Research & Literature

Autoantibody response against NALP5/MATER in primary ovarian insufficiency and in autoimmune Addison's disease.

Brozzetti A, Alimohammadi M, Morelli S, et al.

The Journal of clinical endocrinology and metabolism 2015; (100(5)):1941-8 doi:10.1210/jc.2014-3571.

Clinical and laboratory characteristics of neonatal hypocalcemia.

Cho WI, Yu HW, Chung HR, et al.

Annals of pediatric endocrinology & metabolism 2015; (20(2)):86-91 doi:10.6065/apem.2015.20.2.86.

Stridor and apnea as the initial presentation of primary hypoparathyroidism.

Chou CT, Siegel B, Mehta D

International journal of pediatric otorhinolaryngology 2016; (80()):30-2.

Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.

Landegren N, Sharon D, Freyhult E, et al.

Scientific reports 2016; (6()):20104 doi:10.1038/srep20104.

Epidemiology and Diagnosis of Hypoparathyroidism.

Clarke BL, Brown EM, Collins MT, et al.

The Journal of clinical endocrinology and metabolism 2016; (101(6)):2284-99 doi:10.1210/jc.2015-3908.

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: report of three cases from Iran.

Seifi-Alan M, Shamsi R, Setoodeh A, et al.

Journal of pediatric endocrinology & metabolism : JPEM 2016; (29(8)):979-83.

Suppression of Parathyroid Hormone in a Patient with Severe Magnesium Depletion.

Mutnuri S, Fernandez I, Kochar T

Case reports in nephrology 2016; (2016()):2608538 doi:10.1155/2016/2608538.

FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).

Shao W, Zumer K, Fujinaga K, Peterlin BM

The Journal of biological chemistry 2016; (291(34)):17953-63 doi:10.1074/jbc.M116.724401.

Severe hypocalcemia mimicking ST-segment elevation acute myocardial infarction.

Kukla P, Kulik M, Jastrzębski M, et al.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2017; (22(2)) doi:10.1111/anec.12401.

Assessment of autoantibodies to interferon-ω in patients with autoimmune polyendocrine syndrome type 1: using a new immunoprecipitation assay.

Larosa MDP, Mackenzie R, Burne P, et al.

Clinical chemistry and laboratory medicine 2017; (55(7)):1003-1012.

Hypoparathyroidism after thyroidectomy: prevention, assessment and management.

Dedivitis RA, Aires FT, Cernea CR

Current opinion in otolaryngology & head and neck surgery 2017; (25(2)):142-146 doi:10.1097/MOO.0000000000000346.

Expanding the Phenotypic and Genotypic Landscape of Autoimmune Polyendocrine Syndrome Type 1.

Orlova EM, Sozaeva LS, Kareva MA, et al.

The Journal of clinical endocrinology and metabolism 2017; (102(9)):3546-3556 doi:10.1210/jc.2017-00139.

The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1).

Guo CJ, Leung PSC, Zhang W, et al.

Autoimmunity reviews 2018; (17(1)):78-85 doi:10.1016/j.autrev.2017.11.012.

One-Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy.

Sahli Z, Najafian A, Kahan S, et al.

World journal of surgery 2018; (42(7)):2128-2133 doi:10.1007/s00268-017-4444-2.

Rapid whole-genome sequencing identifies a novel AIRE variant associated with autoimmune polyendocrine syndrome type 1.

Sanford E, Watkins K, Nahas S, et al.

Cold Spring Harbor molecular case studies 2018; (4(3)) doi:10.1101/mcs.a002485.

HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy.

Marcucci G, Cianferotti L, Parri S, et al.

Calcified tissue international 2018; (103(2)):151-163 doi:10.1007/s00223-018-0411-7.

Dengue fever manifesting with tetany as the first presentation of primary hypoparathyroidism: a case report.

Higgoda R, Lokuketagoda K, Poobalasingham T, et al.

BMC research notes 2018; (11(1)):588 doi:10.1186/s13104-018-3701-2.

Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium-sensing receptor.

Chamberlin M, Kemp EH, Weetman AP, et al.

Clinical endocrinology 2019; (90(1)):214-221 doi:10.1111/cen.13886.

Hypoparathyroidism and the Kidney.

Peacock M

Endocrinology and metabolism clinics of North America 2018; (47(4)):839-853 doi:10.1016/j.ecl.2018.07.009.

Conventional Treatment of Hypoparathyroidism.

Babey M, Brandi ML, Shoback D

Endocrinology and metabolism clinics of North America 2018; (47(4)):889-900 doi:10.1016/j.ecl.2018.07.012.

Hypocalcemic disorders.

Bove-Fenderson E, Mannstadt M

Best practice & research. Clinical endocrinology & metabolism 2018; (32(5)):639-656 doi:10.1016/j.beem.2018.05.006.

Standards of care for hypoparathyroidism in adults: a Canadian and International Consensus.

Khan AA, Koch CA, Van Uum S, et al.

European journal of endocrinology 2019; (180(3)):P1-P22.

Probable Hypocalcemia Induced Ventricular Fibrillation and Torsades de Pointes following Blood Product Administration.

Mosebach CM, Kluger J

Cureus 2018; (10(12)):e3765 doi:10.7759/cureus.3765.

[Acute Generalized Chorea, Dystonia and Brain Calcifications: A Case Report].

Ramos-Lopes J, Brás A, Morgadinho A, Moreira F

Acta medica portuguesa 2019; (32(5)):402-406 doi:10.20344/amp.11026.

A novel compound heterozygous mutation of the AIRE gene in a patient with autoimmune polyendocrine syndrome type 1.

Suh J, Choi HS, Kwon A, et al.

Annals of pediatric endocrinology & metabolism 2019; (24(4)):248-252 doi:10.6065/apem.2019.24.4.248.

Hypoparathyroidism.

Bilezikian JP

The Journal of clinical endocrinology and metabolism 2020; (105(6)) doi:10.1210/clinem/dgaa113.

Diagnosis and management of hypocalcemia.

Pepe J, Colangelo L, Biamonte F, et al.

Endocrine 2020; (69(3)):485-495 doi:10.1007/s12020-020-02324-2.

Autoimmune polyendocrine syndrome type 1 (APECED) in the Indian population: case report and review of a series of 45 patients.

Fierabracci A, Arena A, Toto F, et al.

Journal of endocrinological investigation 2021; (44(4)):661-677 doi:10.1007/s40618-020-01376-5.

Hypocalcemia secondary to hypomagnesemia in a patient on liraglutide.

Habnouny JEL, Jandou I, Latrech H, Bourgon C

Annals of medicine and surgery (2012) 2020; (60()):327-329 doi:10.1016/j.amsu.2020.10.052.

A Patient With AIRE Mutation Who Presented With Severe Diarrhea and Lung Abscess.

Soyak Aytekin E, Serin O, Cagdas D, et al.

The Pediatric infectious disease journal 2021; (40(1)):66-69 doi:10.1097/INF.0000000000002887.

Malignant prolongation of the QTc interval due to severe vitamin D deficiency: an unusual presentation.

Gupta P, Agstam S, Yadav A, Ghosh S

BMJ case reports 2020; (13(12)) doi:10.1136/bcr-2020-237157.

Hipopara-Red, Real Life Experience in 322 Patients With Hypoparathyroidism.

Zanchetta MB, Robbiani D, Oliveri B, et al.

Journal of the Endocrine Society 2021; (5(2)):bvaa181 doi:10.1210/jendso/bvaa181.

Challenges in the management of chronic hypoparathyroidism.

Zavatta G, Clarke BL

Endocrine connections 2020; (9(10)):R229-R240.

Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review : Renal disease in chronic hypoparathyroidism.

Gosmanova EO, Houillier P, Rejnmark L, et al.

Reviews in endocrine & metabolic disorders 2021; (22(2)):297-316 doi:10.1007/s11154-020-09613-1.

Canadian national hypoparathyroidism registry: an overview of hypoparathyroidism in Canada.

Khan AA, AbuAlrob H, Punthakee Z, et al.

Endocrine 2021; (72(2)):553-561 doi:10.1007/s12020-021-02629-w.

Risk of Chronic Kidney Disease and Estimated Glomerular Filtration Rate Decline in Patients with Chronic Hypoparathyroidism: A Retrospective Cohort Study.

Gosmanova EO, Chen K, Rejnmark L, et al.

Advances in therapy 2021; (38(4)):1876-1888 doi:10.1007/s12325-021-01658-1.

Risk of Nephrolithiasis and Nephrocalcinosis in Patients with Chronic Hypoparathyroidism: A Retrospective Cohort Study.

Ketteler M, Chen K, Gosmanova EO, et al.

Advances in therapy 2021; (38(4)):1946-1957 doi:10.1007/s12325-021-01649-2.

Clinical, immunological, and genetic features in 938 patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a systematic review.

Sharifinejad N, Zaki-Dizaji M, Tebyanian S, et al.

Expert review of clinical immunology 2021; (17(8)):807-817 doi:10.1080/1744666X.2021.1925543.

Multiplex Autoantibody Detection in Patients with Autoimmune Polyglandular Syndromes.

Savvateeva EN, Yukina MY, Nuralieva NF, et al.

International journal of molecular sciences 2021; (22(11)) doi:10.3390/ijms22115502.

Identifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study.

Konca Degertekin C, Gogas Yavuz D, Pekkolay Z, et al.

Calcified tissue international 2022; (110(2)):204-214 doi:10.1007/s00223-021-00908-2.

[Review of clinical practice guidelines for hypoparathyroidism].

Kovaleva EV, Eremkina AK, Krupinova JA, et al.

Problemy endokrinologii 2021; (67(4)):68-83 doi:10.14341/probl12800.

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy.

Ferré EMN, Schmitt MM, Lionakis MS

Frontiers in pediatrics 2021; (9()):723532 doi:10.3389/fped.2021.723532.

The Russian Registry of Chronic Hypoparathyroidism.

Kovaleva EV, Eremkina AK, Elfimova AR, et al.

Frontiers in endocrinology 2022; (13()):800119 doi:10.3389/fendo.2022.800119.

Spectrum of germline AIRE mutations causing APS-1 and familial hypoparathyroidism.

Cranston T, Boon H, Olesen MK, et al.

European journal of endocrinology 2022; (187(1)):111-122 doi:10.1530/EJE-21-0730.

Unrecognized Primary Hypoparathyroidism with Severe Hypocalcemia in the Presence of COVID-19 Infection.

Grigoravičius D, Šiaulienė L, Visockienė Ž

Acta medica Lituanic 2022; (29(1)):136-143 doi:10.15388/Amed.2021.29.1.9.

Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey.

Van Uum S, Shrayyef M, M'Hiri I, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022; (37(12)):2630-2641 doi:10.1002/jbmr.4698.

New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden.

Bugălă NM, Carsote M, Stoica LE, et al.

Diagnostics (Basel, Switzerland) 2022; (12(9)) doi:10.3390/diagnostics12092080.

Management of Hypoparathyroidism.

Khan AA, Guyatt G, Ali DS, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022; (37(12)):2663-2677 doi:10.1002/jbmr.4716.

Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26-Week Results From the Phase 3 PaTHway Trial.

Khan AA, Rubin MR, Schwarz P, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023; (38(1)):14-25 doi:10.1002/jbmr.4726.

Hypoparathyroidism: Genetics and Diagnosis.

Mannstadt M, Cianferotti L, Gafni RI, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022; (37(12)):2615-2629 doi:10.1002/jbmr.4667.

Complications, Symptoms, Presurgical Predictors in Patients With Chronic Hypoparathyroidism: A Systematic Review.

Yao L, Hui X, Li M, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022; (37(12)):2642-2653 doi:10.1002/jbmr.4673.

Treatment options in hypoparathyroidism.

Sakane EN, Vieira MCC, Vieira GMM, Maeda SS

Archives of endocrinology and metabolism 2022; (66(5)):651-657.

Parathyroid Hormone Therapy for Managing Chronic Hypoparathyroidism: A Systematic Review and Meta-Analysis.

Yao L, Li J, Li M, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022; (37(12)):2654-2662 doi:10.1002/jbmr.4676.

Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes.

Oftedal BE, Assing K, Baris S, et al.

iScience 2023; (26(6)):106818 doi:10.1016/j.isci.2023.106818.

Use of rhPTH(1-84) for hypoparathyroidism during early pregnancy and lactation.

Liao EP, Cusano NE

Endocrinology, diabetes & metabolism case reports 2023; (2023(2)).

Initiation of Continuous rhPTH Infusion With Insulin Pump in an Inpatient Setting.

Lindsay Mart F, Winer KK, Johnson K, Wasserman H

JCEM case reports 2023; (1(6)):luad136 doi:10.1210/jcemcr/luad136.

Serial Estimation of Serum Calcium and Ionic Calcium Level for Early Detection of Hypocalcemia After Total/Completion Thyroidectomy.

Sonkhya N, Agarwal S, Choudhary MP, Gupta N

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 2023; (75(4)):3493-3496 doi:10.1007/s12070-023-04031-6.

Renal complications in chronic hypoparathyroidism - a systematic cross-sectional assessment.

Gronemeyer K, Fuss CT, Hermes F, et al.

Frontiers in endocrinology 2023; (14()):1244647 doi:10.3389/fendo.2023.1244647.

Association Between Disturbed Serum Phosphorus Levels and QT Interval Prolongation.

Sasaki S, Fujisaki K, Nishimura M, et al.

Kidney international reports 2024; (9(6)):1792-1801 doi:10.1016/j.ekir.2024.03.007.

A deep intronic splice-altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion.

Ochoa S, Hsu AP, Oler AJ, et al.

Science translational medicine 2024; (16(765)):eadk0845 doi:10.1126/scitranslmed.adk0845.

The multiple faces of autoimmune Addison's disease in children.

Capalbo D, Esposito A, Gaeta V, et al.

Frontiers in endocrinology 2024; (15()):1411774 doi:10.3389/fendo.2024.1411774.

Efficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial.

Clarke BL, Khan AA, Rubin MR, et al.

The Journal of clinical endocrinology and metabolism 2025; (110(4)):951-960 doi:10.1210/clinem/dgae693.

Cognitive Function in Individuals with Chronic Hypoparathyroidism-A Prospective Observational Study.

Tmava-Berisha A, Fahrleitner-Pammer A, Stross T, et al.

The Journal of clinical endocrinology and metabolism 2025; (110(8)):2157-2163 doi:10.1210/clinem/dgae800.

Asymptomatic Hypocalcemia Related to Denosumab Administration in Bone-Metastatic Patient Affected by Colorectal Cancer: A Case Report.

Corsello A, Torino F, Rosa A, et al.

Endocrine, metabolic & immune disorders drug targets 2024; doi:10.2174/0118715303347379241107095529.

PTH Substitution Therapy for Chronic Hypoparathyroidism: PTH 1-84 and Palopegteriparatide.

Palermo A, Naciu AM, Donovan YKT, et al.

Current osteoporosis reports 2025; (23(1)):12 doi:10.1007/s11914-025-00905-6.

Evaluation of Compliance With International Guidelines During the Follow-Up of Hypoparathyroidism.

Turan Erdogan B, Polat SB, Keskin C, et al.

International journal of endocrinology 2025; (2025()):3174295 doi:10.1155/ije/3174295.

Best practice recommendations for the diagnosis and management of hypoparathyroidism.

Khan AA, Ali DS, Bilezikian JP, et al.

Metabolism: clinical and experimental 2025; (171()):156335 doi:10.1016/j.metabol.2025.156335.

Chronic Hypoparathyroidism-Current and Emerging Therapies.

Khan S, Khan AA

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2025; (31(11)):1478-1487 doi:10.1016/j.eprac.2025.07.011.

Switch From rhPTH1-84 to TransCon PTH With Individual Dose Adjustment in Adult Hypoparathyroidism-4-Week Results.

Siggelkow H, Peschke KA, Tsourdi E, et al.

Journal of the Endocrine Society 2025; (9(9)):bvaf113 doi:10.1210/jendso/bvaf113.

Paradoxical Inadequate Parathyroid Hormone Secretion Secondary to Severe Hypomagnesemia: A Review of the Literature.

Albert A, Hinkel UP, Bohlender T, et al.

Kidney medicine 2025; (7(8)):101046 doi:10.1016/j.xkme.2025.101046.

Consensus-Based Recommendations for the Diagnosis, Treatment, and Monitoring of Hypoparathyroidism: Insights from the DACH Region.

Tsourdi E, Amrein K, Meier C, et al.

Calcified tissue international 2025; (116(1)):107 doi:10.1007/s00223-025-01414-5.

Hydrochlorothiazide with salt restriction in nonsurgical hypoparathyroidism: a placebo-controlled single-blinded randomized crossover trial assessing efficacy and safety.

Jha V, Mukherjee S, Bhadada SK, et al.

JBMR plus 2025; (9(12)):ziaf174 doi:10.1093/jbmrpl/ziaf174.

Patient-reported outcomes in palopegteriparatide-treated adults with hypoparathyroidism: PaTH Forward trial extension.

Rubin M, Palermo A, Vokes T, et al.

The Journal of clinical endocrinology and metabolism 2026; (111(4)):945-952 doi:10.1210/clinem/dgaf653.

Advancing hypoparathyroidism treatment: FDA approval of Palopegteriparatide as a promising orphan drug.

Shahid SR, Shahid K, Ehsan S, et al.

Annals of medicine and surgery (2012) 2026; (88(2)):1209-1212 doi:10.1097/MS9.0000000000004734.

Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway.

Kucuka I, Wolff ASB, Breivik L, et al.

The Journal of clinical endocrinology and metabolism 2026; (111(7)):1927-1939 doi:10.1210/clinem/dgag060.

Natural Course of Neuropsychological Functions in Chronic Non-Surgical Hypoparathyroidism on Conventional Therapy: 12 Years of Follow-Up.

Namjoshi P, Seetharaman S, Saha S, et al.

Calcified tissue international 2026; (117(1)).

Successful transition from rhPTH(1-84) to palopegteriparatide in chronic hypoparathyroidism.

Chiardi I, Trimboli P

JCEM case reports 2026; (4(4)):luag048 doi:10.1210/jcemcr/luag048.

Sustained improvement in renal function with palopegteriparatide in adults with chronic hypoparathyroidism: 2-year results from the phase 3 PaTHway-trial.

Rejnmark L, Gosmanova EO, Khan AA, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2026; (41(9)):922-933 doi:10.1093/jbmr/zjag085.

Clinical Characteristics, Treatment Patterns, and Complications in Permanent Hypoparathyroidism: A Large Retrospective Cross-Sectional Study.

Soyer AK, Polat ŞB, İnönü G, et al.

Calcified tissue international 2026; (117(1)).

Performance of expanded diagnostic criteria for APECED in independent cohorts and implications for earlier diagnosis.

Ferré EM, Pechacek J, Schmitt MM, et al.

JCI insight 2026; (11(14)).

Real-world data for effectiveness and safety of palopegteriparatide in patients with chronic hypoparathyroidism: the PaTH REAL study.

Yavropoulou MP, Tournis S, Chondrogianni ME, et al.

European journal of endocrinology 2026; (195(2)):372-383 doi:10.1093/ejendo/lvag145.

Hypoparathyroidism: translating science from the laboratory to the clinic.

Brandi ML, AbuAlrob H, Chang W, et al.

The lancet. Diabetes & endocrinology 2026; (14(11)):927-951 doi:10.1016/S2213-8587(26)00188-9.

Severe symptomatic hypocalcemia with neuromuscular hyperexcitability associated with long-term pantoprazole use: a case report.

Khaneghahi A, Zamani S, Akbari M, et al.

International journal of emergency medicine 2026; (19(1)).