Research & Literature

The Role of FDG-PET in the Initial Staging and Response Assessment of Anal Cancer: A Systematic Review and Meta-analysis.

Jones M, Hruby G, Solomon M, et al.

Annals of surgical oncology 2015; (22(11)):3574-81 doi:10.1245/s10434-015-4391-9.

HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53.

Meulendijks D, Tomasoa NB, Dewit L, et al.

British journal of cancer 2015; (112(8)):1358-66 doi:10.1038/bjc.2015.20.

Late effects and quality of life after chemo-radiation for the treatment of anal cancer.

Knowles G, Haigh R, McLean C, Phillips H

European journal of oncology nursing : the official journal of European Oncology Nursing Society 2015; (19(5)):479-85.

Surgical Options in the Treatment of Lower Gastrointestinal Tract Cancers.

Porpiglia AS, Sigurdson ER

Current treatment options in oncology 2015; (16(9)):46 doi:10.1007/s11864-015-0363-3.

Phase II Study of Capecitabine in Substitution of 5-FU in the Chemoradiotherapy Regimen for Patients with Localized Squamous Cell Carcinoma of the Anal Canal.

Oliveira SC, Moniz CM, Riechelmann R, et al.

Journal of gastrointestinal cancer 2016; (47(1)):75-81 doi:10.1007/s12029-015-9790-4.

Reasons for delays in diagnosis of anal cancer and the effect on patient satisfaction.

Chiu S, Joseph K, Ghosh S, et al.

Canadian family physician Medecin de famille canadien 2015; (61(11)):e509-16.

Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients.

Sauter M, Keilholz G, Kranzbühler H, et al.

BMC gastroenterology 2016; (16()):46 doi:10.1186/s12876-016-0461-0.

The assessment of local response using magnetic resonance imaging at 3- and 6-month post chemoradiotherapy in patients with anal cancer.

Kochhar R, Renehan AG, Mullan D, et al.

European radiology 2017; (27(2)):607-617 doi:10.1007/s00330-016-4337-z.

Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings.

Surabhi VR, Menias CO, Amer AM, et al.

Radiographics : a review publication of the Radiological Society of North America, Inc 2016; (36(5)):1339-53 doi:10.1148/rg.2016150209.

Replacing 5-fluorouracil by capecitabine in localised squamous cell carcinoma of the anal canal: systematic review and meta-analysis.

Souza KT, Pereira AA, Araujo RL, et al.

Ecancermedicalscience 2016; (10()):699 doi:10.3332/ecancer.2016.699.

Best time to assess complete clinical response after chemoradiotherapy in squamous cell carcinoma of the anus (ACT II): a post-hoc analysis of randomised controlled phase 3 trial.

Glynne-Jones R, Sebag-Montefiore D, Meadows HM, et al.

The Lancet. Oncology 2017; (18(3)):347-356 doi:10.1016/S1470-2045(17)30071-2.

Irradiation of anatomically defined pelvic subsites and acute hematologic toxicity in anal cancer patients undergoing chemoradiation.

Rose B, Mitra D, Hong TS, et al.

Practical radiation oncology 2017; (7(5)):e291-e297 doi:10.1016/j.prro.2017.03.008.

Anal cancer: French Intergroup Clinical Practice Guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SNFCP).

Moureau-Zabotto L, Vendrely V, Abramowitz L, et al.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2017; (49(8)):831-840 doi:10.1016/j.dld.2017.05.011.

Capecitabine With Mitomycin Reduces Acute Hematologic Toxicity and Treatment Delays in Patients Undergoing Definitive Chemoradiation Using Intensity Modulated Radiation Therapy for Anal Cancer.

Goodman KA, Julie D, Cercek A, et al.

International journal of radiation oncology, biology, physics 2017; (98(5)):1087-1095 doi:10.1016/j.ijrobp.2017.03.022.

A Case Series of Anal Carcinoma Misdiagnosed as Idiopathic Chronic Anal Fissure.

Barbeiro S, Atalaia-Martins C, Marcos P, et al.

GE Portuguese journal of gastroenterology 2017; (24(5)):227-231 doi:10.1159/000452869.

The prognostic value of HPV combined p16 status in patients with anal squamous cell carcinoma: a meta-analysis.

Sun G, Dong X, Tang X, et al.

Oncotarget 2018; (9(8)):8081-8088 doi:10.18632/oncotarget.23545.

Management of Common Benign Anorectal Disease: What All Physicians Need to Know.

Parés D, Abcarian H

The American journal of medicine 2018; (131(7)):745-751 doi:10.1016/j.amjmed.2018.01.050.

A National-Level Validation of the New American Joint Committee on Cancer 8th Edition Subclassification of Stage IIA and B Anal Squamous Cell Cancer.

Goffredo P, Garancini M, Robinson TJ, et al.

Annals of surgical oncology 2018; (25(6)):1654-1660 doi:10.1245/s10434-018-6449-y.

Toxicity, Tolerability, and Compliance of Concurrent Capecitabine or 5-Fluorouracil in Radical Management of Anal Cancer With Single-dose Mitomycin-C and Intensity Modulated Radiation Therapy: Evaluation of a National Cohort.

Jones CM, Adams R, Downing A, et al.

International journal of radiation oncology, biology, physics 2018; (101(5)):1202-1211 doi:10.1016/j.ijrobp.2018.04.033.

Determinants of high-grade anal intraepithelial lesions in HIV-positive MSM.

Clifford GM, Siproudhis L, Piroth L, et al.

AIDS (London, England) 2018; (32(16)):2363-2371 doi:10.1097/QAD.0000000000001947.

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

Benson AB, Venook AP, Al-Hawary MM, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2018; (16(7)):852-871 doi:10.6004/jnccn.2018.0060.

Intensity-modulated Radiotherapy for Anal Cancer: Dose-Volume Relationship of Acute Gastrointestinal Toxicity and Disease Outcomes.

Ng M, Ho H, Skelton J, et al.

Clinical oncology (Royal College of Radiologists (Great Britain)) 2018; (30(10)):634-641 doi:10.1016/j.clon.2018.07.020.

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review.

Pan YB, Maeda Y, Wilson A, et al.

Acta oncologica (Stockholm, Sweden) 2018; (57(11)):1427-1437 doi:10.1080/0284186X.2018.1503713.

Squamous cell carcinoma of the anal canal.

Morton M, Melnitchouk N, Bleday R

Current problems in cancer 2018; (42(5)):486-492 doi:10.1016/j.currproblcancer.2018.11.001.

Introducing the eighth edition of the tumor-node-metastasis classification as relevant to colorectal cancer, anal cancer and appendiceal cancer: a comparison study with the seventh edition of the tumor-node-metastasis and the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma.

Shida D, Kanemitsu Y, Hamaguchi T, Shimada Y

Japanese journal of clinical oncology 2019; (49(4)):321-328 doi:10.1093/jjco/hyy198.

MR staging of anal cancer: what the radiologist needs to know.

Golia Pernicka JS, Sheedy SP, Ernst RD, et al.

Abdominal radiology (New York) 2019; (44(11)):3726-3739 doi:10.1007/s00261-019-02020-4.

Comparison of definitive chemoradiation with 5-fluorouracil versus capecitabine in anal cancer.

Pumpalova Y, Kozak MM, von Eyben R, et al.

Journal of gastrointestinal oncology 2019; (10(4)):605-615 doi:10.21037/jgo.2019.02.17.

A multi-disciplinary model of survivorship care following definitive chemoradiation for anal cancer.

Savoie MB, Laffan A, Brickman C, et al.

BMC cancer 2019; (19(1)):906 doi:10.1186/s12885-019-6053-y.

Patterns of Care and Comparison of Outcomes Between Primary Anal Squamous Cell Carcinoma and Anal Adenocarcinoma.

Malakhov N, Kavi AM, Lee A, et al.

Diseases of the colon and rectum 2019; (62(12)):1448-1457 doi:10.1097/DCR.0000000000001506.

Staging of Anal Cancer: Role of MR Imaging.

Maas M, Tielbeek JAW, Stoker J

Magnetic resonance imaging clinics of North America 2020; (28(1)):127-140 doi:10.1016/j.mric.2019.09.005.

Salvage Abdominoperineal Resection for Anal Squamous Cell Carcinoma: Use, Risk Factors, and Outcomes in a Canadian Population.

Patel SV, Ko G, Raphael MJ, et al.

Diseases of the colon and rectum 2020; (63(6)):748-757 doi:10.1097/DCR.0000000000001630.

Squamous cell anal cancer: Management and therapeutic options.

Pessia B, Romano L, Giuliani A, et al.

Annals of medicine and surgery (2012) 2020; (55()):36-46 doi:10.1016/j.amsu.2020.04.016.

Impact of compliance to chemoradiation on long-term outcomes in squamous cell carcinoma of the anus: results of a post hoc analysis from the randomised phase III ACT II trial.

Glynne-Jones R, Meadows HM, Lopes A, et al.

Annals of oncology : official journal of the European Society for Medical Oncology 2020; (31(10)):1376-1385 doi:10.1016/j.annonc.2020.06.012.

Association of Time Between Radiation and Salvage APR and Margin Status in Patients With Anal Cancer Treated With Concurrent Chemoradiation.

Lee GC, Ricciardi R, Stafford C, et al.

The American surgeon 2020; (86(6)):703-714 doi:10.1177/0003134820923326.

How I treat anal squamous cell carcinoma.

Martini G, Arrichiello G, Borrelli C, et al.

ESMO open 2020; (4(Suppl 2)):e000711 doi:10.1136/esmoopen-2020-000711.

Anal Adenocarcinoma: A Rare Malignancy in Need of Multidisciplinary Management.

Lukovic J, Kim JJ, Krzyzanowska M, et al.

JCO oncology practice 2020; (16(10)):635-640 doi:10.1200/OP.20.00363.

State of the art treatment for stage I to III anal squamous cell carcinoma: A systematic review and meta-analysis.

Werner RN, Gaskins M, Avila Valle G, et al.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2021; (157()):188-196 doi:10.1016/j.radonc.2021.01.031.

Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Triantafyllou K, Gkolfakis P, Gralnek IM, et al.

Endoscopy 2021; (53(8)):850-868 doi:10.1055/a-1496-8969.

HIV-Associated Anal Cancer.

Khandwala P, Singhal S, Desai D, et al.

Cureus 2021; (13(5)):e14834 doi:10.7759/cureus.14834.

The association between protease inhibitors and anal cancer outcomes in veterans living with HIV treated with definitive chemoradiation: a retrospective study.

Yoder AK, Lakomy DS, Dong Y, et al.

BMC cancer 2021; (21(1)):776 doi:10.1186/s12885-021-08514-z.

Long-Term Outcomes of NRG Oncology/RTOG 0529: A Phase 2 Evaluation of Dose-Painted Intensity Modulated Radiation Therapy in Combination With 5-Fluorouracil and Mitomycin-C for the Reduction of Acute Morbidity in Anal Canal Cancer.

Kachnic LA, Winter KA, Myerson RJ, et al.

International journal of radiation oncology, biology, physics 2022; (112(1)):146-157 doi:10.1016/j.ijrobp.2021.08.008.

Intensity modulated radiotherapy in anal canal squamous cell carcinoma: Implementation and outcomes.

Das A, Arunsingh M, Bhattacharyya T, et al.

Journal of cancer research and therapeutics 2021; (17(4)):975-981 doi:10.4103/jcrt.JCRT_212_19.

The role of haematological parameters in predicting the response to radical chemoradiotherapy in patients with anal squamous cell cancer.

Stojanovic-Rundic S, Marinkovic M, Cavic M, et al.

Radiology and oncology 2021; (55(4)):449-458 doi:10.2478/raon-2021-0039.

Prognostic impact of lymphopenia and neutrophil-lymphocyte ratio for patients with anal squamous cell carcinoma.

De B, Ludmir EB, Messick CA, et al.

Journal of gastrointestinal oncology 2021; (12(5)):2412-2422 doi:10.21037/jgo-21-323.

Management of late adverse effects after chemoradiation for anal cancer.

Haas S, Mikkelsen AH, Kronborg C, et al.

Acta oncologica (Stockholm, Sweden) 2021; (60(12)):1688-1701 doi:10.1080/0284186X.2021.1983208.

Current treatment and future directions in the management of anal cancer.

Tchelebi LT, Eng C, Messick CA, et al.

CA: a cancer journal for clinicians 2022; (72(2)):183-195 doi:10.3322/caac.21712.

Nonadherence to Multimodality Cancer Treatment Guidelines in the United States.

Tchelebi LT, Shen B, Wang M, et al.

Advances in radiation oncology 2022; (7(5)):100938 doi:10.1016/j.adro.2022.100938.

Trends in utilization of first-line palliative treatments for anal squamous cell carcinoma.

Radhakrishnan SJ, Goksu SY, Radhakrishnan SM, et al.

Cancer medicine 2023; (12(3)):3460-3467 doi:10.1002/cam4.5126.

Evaluation of dosimetric predictors of toxicity after IMRT with concurrent chemotherapy for anal cancer.

Lukovic J, Hosni A, Liu A, et al.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2023; (178()):109429 doi:10.1016/j.radonc.2022.11.018.

Population-Based Analysis of National Comprehensive Cancer Network (NCCN) Guideline Adherence for Patients with Anal Squamous Cell Carcinoma in California.

Kumar P, Del Rosario M, Chang J, et al.

Cancers 2023; (15(5)) doi:10.3390/cancers15051465.

Emotional Distress Prior to Chemoradiation for Rectal or Anal Cancer.

Rades D, Al-Salool A, Yu NY, Bartscht T

In vivo (Athens, Greece) 2023; (37(3)):1205-1210 doi:10.21873/invivo.13197.

Long-Term Patient-Reported Quality of Life of Anal Cancer Survivors Treated With Intensity Modulated Radiation Therapy and Concurrent Chemotherapy: Results From a Prospective Phase II Trial.

Joseph K, Balushi MA, Ghosh S, et al.

International journal of radiation oncology, biology, physics 2023; (117(2)):434-445 doi:10.1016/j.ijrobp.2023.04.023.

Synchronous anal mucinous adenocarcinoma and anal tuberculosis presenting as chronic anal fistula: Challenging management.

Benammi S, Bakali Y, Alaoui M, et al.

Archive of clinical cases 2023; (10(2)):74-77 doi:10.22551/2023.39.1002.10245.

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.

Benson AB, Venook AP, Al-Hawary MM, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2023; (21(6)):653-677 doi:10.6004/jnccn.2023.0030.

An Updated Review on Imaging and Staging of Anal Cancer-Not Just Rectal Cancer.

Congedo A, Mallardi D, Danti G, et al.

Tomography (Ann Arbor, Mich.) 2023; (9(5)):1694-1710 doi:10.3390/tomography9050135.

Daily Vaginal Dilator Use During Radiation for Women With Squamous Cell Carcinoma of the Anus: Vaginal Wall Dosimetry and Patient-Reported Sexual Function.

Arzola A, Chang E, Rooney MK, et al.

Practical radiation oncology 2024; (14(2)):e105-e116 doi:10.1016/j.prro.2023.10.002.

A case of a rare type of cancer: Anal squamous cell carcinoma in a patient without significant risk factors.

English K, Erpelding M, Kaldas S, Semoin S

Qatar medical journal 2024; (2024(1)):7 doi:10.5339/qmj.2024.7.

Perirectal Abscess with Anterior Extension to the Extraperitoneum and Space of Retzius: A Case Report.

Teng H, Wu PH

Medicina (Kaunas, Lithuania) 2024; (60(2)) doi:10.3390/medicina60020293.

Treatment of stage I-III squamous cell anal cancer: a comparative effectiveness systematic review.

Troester A, Parikh R, Southwell B, et al.

Journal of the National Cancer Institute 2025; (117(2)):240-252 doi:10.1093/jnci/djae195.

Management of Recurrent Anal Cancer.

Littlejohn JB, Brister KA

Surgical oncology clinics of North America 2025; (34(1)):91-101 doi:10.1016/j.soc.2024.07.005.

Systemic Therapy for Stage I-III Anal Squamous Cell Carcinoma: ASCO Guideline.

Morris VK, Kennedy EB, Amin MA, et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2025; (43(5)):605-615 doi:10.1200/JCO-24-02120.

Radiation Therapy for Anal Squamous Cell Carcinoma: An ASTRO Clinical Practice Guideline.

Feng M, Hallemeier CL, Almada C, et al.

Practical radiation oncology 2025; (15(4)):367-386 doi:10.1016/j.prro.2025.02.001.

Understanding Disclosure Decisions and Communication About HPV-Related Cancer: A Qualitative Exploration of Stigma and Social Support.

Villalona S, Sanchez J, Mangkalard P, Best AL

Healthcare (Basel, Switzerland) 2025; (13(9)) doi:10.3390/healthcare13090966.

Enhancing quality of life: addressing vulvovaginal atrophy and urinary tract symptoms.

Hirschberg AL

Climacteric : the journal of the International Menopause Society 2025; (28(4)):400-407 doi:10.1080/13697137.2025.2514029.

Anal Squamous Intraepithelial Lesions: A Primer for Gastroenterologists.

Gioe B, Jain S, Qureshi W

Current gastroenterology reports 2025; (27(1)):71.

Pulmonary Metastasis of Anal Squamous Cell Carcinoma Nine Years Following Treatment.

Madani MS, Deogaonkar A, Naum AS, et al.

Cureus 2025; (17(12)):e98238 doi:10.7759/cureus.98238.

Long-term oncological outcomes after salvage surgery for anal squamous cell carcinoma - a national cohort study.

Jacobsen S, Angenete E, Johnsson A, et al.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2026; (52(4)):111482 doi:10.1016/j.ejso.2026.111482.

Vaginal and sexual health after radiotherapy for anal cancer: A Danish prospective cohort study.

Steffensen JH, Serup-Hansen E, Jakobsen AV, et al.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2026; (219()):111496 doi:10.1016/j.radonc.2026.111496.

Trends in primary surgery and overall survival in non-metastatic anal cancer: a population-based analysis.

Shen C, Conces M, Ciombor K, et al.

The oncologist 2026; (31(6)) doi:10.1093/oncolo/oyag148.

Atypical Gastrointestinal Kaposi Sarcoma With Circumferential Anorectal Involvement in a Young Man With Controlled HIV Infection: A Case Report.

García Ramírez MH, Alegria Lopez LB, Ramírez-Preciado II, et al.

Cureus 2026; (18(5)):e108899 doi:10.7759/cureus.108899.

Patients' perspective in anal cancer.

Manfrida S, Dinapoli L, De Luca V, et al.

ESMO gastrointestinal oncology 2026; (13(Pt A)):100203 doi:10.1016/j.esmogo.2025.100203.

Optimising chemoradiotherapy in anal cancer.

Franco P, Deantonio L, Muirhead R, et al.

ESMO gastrointestinal oncology 2026; (13(Pt A)):100141 doi:10.1016/j.esmogo.2025.100141.

MR Imaging of Anal Cancer.

Young PM, Golia Pernicka JS, Jing AB, et al.

Magnetic resonance imaging clinics of North America 2026; (34(4)):649-662 doi:10.1016/j.mric.2026.06.007.