Research & Literature

Chikungunya: an arbovirus infection in the process of establishment and expansion in Brazil.

Honório NA, Câmara DC, Calvet GA, Brasil P

Cadernos de saude publica 2015; (31(5)):906-8.

Zika Virus Outbreak, Bahia, Brazil.

Campos GS, Bandeira AC, Sardi SI

Emerging infectious diseases 2015; (21(10)):1885-6 doi:10.3201/eid2110.150847.

Rheumatic Manifestations in Patients with Chikungunya Infection: Comment on the Article by Arroyo-Ávila and Vilá.

Sánchez-Duque JA, Orozco-Hernández JP, Rodríguez-Morales AJ

Puerto Rico health sciences journal 2015; (34(4)):231-2.

Single-Reaction Multiplex Reverse Transcription PCR for Detection of Zika, Chikungunya, and Dengue Viruses.

Waggoner JJ, Gresh L, Mohamed-Hadley A, et al.

Emerging infectious diseases 2016; (22(7)):1295-7 doi:10.3201/eid2207.160326.

Severe manifestations of chikungunya virus in critically ill patients during the 2013-2014 Caribbean outbreak.

Crosby L, Perreau C, Madeux B, et al.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2016; (48()):78-80.

Brief Report: Management of Chronic Post-Chikungunya Rheumatic Disease: The Martinican Experience.

Blettery M, Brunier L, Polomat K, et al.

Arthritis & rheumatology (Hoboken, N.J.) 2016; (68(11)):2817-2824 doi:10.1002/art.39775.

Detection of chikungunya virus in saliva and urine.

Musso D, Teissier A, Rouault E, et al.

Virology journal 2016; (13()):102 doi:10.1186/s12985-016-0556-9.

Viremia and Clinical Presentation in Nicaraguan Patients Infected With Zika Virus, Chikungunya Virus, and Dengue Virus.

Waggoner JJ, Gresh L, Vargas MJ, et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016; (63(12)):1584-1590 doi:10.1093/cid/ciw589.

Chikungunya Infection: a Global Public Health Menace.

Mathew AJ, Ganapati A, Kabeerdoss J, et al.

Current allergy and asthma reports 2017; (17(2)):13 doi:10.1007/s11882-017-0680-7.

Rheumatic manifestations associated with Chikungunya virus infection: A study of 307 patients with 32-month follow-up (RHUMATOCHIK study).

Bouquillard E, Fianu A, Bangil M, et al.

Joint bone spine 2018; (85(2)):207-210 doi:10.1016/j.jbspin.2017.01.014.

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies.

Silva LA, Dermody TS

The Journal of clinical investigation 2017; (127(3)):737-749 doi:10.1172/JCI84417.

Re-evaluation of routine dengue virus serology in travelers in the era of Zika virus emergence.

van Meer MPA, Mögling R, Klaasse J, et al.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2017; (92()):25-31 doi:10.1016/j.jcv.2017.05.001.

Recommendations of the Brazilian Society of Rheumatology for diagnosis and treatment of Chikungunya fever. Part 1 - Diagnosis and special situations.

Marques CDL, Duarte ALBP, Ranzolin A, et al.

Revista brasileira de reumatologia 2017; (57 Suppl 2()):421-437 doi:10.1016/j.rbre.2017.05.006.

Pregnant Women Hospitalized with Chikungunya Virus Infection, Colombia, 2015.

Escobar M, Nieto AJ, Loaiza-Osorio S, et al.

Emerging infectious diseases 2017; (23(11)) doi:10.3201/eid2311.170480.

Clinical Profile, Intensive Care Unit Course, and Outcome of Patients Admitted in Intensive Care Unit with Chikungunya.

Gupta A, Juneja D, Singh O, et al.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2018; (22(1)):5-9 doi:10.4103/ijccm.IJCCM_336_17.

Smoking and female sex as key risk factors associated with severe arthralgia in acute and chronic phases of Chikungunya virus infection.

Delgado-Enciso I, Paz-Michel B, Melnikov V, et al.

Experimental and therapeutic medicine 2018; (15(3)):2634-2642 doi:10.3892/etm.2017.5668.

Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island.

Duvignaud A, Fianu A, Bertolotti A, et al.

Epidemiology and infection 2018; (146(5)):633-641 doi:10.1017/S0950268818000031.

Treatment of chikungunya musculoskeletal disorders: a systematic review.

Guaraldo L, Wakimoto MD, Ferreira H, et al.

Expert review of anti-infective therapy 2018; (16(4)):333-344 doi:10.1080/14787210.2018.1450629.

Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia.

Huits R, De Kort J, Van Den Berg R, et al.

PloS one 2018; (13(4)):e0196630 doi:10.1371/journal.pone.0196630.

Evaluation of an immunochromatography rapid diagnosis kit for detection of chikungunya virus antigen in India, a dengue-endemic country.

Jain J, Okabayashi T, Kaur N, et al.

Virology journal 2018; (15(1)):84 doi:10.1186/s12985-018-1000-0.

Zika Virus IgM Detection and Neutralizing Antibody Profiles 12-19 Months after Illness Onset.

Griffin I, Martin SW, Fischer M, et al.

Emerging infectious diseases 2019; (25(2)):299-303 doi:10.3201/eid2502.181286.

Chronic Joint Pain 3 Years after Chikungunya Virus Infection Largely Characterized by Relapsing-remitting Symptoms.

Tritsch SR, Encinales L, Pacheco N, et al.

The Journal of rheumatology 2020; (47(8)):1267-1274 doi:10.3899/jrheum.190162.

Combining anti-IgM and IgG immunoassays for comprehensive chikungunya virus diagnostic testing.

Mendoza EJ, Robinson A, Dimitrova K, et al.

Zoonoses and public health 2019; (66(8)):909-917 doi:10.1111/zph.12641.

Chikungunya arthritis.

Pathak H, Mohan MC, Ravindran V

Clinical medicine (London, England) 2019; (19(5)):381-385 doi:10.7861/clinmed.2019-0035.

Chikungunya Virus: Role of Vectors in Emergence from Enzootic Cycles.

Weaver SC, Chen R, Diallo M

Annual review of entomology 2020; (65()):313-332 doi:10.1146/annurev-ento-011019-025207.

Chronic Chikungunya Arthritis and Rheumatoid Arthritis: What They Have in Common.

Amaral JK, Bilsborrow JB, Schoen RT

The American journal of medicine 2020; (133(3)):e91-e97 doi:10.1016/j.amjmed.2019.10.005.

Pathogenic Th1 responses in CHIKV-induced inflammation and their modulation upon Plasmodium parasites co-infection.

Torres-Ruesta A, Teo TH, Chan YH, et al.

Immunological reviews 2020; (294(1)):80-91 doi:10.1111/imr.12825.

Comparative specificity and sensitivity of NS1-based serological assays for the detection of flavivirus immune response.

Mora-Cárdenas E, Aloise C, Faoro V, et al.

PLoS neglected tropical diseases 2020; (14(1)):e0008039 doi:10.1371/journal.pntd.0008039.

Chikungunya Virus Evades Antiviral CD8+ T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues.

Davenport BJ, Bullock C, McCarthy MK, et al.

Journal of virology 2020; (94(9)) doi:10.1128/JVI.02036-19.

Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): A prospective cohort study.

Bertolotti A, Thioune M, Abel S, et al.

PLoS neglected tropical diseases 2020; (14(3)):e0007327 doi:10.1371/journal.pntd.0007327.

Structural basis of Chikungunya virus inhibition by monoclonal antibodies.

Zhou QF, Fox JM, Earnest JT, et al.

Proceedings of the National Academy of Sciences of the United States of America 2020; (117(44)):27637-27645 doi:10.1073/pnas.2008051117.

Adaptation of WHO Definitions of Clinical Forms of Chikungunya Virus Infection for the Elderly.

Godaert L, Cofais C, Hequet F, et al.

The American journal of tropical medicine and hygiene 2021; (104(1)):106-109.

Resistance exercises improve physical function in chronic Chikungunya fever patients: a randomized controlled trial.

Neumann IL, de Oliveira DA, de Barros EL, et al.

European journal of physical and rehabilitation medicine 2021; (57(4)):620-629 doi:10.23736/S1973-9087.21.06520-5.

Live attenuated vaccines under immunosuppressive agents or biological agents: survey and clinical data from Japan.

Kamei K, Miyairi I, Shoji K, et al.

European journal of pediatrics 2021; (180(6)):1847-1854 doi:10.1007/s00431-021-03927-1.

Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil.

Silva MMO, Kikuti M, Anjos RO, et al.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021; (105()):608-616 doi:10.1016/j.ijid.2021.03.003.

A review targeting the infection by CHIKV using computational and experimental approaches.

Kumar D, Kumari K, Chandra R, et al.

Journal of biomolecular structure & dynamics 2022; (40(17)):8127-8141 doi:10.1080/07391102.2021.1904004.

Post-Chikungunya Virus Infection Musculoskeletal Disorders: Syndromic Sequelae after an Outbreak.

Imad HA, Matsee W, Kludkleeb S, et al.

Tropical medicine and infectious disease 2021; (6(2)) doi:10.3390/tropicalmed6020052.

A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development.

de Lima Cavalcanti TYV, Pereira MR, de Paula SO, Franca RFO

Viruses 2022; (14(5)) doi:10.3390/v14050969.

Determinants of Health-Related Quality of Life in Chronic Chikungunya Disease in Guadeloupe.

Simon F, Bossy R, Federico D, et al.

Pathogens (Basel, Switzerland) 2022; (11(9)) doi:10.3390/pathogens11090989.

Re-emergence of dengue, chikungunya, and Zika viruses in 2021 after a 10-year gap in Gabon.

Ushijima Y, Abe H, Mbadinga MJVM, et al.

IJID regions 2022; (5()):68-71 doi:10.1016/j.ijregi.2022.08.013.

Interferon-induced restriction of Chikungunya virus infection.

Suzuki Y

Antiviral research 2023; (210()):105487 doi:10.1016/j.antiviral.2022.105487.

Diagnosis of Imported Dengue and Zika Virus Infections in Italy from November 2015 to November 2022: Laboratory Surveillance Data from a National Reference Laboratory.

Merakou C, Amendola A, Fortuna C, et al.

Viruses 2023; (16(1)) doi:10.3390/v16010050.

Live-attenuated chikungunya virus vaccine.

Ng LFP, Rénia L

Cell 2024; (187(4)):813-813.e1 doi:10.1016/j.cell.2024.01.033.

Chronic chikungunya disease (CCD): clinical insights, immunopathogenesis and therapeutic perspectives.

Ng WH, Amaral K, Javelle E, Mahalingam S

QJM : monthly journal of the Association of Physicians 2024; (117(7)):489-494 doi:10.1093/qjmed/hcae028.

Increased threat of urban arboviral diseases from Aedes aegypti mosquitoes in Colombia.

Ramírez RMG, Bohers C, Mousson L, et al.

IJID regions 2024; (11()):100360 doi:10.1016/j.ijregi.2024.100360.

Bone erosions and joint damage caused by chikungunya virus: a systematic review.

Amaral JK, Taylor PC, Schoen RT

Revista da Sociedade Brasileira de Medicina Tropical 2024; (57()):e00404 doi:10.1590/0037-8682-0433-2023.

Detectable Viremia at Presentation Is a Predictor of Disease Severity in Chikungunya.

Rawat SK, Kale D, Nema S, et al.

Cureus 2024; (16(4)):e58188 doi:10.7759/cureus.58188.

Combined immunogenicity evaluation for a new single-dose live-attenuated chikungunya vaccine.

Buerger V, Maurer G, Kosulin K, et al.

Journal of travel medicine 2024; (31(7)) doi:10.1093/jtm/taae084.

Antibody persistence and safety of a live-attenuated chikungunya virus vaccine up to 2 years after single-dose administration in adults in the USA: a single-arm, multicentre, phase 3b study.

McMahon R, Toepfer S, Sattler N, et al.

The Lancet. Infectious diseases 2024; (24(12)):1383-1392 doi:10.1016/S1473-3099(24)00357-8.

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection.

Weber WC, Streblow ZJ, Kreklywich CN, et al.

Vaccines 2024; (12(8)) doi:10.3390/vaccines12080893.

From bench to clinic: the development of VLA1553/IXCHIQ, a live-attenuated chikungunya vaccine.

Chen LH, Fritzer A, Hochreiter R, et al.

Journal of travel medicine 2024; (31(7)) doi:10.1093/jtm/taae123.

Acute Chikungunya Virus Infection Triggers a Diverse Range of T Helper Lymphocyte Profiles.

Brito RMM, de Melo MF, Fernandes JV, et al.

Viruses 2024; (16(9)) doi:10.3390/v16091387.

Infectomics of Chikungunya Virus: Roles Played by Host Factors.

Binti Adnan NAA, Kalam N, Lim Zi Jiunn G, et al.

The American journal of tropical medicine and hygiene 2025; (112(3)):481-490 doi:10.4269/ajtmh.23-0819.

Acute Immunological Profile and Prognostic Biomarkers of Persistent Joint Pain in Chikungunya Fever: A Systematic Review.

Lozano-Parra A, Herrera V, Urcuqui-Inchima S, et al.

The Yale journal of biology and medicine 2024; (97(4)):473-489 doi:10.59249/RQYJ3197.

Acute Clinical Features and Persistence of Joint Pain in Probable Cases of Chikungunya Fever in Eritrea.

Frezgi O, Berhane A, Ghebrewelde G, et al.

Open access rheumatology : research and reviews 2025; (17()):13-24 doi:10.2147/OARRR.S465082.

Cross-neutralizing activity of the chikungunya vaccine VLA1553 against three prevalent chikungunya lineages.

Kosulin K, Brasel TL, Smith J, et al.

Emerging microbes & infections 2025; (14(1)):2469653 doi:10.1080/22221751.2025.2469653.

Chikungunya virus in Europe: A retrospective epidemiology study from 2007 to 2023.

Liu Q, Shen H, Gu L, et al.

PLoS neglected tropical diseases 2025; (19(3)):e0012904 doi:10.1371/journal.pntd.0012904.

Chikungunya fever in hospitalized children and adolescents: clinical and epidemiological aspects in a region of northeastern Brazil.

Tavares WGS, Leite RD, Christofolini DM

Jornal de pediatria 2025; (101(3)):466-472 doi:10.1016/j.jped.2025.01.010.

Clinical variables associated with functional deficits in patients affected by chronic chikungunya arthralgia: A cross-sectional study.

Sacha Cunha Brito Holanda J, Fonseca Mendes E, Silva-Filho E, et al.

Journal of back and musculoskeletal rehabilitation 2025; (38(5)):1139-1147 doi:10.1177/10538127251325838.

Development of a Chikungunya Arthritis Disease Activity Score (CHIK-DAS) Based on a Prospective Cohort Study.

Chang AY, Simmens S, Watson H, et al.

Journal of cellular immunology 2024; (6(6)):236-246 doi:10.33696/immunology.6.211.

Diagnostic utility of real-time RT-PCR for chikungunya virus detection in the acute phase of infection: a retrospective study.

Sajith A, Iyengar V, Varamballi P, et al.

Annals of medicine 2025; (57(1)):2523559 doi:10.1080/07853890.2025.2523559.

Immunomodulatory therapy of chikungunya arthritis: systematic review and meta-analysis.

Amaral JK, Schoen RT, Bingham CO, et al.

Journal of travel medicine 2025; (32(6)) doi:10.1093/jtm/taaf067.

Fatal Adverse Event After VLA1553 Chikungunya Vaccination in an Elderly Patient: A Case Report From Reunion Island.

Mosnier E, Jaffar-Bandjee MC, Cally R, et al.

Open forum infectious diseases 2025; (12(9)):ofaf550 doi:10.1093/ofid/ofaf550.

Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis.

Gervais A, Bastard P, Zhang Q, et al.

Proceedings of the National Academy of Sciences of the United States of America 2026; (123(4)):e2532212123 doi:10.1073/pnas.2532212123.

A brief review of chikungunya fever: From molecular virology to countermeasures.

Zhang X, Li X, Jiang T, Fu J

Infectious medicine 2026; (5(1)):100231 doi:10.1016/j.imj.2025.100231.

Clinical Features and Factors Associated with Disease Severity in Acute Chikungunya Fever: A Retrospective Analysis.

Lin H, Xie S, Li K, et al.

Infection and drug resistance 2026; (19()):569624 doi:10.2147/IDR.S569624.