Research & Literature

Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies.

Greving JP, Wermer MJ, Brown RD, et al.

The Lancet. Neurology 2014; (13(1)):59-66.

Prediction model for 3-year rupture risk of unruptured cerebral aneurysms in Japanese patients.

Tominari S, Morita A, Ishibashi T, et al.

Annals of neurology 2015; (77(6)):1050-9 doi:10.1002/ana.24400.

PHASES Score for Prediction of Intracranial Aneurysm Growth.

Backes D, Vergouwen MD, Tiel Groenestege AT, et al.

Stroke 2015; (46(5)):1221-6 doi:10.1161/STROKEAHA.114.008198.

Neuroradiologic Diagnosis of Minor Leak prior to Major SAH: Diagnosis by T1-FLAIR Mismatch.

Oda S, Shimoda M, Hirayama A, et al.

AJNR. American journal of neuroradiology 2015; (36(9)):1616-22 doi:10.3174/ajnr.A4325.

Unruptured Cerebral Aneurysms: Evaluation and Management.

Ajiboye N, Chalouhi N, Starke RM, et al.

TheScientificWorldJournal 2015; (2015()):954954 doi:10.1155/2015/954954.

Risk Factors for Growth of Intracranial Aneurysms: A Systematic Review and Meta-Analysis.

Brinjikji W, Zhu YQ, Lanzino G, et al.

AJNR. American journal of neuroradiology 2016; (37(4)):615-20 doi:10.3174/ajnr.A4575.

Atypical Presentation of Aneurysmal Subarachnoid Hemorrhage: Incidence and Clinical Importance.

Ogasawara Y, Ito K, Ohkuma H

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2016; (25(5)):1208-1214 doi:10.1016/j.jstrokecerebrovasdis.2016.01.004.

De Novo Aneurysm Formation in Carriers of Saccular Intracranial Aneurysm Disease in Eastern Finland.

Lindgren AE, Räisänen S, Björkman J, et al.

Stroke 2016; (47(5)):1213-8 doi:10.1161/STROKEAHA.115.012573.

Incidence and predictors of headache relief after endovascular treatment in patients with unruptured intracranial aneurysms.

Ji W, Liu A, Yang X, et al.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 2017; (23(1)):18-27 doi:10.1177/1591019916666503.

Morphology of Ruptured and Unruptured Intracranial Aneurysms.

Abboud T, Rustom J, Bester M, et al.

World neurosurgery 2017; (99()):610-617 doi:10.1016/j.wneu.2016.12.053.

Dual- versus Single-Energy CT-Angiography Imaging for Patients Undergoing Intracranial Aneurysm Repair.

Abdulazim A, Rubbert C, Reichelt D, et al.

Cerebrovascular diseases (Basel, Switzerland) 2017; (43(5-6)):272-282 doi:10.1159/000464356.

ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms.

Backes D, Rinkel GJE, Greving JP, et al.

Neurology 2017; (88(17)):1600-1606 doi:10.1212/WNL.0000000000003865.

Quantitative Susceptibility Mapping as a Possible Tool to Radiographically Diagnose Sentinel Headache Associated with Intracranial Aneurysm: Case Report.

Nakagawa D, Cushing C, Nagahama Y, et al.

World neurosurgery 2017; (103()):954.e1-954.e4 doi:10.1016/j.wneu.2017.04.151.

Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis.

Zhou Z, Xu Y, Delcourt C, et al.

Cerebrovascular diseases (Basel, Switzerland) 2017; (44(1-2)):75-82 doi:10.1159/000476073.

Clinical Significance of Circumferential Aneurysmal Wall Enhancement in Symptomatic Patients with Unruptured Intracranial Aneurysms: a High-resolution MRI Study.

Fu Q, Guan S, Liu C, et al.

Clinical neuroradiology 2018; (28(4)):509-514 doi:10.1007/s00062-017-0598-4.

Association of intracranial aneurysm rupture with smoking duration, intensity, and cessation.

Can A, Castro VM, Ozdemir YH, et al.

Neurology 2017; (89(13)):1408-1415 doi:10.1212/WNL.0000000000004419.

Diagnostic value of 3D time-of-flight magnetic resonance angiography for detecting intracranial aneurysm: a meta-analysis.

HaiFeng L, YongSheng X, YangQin X, et al.

Neuroradiology 2017; (59(11)):1083-1092 doi:10.1007/s00234-017-1905-0.

Smooth muscle cells of intracranial vessels: from development to disease.

Frösen J, Joutel A

Cardiovascular research 2018; (114(4)):501-512 doi:10.1093/cvr/cvy002.

Current Perspectives in Imaging Modalities for the Assessment of Unruptured Intracranial Aneurysms: A Comparative Analysis and Review.

Turan N, Heider RA, Roy AK, et al.

World neurosurgery 2018; (113()):280-292 doi:10.1016/j.wneu.2018.01.054.

[A Ruptured Middle Cerebral Artery Dissecting Aneurysm Operation in a 2-Year-Old Boy].

Oya S, Kiko I, Suyama K, et al.

No shinkei geka. Neurological surgery 2018; (46(1)):27-34 doi:10.11477/mf.1436203670.

Strictly Limited Orbital Pain as Sentinel Headache of Subarachnoid Hemorrhage.

Yokoya S, Hino A, Goto Y, et al.

World neurosurgery 2018; (114()):27-29 doi:10.1016/j.wneu.2018.03.023.

PHASES and ELAPSS Scores Are Associated with Aneurysm Growth: A Study of 431 Unruptured Intracranial Aneurysms.

Brinjikji W, Pereira VM, Khumtong R, et al.

World neurosurgery 2018; (114()):e425-e432 doi:10.1016/j.wneu.2018.03.003.

Management of Small Unruptured Intracranial Aneurysms: A Survey of Neuroradiologists.

Malhotra A, Wu X, Geng B, et al.

AJNR. American journal of neuroradiology 2018; (39(5)):875-880 doi:10.3174/ajnr.A5631.

Application of PHASES and ELAPSS scores to ruptured cerebral aneurysms: how many would have been conservatively managed?

Hilditch CA, Brinjikji W, Tsang A, et al.

Journal of neurosurgical sciences 2021; (65(1)):33-37 doi:10.23736/S0390-5616.18.04498-3.

Role of hemodynamics in initiation/growth of intracranial aneurysms.

Diagbouga MR, Morel S, Bijlenga P, Kwak BR

European journal of clinical investigation 2018; (48(9)):e12992 doi:10.1111/eci.12992.

Risk of de novo aneurysm formation in patients with a prior diagnosis of ruptured or unruptured aneurysm: systematic review and meta-analysis.

Giordan E, Lanzino G, Rangel-Castilla L, et al.

Journal of neurosurgery 2019; (131(1)):14-24.

Intracranial Giant Mycotic Aneurysm without Endocarditis and Vasculitis: Report of Rare Entity and Review of Literature.

Boissonneau S, Graillon T, Meyer M, et al.

World neurosurgery 2018; (119()):353-357 doi:10.1016/j.wneu.2018.08.086.

Rupture risk of small unruptured cerebral aneurysms.

Ikawa F, Morita A, Tominari S, et al.

Journal of neurosurgery 2020; (132(1)):69-78 doi:10.3171/2018.9.JNS181736.

The Thunderclap Headache: Approach and Management in the Emergency Department.

Long D, Koyfman A, Long B

The Journal of emergency medicine 2019; (56(6)):633-641 doi:10.1016/j.jemermed.2019.01.026.

Headache and Aneurysm.

Kwon OK

Neuroimaging clinics of North America 2019; (29(2)):255-260 doi:10.1016/j.nic.2019.01.004.

Surveillance of Unruptured Intracranial Saccular Aneurysms Using Noncontrast 3D-Black-Blood MRI: Comparison of 3D-TOF and Contrast-Enhanced MRA with 3D-DSA.

Zhu C, Wang X, Eisenmenger L, et al.

AJNR. American journal of neuroradiology 2019; (40(6)):960-966 doi:10.3174/ajnr.A6080.

External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk.

Sánchez van Kammen M, Greving JP, Kuroda S, et al.

Journal of stroke 2019; (21(3)):340-346 doi:10.5853/jos.2019.01277.

Headache Outcomes After Treatment of Unruptured Intracranial Aneurysm: A Systematic Review and Meta-Analysis.

Dandurand C, Parhar HS, Naji F, et al.

Stroke 2019; (50(12)):3628-3631 doi:10.1161/STROKEAHA.119.026864.

Comprehensive review of imaging of intracranial aneurysms and angiographically negative subarachnoid hemorrhage.

Howard BM, Hu R, Barrow JW, Barrow DL

Neurosurgical focus 2019; (47(6)):E20.

The Evolution of Flow-Diverting Stents for Cerebral Aneurysms; Historical Review, Modern Application, Complications, and Future Direction.

Shin DS, Carroll CP, Elghareeb M, et al.

Journal of Korean Neurosurgical Society 2020; (63(2)):137-152 doi:10.3340/jkns.2020.0034.

Prognostic Significance of Sentinel Headache Preceding Aneurysmal Subarachnoid Hemorrhage.

Viarasilpa T, Ghosh P, Gidwani S, et al.

World neurosurgery 2020; (139()):e672-e676 doi:10.1016/j.wneu.2020.04.097.

Small Aneurysms with Low PHASES Scores Account for Most Subarachnoid Hemorrhage Cases.

Rutledge C, Jonzzon S, Winkler EA, et al.

World neurosurgery 2020; (139()):e580-e584 doi:10.1016/j.wneu.2020.04.074.

Unruptured Intracranial Aneurysms- Pathogenesis and Individualized Management.

Etminan N, Dörfler A, Steinmetz H

Deutsches Arzteblatt international 2020; (117(14)):235-242.

Wall enhancement on black-blood MRI is independently associated with symptomatic status of unruptured intracranial saccular aneurysm.

Zhu C, Wang X, Eisenmenger L, et al.

European radiology 2020; (30(12)):6413-6420 doi:10.1007/s00330-020-07063-6.

Survey of European neurosurgeons' management of unruptured intracranial aneurysms: inconsistent practice and organization.

Skodvin TØ, Kloster R, Sorteberg W, Isaksen JG

Acta neurochirurgica 2021; (163(1)):113-121 doi:10.1007/s00701-020-04539-8.

Aspirin and Growth of Small Unruptured Intracranial Aneurysm: Results of a Prospective Cohort Study.

Weng JC, Wang J, Li H, et al.

Stroke 2020; (51(10)):3045-3054 doi:10.1161/STROKEAHA.120.029967.

Cognitive behavioral therapy reduces illness perceptions and anxiety symptoms in patients with unruptured intracranial aneurysm.

Lemos M, Román-Calderón JP, Restrepo J, et al.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020; (80()):56-62 doi:10.1016/j.jocn.2020.07.071.

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.

Bakker MK, van der Spek RAA, van Rheenen W, et al.

Nature genetics 2020; (52(12)):1303-1313 doi:10.1038/s41588-020-00725-7.

Neurovascular disease, diagnosis, and therapy: Brain aneurysms.

Hackenberg KAM, Etminan N

Handbook of clinical neurology 2021; (176()):121-134 doi:10.1016/B978-0-444-64034-5.00001-8.

Rupture risk assessment for multiple intracranial aneurysms: why there is no need for dozens of clinical, morphological and hemodynamic parameters.

Neyazi B, Swiatek VM, Skalej M, et al.

Therapeutic advances in neurological disorders 2020; (13()):1756286420966159 doi:10.1177/1756286420966159.

Long-term outcomes of endovascular simple coiling versus neurosurgical clipping of unruptured intracranial aneurysms: A systematic review and meta-analysis.

Krag CH, Speiser L, Dalby RB

Journal of the neurological sciences 2021; (422()):117338 doi:10.1016/j.jns.2021.117338.

Treatments for unruptured intracranial aneurysms.

Pontes FGB, da Silva EM, Baptista-Silva JC, Vasconcelos V

The Cochrane database of systematic reviews 2021; (5()):CD013312 doi:10.1002/14651858.CD013312.pub2.

When Is Diagnostic Subtraction Angiography Indicated Before Clipping of Unruptured and Ruptured Intracranial Aneurysms? An International Survey of Current Practice.

Sebök M, Dufour JP, Cenzato M, et al.

Acta neurochirurgica. Supplement 2021; (132()):9-17 doi:10.1007/978-3-030-63453-7_2.

Diagnosis and Treatment of Unruptured Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage.

Tawk RG, Hasan TF, D'Souza CE, et al.

Mayo Clinic proceedings 2021; (96(7)):1970-2000 doi:10.1016/j.mayocp.2021.01.005.

Preventive screening for intracranial aneurysms.

Rinkel GJ, Ruigrok YM

International journal of stroke : official journal of the International Stroke Society 2022; (17(1)):30-36 doi:10.1177/17474930211024584.

Risk of Rupture After Intracranial Aneurysm Growth.

van der Kamp LT, Rinkel GJE, Verbaan D, et al.

JAMA neurology 2021; (78(10)):1228-1235 doi:10.1001/jamaneurol.2021.2915.

Modifiable Risk Factors for Intracranial Aneurysm and Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study.

Karhunen V, Bakker MK, Ruigrok YM, et al.

Journal of the American Heart Association 2021; (10(22)):e022277 doi:10.1161/JAHA.121.022277.

Patient and aneurysm factors associated with aneurysm recanalization after coiling.

Pierot L, Barbe C, Thierry A, et al.

Journal of neurointerventional surgery 2022; (14(11)):1096-1101 doi:10.1136/neurintsurg-2021-017972.

Successful endovascular coiling of infectious cerebral aneurysm following Staphylococcus haemolyticus endocarditis.

Matsuzono K, Ishiyama Y, Higaki A, et al.

The Journal of international medical research 2021; (49(11)):3000605211058857 doi:10.1177/03000605211058857.

Staged hybrid treatment for giant thrombosed fusiform aneurysm.

Noh Y, Lee SH, Yoon SM, et al.

Journal of cerebrovascular and endovascular neurosurgery 2021; (23(4)):359-364 doi:10.7461/jcen.2021.E2021.06.004.

Prospective study on embolization of intracranial aneurysms with the pipeline device (PREMIER study): 3-year results with the application of a flow diverter specific occlusion classification.

Hanel RA, Cortez GM, Lopes DK, et al.

Journal of neurointerventional surgery 2023; (15(3)):248-254 doi:10.1136/neurintsurg-2021-018501.

Association Between Regular Blood Pressure Monitoring and the Risk of Intracranial Aneurysm Rupture: a Multicenter Retrospective Study with Propensity Score Matching.

Zhong P, Lu Z, Li T, et al.

Translational stroke research 2022; (13(6)):983-994 doi:10.1007/s12975-022-01006-7.

Evolution of the patient-first approach: a dual-trained, single-neurosurgeon experience with 2002 consecutive intracranial aneurysm treatments.

Waqas M, Monteiro A, Cappuzzo JM, et al.

Journal of neurosurgery 2022; (137(6)):1751-1757 doi:10.3171/2022.2.JNS22105.

Risk factor management matters more than pharmaceutical cyclooxygenase-2 inhibition in the prevention of de novo intracranial aneurysms.

Räisänen S, Huttunen J, Huuskonen TJ, et al.

European journal of neurology 2022; (29(9)):2734-2743 doi:10.1111/ene.15442.

Quality of Life Outcomes Over Time in Patients With Unruptured Intracranial Aneurysms With and Without Preventive Occlusion: A Prospective Cohort Study.

Algra AM, Greving JP, Wermer MJH, et al.

Neurology 2022; (99(16)):e1715-e1724 doi:10.1212/WNL.0000000000200831.

Risk of intracranial aneurysm recurrence after microsurgical clipping based on 3D digital subtraction angiography.

Marbacher S, Grüter BE, Wanderer S, et al.

Journal of neurosurgery 2023; (138(3)):717-723 doi:10.3171/2022.5.JNS22424.

European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms.

Etminan N, de Sousa DA, Tiseo C, et al.

European stroke journal 2022; (7(3)):V doi:10.1177/23969873221099736.

Development of the SAFETEA Scores for Predicting Risks of Complications of Preventive Endovascular or Microneurosurgical Intracranial Aneurysm Occlusion.

Algra AM, Greving JP, de Winkel J, et al.

Neurology 2022; (99(16)):e1725-e1737 doi:10.1212/WNL.0000000000200978.

Comaneci-Assisted Coiling of Wide-Necked Intracranial Aneurysm: A Single-Center Preliminary Experience.

Vinacci G, Celentano A, Agosti E, et al.

Journal of clinical medicine 2022; (11(22)) doi:10.3390/jcm11226650.

Management of Unruptured Intracranial Aneurysms and Brain Arteriovenous Malformations.

Nguyen TN

Continuum (Minneapolis, Minn.) 2023; (29(2)):584-604 doi:10.1212/CON.0000000000001247.

A comprehensive assessment of self-reported symptoms among patients harboring an unruptured intracranial aneurysm.

Hackett AM, Koester SW, Rhodenhiser EG, et al.

Frontiers in surgery 2023; (10()):1148274 doi:10.3389/fsurg.2023.1148274.

A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms.

Darsaut TE, Findlay JM, Bojanowski MW, et al.

AJNR. American journal of neuroradiology 2023; (44(6)):634-640 doi:10.3174/ajnr.A7865.

The markers and risk stratification model of intracranial aneurysm instability in a large Chinese cohort.

Liu Q, Li K, He H, et al.

Science bulletin 2023; (68(11)):1162-1175 doi:10.1016/j.scib.2023.05.001.

A review and journey in intrasaccular treatment of intracranial aneurysms.

Islim FI, Saleem N, Patankar T

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 2025; (31(5)):705-714 doi:10.1177/15910199231182460.

Optimal duration of dual antiplatelet therapy for stent-assisted coiling or flow diverter placement.

Enomoto Y, Matsubara H, Ishihara T, et al.

Journal of neurointerventional surgery 2024; (16(5)):491-497 doi:10.1136/jnis-2023-020285.

Interobserver reliability of computed tomography angiography in the assessment of ruptured intracranial aneurysm and impact on patient management.

Elmokadem AH, Elged BA, Abdel Razek A, et al.

World journal of radiology 2023; (15(6)):201-215 doi:10.4329/wjr.v15.i6.201.

Global Outcomes for Microsurgical Clipping of Unruptured Intracranial Aneurysms: A Benchmark Analysis of 2245 Cases.

Drexler R, Sauvigny T, Pantel TF, et al.

Neurosurgery 2024; (94(2)):369-378 doi:10.1227/neu.0000000000002689.

A Review of Intracranial Aneurysm Imaging Modalities, from CT to State-of-the-Art MR.

Allaw S, Khabaz K, Given TC, et al.

AJNR. American journal of neuroradiology 2025; (46(6)):1082-1092 doi:10.3174/ajnr.A8549.

Managing thrombosis risk in flow diversion: A review of antiplatelet approaches.

Toma A, Essibayi MA, Osama M, et al.

The neuroradiology journal 2025; (38(5)):588-598 doi:10.1177/19714009251313515.

Review of Endosaccular Flow Disrupters for Wide-Neck Aneurysm Treatment.

DeMessie B, Vaishnav D, Karandish A, et al.

Cardiology in review 2025; doi:10.1097/CRD.0000000000000869.

High risk and low incidence diseases: Aneurysmal subarachnoid hemorrhage.

Gerhart CR, Lacy AJ, Long B, et al.

The American journal of emergency medicine 2025; (92()):138-151 doi:10.1016/j.ajem.2025.03.024.

Efficacy and Safety of Adjunctive Coiling in Pipeline Embolization Device Implantation for Small- and Medium-Sized Unruptured Cerebral Aneurysms: A Retrospective Cohort Study and Literature Review.

Fuga M, Ishibashi T, Kan I, et al.

World neurosurgery 2025; (197()):123933 doi:10.1016/j.wneu.2025.123933.

Shedding light on tiny intracranial aneurysms: a retrospective risk assessment.

Sauvigny J, Muzaiek S, Czorlich P, et al.

Journal of neurosurgery 2025; (143(3)):634-640 doi:10.3171/2025.2.JNS242537.

Conservative management of 661 patients with unruptured intracranial aneurysms: an observational study over 4 decades.

Dodier P, Lederer P, Ecker B, et al.

Journal of neurosurgery 2025; (143(3)):641-653 doi:10.3171/2025.1.JNS241986.

Epidemiology, pathogenesis, and emerging concepts in unruptured intracranial aneurysms.

Etminan N, Ruigrok YM, Hackenberg KAM, et al.

The Lancet. Neurology 2025; (24(11)):945-957 doi:10.1016/S1474-4422(25)00264-9.

Mechanisms of Intracranial Aneurysm Rupture: An Integrative Review of Experimental and Clinical Evidence.

Itani M, Aoki T

Journal of clinical medicine 2025; (14(22)) doi:10.3390/jcm14228256.

Approach to a symptomatic unruptured intracranial aneurysm presenting as status epilepticus: a case report and literature review.

Sindaka JK, Sasmita PK

Radiology case reports 2026; (21(2)):480-485 doi:10.1016/j.radcr.2025.10.011.

Outcomes of Microsurgical Treatment for Unruptured Intracranial Aneurysms: A 7-Year Institutional Review.

Catapano JS, Koester SW, McCann MM, et al.

Neurosurgery practice 2026; (7(1)):e000201 doi:10.1227/neuprac.0000000000000201.

Psychological and Functional Impact of a Small Unruptured Intracranial Aneurysm Diagnosis: A Mixed-Methods Evaluation of the Patient Journey.

Jelen MB, Clarke RE, Jones B, et al.

Stroke (Hoboken, N.J.) 2023; (3(1)):e000531 doi:10.1161/SVIN.122.000531.

Long-term Cerebrovascular Risk after Microsurgical Clipping of Unruptured Anterior Circulation Aneurysms: Low Subarachnoid Hemorrhage Incidence and Persistent Stroke Susceptibility over 7,600 Patient-years.

Kawamoto S, Ikeda G, Fukaya S, et al.

Neurologia medico-chirurgica 2026; (66(6)):377-386 doi:10.2176/jns-nmc.2026-0003.

Feasibility and diagnostic performance of PETRA-MRA for postoperative follow-up of intracranial aneurysms: a prospective comparative study.

Jiang Q, Wang X, Zhao J, Hu J

Frontiers in neurology 2026; (17()):1786151 doi:10.3389/fneur.2026.1786151.