Research & Literature

NSAID enteropathy: appearance at CT and MR enterography in the age of multi-modality imaging and treatment.

Frye JM, Hansel SL, Dolan SG, et al.

Abdominal imaging 2015; (40(5)):1011-25 doi:10.1007/s00261-015-0367-2.

Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.

Pennazio M, Spada C, Eliakim R, et al.

Endoscopy 2015; (47(4)):352-76 doi:10.1055/s-0034-1391855.

Long-term Outcomes in Patients with Small Intestinal Strictures Secondary to Crohn's Disease After Double-balloon Endoscopy-assisted Balloon Dilation.

Sunada K, Shinozaki S, Nagayama M, et al.

Inflammatory bowel diseases 2016; (22(2)):380-6 doi:10.1097/MIB.0000000000000627.

A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter.

Umeno J, Hisamatsu T, Esaki M, et al.

PLoS genetics 2015; (11(11)):e1005581 doi:10.1371/journal.pgen.1005581.

Pediatric-onset Chronic Nonspecific Multiple Ulcers of Small Intestine: A Nationwide Survey and Genetic Study in Japan.

Uchida K, Nakajima A, Ushijima K, et al.

Journal of pediatric gastroenterology and nutrition 2017; (64(4)):565-568 doi:10.1097/MPG.0000000000001321.

Differentiation Between Crohn Disease and Intestinal Tuberculosis in Children.

Singh SK, Srivastava A, Kumari N, et al.

Journal of pediatric gastroenterology and nutrition 2018; (66(1)):e6-e11 doi:10.1097/MPG.0000000000001625.

Chronic Enteropathy Associated With SLCO2A1 Gene [CEAS]-Characterisation of an Enteric Disorder to be Considered in the Differential Diagnosis of Crohn's Disease.

Hosoe N, Ohmiya N, Hirai F, et al.

Journal of Crohn's & colitis 2017; (11(10)):1277-1281 doi:10.1093/ecco-jcc/jjx068.

Capsule retention: prevention, diagnosis and management.

Rondonotti E

Annals of translational medicine 2017; (5(9)):198 doi:10.21037/atm.2017.03.15.

Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins.

Nakanishi T, Tamai I

The AAPS journal 2017; (20(1)):13 doi:10.1208/s12248-017-0163-8.

Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease.

Umeno J, Esaki M, Hirano A, et al.

Journal of gastroenterology 2018; (53(8)):907-915 doi:10.1007/s00535-017-1426-y.

Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn's Disease.

Bruining DH, Zimmermann EM, Loftus EV, et al.

Gastroenterology 2018; (154(4)):1172-1194 doi:10.1053/j.gastro.2017.11.274.

Predictive factors of management outcome in adult patients with mechanical intestinal obstruction.

Bankole AO, Osinowo AO, Adesanya AA

The Nigerian postgraduate medical journal 2017; (24(4)):217-223 doi:10.4103/npmj.npmj_143_17.

Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group.

Ten Broek RPG, Krielen P, Di Saverio S, et al.

World journal of emergency surgery : WJES 2018; (13()):24 doi:10.1186/s13017-018-0185-2.

Genetic analysis is helpful for the diagnosis of small bowel ulceration.

Umeno J, Matsumoto T, Hirano A, et al.

World journal of gastroenterology 2018; (24(28)):3198-3200 doi:10.3748/wjg.v24.i28.3198.

Immunohistochemical differentiation between chronic enteropathy associated with SLCO2A1 gene and other inflammatory bowel diseases.

Yamaguchi S, Yanai S, Nakamura S, et al.

Intestinal research 2018; (16(3)):393-399 doi:10.5217/ir.2018.16.3.393.

Successful azathioprine treatment in an adolescent with chronic enteropathy associated with SLCO2A1 gene: A case report.

Eda K, Mizuochi T, Takaki Y, et al.

Medicine 2018; (97(41)):e12811 doi:10.1097/MD.0000000000012811.

The role of small bowel endoscopy for Crohn's disease.

Chetcuti Zammit S, Ellul P, Sidhu R

Current opinion in gastroenterology 2019; (35(3)):223-234 doi:10.1097/MOG.0000000000000519.

Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.

Matsuno Y, Umeno J, Esaki M, et al.

World journal of gastroenterology 2019; (25(14)):1753-1763 doi:10.3748/wjg.v25.i14.1753.

Estimated Prevalence of Cronkhite-Canada Syndrome, Chronic Enteropathy Associated With SLCO2A1 Gene, and Intestinal Behçet's Disease in Japan in 2017: A Nationwide Survey.

Oba MS, Murakami Y, Nishiwaki Y, et al.

Journal of epidemiology 2021; (31(2)):139-144 doi:10.2188/jea.JE20190349.

Obscure gastrointestinal bleeding caused by congenital enteropathy in a Chinese young child-a case report.

Fang Y, Gu W, Luo Y, Chen J

BMC pediatrics 2020; (20(1)):438 doi:10.1186/s12887-020-02333-0.

Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis.

Tsuzuki Y, Aoyagi R, Miyaguchi K, et al.

Internal medicine (Tokyo, Japan) 2020; (59(24)):3147-3154 doi:10.2169/internalmedicine.4756-20.

[Clinical and genetic characteristics of patients with chronic enteropathy associated with SLCO2A1 gene].

Wang Q, Xu H, Li Y, et al.

Zhonghua nei ke za zhi 2021; (60(1)):45-50 doi:10.3760/cma.j.cn112138-20200318-00259.

Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action.

Nakanishi T, Nakamura Y, Umeno J

Pharmacology & therapeutics 2021; (223()):107803 doi:10.1016/j.pharmthera.2021.107803.

Monoallelic mutations in SLCO2A1 cause autosomal dominant primary hypertrophic osteoarthropathy.

Xu Y, Zhang Z, Yue H, et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021; (36(8)):1459-1468 doi:10.1002/jbmr.4310.

Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with SLCO2A1 Gene: A KASID Multicenter Study.

Hong HS, Baek J, Park JC, et al.

Gut and liver 2022; (16(6)):942-951 doi:10.5009/gnl210415.

[A case of chronic enteropathy associated with SLCO2A1 gene diagnosed by capsule endoscopy and successfully treated by ferric carboxymaltose].

Harada A, Umeno J, Morisaki S, et al.

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2022; (119(7)):651-657 doi:10.11405/nisshoshi.119.651.

Chronic enteropathy associated with SLCO2A1 gene and hereditary fructose intolerance: A coincidence of two rare diseases.

Dönger U, Warasnhe K, Özçay F, et al.

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2022; (23(4)):290-293 doi:10.1016/j.ajg.2022.10.007.

Crohn-like Disease Affecting Small Bowel Due to Monogenic SLCO2A1 Mutations: First Cases of Chronic Enteropathy Associated with SLCO2A1 Gene [CEAS] in France.

Hamon A, Cazals-Hatem D, Stefanescu C, et al.

Journal of Crohn's & colitis 2023; (17(5)):816-820 doi:10.1093/ecco-jcc/jjac181.

A Novel Chronic Enteropathy Associated with SLCO2A1 Gene Mutation: Enterography Findings in a Multicenter Korean Registry.

Jeong B, Park SH, Ye BD, et al.

Korean journal of radiology 2023; (24(4)):305-312 doi:10.3348/kjr.2022.0684.

Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with SLCO2A1 gene: A case report.

Kimura K, Jimbo K, Arai N, et al.

World journal of gastroenterology 2023; (29(11)):1757-1764 doi:10.3748/wjg.v29.i11.1757.

Retention of small bowel capsule endoscopy.

Rosa B, Dray X, Koulaouzidis A

Current opinion in gastroenterology 2023; (39(3)):227-233 doi:10.1097/MOG.0000000000000921.

Genotype and phenotype characterization of primary hypertrophic osteoarthropathy type 2 and chronic enteropathy associated with SLCO2A1: Report of two cases and literature review.

Kimball TN, Rivero-García P, Barrera-Godínez A, Domínguez-Cherit J

American journal of medical genetics. Part A 2024; (194(3)):e63446 doi:10.1002/ajmg.a.63446.

Clinical and genetic characteristics of Chinese patients diagnosed with chronic enteropathy associated with SLCO2A1 gene.

Shang Q, Dai Y, Huang J, et al.

Orphanet journal of rare diseases 2024; (19(1)):201 doi:10.1186/s13023-024-03177-y.

A novel variant in the SLCO2A1 gene in a Chinese patient with chronic gastroenteropathy and primary hypertrophic osteoarthropathy.

Dai Y, He M, Xu H, et al.

Orphanet journal of rare diseases 2024; (19(1)):229 doi:10.1186/s13023-024-03221-x.

Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease.

Lim JG, Ko JS, Ko JM, et al.

BMC pediatrics 2024; (24(1)):396 doi:10.1186/s12887-024-04877-x.

Discrimination of pediatric cryptogenic multifocal ulcerous stenosing enteritis from small bowel Crohn's disease and gastrointestinal tuberculosis: A retrospective study (with videos).

Samanta A, Sen Sarma M, Singh SK, et al.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2024; (43(6)):1144-1155 doi:10.1007/s12664-024-01604-3.

The Utility of Magnetic Resonance Enterography and Double Balloon Enteroscopy-Assisted Endoscopic Balloon Dilatation for Small Bowel Strictures in Crohn's Disease: A Retrospective Observational Study.

Arzivian A, Alrubaie A, Yang J, et al.

Inflammatory intestinal diseases 2024; (9(1)):147-156 doi:10.1159/000539401.

Chronic enteropathy associated with SLCO2A1 from North India: a rare monogenic condition mimicking Crohn's disease.

Prasad G, Kulkarni K, Dhua AK, Malik R

BMJ case reports 2025; (18(1)) doi:10.1136/bcr-2024-263684.

A pediatric patient with chronic enteropathy associated with SLCO2A1 who underwent multimodal treatment including several surgeries: a case report.

Jung Y, Chung J, Yoo I

Frontiers in surgery 2025; (12()):1516960 doi:10.3389/fsurg.2025.1516960.

Chronic Enteropathy Associated with SLCO2A1 Gene.

Umeno J, Esaki M, Uchida K, Matsumoto T

Inflammatory intestinal diseases 2025; (10(1)):193-203 doi:10.1159/000546888.

Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 gene: A case report and review of literature.

Wang JY, Liu Y, Xu J, et al.

World journal of gastrointestinal endoscopy 2025; (17(12)):112344 doi:10.4253/wjge.v17.i12.112344.

Is There a Reliable, Rapid, and Economic Diagnostic Approach for SLCO2A1-Related Chronic Enteropathy?

Liu R, Fu Y, Mao J, et al.

Journal of clinical medicine 2026; (15(6)) doi:10.3390/jcm15062433.

What we know about prostaglandin pathway dysfunction in chronic enteropathies: From endoscopy to molecular diagnosis.

Ruan S, Yan P, Yan Q, et al.

Journal of translational internal medicine 2026; (14(2)):204-224 doi:10.1515/jtim-2026-0020.

Phytobezoar Impaction Within Meckel's Diverticulum Causing Distal Small Bowel Obstruction: A Case Report With Characteristic Computed Tomography Small Bowel Feces Sign.

Almadani HS, Alasmari A, Alotaif MA, et al.

Cureus 2026; (18(8)):e114531 doi:10.7759/cureus.114531.