):280-287 doi:10.1016/j.neurol.2017.04.003.

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.

,

The Lancet. Neurology 2017; (16(7)):505-512 doi:10.1016/S1474-4422(17)30115-1.

Predictive genetic testing for amyotrophic lateral sclerosis and frontotemporal dementia: genetic counselling considerations.

Crook A, Williams K, Adams L, et al.

Amyotrophic lateral sclerosis & frontotemporal degeneration 2017; (18(7-8)):475-485 doi:10.1080/21678421.2017.1332079.

Genetic screening in sporadic ALS and FTD.

Turner MR, Al-Chalabi A, Chio A, et al.

Journal of neurology, neurosurgery, and psychiatry 2017; (88(12)):1042-1044 doi:10.1136/jnnp-2017-315995.

Supportive care needs of patients with amyotrophic lateral sclerosis/motor neuron disease and their caregivers: A scoping review.

Oh J, Kim JA

Journal of clinical nursing 2017; (26(23-24)):4129-4152 doi:10.1111/jocn.13945.

NEK1 genetic variability in a Belgian cohort of ALS and ALS-FTD patients.

Nguyen HP, Van Mossevelde S, Dillen L, et al.

Neurobiology of aging 2018; (61()):255.e1-255.e7 doi:10.1016/j.neurobiolaging.2017.08.021.

Amyotrophic lateral sclerosis.

Hardiman O, Al-Chalabi A, Chio A, et al.

Nature reviews. Disease primers 2017; (3()):17071 doi:10.1038/nrdp.2017.71.

Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease.

Radunovic A, Annane D, Rafiq MK, et al.

The Cochrane database of systematic reviews 2017; (10()):CD004427 doi:10.1002/14651858.CD004427.pub4.

Atypical Initial Presentation of Painful Muscle Cramps in a Patient with Amyotrophic Lateral Sclerosis: A Case Report and Brief Review of the Literature.

Kuzel AR, Lodhi MU, Syed IA, Rahim M

Cureus 2017; (9(11)):e1837 doi:10.7759/cureus.1837.

Towards a TDP-43-Based Biomarker for ALS and FTLD.

Feneberg E, Gray E, Ansorge O, et al.

Molecular neurobiology 2018; (55(10)):7789-7801 doi:10.1007/s12035-018-0947-6.

NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons.

Higelin J, Catanese A, Semelink-Sedlacek LL, et al.

Stem cell research 2018; (30()):150-162 doi:10.1016/j.scr.2018.06.005.

Riluzole: real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis.

Hinchcliffe M, Smith A

Degenerative neurological and neuromuscular disease 2017; (7()):61-70 doi:10.2147/DNND.S135748.

Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions.

Ngo ST, Mi JD, Henderson RD, et al.

Degenerative neurological and neuromuscular disease 2017; (7()):95-108 doi:10.2147/DNND.S120607.

Quantifying the potential of functional evidence to reclassify variants of uncertain significance in the categorical and Bayesian interpretation frameworks.

Brnich SE, Rivera-Muñoz EA, Berg JS

Human mutation 2018; (39(11)):1531-1541 doi:10.1002/humu.23609.

Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis.

Volk AE, Weishaupt JH, Andersen PM, et al.

Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V 2018; (30(2)):252-258 doi:10.1007/s11825-018-0185-3.

Variation in assistive technology use in Motor Neuron Disease according to clinical phenotypes and ALS Functional Rating Scale - Revised Score: A prospective observational study.

Connors K, Mahony L, Morgan P

NeuroRehabilitation 2019; (44(2)):303-313 doi:10.3233/NRE-182511.

The optimisation of noninvasive ventilation in amyotrophic lateral sclerosis: a systematic review.

O'Brien D, Stavroulakis T, Baxter S, et al.

The European respiratory journal 2019; (54(3)) doi:10.1183/13993003.00261-2019.

Use of non-invasive ventilation to facilitate extubation in a patient with amyotrophic lateral sclerosis with hypercapnic respiratory failure.

Diaz-Abad M, Chauhan C, Epps D, et al.

Neurology international 2019; (11(2)):8102 doi:10.4081/ni.2019.8102.

Sleep disturbances in patients with amyotrophic lateral sclerosis: current perspectives.

Boentert M

Nature and science of sleep 2019; (11()):97-111 doi:10.2147/NSS.S183504.

Quality of life and functional independence in amyotrophic lateral sclerosis: A systematic review.

Rosa Silva JP, Santiago Júnior JB, Dos Santos EL, et al.

Neuroscience and biobehavioral reviews 2020; (111()):1-11 doi:10.1016/j.neubiorev.2019.12.032.

Predictive factors for gastrostomy at time of diagnosis and impact on survival in patients with amyotrophic lateral sclerosis.

Vergonjeanne M, Fayemendy P, Marin B, et al.

Clinical nutrition (Edinburgh, Scotland) 2020; (39(10)):3112-3118 doi:10.1016/j.clnu.2020.01.018.

Hand-onset weakness is a common feature of ALS patients with a NEK1 loss-of-function variant.

Tsai YS, Lin KP, Jih KY, et al.

Annals of clinical and translational neurology 2020; (7(6)):965-971 doi:10.1002/acn3.51064.

Spreading in ALS: The relative impact of upper and lower motor neuron involvement.

Gromicho M, Figueiral M, Uysal H, et al.

Annals of clinical and translational neurology 2020; (7(7)):1181-1192 doi:10.1002/acn3.51098.

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.

Miller T, Cudkowicz M, Shaw PJ, et al.

The New England journal of medicine 2020; (383(2)):109-119 doi:10.1056/NEJMoa2003715.

ALS: Management Problems.

Brent JR, Franz CK, Coleman JM, Ajroud-Driss S

Neurologic clinics 2020; (38(3)):565-575 doi:10.1016/j.ncl.2020.03.013.

Effectiveness of percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis.

Elbe P, Markus K, Valente R, et al.

Minerva gastroenterologica e dietologica 2020; (66(3)):219-224 doi:10.23736/S1121-421X.20.02695-1.

An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3.

Watanabe Y, Nakagawa T, Akiyama T, et al.

iScience 2020; (23(9)):101491 doi:10.1016/j.isci.2020.101491.

High-Throughput Genetic Testing in ALS: The Challenging Path of Variant Classification Considering the ACMG Guidelines.

Lattante S, Marangi G, Doronzio PN, et al.

Genes 2020; (11(10)) doi:10.3390/genes11101123.

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases.

Quinn C, Elman L

Continuum (Minneapolis, Minn.) 2020; (26(5)):1323-1347 doi:10.1212/CON.0000000000000911.

Pathogenic Genome Signatures That Damage Motor Neurons in Amyotrophic Lateral Sclerosis.

Yousefian-Jazi A, Seol Y, Kim J, et al.

Cells 2020; (9(12)) doi:10.3390/cells9122687.

Multidisciplinary care in Amyotrophic Lateral Sclerosis: a systematic review and meta-analysis.

de Almeida FEO, do Carmo Santana AK, de Carvalho FO

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2021; (42(3)):911-923 doi:10.1007/s10072-020-05011-2.

Novel variants and cellular studies on patients' primary fibroblasts support a role for NEK1 missense variants in ALS pathogenesis.

Lattante S, Doronzio PN, Conte A, et al.

Human molecular genetics 2021; (30(1)):65-71 doi:10.1093/hmg/ddab015.

NEK1 mutations and the risk of amyotrophic lateral sclerosis (ALS): a meta-analysis.

Yao L, He X, Cui B, et al.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2021; (42(4)):1277-1285 doi:10.1007/s10072-020-05037-6.

Diagnostics of Amyotrophic Lateral Sclerosis: Up to Date.

Štětkářová I, Ehler E

Diagnostics (Basel, Switzerland) 2021; (11(2)) doi:10.3390/diagnostics11020231.

Mapping of critical events in disease progression through binary classification: Application to amyotrophic lateral sclerosis.

Dalgıç ÖO, Wu H, Safa Erenay F, et al.

Journal of biomedical informatics 2021; (123()):103895 doi:10.1016/j.jbi.2021.103895.

Reanalysis of eMERGE phase III sequence variants in 10,500 participants and infrastructure to support the automated return of knowledge updates.

Zouk H, Yu W, Oza A, et al.

Genetics in medicine : official journal of the American College of Medical Genetics 2022; (24(2)):454-462 doi:10.1016/j.gim.2021.10.010.

ALS in Finland: Major Genetic Variants and Clinical Characteristics of Patients With and Without the C9orf72 Hexanucleotide Repeat Expansion.

Laaksovirta H, Launes J, Jansson L, et al.

Neurology. Genetics 2022; (8(2)):e665 doi:10.1212/NXG.0000000000000665.

SOD-1 Variants in Amyotrophic Lateral Sclerosis: Systematic Re-Evaluation According to ACMG-AMP Guidelines.

Ruffo P, Perrone B, Conforti FL

Genes 2022; (13(3)) doi:10.3390/genes13030537.

Comparative Performance of Different Respiratory Test Parameters for Detection of Early Respiratory Insufficiency in Patients With ALS.

Kelly CR, Parra-Cantu C, Thapa P, et al.

Neurology 2022; (99(7)):e743-e750 doi:10.1212/WNL.0000000000200758.

Oropharyngeal Dysphagia as the Main Expression of Amyotrophic Lateral Sclerosis.

Rugaitienė M, Damulevičienė G, Lesauskaitė V, Ulozienė I

Medicina (Kaunas, Lithuania) 2022; (58(5)) doi:10.3390/medicina58050647.

Motor neuron, peripheral nerve, and neuromuscular junction disorders.

Vianello A, Racca F, Vita GL, et al.

Handbook of clinical neurology 2022; (189()):259-270 doi:10.1016/B978-0-323-91532-8.00014-8.

Analysis of hereditary cancer gene variant classifications from ClinVar indicates a need for regular reassessment of clinical assertions.

Davidson AL, Kondrashova O, Leonard C, et al.

Human mutation 2022; (43(12)):2054-2062 doi:10.1002/humu.24468.

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.

Miller TM, Cudkowicz ME, Genge A, et al.

The New England journal of medicine 2022; (387(12)):1099-1110 doi:10.1056/NEJMoa2204705.

Palliative care principles in ALS.

Shoesmith C

Handbook of clinical neurology 2023; (191()):139-155 doi:10.1016/B978-0-12-824535-4.00007-0.

Percutaneous Endoscopic Gastrostomy Placement under NIV in Amyotrophic Lateral Sclerosis with Severe Ventilatory Dysfunction: A Safe and Effective Procedure.

Gaspar R, Ramalho R, Coelho R, et al.

GE Portuguese journal of gastroenterology 2023; (30(1)):61-67 doi:10.1159/000519926.

Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.

Gregorczyk M, Pastore G, Muñoz I, et al.

Life science alliance 2023; (6(7)) doi:10.26508/lsa.202201740.

Diagnostic delay in amyotrophic lateral sclerosis.

Gwathmey KG, Corcia P, McDermott CJ, et al.

European journal of neurology 2023; (30(9)):2595-2601 doi:10.1111/ene.15874.

Guideline "Motor neuron diseases" of the German Society of Neurology (Deutsche Gesellschaft für Neurologie).

Petri S, Grehl T, Grosskreutz J, et al.

Neurological research and practice 2023; (5(1)):25 doi:10.1186/s42466-023-00251-x.

Palliative Care in Amyotrophic Lateral Sclerosis.

Mercadante S, Al-Husinat L

Journal of pain and symptom management 2023; (66(4)):e485-e499 doi:10.1016/j.jpainsymman.2023.06.029.

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.

Mann JR, McKenna ED, Mawrie D, et al.

Science advances 2023; (9(33)):eadi5548 doi:10.1126/sciadv.adi5548.

Evidence-based consensus guidelines for ALS genetic testing and counseling.

Roggenbuck J, Eubank BHF, Wright J, et al.

Annals of clinical and translational neurology 2023; (10(11)):2074-2091 doi:10.1002/acn3.51895.

A large-scale comparison of two voice synthesis techniques on intelligibility, naturalness, preferences, and attitudes toward voices banked by individuals with amyotrophic lateral sclerosis.

Hyppa-Martin J, Lilley J, Chen M, et al.

Augmentative and alternative communication (Baltimore, Md. : 1985) 2024; (40(1)):31-45 doi:10.1080/07434618.2023.2262032.

Racial disparities in ALS diagnostic delay: a single center's experience and review of potential contributing factors.

Chen S, Carter D, Brockenbrough PB, et al.

Amyotrophic lateral sclerosis & frontotemporal degeneration 2024; (25(1-2)):112-118 doi:10.1080/21678421.2023.2273361.

Pharmacokinetics of Edaravone Oral Suspension in Patients With Amyotrophic Lateral Sclerosis.

Shimizu H, Nishimura Y, Shiide Y, et al.

Clinical therapeutics 2023; (45(12)):1251-1258 doi:10.1016/j.clinthera.2023.09.025.

Reduced penetrance of gene variants causing amyotrophic lateral sclerosis.

Douglas AGL, Baralle D

Journal of medical genetics 2024; (61(3)):294-297 doi:10.1136/jmg-2023-109580.

Dental Management of Patients With Amyotrophic Lateral Sclerosis.

AlMadan N, AlMajed A, AlAbbad M, et al.

Cureus 2023; (15(12)):e50602 doi:10.7759/cureus.50602.

Human Genetics Society of Australasia Position Statement: Predictive and Presymptomatic Genetic Testing in Adults and Children.

Vears DF, McLean A, La Spina C, et al.

Twin research and human genetics : the official journal of the International Society for Twin Studies 2024; (27(2)):120-127 doi:10.1017/thg.2024.9.

Edaravone Oral Suspension: A Neuroprotective Agent to Treat Amyotrophic Lateral Sclerosis.

Singh P, Belliveau P, Towle J, et al.

American journal of therapeutics 2024; (31(3)):e258-e267 doi:10.1097/MJT.0000000000001742.

Sodium Phenylbutyrate and Tauroursodeoxycholic Acid: A Story of Hope Turned to Disappointment in Amyotrophic Lateral Sclerosis Treatment.

Ketabforoush A, Faghihi F, Azedi F, et al.

Clinical drug investigation 2024; (44(7)):495-512 doi:10.1007/s40261-024-01371-1.

Treatment continuity of amyotrophic lateral sclerosis with available riluzole formulations: state of the art and current challenges in a 'real-world' setting.

Corcia P, Guy N, Pradat PF, et al.

Amyotrophic lateral sclerosis & frontotemporal degeneration 2025; (26(1-2)):15-21 doi:10.1080/21678421.2024.2375330.

ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons.

Zelina P, de Ruiter AA, Kolsteeg C, et al.

Acta neuropathologica communications 2024; (12(1)):144 doi:10.1186/s40478-024-01852-6.

A nurse coaching intervention to improve support to individuals living with ALS.

Walsh S, Simmons Z, Miyamoto S, Geronimo A

Amyotrophic lateral sclerosis & frontotemporal degeneration 2025; (26(1-2)):22-28 doi:10.1080/21678421.2024.2399154.

Clinical Variant Reclassification in Hereditary Disease Genetic Testing.

Kobayashi Y, Chen E, Facio FM, et al.

JAMA network open 2024; (7(11)):e2444526 doi:10.1001/jamanetworkopen.2024.44526.

How the prospect of a clinical trial impacts decision-making for predictive genetic testing in ALS.

Fontaine M, Horowitz K, Anoja N, et al.

Amyotrophic lateral sclerosis & frontotemporal degeneration 2025; (26(3-4)):343-351 doi:10.1080/21678421.2024.2423718.

Initiating non-invasive ventilation in patients with Amyotrophic Lateral Sclerosis in The Netherlands: A centralised approach to respiratory care.

Jaspers Focks RJ, Helleman J, van den Berg LH, et al.

Journal of neuromuscular diseases 2025; (12(3)):372-381 doi:10.1177/22143602251319167.

TARDBP variants in Taiwanese ALS patients: Genetic spectrum, clinical features, and founder effects.

Jih KY, Fang SY, Tsai YS, et al.

Journal of the neurological sciences 2025; (474()):123531 doi:10.1016/j.jns.2025.123531.

Exploring NEK1 genetic variability in Italian amyotrophic lateral sclerosis patients.

Pensato V, Peverelli S, Tiloca C, et al.

Journal of neurology 2025; (272(7)):469 doi:10.1007/s00415-025-13153-6.

Real-World Clinical Experience With Sodium Phenylbutyrate and Taurursodiol at a Single Amyotrophic Lateral Sclerosis Center in the United States.

Calcagno N, Scirocco E, Clampffer E, et al.

European journal of neurology 2025; (32(9)):e70360 doi:10.1111/ene.70360.

Emerging roles of primary cilia in the pathogenesis of amyotrophic lateral sclerosis.

Takahashi H, Kasai T, Miyagawa-Hayashino A, Ohara T

Frontiers in neuroscience 2025; (19()):1688839 doi:10.3389/fnins.2025.1688839.

MaveMD: A functional data resource for genomic medicine.

McEwen AE, Stone J, Tejura M, et al.

medRxiv : the preprint server for health sciences 2025; doi:10.1101/2025.11.15.25336228.

Recurarization after sugammadex reversal in a patient with amyotrophic lateral sclerosis: Case report.

Wang YW, Zhang Y, Hu X, et al.

Medicine 2026; (105(1)):e46928 doi:10.1097/MD.0000000000046928.

Stage-Based Communication Rehabilitation in Amyotrophic Lateral Sclerosis (ALS): A Review of Strategies for Enhancing Quality of Life.

Jackson MC, Azarraga RB, Fraix MP, Agrawal DK

Archives of internal medicine research 2025; (8(4)):359-371 doi:10.26502/aimr.0230.

Reasons for and against presymptomatic genetic testing in frontotemporal dementia: a qualitative study.

Graafland CH, Seelaar H, Panman JL, et al.

Human genetics 2026; (145(1)):21 doi:10.1007/s00439-025-02795-1.

Predictive genetic testing in amyotrophic lateral sclerosis (ALS): Experiences of decision-making and engagement with UK genetic counseling services.

Howard J, Bekker HL, McDermott CJ, McNeill A

Journal of genetic counseling 2026; (35(1)):e70184 doi:10.1002/jgc4.70184.

High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis.

Gagliardi D, Villella C, Zanovello M, et al.

Annals of neurology 2026; (99(6)):1502-1515 doi:10.1002/ana.78195.

Emerging strategies for interpreting variants of uncertain significance (VUS) in amyotrophic lateral sclerosis.

Ahmed M, Volkening K, Mclellan C, et al.

Amyotrophic lateral sclerosis & frontotemporal degeneration 2026; 1-15 doi:10.1080/21678421.2026.2655734.

Oligogenic variants in NEK1 and ATXN2 in amyotrophic lateral sclerosis: report of two cases and review of the literature.

Roy É, Blais M, Dion P, et al.

Amyotrophic lateral sclerosis & frontotemporal degeneration 2026; 1-9 doi:10.1080/21678421.2026.2685158.

A rare missense variant impacting NEK1 kinase function is associated with ALS.

Brenner D, Ponomarenko A, Petrut I, et al.

Acta neuropathologica communications 2026; (14(1)).

Amyotrophic lateral sclerosis and degenerative cervical myelopathy: phenotype-based diagnostic pitfalls, investigative mismatch, and practical clinical reasoning.

Chen D, Shen T, Ren H, Qiu P

Frontiers in neurology 2026; (17()):1901811 doi:10.3389/fneur.2026.1901811.