Research & Literature

Calciphylaxis: from the disease to the diseased.

Oliveira TM, Frazão JM

Journal of nephrology 2015; (28(5)):531-40 doi:10.1007/s40620-015-0192-2.

The Effect of Cinacalcet on Calcific Uremic Arteriolopathy Events in Patients Receiving Hemodialysis: The EVOLVE Trial.

Floege J, Kubo Y, Floege A, et al.

Clinical journal of the American Society of Nephrology : CJASN 2015; (10(5)):800-7 doi:10.2215/CJN.10221014.

Calciphylaxis: risk factors, diagnosis, and treatment.

Nigwekar SU, Kroshinsky D, Nazarian RM, et al.

American journal of kidney diseases : the official journal of the National Kidney Foundation 2015; (66(1)):133-46.

Penile lesion in end-stage renal failure - cancer or otherwise?: Calcific uremic arteriolopathy presenting with a penile lesion.

Malthouse T, Lam W, Brewin J, et al.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada 2015; (9(3-4)):136-7 doi:10.5489/cuaj.2331.

Raman spectroscopy for label-free identification of calciphylaxis.

Lloyd WR, Agarwal S, Nigwekar SU, et al.

Journal of biomedical optics 2015; (20(8)):80501 doi:10.1117/1.JBO.20.8.080501.

Multidisciplinary approach to calcific uremic arteriolopathy.

Nigwekar SU

Current opinion in nephrology and hypertension 2015; (24(6)):531-7 doi:10.1097/MNH.0000000000000175.

Sodium thiosulfate is effective in calcific uremic arteriolopathy complicating chronic hemodialysis.

Malbos S, Ureña-Torres P, Bardin T, Ea HK

Joint bone spine 2016; (83(1)):89-92.

Calciphylaxis: a case series and the role of radiology in diagnosis.

Bonchak JG, Park KK, Vethanayagamony T, et al.

International journal of dermatology 2016; (55(5)):e275-9 doi:10.1111/ijd.13043.

Gastrointestinal Bleeding Secondary to Calciphylaxis.

Gupta N, Haq KF, Mahajan S, et al.

The American journal of case reports 2015; (16()):818-22 doi:10.12659/ajcr.895164.

Warfarin and Vascular Calcification.

Poterucha TJ, Goldhaber SZ

The American journal of medicine 2016; (129(6)):635.e1-4.

Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry.

Brandenburg VM, Kramann R, Rothe H, et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2017; (32(1)):126-132 doi:10.1093/ndt/gfv438.

Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis?

Brandenburg VM, Evenepoel P, Floege J, et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2016; (31(8)):1211-9 doi:10.1093/ndt/gfw025.

Calciphylaxis of the Breast: A Case Report and Literature Review.

Hall DJ, Gentile LF, Duckworth LV, et al.

The breast journal 2016; (22(5)):568-72 doi:10.1111/tbj.12632.

Calciphylaxis in peritoneal dialysis patients: a single center cohort study.

Zhang Y, Corapi KM, Luongo M, et al.

International journal of nephrology and renovascular disease 2016; (9()):235-241 doi:10.2147/IJNRD.S115701.

Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis.

McCarthy JT, El-Azhary RA, Patzelt MT, et al.

Mayo Clinic proceedings 2016; (91(10)):1384-1394 doi:10.1016/j.mayocp.2016.06.025.

Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.

Nigwekar SU, Bloch DB, Nazarian RM, et al.

Journal of the American Society of Nephrology : JASN 2017; (28(6)):1717-1722 doi:10.1681/ASN.2016060651.

Warfarin-Associated Nonuremic Calciphylaxis.

Yu WY, Bhutani T, Kornik R, et al.

JAMA dermatology 2017; (153(3)):309-314 doi:10.1001/jamadermatol.2016.4821.

Calciphylaxis.

Nigwekar SU

Current opinion in nephrology and hypertension 2017; (26(4)):276-281 doi:10.1097/MNH.0000000000000328.

Early clinical presentations and progression of calciphylaxis.

Ghosh T, Winchester DS, Davis MDP, et al.

International journal of dermatology 2017; (56(8)):856-861 doi:10.1111/ijd.13622.

The Role of Bone Scintigraphy with Single-photon Emission Computed Tomography-computed Tomography in the Diagnosis and Evaluation of Calciphylaxis.

Martineau P, Pelletier-Galarneau M, Bazarjani S

World journal of nuclear medicine 2017; (16(2)):172-174 doi:10.4103/1450-1147.203076.

Underreported use of palliative care and patient-reported outcome measures to address reduced quality of life in patients with calciphylaxis: a systematic review.

Riemer CA, El-Azhary RA, Wu KL, et al.

The British journal of dermatology 2017; (177(6)):1510-1518 doi:10.1111/bjd.15702.

Systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients.

Peng T, Zhuo L, Wang Y, et al.

Nephrology (Carlton, Vic.) 2018; (23(7)):669-675 doi:10.1111/nep.13081.

Management of a Complex Peristomal Calciphylaxis: A Case Study.

Famorca M, Beauchaine D, Angulo N

Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society 2017; (44(4)):380-383 doi:10.1097/WON.0000000000000343.

Extraosseous Calcification of the Esophagus: Clinicopathologic Correlates of Esophageal Mucosal Calcinosis.

Garber A, Arora Z, Welch N, et al.

ACG case reports journal 2017; (4()):e108 doi:10.14309/crj.2017.108.

Histopathology of Calciphylaxis: Cohort Study With Clinical Correlations.

Chen TY, Lehman JS, Gibson LE, et al.

The American Journal of dermatopathology 2017; (39(11)):795-802 doi:10.1097/DAD.0000000000000824.

Calciphylaxis after parathyroidectomy.

Karmegam S, Shetty A

Hemodialysis international. International Symposium on Home Hemodialysis 2017; (21 Suppl 2()):S62-S66 doi:10.1111/hdi.12599.

[Calcific uremic arteriolopathy (calciphylaxis)  : update in 2018].

Alves C, Ernandez T, Stoermann Chopard C

Revue medicale suisse 2018; (14(595)):426-429.

Calciphylaxis in end-stage liver and renal disease patients before and after transplant.

Couri T, Stier M, Mikolajczyk A, Aronsohn A

Clinical transplantation 2018; (32(6)):e13272 doi:10.1111/ctr.13272.

An Update on Calciphylaxis.

García-Lozano JA, Ocampo-Candiani J, Martínez-Cabriales SA, Garza-Rodríguez V

American journal of clinical dermatology 2018; (19(4)):599-608 doi:10.1007/s40257-018-0361-x.

A case report of pediatric calciphylaxis-a rare and potentially fatal under diagnosed condition.

Stârcea M, Gavrilovici C, Elsayed A, et al.

Medicine 2018; (97(27)):e11300 doi:10.1097/MD.0000000000011300.

The Role of Matrix Gla Protein (MGP) in Vascular Calcification.

Bjørklund G, Svanberg E, Dadar M, et al.

Current medicinal chemistry 2020; (27(10)):1647-1660 doi:10.2174/0929867325666180716104159.

Metabolic acidosis after sodium thiosulfate infusion and the role of hydrogen sulfide.

Hunt GM, Ryder HF

Clinical case reports 2018; (6(8)):1595-1599 doi:10.1002/ccr3.1673.

Factors associated with false-negative pathologic diagnosis of calciphylaxis.

Williams EA, Moy AP, Cipriani NA, et al.

Journal of cutaneous pathology 2019; (46(1)):16-25 doi:10.1111/cup.13364.

Management of Penile Calciphylaxis: A Case Study.

Zillioux JM, Geisenhoff A, Gray M

Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society 2018; (45(6)):536-539 doi:10.1097/WON.0000000000000483.

Calciphylaxis in patients with chronic kidney disease: A disease which is still bewildering and potentially fatal.

Cucchiari D, Torregrosa JV

Nefrologia 2018; (38(6)):579-586 doi:10.1016/j.nefro.2018.05.007.

A Rare Case of Multiorgan Calciphylaxis in a Patient with Stage 5 Chronic Kidney Disease.

Ahmad A, Albaghli A, Michael A, et al.

Case reports in urology 2018; (2018()):9603680 doi:10.1155/2018/9603680.

Calciphylaxis-as a drug induced adverse event.

Portales-Castillo I, Kroshinsky D, Malhotra CK, et al.

Expert opinion on drug safety 2019; (18(1)):29-35 doi:10.1080/14740338.2019.1559813.

The use of cinacalcet for the treatment of calciphylaxis in patients with chronic kidney disease: A comprehensive review.

Deen J, Schaider H

The Australasian journal of dermatology 2019; (60(3)):e186-e194 doi:10.1111/ajd.12992.

Revisiting therapeutic options for calciphylaxis.

Seethapathy H, Nigwekar SU

Current opinion in nephrology and hypertension 2019; (28(5)):448-454 doi:10.1097/MNH.0000000000000520.

Clinicopathologic Features and Calcium Deposition Patterns in Calciphylaxis: Comparison With Gangrene, Peripheral Artery Disease, Chronic Stasis, and Thrombotic Vasculopathy.

McMullen ER, Harms PW, Lowe L, et al.

The American journal of surgical pathology 2019; (43(9)):1273-1281 doi:10.1097/PAS.0000000000001302.

Correlation between clinical and pathological features of cutaneous calciphylaxis.

Dutta P, Chaudet KM, Nazarian RM, et al.

PloS one 2019; (14(6)):e0218155 doi:10.1371/journal.pone.0218155.

Calciphylaxis After Kidney Transplant.

Ryan MP, Ross LS

Cureus 2019; (11(5)):e4695 doi:10.7759/cureus.4695.

[The nightmare of calciphylaxis].

Ulrich M, Götz M, Krah X

Aktuelle Urologie 2021; (52(1)):70-72 doi:10.1055/a-0892-1899.

Calciphylaxis epidemiology, risk factors, treatment and survival among French chronic kidney disease patients: a case-control study.

Gaisne R, Péré M, Menoyo V, et al.

BMC nephrology 2020; (21(1)):63 doi:10.1186/s12882-020-01722-y.

Hyperbaric oxygen therapy in patients suffering from wounds in calciphylaxis: a narrative review.

Charaghvandi DA, Teguh DN, van Hulst RA

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 2020; (47(1)):111-123 doi:10.22462/01.03.2020.12.

Vascular Calcification in Chronic Kidney Disease: The Role of Vitamin K- Dependent Matrix Gla Protein.

Roumeliotis S, Dounousi E, Salmas M, et al.

Frontiers in medicine 2020; (7()):154 doi:10.3389/fmed.2020.00154.

Diagnosing Calciphylaxis: A Review With Emphasis on Histopathology.

Bahrani E, Perkins IU, North JP

The American Journal of dermatopathology 2020; (42(7)):471-480 doi:10.1097/DAD.0000000000001526.

Isolated Mesenteric Calciphylaxis With Ischemic Colitis in a Hemodialysis Patient Without Active Cutaneous Calciphylaxis: A Case Report of Calcific Uremic Arteriolopathy.

Tan RYP, Juneja R, Gunawardane DN, Milton CA

Kidney medicine 2020; (2(2)):209-212 doi:10.1016/j.xkme.2019.12.005.

Calciphylaxis - Case Report.

Prohic N, Masnic F, Fazlic MK, et al.

Medical archives (Sarajevo, Bosnia and Herzegovina) 2020; (74(3)):233-235 doi:10.5455/medarh.2020.74.233-235.

Management of Cutaneous Calciphylaxis.

Kodumudi V, Jeha GM, Mydlo N, Kaye AD

Advances in therapy 2020; (37(12)):4797-4807 doi:10.1007/s12325-020-01504-w.

Risk factors for calciphylaxis in Chinese hemodialysis patients: a matched case-control study.

Liu Y, Zhang X, Xie X, et al.

Renal failure 2021; (43(1)):406-416 doi:10.1080/0886022X.2021.1884094.

Clinical mimickers of calciphylaxis: A retrospective study.

Gabel CK, Blum AE, François J, et al.

Journal of the American Academy of Dermatology 2021; (85(6)):1520-1527 doi:10.1016/j.jaad.2021.03.035.

The Multifactorial Pathogenesis of Calciphylaxis: A Case Report.

Turek M, Stępniewska J, Różański J

The American journal of case reports 2021; (22()):e930026 doi:10.12659/AJCR.930026.

Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate-A Case Report and Literature Review.

Roy S, Reddy SN, Garcha AS, et al.

Journal of investigative medicine high impact case reports 2021; (9()):23247096211060580 doi:10.1177/23247096211060580.

Manifestation of Nonuremic Calciphylaxis in the Extremities: Case Report and Review.

Zulauf EE, Connors JC, Hardy MA

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 2022; (61(5)):e41-e47 doi:10.1053/j.jfas.2021.10.024.

Prevalence and Clinical Characteristics of Calciphylaxis in Chinese Hemodialysis Patients.

Liu Y, Yang C, Yang X, et al.

Frontiers in medicine 2022; (9()):902171 doi:10.3389/fmed.2022.902171.

Calciphylaxis and Kidney Disease: A Review.

Gallo Marin B, Aghagoli G, Hu SL, et al.

American journal of kidney diseases : the official journal of the National Kidney Foundation 2023; (81(2)):232-239 doi:10.1053/j.ajkd.2022.06.011.

Perioperative Management of Calciphylaxis: Literature Review and Treatment Recommendations.

Strand N, Maloney J, Wu S, et al.

Orthopedic reviews 2022; (14(3)):37573 doi:10.52965/001c.37573.

Characterization of Risk Factors for Calciphylaxis in Hemodialysis Patients in the Fraser Health Renal Program - A Matched Case-Control Retrospective Review.

Jang A, Mark Ho MH, Yan L

Journal of pharmacy practice 2023; (36(6)):1424-1437 doi:10.1177/08971900221118444.

Patient-Reported and Clinical Outcomes Among Patients With Calciphylaxis.

Wen W, Krinsky S, Kroshinsky D, et al.

Mayo Clinic proceedings. Innovations, quality & outcomes 2023; (7(1)):81-92 doi:10.1016/j.mayocpiqo.2022.12.006.

Clinical features and outcomes of calciphylaxis in Chinese patients with chronic kidney disease.

Jiao Y, Sun L, Xie X, et al.

Nephrology (Carlton, Vic.) 2023; (28(6)):305-314 doi:10.1111/nep.14156.

Intravenous Sodium Thiosulphate for Calciphylaxis of Chronic Kidney Disease: A Systematic Review and Meta-analysis.

Wen W, Portales-Castillo I, Seethapathy R, et al.

JAMA network open 2023; (6(4)):e2310068 doi:10.1001/jamanetworkopen.2023.10068.

Profound metabolic acidosis in association with sodium thiosulfate therapy in a patient with calcific uremic arteriolopathy: a case report and literature review.

Abdalla M, Faris ME, Saad E, et al.

CEN case reports 2024; (13(1)):59-65 doi:10.1007/s13730-023-00801-x.

The application of MDT model for calciphylaxis management in patients with end-stage renal disease.

Pan Y, Wang H, Ye Y, et al.

International wound journal 2023; (20(9)):3717-3723 doi:10.1111/iwj.14265.

Calciphylaxis, A Case Series: The Importance of Early Detection.

Sijapati N, Fong SSH, Ansari O, et al.

HCA healthcare journal of medicine 2023; (4(1)):43-49 doi:10.36518/2689-0216.1214.

A retrospective review of outcomes after hyperbaric oxygen therapy for the treatment of calciphylaxis.

Biglione B, Cucka B, Iriarte C, et al.

Journal of the American Academy of Dermatology 2024; (90(1)):45-51 doi:10.1016/j.jaad.2023.07.1031.

Multimodality approach to treat calciphylaxis in end-stage kidney disease patients.

Lajoie C, Ghanemi A, Bourbeau K, et al.

Renal failure 2023; (45(2)):2256413 doi:10.1080/0886022X.2023.2256413.

Calcific Uremic Arteriolopathy in End-Stage Renal Disease: A Rare Life-Threatening Condition.

Okan T, Ghuman K, Chaudhary F, et al.

Cureus 2023; (15(10)):e48002 doi:10.7759/cureus.48002.

Clinical characteristics and treatment modalities in uremic and non uremic calciphylaxis - a dermatological single-center experience.

Yousuf S, Busch D, Renner R, et al.

Renal failure 2024; (46(1)):2297566 doi:10.1080/0886022X.2023.2297566.

Occlusive cutaneous vasculopathies as cause of chronic ulcers.

Ronicke M, Berking C, Erfurt-Berge C

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2024; (22(4)):553-567 doi:10.1111/ddg.15276.

Penile Calciphylaxis: A Successfully Treated Case.

Misakyan N, Abu-Shanab A, Shah S

Cureus 2024; (16(2)):e54824 doi:10.7759/cureus.54824.

Assessment of diagnostic delay, morbidity, and mortality outcomes in 302 calciphylaxis patients over a 17-year period: A retrospective cohort study.

Tan AJ, Xia J, Glennon CM, et al.

Journal of the American Academy of Dermatology 2024; (91(5)):834-842 doi:10.1016/j.jaad.2024.06.058.

Advanced Calciphylaxis in a Patient With End-Stage Renal Disease: A Case Report Highlighting Diagnostic and Therapeutic Challenges in Late-Stage Presentation.

Chaganlal PP, Kalandoor V, Jones DT, et al.

Cureus 2024; (16(9)):e68866 doi:10.7759/cureus.68866.

Penile Calciphylaxis Obscured by Phimosis in an End-Stage Renal Disease Patient: A Case Report.

Angammana CU, Fernando H, Silva F

Cureus 2024; (16(8)):e67156 doi:10.7759/cureus.67156.

Risk Factors Associated With the Development of Calciphylaxis in Patients With Chronic Kidney Disease: A Systematic Review.

Ogah CO, Mohammed H, Gabra IM, et al.

Cureus 2024; (16(12)):e75314 doi:10.7759/cureus.75314.

Livedoid vasculopathy, calciphylaxis, and Martorell's hypertensive ulcer: update on ischemic ulcers due to impaired microcirculation of the lower limbs.

Lacerda PN, Garcia LC, Mazeto IFDS, et al.

Anais brasileiros de dermatologia 2025; (100(2)):215-227 doi:10.1016/j.abd.2024.09.004.

Calciphylaxis: ongoing challenges and treatment opportunities with mesenchymal stem cells.

Wu D, Lu S, Hu J, et al.

Journal of molecular cell biology 2025; (17(2)) doi:10.1093/jmcb/mjaf009.

Calciphylaxis Penile Lesion: An Unusual Complication of End-Stage Renal Disease.

Grote J, Geyer-Roberts E, Banuelos A, et al.

Cureus 2025; (17(3)):e80625 doi:10.7759/cureus.80625.

Calciphylaxis of the Upper Limbs-A Rare and Serious Disease with Multidisciplinary Treatments-A Case Series and Literature Review.

Pertea M, Benamor M, Bulgaru-Iliescu AI, et al.

Diagnostics (Basel, Switzerland) 2025; (15(9)) doi:10.3390/diagnostics15091179.

Calciphylaxis: A Rare Manifestation of a Common Disease.

Nancassa C, Baiherych T, Figueiredo A

Cureus 2025; (17(5)):e84550 doi:10.7759/cureus.84550.

Buprenorphine for the Management of Intractable Pain in Skin Ulcers Associated With Calcific Uremic Arteriolopathy.

Whitfield S, Pellecer DS

Pain medicine case reports 2024; (8(6)):223-227.

Ten tips on how to deal with calciphylaxis patients.

Chewcharat A, Nigwekar SU

Clinical kidney journal 2025; (18(4)):sfaf098 doi:10.1093/ckj/sfaf098.

Elevated Perioperative Morbidity After Parathyroidectomy for Calciphylaxis Patients: A Nationwide Retrospective Observational Study.

Bauzon J, Perez-Soto R, Jin J, et al.

The Journal of surgical research 2025; (314()):185-190 doi:10.1016/j.jss.2025.07.011.

A Case Report of Non-Uremic Calciphylaxis Refractory to Treatment Requiring Multidisciplinary Care.

Lee R, Kahn H, Aiad M, Wilson M

Case reports in dermatology 2025; (17(1)):471-477 doi:10.1159/000547832.

Calciphylaxis diagnosis, management and future directions: a comprehensive update on behalf of the European Renal Association CKD-MBD Working Group.

Huish S, Moore S, Alfieri C, et al.

Clinical kidney journal 2025; (18(12)):sfaf338 doi:10.1093/ckj/sfaf338.

Navigating Calciphylaxis in End-Stage Renal Disease: A Case Report Highlighting the Complexities of Pain Control and the Need for Greater Clinical Vigilance.

Lau RCN, Whitwell BL, Chinawanitkit C, Ahmed F

Cureus 2025; (17(11)):e96962 doi:10.7759/cureus.96962.

Calciphylaxis in the Upper GI Tract in an ESRD Patient: An Atypical Presentation and Review of Literature.

D Shirsat P, Sonavane K, Botana LR, Sachdeva B

Case reports in nephrology 2025; (2025()):3967671 doi:10.1155/crin/3967671.

Calciphylaxis in a patient with end-stage renal disease: Multimodality imaging and clinical correlation.

Zaki C, Stevens KJ

Radiology case reports 2026; (21(3)):1255-1260 doi:10.1016/j.radcr.2025.11.024.

Lived experiences of patients with calciphylaxis (CALCI-E): a qualitative study.

Huish S, Bingham C, Treadgold BM, Sinha S

Journal of nephrology 2026; (39(2)):381-389 doi:10.1093/joneph/aajaf017.

Calciphylaxis Mimicry in End-Stage Renal Disease: Acute Limb Ischemia From Calcific Peripheral Arterial Disease.

Izadian Bidgoli A, Isayan E, Buryk Y, et al.

Cureus 2026; (18(5)):e109854 doi:10.7759/cureus.109854.

Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy.

Søndergaard C, Nagarajah S, Shen J, et al.

Renal failure 2026; (48(1)):2710397 doi:10.1080/0886022X.2026.2710397.