Research & Literature

Toxic Profile of Benznidazole in Patients with Chronic Chagas Disease: Risk Factors and Comparison of the Product from Two Different Manufacturers.

Molina I, Salvador F, Sánchez-Montalvá A, et al.

Antimicrobial agents and chemotherapy 2015; (59(10)):6125-31 doi:10.1128/AAC.04660-14.

Prevalence and Impact of Chagas Disease Among Latin American Immigrants With Nonischemic Cardiomyopathy in Los Angeles, California.

Traina MI, Sanchez DR, Hernandez S, et al.

Circulation. Heart failure 2015; (8(5)):938-43 doi:10.1161/CIRCHEARTFAILURE.115.002229.

Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy.

Morillo CA, Marin-Neto JA, Avezum A, et al.

The New England journal of medicine 2015; (373(14)):1295-306 doi:10.1056/NEJMoa1507574.

Prevalence and risk factors of embolic cerebrovascular events associated with Chagas heart disease.

Nunes MC, Kreuser LJ, Ribeiro AL, et al.

Global heart 2015; (10(3)):151-7.

Myocardial tissue characterization in Chagas' heart disease by cardiovascular magnetic resonance.

Torreão JA, Ianni BM, Mady C, et al.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2015; (17()):97 doi:10.1186/s12968-015-0200-7.

Chronic Chagas Disease Diagnosis: A Comparative Performance of Commercial Enzyme Immunoassay Tests.

Santos FL, de Souza WV, Barros Mda S, et al.

The American journal of tropical medicine and hygiene 2016; (94(5)):1034-9 doi:10.4269/ajtmh.15-0820.

Chagas Cardiomyopathy: Usefulness of EKG and Echocardiogram in a Non-Endemic Country.

Sánchez-Montalvá A, Salvador F, Rodríguez-Palomares J, et al.

PloS one 2016; (11(6)):e0157597 doi:10.1371/journal.pone.0157597.

Pathology of Chronic Chagas Cardiomyopathy in the United States:  A Detailed Review of 13 Cardiectomy Cases.

Kransdorf EP, Fishbein MC, Czer LS, et al.

American journal of clinical pathology 2016; (146(2)):191-8 doi:10.1093/ajcp/aqw098.

Putting Infection Dynamics at the Heart of Chagas Disease.

Lewis MD, Kelly JM

Trends in parasitology 2016; (32(11)):899-911 doi:10.1016/j.pt.2016.08.009.

Cardiac Magnetic Resonance-Verified Myocardial Fibrosis in Chagas Disease: Clinical Correlates and Risk Stratification.

Uellendahl M, Siqueira ME, Calado EB, et al.

Arquivos brasileiros de cardiologia 2016; (107(5)):460-466 doi:10.5935/abc.20160168.

Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging.

Moreira HT, Volpe GJ, Marin-Neto JA, et al.

Circulation. Cardiovascular imaging 2017; (10(3)) doi:10.1161/CIRCIMAGING.116.005571.

The Prevalence of Chagas Disease Among Latin American Immigrants with Pacemakers in Los Angeles, California.

Park S, Sanchez DR, Traina MI, et al.

The American journal of tropical medicine and hygiene 2017; (96(5)):1139-1142 doi:10.4269/ajtmh.16-0826.

An Infrequent Cause of Apical Ventricular Aneurysm in the United States.

Taleb MM

Heart views : the official journal of the Gulf Heart Association 2017; (18(2)):54-57 doi:10.4103/1995-705X.208675.

Multimodality imaging evaluation of Chagas disease: an expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI).

Nunes MCP, Badano LP, Marin-Neto JA, et al.

European heart journal. Cardiovascular Imaging 2018; (19(4)):459-460n doi:10.1093/ehjci/jex154.

Analysis of over 1500 triatomine vectors from across the US, predominantly Texas, for Trypanosoma cruzi infection and discrete typing units.

Curtis-Robles R, Auckland LD, Snowden KF, et al.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2018; (58()):171-180 doi:10.1016/j.meegid.2017.12.016.

What to expect and when: benznidazole toxicity in chronic Chagas' disease treatment.

Aldasoro E, Posada E, Requena-Méndez A, et al.

The Journal of antimicrobial chemotherapy 2018; (73(4)):1060-1067 doi:10.1093/jac/dkx516.

Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins.

Coelho LL, Pereira IR, Pereira MCS, et al.

Parasites & vectors 2018; (11(1)):72 doi:10.1186/s13071-018-2614-1.

Clinical findings and prognosis of patients hospitalized for acute decompensated heart failure: Analysis of the influence of Chagas etiology and ventricular function.

Terhoch CB, Moreira HF, Ayub-Ferreira SM, et al.

PLoS neglected tropical diseases 2018; (12(2)):e0006207 doi:10.1371/journal.pntd.0006207.

The Presence and Extension of Myocardial Fibrosis in the Undetermined Form of Chagas' Disease: A Study Using Magnetic Resonance.

Noya-Rabelo MM, Macedo CT, Larocca T, et al.

Arquivos brasileiros de cardiologia 2018; (110(2)):124-131 doi:10.5935/abc.20180016.

Regulatory Lymphoid and Myeloid Cells Determine the Cardiac Immunopathogenesis of Trypanosoma cruzi Infection.

Fresno M, Gironès N

Frontiers in microbiology 2018; (9()):351 doi:10.3389/fmicb.2018.00351.

Long-term follow-up of Chagas heart disease patients receiving an implantable cardioverter-defibrillator for secondary prevention.

Pavão MLRC, Arfelli E, Scorzoni-Filho A, et al.

Pacing and clinical electrophysiology : PACE 2018; (41(6)):583-588 doi:10.1111/pace.13333.

Regional Myocardial Perfusion Disturbance in Experimental Chronic Chagas Cardiomyopathy.

Lemos de Oliveira LF, Thackeray JT, Marin Neto JA, et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018; (59(9)):1430-1436 doi:10.2967/jnumed.117.205450.

Chagas Disease-induced Sudden Cardiac Arrest.

Neeki MM, Park M, Sandhu K, et al.

Clinical practice and cases in emergency medicine 2017; (1(4)):354-358 doi:10.5811/cpcem.2017.5.33626.

Implantable cardioverter-defibrillator in Chagas heart disease: A systematic review and meta-analysis of observational studies.

Carmo AAL, de Sousa MR, Agudelo JF, et al.

International journal of cardiology 2018; (267()):88-93 doi:10.1016/j.ijcard.2018.05.091.

Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail.

Crespillo-Andújar C, Chamorro-Tojeiro S, Norman F, et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018; (24(12)):1344.e1-1344.e4 doi:10.1016/j.cmi.2018.06.006.

Reactivation of Chagas disease among heart transplant recipients in the United States, 2012-2016.

Gray EB, La Hoz RM, Green JS, et al.

Transplant infectious disease : an official journal of the Transplantation Society 2018; (20(6)):e12996 doi:10.1111/tid.12996.

Treatment of Chagas Disease in the United States.

Meymandi S, Hernandez S, Park S, et al.

Current treatment options in infectious diseases 2018; (10(3)):373-388 doi:10.1007/s40506-018-0170-z.

Diagnosis and Management of Chagas Cardiomyopathy in the United States.

Benck L, Kransdorf E, Patel J

Current cardiology reports 2018; (20(12)):131 doi:10.1007/s11886-018-1077-5.

Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association.

Nunes MCP, Beaton A, Acquatella H, et al.

Circulation 2018; (138(12)):e169-e209 doi:10.1161/CIR.0000000000000599.

Left Ventricular Scar and Prognosis in Chronic Chagas Cardiomyopathy.

Volpe GJ, Moreira HT, Trad HS, et al.

Journal of the American College of Cardiology 2018; (72(21)):2567-2576 doi:10.1016/j.jacc.2018.09.035.

Long-Term Prognostic Value of Myocardial Fibrosis in Patients With Chagas Cardiomyopathy.

Senra T, Ianni BM, Costa ACP, et al.

Journal of the American College of Cardiology 2018; (72(21)):2577-2587 doi:10.1016/j.jacc.2018.08.2195.

American Trypanosomiasis (Chagas Disease).

Echeverria LE, Morillo CA

Infectious disease clinics of North America 2019; (33(1)):119-134 doi:10.1016/j.idc.2018.10.015.

An evaluation of benznidazole as a Chagas disease therapeutic.

Caldas IS, Santos EG, Novaes RD

Expert opinion on pharmacotherapy 2019; (20(15)):1797-1807 doi:10.1080/14656566.2019.1650915.

Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease.

Rios L, Campos EE, Menon R, et al.

Biochimica et biophysica acta. Molecular basis of disease 2020; (1866(3)):165591 doi:10.1016/j.bbadis.2019.165591.

Sequential measurement of Trypanosoma cruzi parasitic load in endomyocardial biopsies for early detection and follow-up of Chagas disease reactivation after heart transplantation.

Benvenuti LA, Roggério A, Nishiya AS, et al.

Transplant infectious disease : an official journal of the Transplantation Society 2020; (22(1)):e13209 doi:10.1111/tid.13209.

Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy.

Hoffman KA, Reynolds C, Bottazzi ME, et al.

Journal of the American Heart Association 2019; (8(22)):e013365 doi:10.1161/JAHA.119.013365.

Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas' disease.

Jackson Y, Wyssa B, Chappuis F

The Journal of antimicrobial chemotherapy 2020; (75(3)):690-696 doi:10.1093/jac/dkz473.

The role of the first level of health care in the approach to Chagas disease in a non-endemic country.

Iglesias-Rus L, Romay-Barja M, Boquete T, et al.

PLoS neglected tropical diseases 2019; (13(12)):e0007937 doi:10.1371/journal.pntd.0007937.

Case Report: Malignant Ventricular Arrhythmias Mimicking Acute Coronary Syndrome in Chagas Disease.

Moll-Bernardes RJ, Saraiva RM, Oliveira RS, et al.

The American journal of tropical medicine and hygiene 2020; (102(4)):797-799 doi:10.4269/ajtmh.19-0920.

Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study.

Di Lorenzo Oliveira C, Nunes MCP, Colosimo EA, et al.

Journal of the American Heart Association 2020; (9(6)):e014176 doi:10.1161/JAHA.119.014176.

Radionuclide esophageal transit scintigraphy in chronic indeterminate and cardiac forms of Chagas disease.

Dumont SM, Costa HS, Chaves AT, et al.

Nuclear medicine communications 2020; (41(6)):510-516 doi:10.1097/MNM.0000000000001186.

Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease.

Pinheiro MVT, Moll-Bernardes RJ, Camargo GC, et al.

The American journal of tropical medicine and hygiene 2020; (103(2)):745-751.

Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease: A Systematic Review and Meta-analysis.

Chadalawada S, Sillau S, Archuleta S, et al.

JAMA network open 2020; (3(8)):e2015072 doi:10.1001/jamanetworkopen.2020.15072.

Trypanosoma cruzi infection in Latin American pregnant women living outside endemic countries and frequency of congenital transmission: a systematic review and meta-analysis.

Colombo V, Giacomelli A, Casazza G, et al.

Journal of travel medicine 2021; (28(1)) doi:10.1093/jtm/taaa170.

Anthropological study on Chagas Disease: Sociocultural construction of illness and embodiment of health barriers in Bolivian migrants in Rome, Italy.

Castaldo M, Cavani A, Segneri MC, et al.

PloS one 2020; (15(10)):e0240831 doi:10.1371/journal.pone.0240831.

Prevalence of Chagas heart disease in dilated cardiomyopathy.

González-Zambrano H, Amaya-Tapia G, Franco-Ramos MC, López León-Murguía OJ

Archivos de cardiologia de Mexico 2020; (91(1)):50-57 doi:10.24875/ACM.20000042.

Shared neuroimmune and oxidative pathways underpinning Chagas disease and major depressive disorder.

Duarte-Silva E, Maes M, Macedo D, et al.

Translational psychiatry 2020; (10(1)):419 doi:10.1038/s41398-020-01105-9.

Trypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection).

Vallejo M, Reyes PP, Martinez Garcia M, Gonzalez Garay AG

The Cochrane database of systematic reviews 2020; (12()):CD004102 doi:10.1002/14651858.CD004102.pub3.

Survival after heart transplantation for Chagas cardiomyopathy using a conventional protocol: A 10-year experience in a single center.

Echeverría LE, Figueredo A, Rodriguez MJ, et al.

Transplant infectious disease : an official journal of the Transplantation Society 2021; (23(4)):e13549 doi:10.1111/tid.13549.

Sudden Cardiac Death Risk Stratification and Prevention in Chagas Disease: A Non-systematic Review of the Literature.

Keegan R, Yeung C, Baranchuk A

Arrhythmia & electrophysiology review 2020; (9(4)):175-181 doi:10.15420/aer.2020.27.

Correlation between Cardiomegaly on Chest X-Ray and Left Ventricular Diameter on Echocardiography in Patients with Chagas Disease.

Ramos MRF, Moreira HT, Volpe GJ, et al.

Arquivos brasileiros de cardiologia 2021; (116(1)):68-74 doi:10.36660/abc.20190673.

Advanced Therapies for Ventricular Arrhythmias in Patients With Chagasic Cardiomyopathy: JACC State-of-the-Art Review.

Romero J, Velasco A, Pisani CF, et al.

Journal of the American College of Cardiology 2021; (77(9)):1225-1242 doi:10.1016/j.jacc.2020.12.056.

Updated review on the pathophysiology of Chagas cardiomyopathy.

Pech-Aguilar AG, Haro-Álvarez AP, Rosado-Vallado ME

Revista medica del Instituto Mexicano del Seguro Social 2020; (58(3)):328-334 doi:10.24875/RMIMSS.M20000037.

The effects of antidiabetic agents on heart failure.

Wijnen M, Duschek EJJ, Boom H, van Vliet M

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 2022; (30(2)):65-75 doi:10.1007/s12471-021-01579-2.

Social determinants in the access to health care for Chagas disease: A qualitative research on family life in the "Valle Alto" of Cochabamba, Bolivia.

Jimeno I, Mendoza N, Zapana F, et al.

PloS one 2021; (16(8)):e0255226 doi:10.1371/journal.pone.0255226.

Recommendations for Screening and Diagnosis of Chagas Disease in the United States.

Forsyth CJ, Manne-Goehler J, Bern C, et al.

The Journal of infectious diseases 2022; (225(9)):1601-1610 doi:10.1093/infdis/jiab513.

Cardiac Fibrosis and Changes in Left Ventricle Function in Patients with Chronic Chagas Heart Disease.

Santos JBF, Gottlieb I, Tassi EM, et al.

Arquivos brasileiros de cardiologia 2021; (117(6)):1081-1090 doi:10.36660/abc.20200597.

Association of HLA-B∗35 and moderate or severe cutaneous reactions secondary to benznidazole treatment in chronic chagas disease.

Bosch-Nicolau P, Salvador F, Sánchez-Montalvá A, et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2022; (28(6)):881.e1-881.e5 doi:10.1016/j.cmi.2021.11.021.

The Oxidative Stress and Chronic Inflammatory Process in Chagas Disease: Role of Exosomes and Contributing Genetic Factors.

Maldonado E, Rojas DA, Urbina F, Solari A

Oxidative medicine and cellular longevity 2021; (2021()):4993452 doi:10.1155/2021/4993452.

Advanced management of ventricular arrhythmias in chronic Chagas cardiomyopathy.

Santacruz D, Rosas F, Hardy CA, et al.

Heart rhythm O2 2021; (2(6Part B)):807-818 doi:10.1016/j.hroo.2021.10.010.

The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication field.

Sanmartino M, Forsyth CJ, Avaria A, et al.

Memorias do Instituto Oswaldo Cruz 2022; (117()):e200460 doi:10.1590/0074-02760200460.

Stroke in Chagas disease: from pathophysiology to clinical practice.

Lage TAR, Tupinambás JT, Pádua LB, et al.

Revista da Sociedade Brasileira de Medicina Tropical 2022; (55()):e0575 doi:10.1590/0037-8682-0575-2021.

Evaluation of the Performance of Ortho T. cruzi ELISA Test System for the Detection of Antibodies to Trypanosoma cruzi.

Rivera HN, McAuliffe I, Aderohunmu T, et al.

Journal of clinical microbiology 2022; (60(8)):e0013422 doi:10.1128/jcm.00134-22.

Transplantation for chagas' disease: closing the knowledge gap.

La Hoz RM

Current opinion in infectious diseases 2022; (35(5)):397-403 doi:10.1097/QCO.0000000000000868.

Atrial Fibrillation and Dapagliflozin Efficacy in Patients With Preserved or Mildly Reduced Ejection Fraction.

Butt JH, Kondo T, Jhund PS, et al.

Journal of the American College of Cardiology 2022; (80(18)):1705-1717 doi:10.1016/j.jacc.2022.08.718.

Western blot using Trypanosoma cruzi chimeric recombinant proteins for the serodiagnosis of chronic Chagas disease: A proof-of-concept study.

Daltro RT, Santos EF, Silva ÂAO, et al.

PLoS neglected tropical diseases 2022; (16(11)):e0010944 doi:10.1371/journal.pntd.0010944.

Risk Factors for Progression to Chronic Chagas Cardiomyopathy: A Systematic Review and Meta-Analysis.

Cutshaw MK, Sciaudone M, Bowman NM

The American journal of tropical medicine and hygiene 2023; (108(4)):791-800 doi:10.4269/ajtmh.22-0630.

Efficacy and Safety of Nifurtimox in Pediatric Patients with Chagas Disease: Results at 4-Year Follow-Up in a Prospective, Historically Controlled Study (CHICO SECURE).

Altcheh J, Sierra V, Ramirez T, et al.

Antimicrobial agents and chemotherapy 2023; (67(4)):e0119322 doi:10.1128/aac.01193-22.

Anxiety, depression, and memory loss in Chagas disease: a puzzle far beyond neuroinflammation to be unpicked and solved.

Lannes-Vieira J, Vilar-Pereira G, Barrios LC, Silva AA

Memorias do Instituto Oswaldo Cruz 2023; (118()):e220287 doi:10.1590/0074-02760220287.

Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy.

de Brito ASX, Moll-Bernardes RJ, Pinheiro MVT, et al.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2023; (30(6)):2379-2388 doi:10.1007/s12350-023-03281-9.

WHF Recommendations for the Use of Echocardiography in Chagas Disease.

Ralston K, Zaidel E, Acquatella H, et al.

Global heart 2023; (18(1)):27 doi:10.5334/gh.1207.

Clinical Characteristics and Outcomes of Chagas Disease in the United States: A Multicenter Retrospective Analysis.

Henao-Martínez AF, Olivo-Freites C, Higuita NIA, et al.

The American journal of tropical medicine and hygiene 2023; (109(5)):1006-1011 doi:10.4269/ajtmh.23-0361.

Reactivation of Trypanosoma cruzi infection in immunosuppressed patients: a systematic review and meta-analysis.

Antequera A, Molin-Veglia AD, López-Alcalde J, et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2024; (30(8)):980-988 doi:10.1016/j.cmi.2024.04.013.

Chagas disease in the immunocompromised host.

Clark EH, Bern C

Current opinion in infectious diseases 2024; (37(5)):333-341 doi:10.1097/QCO.0000000000001035.

Right-Sided Cardiac Thrombosis and Pulmonary Thromboembolism in Chronic Chagas Disease: A Review of Clinical Features and Post-Mortem Examination.

Bestetti RB, Soares MJF, Furlan-Daniel R, et al.

Reviews in cardiovascular medicine 2024; (25(6)):220 doi:10.31083/j.rcm2506220.

Chagas Disease in the Non-Endemic Area of Rome, Italy: Ten Years of Experience and a Brief Overview.

Giancola ML, Angheben A, Scorzolini L, et al.

Infectious disease reports 2024; (16(4)):650-663 doi:10.3390/idr16040050.

Enhancing risk assessment in Chagas cardiomyopathy: Electrophysiology study stratified by Rassi score.

Costa IP, Lima NA, Vieira JL, et al.

International journal of cardiology 2024; (417()):132553 doi:10.1016/j.ijcard.2024.132553.

Causality and Severity of Adverse Reactions and Biochemical Changes to Benznidazole Treatment in Patients with Chronic Chagas Disease.

Belmino ACDC, Sousa EKS, Silva Filho JDD, et al.

Arquivos brasileiros de cardiologia 2024; (121(8)):e20230787 doi:10.36660/abc.20230787.

Amiodarone or Implantable Cardioverter-Defibrillator in Chagas Cardiomyopathy: The CHAGASICS Randomized Clinical Trial.

Martinelli-Filho M, Marin-Neto JA, Scanavacca MI, et al.

JAMA cardiology 2024; (9(12)):1073-1081 doi:10.1001/jamacardio.2024.3169.

Bridging the critical gap between infectious disease blood donation screening and connection to healthcare services: the American Chagas disease example.

Lynn MK, Parker M, Stramer SL, et al.

Journal of public health policy 2025; (46(1)):168-179 doi:10.1057/s41271-024-00539-5.

Up-titration of medication in patients with new-onset heart failure with and without atrial fibrillation.

Zandijk AJL, Santema BT, Inkelaar FDJ, et al.

ESC heart failure 2025; (12(3)):1703-1713 doi:10.1002/ehf2.15188.

Electrocardiographic abnormalities in chagasic patients compared to the general population: A systematic review with updated meta-analysis.

de Oliveira BFS, de Santana CVC, Pereira LFV, et al.

Journal of electrocardiology 2025; (90()):153893 doi:10.1016/j.jelectrocard.2025.153893.

Low risk for locally acquired Chagas disease in California: A review of human cases and triatomine submissions, 2013-2023.

Lund AJ, Metzger ME, Kramer VL, Kjemtrup AM

PLoS neglected tropical diseases 2025; (19(4)):e0013036 doi:10.1371/journal.pntd.0013036.

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic Targets.

Frade AF, Guérin H, Nunes JPS, et al.

Mediators of inflammation 2025; (2025()):8862004 doi:10.1155/mi/8862004.

Adherence to Guideline-Directed Medical Therapy Target in patients with heart failure and reduced ejection fraction: a cross-sectional study.

Costa FF, Chagas AKR, Santos ACML, et al.

Sao Paulo medical journal = Revista paulista de medicina 2025; (143(3)):e2023315 doi:10.1590/1516-3180.2023.0315.R2.13082024.

Cutaneous reactions during treatment with Nifurtimox or Benznidazole among Trypanosoma cruzi seropositive adults without symptomatic cardiomyopathy: A safety sub analysis of a placebo-controlled randomised trial.

Villar JC, Saavedra MF, Bermúdez PA, et al.

Tropical medicine & international health : TM & IH 2025; (30(7)):673-684 doi:10.1111/tmi.14123.

Chagas Disease in Latin America and the United States: Factors Influencing Differences in Transmission Rates Among Differing Populations and Vectors.

Klotz SA

Insects 2025; (16(6)) doi:10.3390/insects16060570.

Antitrypanosomal therapy for Chagas disease: A single center experience with adverse drug reactions and strategies for enhancing treatment completion.

Reifler K, Wheelock A, Hall SM, et al.

PLoS neglected tropical diseases 2025; (19(7)):e0013218 doi:10.1371/journal.pntd.0013218.

Trypanosoma cruzi infection-induced changes in cardiac microvascular endothelial cell morphology and function.

Gisclair LN, Johnston DA

Journal of medical microbiology 2025; (74(11)) doi:10.1099/jmm.0.002095.

The efficacy and safety of benznidazole in adults with seropositive indeterminate form, Trypanosoma cruzi infection: a systematic review and meta-analysis.

Trowell JW, Mitre E, Marcus R, et al.

BMC infectious diseases 2025; (26(1)):154 doi:10.1186/s12879-025-12231-4.

Health-related quality-of-life associated with Chagas disease in Argentina and Spain.

Ramponi F, Sartor P, Pinazo MJ, et al.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2026; (164()):108363 doi:10.1016/j.ijid.2025.108363.

Left Atrial Thrombus and Cardioembolic Stroke in Chagas Cardiomyopathy Presenting with Atrial Flutter: A Case Report.

Moreno-Bejarano MS, Silva-Patiño I, Aragón-Jácome AC, et al.

Journal of clinical medicine 2026; (15(2)) doi:10.3390/jcm15020456.

Barriers to Chagas Disease Screening among Primary Care Providers in the United States.

Carrion MN, Kienle RM, Bourque D, et al.

The American journal of tropical medicine and hygiene 2026; (114(5)):857-864 doi:10.4269/ajtmh.25-0559.

Chagas Heart Disease: Social Determinants and Delayed Diagnosis.

Ho K, Ding E, Ding HH, Burtt DM

JACC. Case reports 2026; (31(16)):107514 doi:10.1016/j.jaccas.2026.107514.

ANSWER-HF: sacubitril-valsartan reduces NT-proBNP in heart failure due to Chagas cardiomyopathy despite no reverse remodeling.

Martins EB, Madrini V, Ramos Souza PV, et al.

Heart failure reviews 2026; (31(1)).

Outcomes comparison between catheter ablation of ventricular tachycardia in Chagas disease versus ischemic and dilated cardiomyopathy - a retrospective cohort study.

Kulchetscki RM, Rodrigues LV, Pisani CF, et al.

Lancet regional health. Americas 2026; (55()):101394 doi:10.1016/j.lana.2026.101394.

Chagas cardiomyopathy.

Nunes MCP, Ribeiro ALP, Dutra W, et al.

Heart (British Cardiac Society) 2026; doi:10.1136/heartjnl-2025-326968.

Evaluation of Chagas TESA VirClia assay for chronic Trypanosoma cruzi infection diagnosis and post-treatment follow-up.

Silgado A, Mediavilla A, Martínez-Vallejo P, et al.

Journal of clinical microbiology 2026; (64(7)):e0173925 doi:10.1128/jcm.01739-25.

Development of an ICF Core Set for adults with Chagas disease: a qualitative study capturing patients' perspective on functioning.

Ottone NCS, Costa HS, Souza SG, et al.

Revista da Sociedade Brasileira de Medicina Tropical 2026; (59()):e04012025 doi:10.1590/0037-8682-0401-2025.