Research & Literature

Substaging Nodal Status in Ampullary Carcinomas has Significant Prognostic Value: Proposed Revised Staging Based on an Analysis of 313 Well-Characterized Cases.

Balci S, Basturk O, Saka B, et al.

Annals of surgical oncology 2015; (22(13)):4392-401 doi:10.1245/s10434-015-4499-y.

Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2).

Hechtman JF, Liu W, Sadowska J, et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2015; (28(8)):1123-9 doi:10.1038/modpathol.2015.57.

FLUCTUATING JAUNDICE IN THE ADENOCARCINOMA OF THE AMPULLA OF VATER: a classic sign or an exception?

Alves JR, Amico EC, Souza DL, et al.

Arquivos de gastroenterologia 2015; (52(2)):147-51.

The role of lymph nodes in predicting the prognosis of ampullary carcinoma after curative resection.

Chen SC, Shyr YM, Chou SC, Wang SE

World journal of surgical oncology 2015; (13()):224 doi:10.1186/s12957-015-0643-1.

Transduodenal Ampullectomy for the Treatment of Early-Stage Ampulla of Vater Cancer.

Lee H, Park JY, Kwon W, et al.

World journal of surgery 2016; (40(4)):967-73 doi:10.1007/s00268-015-3316-x.

Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancer.

Yun SP, Seo HI

BMC gastroenterology 2015; (15()):165 doi:10.1186/s12876-015-0396-x.

Analysis of Founder Mutations in Rare Tumors Associated With Hereditary Breast/Ovarian Cancer Reveals a Novel Association of BRCA2 Mutations with Ampulla of Vater Carcinomas.

Pinto P, Peixoto A, Santos C, et al.

PloS one 2016; (11(8)):e0161438 doi:10.1371/journal.pone.0161438.

Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations.

Mafficini A, Amato E, Cataldo I, et al.

Annals of surgery 2018; (267(1)):149-156 doi:10.1097/SLA.0000000000001999.

[Neuroendocrine Tumor of the Ampulla of Vater and Gastrointestinal Stromal Tumor of the Duodenum in a Patient with Von Recklinghausen's Disease].

Yamada Y, Shiozawa S, Usui T, et al.

Gan to kagaku ryoho. Cancer & chemotherapy 2016; (43(12)):2365-2367.

Carcinoma of the Papilla of Vater after Diversion Operation for Pancreaticobiliary Maljunction.

Yamanaka T, Araki K, Ishii N, et al.

Case reports in gastroenterology 2017; (11(2)):265-270 doi:10.1159/000462967.

Simultaneous Courvoisier's and double duct signs.

Agrawal S, Vohra S

World journal of gastrointestinal endoscopy 2017; (9(8)):425-427 doi:10.4253/wjge.v9.i8.425.

Association of Adjuvant Therapy with Improved Survival in Ampullary Cancer: A National Cohort Study.

Nassour I, Hynan LS, Christie A, et al.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2018; (22(4)):695-702 doi:10.1007/s11605-017-3624-6.

Early Contact after Hospital Discharge Does Not Prevent Readmission in Patients Undergoing Pancreaticoduodenectomy.

Gebhardt KM, Young S, DiFronzo LA

The American surgeon 2017; (83(10)):1157-1160.

Validation of the eighth edition of the American Joint Committee on Cancer staging system for ampulla of Vater cancer.

Kim SJ, An S, Kang HJ, et al.

Surgery 2018; (163(5)):1071-1079 doi:10.1016/j.surg.2017.12.018.

Surgical Treatment of Ampullary Adenocarcinoma - Single Center Experience and a Review of Literature.

Kunovský L, Kala Z, Procházka V, et al.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 2017; (31(1)):46-52 doi:10.14735/amko201846.

Prognostic factors and benefits of adjuvant therapy after pancreatoduodenectomy for ampullary adenocarcinoma: Mayo Clinic experience.

Jin Z, Hartgers ML, Sanhueza CT, et al.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2018; (44(5)):677-683 doi:10.1016/j.ejso.2018.02.008.

Signet Ring Cell Carcinoma of the Ampulla of Vater: A Rare Histopathological Variant.

de Klein GW, van Baarlen J, Mekenkamp LJ, et al.

Case reports in gastroenterology 2018; (12(1)):194-201 doi:10.1159/000488903.

'Bleeding Dilemma': The Story of a Periampullary Mass.

Bahl B, Vadlamudi R, Yedla P, Smalligan RD

Cureus 2018; (10(7)):e3035 doi:10.7759/cureus.3035.

Predictive value of sarcopenia and visceral obesity for postoperative pancreatic fistula after pancreaticoduodenectomy analyzed on clinically acquired CT and MRI.

Jang M, Park HW, Huh J, et al.

European radiology 2019; (29(5)):2417-2425 doi:10.1007/s00330-018-5790-7.

New experience of endoscopic papillectomy for ampullary neoplasms.

Li S, Wang Z, Cai F, et al.

Surgical endoscopy 2019; (33(2)):612-619 doi:10.1007/s00464-018-6577-2.

Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes.

Wong W, Lowery MA, Berger MF, et al.

Cancer 2019; (125(9)):1441-1448 doi:10.1002/cncr.31951.

Histopathologic Predictors of Survival and Recurrence in Resected Ampullary Adenocarcinoma: International Multicenter Cohort Study.

Moekotte AL, Lof S, Van Roessel S, et al.

Annals of surgery 2020; (272(6)):1086-1093 doi:10.1097/SLA.0000000000003177.

Ampullary Cancer.

Zheng-Pywell R, Reddy S

The Surgical clinics of North America 2019; (99(2)):357-367 doi:10.1016/j.suc.2018.12.001.

Carcinoma of the ampulla of Vater diagnosed after surgical treatment for Lemmel's syndrome.

Matsunaga M, Tahara K, Ohta R, et al.

International cancer conference journal 2016; (5(1)):57-60 doi:10.1007/s13691-015-0227-5.

Carcinosarcoma of the ampulla of Vater.

Guzmán Calderón E

Revista espanola de enfermedades digestivas 2019; (111(8)):649-650 doi:10.17235/reed.2019.5932/2018.

The pathohistological subtype strongly predicts survival in patients with ampullary carcinoma.

Zimmermann C, Wolk S, Aust DE, et al.

Scientific reports 2019; (9(1)):12676 doi:10.1038/s41598-019-49179-w.

When Adenocarcinoma Went Hand in Hand with Neuroendocrine Tumor: A Rare Case of Adenocarcinoma Synchronous with Neuroendocrine Tumor in Ampulla of Vater.

Kochar T, Dhingra P, Shah H

Cureus 2019; (11(7)):e5168 doi:10.7759/cureus.5168.

Poorly Cohesive (Signet Ring Cell) Carcinoma of the Ampulla of Vater.

Tuncel D, Basturk O, Bradley KT, et al.

International journal of surgical pathology 2020; (28(3)):236-244 doi:10.1177/1066896919880968.

Trans-duodenal ampullectomy for ampullary neoplasms: early and long-term outcomes in 36 consecutive patients.

Nappo G, Gentile D, Galvanin J, et al.

Surgical endoscopy 2020; (34(10)):4358-4368 doi:10.1007/s00464-019-07206-x.

Very early recurrence following pancreaticoduodenectomy in patients with ampullary cancer.

Park HM, Park SJ, Han SS, et al.

Medicine 2019; (98(44)):e17711 doi:10.1097/MD.0000000000017711.

Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies.

Ikeda C, Makino N, Matsuda A, et al.

Clinical journal of gastroenterology 2020; (13(4)):607-614 doi:10.1007/s12328-020-01097-5.

Resection of the duodenum causes long-term endocrine and exocrine dysfunction after Whipple procedure for benign tumors - Results of a systematic review and meta-analysis.

Beger HG, Mayer B, Poch B

HPB : the official journal of the International Hepato Pancreato Biliary Association 2020; (22(6)):809-820 doi:10.1016/j.hpb.2019.12.016.

Prognostic factors and benefits of adjuvant therapy for ampullary cancer following pancreatoduodenectomy: A systematic review and meta-analysis.

Zhou YM, Liao S, Wei YZ, Wang SJ

Asian journal of surgery 2020; (43(12)):1133-1141 doi:10.1016/j.asjsur.2020.03.007.

Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States.

Kinslow CJ, May MS, Kozak M, et al.

HPB : the official journal of the International Hepato Pancreato Biliary Association 2020; (22(12)):1759-1765 doi:10.1016/j.hpb.2020.03.024.

Prognostic Factors of Long-term Survival Following Radical Resection for Ampullary Carcinoma.

Vilhordo DW, Gregório C, Valentini DF, et al.

Journal of gastrointestinal cancer 2021; (52(3)):872-881 doi:10.1007/s12029-020-00479-9.

Ampullary adenocarcinoma: the current state of adjuvant therapies.

Vining CC, Schuitevoerder D, Turaga KK

Hepatobiliary surgery and nutrition 2020; (9(5)):647-649 doi:10.21037/hbsn.2019.11.37.

Survival Benefit of Adjuvant Chemotherapy After Pancreatoduodenectomy for Ampullary Adenocarcinoma: a Propensity-Matched National Cancer Database (NCDB) Analysis.

Kamarajah SK, Bednar F, Cho CS, Nathan H

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2021; (25(7)):1805-1814 doi:10.1007/s11605-020-04879-x.

Gastrointestinal side effects of upper gastrointestinal cancer surgery.

Antonowicz S, Reddy S, Sgromo B

Best practice & research. Clinical gastroenterology 2020; (48-49()):101706 doi:10.1016/j.bpg.2020.101706.

Transduodenal ampullectomy for ampullary tumor.

Jung YK, Paik SS, Choi D, Lee KG

Asian journal of surgery 2021; (44(5)):723-729 doi:10.1016/j.asjsur.2020.12.021.

Neoadjuvant therapy versus surgery first for ampullary carcinoma: A propensity score-matched analysis of the NCDB.

Guo M, Beal EW, Miller ED, et al.

Journal of surgical oncology 2021; (123(7)):1558-1567 doi:10.1002/jso.26435.

Prognostic value of the lymph node metastasis in patients with ampulla of Vater cancer after surgical resection.

Lee JW, Choi SB, Lim TW, et al.

Annals of hepato-biliary-pancreatic surgery 2021; (25(1)):90-96 doi:10.14701/ahbps.2021.25.1.90.

A population-based study on incidence, treatment, and survival in ampullary cancer in the Netherlands.

de Jong EJM, Geurts SME, van der Geest LG, et al.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2021; (47(7)):1742-1749 doi:10.1016/j.ejso.2021.02.028.

Efficacy and safety of adjuvant therapy after curative surgery for ampullary carcinoma: A systematic review and meta-analysis.

Vo NP, Nguyen HS, Loh EW, Tam KW

Surgery 2021; (170(4)):1205-1214 doi:10.1016/j.surg.2021.03.046.

Prevention, prediction, and mitigation of postoperative pancreatic fistula.

Marchegiani G, Bassi C

The British journal of surgery 2021; (108(6)):602-604 doi:10.1093/bjs/znab125.

Genome-Derived Classification Signature for Ampullary Adenocarcinoma to Improve Clinical Cancer Care.

Chakraborty S, Ecker BL, Seier K, et al.

Clinical cancer research : an official journal of the American Association for Cancer Research 2021; (27(21)):5891-5899 doi:10.1158/1078-0432.CCR-21-1906.

Complications After Pancreaticoduodenectomy.

Simon R

The Surgical clinics of North America 2021; (101(5)):865-874 doi:10.1016/j.suc.2021.06.011.

[Standardized structured reports for gastrointestinal tumors].

Hewer E, Rump A, Langer R

Der Pathologe 2022; (43(1)):57-62 doi:10.1007/s00292-021-00986-x.

Factors influencing patterns of recurrence following pancreaticoduodenectomy for patients with distal bile duct cancer and ampulla of Vater cancer.

Lee DH, Kim HJ, Cho CW, et al.

Annals of hepato-biliary-pancreatic surgery 2022; (26(2)):138-143 doi:10.14701/ahbps.21-129.

Microsatellite instability in pancreatic and ampullary carcinomas: histology, molecular pathology, and clinical implications.

Luchini C, Scarpa A

Human pathology 2023; (132()):176-182 doi:10.1016/j.humpath.2022.06.009.

Transduodenal ampullectomy for early ampullary cancer: Clinical management, histopathological findings and long-term outcomes at a single center.

Miyamoto R, Takahashi A, Ogura T, et al.

Surgery 2023; (173(4)):912-919 doi:10.1016/j.surg.2022.12.005.

Pancreatic Dysfunction and Reduction in Quality of Life Is Common After Pancreaticoduodenectomy.

Kanwat S, Singh H, Sharma AK, et al.

Digestive diseases and sciences 2023; (68(7)):3167-3173 doi:10.1007/s10620-023-07966-6.

A Complex Diagnosis of Ampullary Adenocarcinoma Presenting As Decompensated Cirrhosis.

Iqbal H, Petrosyan A, Yoon J, Roytman M

Cureus 2023; (15(4)):e37566 doi:10.7759/cureus.37566.

Ampulla of Vater carcinoma: advancement in the relationships between histological subtypes, molecular features, and clinical outcomes.

Liang H, Zhu Y, Wu YK

Frontiers in oncology 2023; (13()):1135324 doi:10.3389/fonc.2023.1135324.

Prevalence of pancreatic exocrine insufficiency after pancreatic surgery measured by 13C mixed triglyceride breath test: A prospective cohort study.

Hartman V, Roeyen E, Bracke B, et al.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2023; (23(5)):563-568 doi:10.1016/j.pan.2023.05.012.

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.

Chiorean EG, Chiaro MD, Tempero MA, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2023; (21(7)):753-782 doi:10.6004/jnccn.2023.0034.

Nab-Paclitaxel and Gemcitabine as First-Line Treatment of Metastatic Ampullary Adenocarcinoma with a Novel R-Spondin2 RNA Fusion and NTRK3 Mutation.

Linscott MP, Markus H, Sennett M, et al.

Biomedicines 2023; (11(8)) doi:10.3390/biomedicines11082326.

Elevated CA 19-9 is associated with worse survival in patients with resected ampullary adenocarcinoma.

Boyev A, Prakash LR, Chiang YJ, et al.

Surgical oncology 2023; (51()):101994 doi:10.1016/j.suronc.2023.101994.

Perioperative management of pancreatic exocrine insufficiency-evidence-based proposal for a paradigm shift in pancreatic surgery.

Stern L, Schuette M, Goetz MR, et al.

HPB : the official journal of the International Hepato Pancreato Biliary Association 2024; (26(1)):117-124 doi:10.1016/j.hpb.2023.09.003.

Evaluation of HER2Neu Status in Periampullary Cancers in Tertiary Care Centre in Northern India: A Three-Year Retrospective Study.

Qayoom S, Agarwal A, Agarwal P, et al.

Cureus 2023; (15(10)):e46646 doi:10.7759/cureus.46646.

Prognostic importance of margin clearance in ampullary adenocarcinoma following pancreaticoduodenectomy in a Danish population-based nationwide study.

Aaquist T, Fristrup CW, Hasselby JP, et al.

HPB : the official journal of the International Hepato Pancreato Biliary Association 2024; (26(2)):241-250 doi:10.1016/j.hpb.2023.10.009.

A Case of Metastatic Ampulla of Vater Carcinoma Masked Under Recurrent Acute Pancreatitis: A Diagnostic Challenge.

Rahman AU, Naveed J, Asghar MS, et al.

Cureus 2023; (15(11)):e48675 doi:10.7759/cureus.48675.

Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment.

Tsagkalidis V, Langan RC, Ecker BL

Cancers 2023; (15(24)) doi:10.3390/cancers15245772.

Molecular Targets and Therapies for Ampullary Cancer.

Patel MA, Kratz JD, Carlson AS, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2024; (22(2 D)).

Predictive Factors Associated With Survival in Periampullary Cancers Following Pancreaticoduodenectomy: A Retrospective Analysis.

Maharjan N, Bhandari RS, Lakhey PJ

Cureus 2023; (15(12)):e50607 doi:10.7759/cureus.50607.

Machine learning for differentiating between pancreatobiliary-type and intestinal-type periampullary carcinomas based on CT imaging and clinical findings.

Chen T, Zhang D, Chen S, et al.

Abdominal radiology (New York) 2024; (49(3)):748-761 doi:10.1007/s00261-023-04151-1.

Whipple's cephalic pancreaticoduodenectomy versus pyloric-preserving pancreaticoduodenectomy. Retrospective study.

Justo Alonso I, Marcacuzco Quinto A, Caso Maestro O, et al.

Cirugia espanola 2024; (102(5)):265-274 doi:10.1016/j.cireng.2024.02.007.

Pancreatic head resection for carcinoma of the ampulla vateri - better long-term prognosis, but more postoperative complications.

Kuesters S, Sundheimer J, Wittel UA, et al.

Langenbeck's archives of surgery 2024; (409(1)):129 doi:10.1007/s00423-024-03319-7.

A Case of Pedunculated Adenoma of the Bile Duct Proving Adenoma to Cancer Sequence.

Ahsan M, Jarbath M, Davis B, Provance WJ

Cureus 2024; (16(4)):e58304 doi:10.7759/cureus.58304.

Evaluation of pancreatic morphometric parameters, exocrine function, and nutritional status and their causal relationships in long-term survivors following pancreatectomy.

Ichida H, Imamura H, Takahashi A, et al.

Surgery 2024; (176(4)):1189-1197 doi:10.1016/j.surg.2024.05.046.

Intra-ampullary and Periampullary Carcinoma: Clinicopathological Comparison and Survival Outcomes.

Hashmi AA, Ali R, Jamal SS, et al.

Cureus 2024; (16(8)):e67030 doi:10.7759/cureus.67030.

The clinical significance of the lymph node ratio as a recurrence indicator in ampullary cancer after curative pancreaticoduodenectomy.

Hasegawa S, Wada H, Kubo M, et al.

Langenbeck's archives of surgery 2024; (409(1)):302 doi:10.1007/s00423-024-03481-y.

Diagnostic work-up of bile duct strictures: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Facciorusso A, Crinò SF, Gkolfakis P, et al.

Endoscopy 2025; (57(2)):166-185 doi:10.1055/a-2481-7048.

[Factors of delayed gastric emptying after pancreaticoduodenectomy].

Suvorov VA, Panin SI, Postolov MP, et al.

Khirurgiia 2025; 23-29 doi:10.17116/hirurgia202504123.

Association of PD-L1 Expression with Lymph Node Metastasis and Clinical Stage in Ampulla of Vater Cancer: An Observational Study.

Andrianto A, Rudiman R, Ruchimat T, et al.

Cancer management and research 2025; (17()):965-974 doi:10.2147/CMAR.S513961.

Histologic- and Genomic-Directed Adjuvant Therapy for Ampullary Adenocarcinoma: A Hidden Genome-Derived Analysis.

Ecker BL, Seier K, Choubey A, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2025; (23(6)):234-240 doi:10.6004/jnccn.2025.7008.

Signet ring cell adenocarcinoma of the ampulla of Vater: does the presence of signet ring cells always suggest a poorer outcome?

Nandy K, Dhaiya A, Vipin T, et al.

Langenbeck's archives of surgery 2025; (410(1)):195 doi:10.1007/s00423-025-03708-6.

The efficacy of early progressive resistance exercise in the postoperative management of pancreaticoduodenectomy for pancreatic cancer: a randomized controlled trial.

Liu X, Shi N, Li R, Song Y

Frontiers in surgery 2025; (12()):1609788 doi:10.3389/fsurg.2025.1609788.

Comparison of Frontline FOLFIRINOX with Fluorouracil-Based and Gemcitabine-Based Chemotherapies in Metastatic Ampullary Adenocarcinoma: A Multicenter Study by the Turkish Oncology Group (TOG).

Kalem A, Kus T, Gokcek S, et al.

Journal of clinical medicine 2025; (14(16)) doi:10.3390/jcm14165868.

[Endoscopic treatment of patients with adenomas of the major duodenal papilla and familial adenomatous polyposis].

Starkov YG, Vagapov AI, Zamolodchikov RD, Dzhantukhanova SV

Khirurgiia 2025; 5-11 doi:10.17116/hirurgia20250915.

The Triage Role of Transabdominal Ultrasonography (TAUS) in the Diagnostic Management of Pancreatic and Distal Biliary Pathologies: A Comparative Efficacy Analysis with Endoscopic Ultrasonography (EUS).

Yaraş S, Özdoğan O, Sezgin O

Diagnostics (Basel, Switzerland) 2025; (15(23)) doi:10.3390/diagnostics15232955.

Sarcomatoid Carcinoma of the Ampulla of Vater: A Case Report.

Gong JI, Jang SK, Kim HJ, Han EM

Journal of the Korean Society of Radiology 2026; (87(1)):141-146 doi:10.3348/jksr.2025.0037.