Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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University of Michigan
Ann Arbor, United States
University of Miami
Coral Gables, United States
University of Manchester
Manchester, United Kingdom
Imperial College London
London, United Kingdom
Brigham and Women's Hospital
Boston, United States
Medical University of Vienna
Vienna, Austria
Monash University
Melbourne, Australia
IMT School for Advanced Studies Lucca
Lucca, Italy
University of Bonn
Bonn, Germany
Mayo Clinic
Rochester, United States
References
References (104)
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Donning devices (foot slips and frames) enable elderly people with severe chronic venous insufficiency to put on compression stockings.
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Use of the Clinical, Etiologic, Anatomic, and Pathophysiologic classification and Venous Clinical Severity Score to establish a treatment plan for chronic venous disorders.
Almeida JI, Wakefield T, Kabnick LS, et al.
Journal of vascular surgery. Venous and lymphatic disorders 2015; (3(4)):456-460 doi:10.1016/j.jvsv.2015.05.007.
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Journal de medecine vasculaire 2018; (43(4)):225-230 doi:10.1016/j.jdmv.2018.05.006.
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ABPI reporting and compression recommendations in global clinical practice guidelines on venous leg ulcer management: A scoping review.
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International wound journal 2019; (16(2)):406-419 doi:10.1111/iwj.13048.
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Compression therapy after invasive treatment of superficial veins of the lower extremities: Clinical practice guidelines of the American Venous Forum, Society for Vascular Surgery, American College of Phlebology, Society for Vascular Medicine, and International Union of Phlebology.
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Journal of vascular surgery. Venous and lymphatic disorders 2019; (7(1)):17-28 doi:10.1016/j.jvsv.2018.10.002.
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Early versus deferred endovenous ablation of superficial venous reflux in patients with venous ulceration: the EVRA RCT.
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A scoping review on Chronic Venous Disease and the development of a Venous Leg Ulcer: The role of obesity and mobility.
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Acute peripheral pulmonary embolism attributed to autoimmune haemolytic anaemia: a case report.
Xu J, Wang L, Chen F
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The 2020 appropriate use criteria for chronic lower extremity venous disease of the American Venous Forum, the Society for Vascular Surgery, the American Vein and Lymphatic Society, and the Society of Interventional Radiology.
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Journal of vascular surgery. Venous and lymphatic disorders 2020; (8(4)):505-525.e4 doi:10.1016/j.jvsv.2020.02.001.
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Diagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review.
Chopard R, Albertsen IE, Piazza G
JAMA 2020; (324(17)):1765-1776 doi:10.1001/jama.2020.17272.
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Strategies and challenges in the treatment of chronic venous leg ulcers.
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World journal of clinical cases 2020; (8(21)):5070-5085 doi:10.12998/wjcc.v8.i21.5070.
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Nrf2-activating Therapy Accelerates Wound Healing in a Model of Cutaneous Chronic Venous Insufficiency.
Kuhn J, Sultan DL, Waqas B, et al.
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Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment.
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Validity of Chronic Venous Disease Diagnoses and Epidemiology Using Validated Electronic Health Records From Primary Care: A Real-World Data Analysis.
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Modified compression therapy in mixed arterial-venous leg ulcers: An integrative review.
Lim SLX, Chung RE, Holloway S, Harding KG
International wound journal 2021; (18(6)):822-842 doi:10.1111/iwj.13585.
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Treatment of Nonthrombotic Iliac Vein Lesions.
Joh M, Desai KR
Seminars in interventional radiology 2021; (38(2)):155-159 doi:10.1055/s-0041-1727101.
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Physical Examination and Ultrasound Evaluation of Patients with Superficial Venous Disease.
Casadaban LC, Moriarty JM, Hoffman CH
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Patient Explanation of Adherence and Non-Adherence to Venous Leg Ulcer Treatment: A Qualitative Study.
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What's new in the 2020 update of the CEAP classification system of chronic venous disease?
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Vnitrni lekarstvi 2021; (67(3)):143-148.
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Effectiveness of therapeutic exercises for improving the quality of life of patients with chronic venous insufficiency: a systematic review.
da Silva JL, Lima AG, Diniz NR, Leite JC
Jornal vascular brasileiro 2021; (20()):e20200248 doi:10.1590/1677-5449.200248.
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Nonthermal Endovenous Procedures for Varicose Veins: A Health Technology Assessment.
Ontario health technology assessment series 2021; (21(8)):1-188.
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Compression bandages or stockings versus no compression for treating venous leg ulcers.
Shi C, Dumville JC, Cullum N, et al.
The Cochrane database of systematic reviews 2021; (7()):CD013397 doi:10.1002/14651858.CD013397.pub2.
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Chronic venous insufficiency, cardiovascular disease, and mortality: a population study.
Prochaska JH, Arnold N, Falcke A, et al.
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A systematic review supporting the Society for Vascular Surgery, the American Venous Forum, and the American Vein and Lymphatic Society guidelines on the management of varicose veins.
Farah MH, Nayfeh T, Urtecho M, et al.
Journal of vascular surgery. Venous and lymphatic disorders 2022; (10(5)):1155-1171 doi:10.1016/j.jvsv.2021.08.011.
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Initiating compression therapy for those living with heart failure.
Saucedo D, Evans N, Lim CS
British journal of community nursing 2021; (26(Sup9)):S12-S17 doi:10.12968/bjcn.2021.26.Sup9.S12.
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Cellulitis: A Review of Current Practice Guidelines and Differentiation from Pseudocellulitis.
Boettler MA, Kaffenberger BH, Chung CG
American journal of clinical dermatology 2022; (23(2)):153-165 doi:10.1007/s40257-021-00659-8.
PMID: 34902109 - 52
A prospective multicenter randomized clinical trial comparing endovenous laser ablation, using a 1470 nm diode laser in combination with a Tulip-TipTM fiber versus radiofrequency (Closure FAST™ VNUS®), in the treatment of primary varicose veins.
Kempeneers AC, Bechter-Hugl B, Thomis S, et al.
International angiology : a journal of the International Union of Angiology 2022; (41(4)):322-331 doi:10.23736/S0392-9590.22.04747-2.
PMID: 35166103 - 53
Chronic venous disease. Part 1: pathophysiology and clinical features.
Kumar P, Khan IA, Das A, Shah H
Clinical and experimental dermatology 2022; (47(7)):1228-1239 doi:10.1111/ced.15143.
PMID: 35167156 - 54
Contribution of the Elastic Component and Venous Wall Arterialization in Patients with Venous Reflux.
Ortega MA, Fraile-Martínez O, García-Montero C, et al.
Journal of personalized medicine 2022; (12(2)) doi:10.3390/jpm12020260.
PMID: 35207748 - 55
A meta-review of the impact of compression therapy on venous leg ulcer healing.
Patton D, Avsar P, Sayeh A, et al.
International wound journal 2023; (20(2)):430-447 doi:10.1111/iwj.13891.
PMID: 35855678 - 56
Clinical Perspectives and Management of Edema in Chronic Venous Disease-What about Ruscus?
Bihari I, Guex JJ, Jawien A, Szolnoky G
Medicines (Basel, Switzerland) 2022; (9(8)) doi:10.3390/medicines9080041.
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Fluid handling performance of wound dressings tested in a robotic venous leg ulcer system under compression therapy.
Orlov A, Gefen A
International wound journal 2023; (20(5)):1384-1392 doi:10.1111/iwj.13985.
PMID: 36267049 - 58
The 2022 Society for Vascular Surgery, American Venous Forum, and American Vein and Lymphatic Society clinical practice guidelines for the management of varicose veins of the lower extremities. Part I. Duplex Scanning and Treatment of Superficial Truncal Reflux: Endorsed by the Society for Vascular Medicine and the International Union of Phlebology.
Gloviczki P, Lawrence PF, Wasan SM, et al.
Journal of vascular surgery. Venous and lymphatic disorders 2023; (11(2)):231-261.e6 doi:10.1016/j.jvsv.2022.09.004.
PMID: 36326210 - 59
Ultrasound Evaluation of Chronic Venous Insufficiency.
Zalaquett E, Gunabushanam G, Vallejos A, Dahiya N
Ultrasound quarterly 2023; (39(1)):2-9 doi:10.1097/RUQ.0000000000000634.
PMID: 36651650 - 60
Venous leg ulcers and prevalence of surgically correctable reflux disease in a national registry.
Schul MW, Melin MM, Keaton TJ
Journal of vascular surgery. Venous and lymphatic disorders 2023; (11(3)):511-516 doi:10.1016/j.jvsv.2022.11.005.
PMID: 36681297 - 61
Clinical outcomes following mechanochemical ablation of superficial venous incompetence compared with endothermal ablation: meta-analysis.
Lim AJM, Mohamed AH, Hitchman LH, et al.
The British journal of surgery 2023; (110(5)):562-567 doi:10.1093/bjs/znad048.
PMID: 36894167 - 62
Consistent application of compression: An under-considered variable in the prevention of venous leg ulcers.
Shawa HJ, Dahle SE, Isseroff RR
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2023; (31(3)):393-400 doi:10.1111/wrr.13078.
PMID: 36905199 - 63
Narrative Review of the Pathogenesis of Stasis Dermatitis: An Inflammatory Skin Manifestation of Venous Hypertension.
Silverberg J, Jackson JM, Kirsner RS, et al.
Dermatology and therapy 2023; (13(4)):935-950 doi:10.1007/s13555-023-00908-0.
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Cyanoacrylate glue reactions: A systematic review, cases, and proposed mechanisms.
Athavale A, Thao M, Sassaki VS, et al.
Journal of vascular surgery. Venous and lymphatic disorders 2023; (11(4)):876-888.e1 doi:10.1016/j.jvsv.2023.03.018.
PMID: 37054883 - 65
The Effect of Standard Compression Adjuvant with a Tailored Exercise Training Program on Health-Related Quality of Life Outcomes in Treating Adults with Venous Leg Ulcer: A Randomized Controlled Trial.
Rerkasem A, Nantakool S, Kulprachakarn K, et al.
The international journal of lower extremity wounds 2026; (25(1)):65-73 doi:10.1177/15347346231172566.
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A randomised controlled trial of compression therapies for the treatment of venous leg ulcers (VenUS 6): study protocol for a pragmatic, multicentre, parallel-group, three-arm randomised controlled trial.
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Trials 2023; (24(1)):357 doi:10.1186/s13063-023-07349-2.
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An Atypical presentation of pulmonary embolism in a critically ill patient.
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Radiology case reports 2023; (18(8)):2633-2636 doi:10.1016/j.radcr.2023.05.015.
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Association between the degree of iliac venous outflow obstruction by intravascular ultrasound and lower limb venous reflux.
Metzger PB, Rossi FH, Fernandez MG, et al.
Journal of vascular surgery. Venous and lymphatic disorders 2023; (11(5)):1004-1013.e1 doi:10.1016/j.jvsv.2023.05.018.
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Long-term results and predictors of failure after mechanochemical endovenous ablation in the treatment of primary great saphenous vein incompetence.
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Phlebology 2024; (39(1)):9-19 doi:10.1177/02683555231202181.
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Stasis Dermatitis: The Burden of Disease, Diagnosis, and Treatment.
Yosipovitch G, Jackson JM, Nedorost ST, et al.
Dermatitis : contact, atopic, occupational, drug 2024; (35(4)):337-344 doi:10.1089/derm.2022.0076.
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Medical device-related pressure injury from compression therapy.
Robinson H, Atkin L, Gray S
British journal of nursing (Mark Allen Publishing) 2023; (32(Sup20)):S30-S38 doi:10.12968/bjon.2023.32.Sup20.S30.
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The relationship between the clinical severity of chronic venous insufficiency and the calf muscle pump: A cross-sectional study.
Vieira Santos E Santos L, Netto Maia J, de Vasconcelos CR, et al.
Journal of bodywork and movement therapies 2023; (36()):153-157 doi:10.1016/j.jbmt.2023.04.068.
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Brazilian guidelines on chronic venous disease of the Brazilian Society of Angiology and Vascular Surgery.
Kikuchi R, Nhuch C, Drummond DAB, et al.
Jornal vascular brasileiro 2023; (22()):e20230064 doi:10.1590/1677-5449.202300642.
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Prevalence, clinical presentation, and risk factors of chronic venous disease in Cameroon: A general population-based study.
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Phlebology 2024; (39(4)):259-266 doi:10.1177/02683555231224111.
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Diagnosis of chronic iliac venous obstruction.
Jayaraj A, Rossi FH, Lurie F, Muck P
Journal of vascular surgery. Venous and lymphatic disorders 2024; (12(4)):101744 doi:10.1016/j.jvsv.2023.101744.
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Improvement of Chronic Venous Insufficiency Related Leg Xerosis and Dermatitis With Ceramide-Containing Cleansers and Moisturizers: An Expert-Based Consensus.
Kirsner RS, Andriessen A, Hanft JR, et al.
Journal of drugs in dermatology : JDD 2024; (23(2)):61-66 doi:10.36849/JDD.7588.
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Differences in risk profile associated with varicose veins and chronic venous insufficiency - results from the Bonn Vein Study 1.
Kraus AL, Rabe E, Kowall B, et al.
VASA. Zeitschrift fur Gefasskrankheiten 2024; (53(2)):145-154 doi:10.1024/0301-1526/a001115.
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Compression for preventing recurrence of venous ulcers.
de Moraes Silva MA, Nelson A, Bell-Syer SE, et al.
The Cochrane database of systematic reviews 2024; (3()):CD002303 doi:10.1002/14651858.CD002303.pub4.
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[Varicosis-Current treatment concepts].
Lisii C, Heckenkamp J
Chirurgie (Heidelberg, Germany) 2024; (95(5)):415-426 doi:10.1007/s00104-024-02063-4.
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[Translated article] Compression Therapy in Dermatology.
Conde-Montero E, Dissemond J, Protz K
Actas dermo-sifiliograficas 2024; (115(7)):T693-T701 doi:10.1016/j.ad.2024.05.012.
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Consensus Statement on the Management of Nonthrombotic Iliac Vein Lesions From the VIVA Foundation, the American Venous Forum, and the American Vein and Lymphatic Society.
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Circulation. Cardiovascular interventions 2024; (17(8)):e014160 doi:10.1161/CIRCINTERVENTIONS.124.014160.
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Appropriateness of care in superficial venous disease.
Kiguchi MM, Cutler B
Seminars in vascular surgery 2024; (37(2)):150-155 doi:10.1053/j.semvascsurg.2024.05.005.
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The Unique Case of Acute Limb Ischemia in a Patient With a Patent Foramen Ovale.
Elzawy G, Petrasek P, Fatehi Hassanabad A
Vascular and endovascular surgery 2024; (58(8)):894-899 doi:10.1177/15385744241276615.
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Automated devices for identifying peripheral arterial disease in people with leg ulceration: an evidence synthesis and cost-effectiveness analysis.
Boyers D, Cruickshank M, Aucott L, et al.
Health technology assessment (Winchester, England) 2024; (28(37)):1-158 doi:10.3310/TWCG3912.
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1H Nuclear Magnetic Resonance Spectroscopy Reveals Changes in Metabolic Phenotype Associated with Disease Stage in Patients with Chronic Venous Disease.
Onida S, Lees HJ, Bergner R, et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2025; (69(2)):325-333 doi:10.1016/j.ejvs.2024.09.019.
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Ultrasound-guided foam sclerotherapy using physician-compounded foam: Position statement from the American vein and lymphatic society.
Cartee T, Friedmann DP, Blebea J, et al.
Phlebology 2025; (40(7)):466-472 doi:10.1177/02683555241309808.
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Glycocalyx disruption, endothelial dysfunction and vascular remodeling as underlying mechanisms and treatment targets of chronic venous disease.
Diaz JA, Gianesini S, Khalil RA
International angiology : a journal of the International Union of Angiology 2024; (43(6)):563-590 doi:10.23736/S0392-9590.24.05339-2.
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Ankle Brachial Index: Quick Reference Guide for Clinicians: WOCN Society Ankle Brachial Task Force.
Conyers Y, Lomauro C, Richmond A, et al.
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society 2025; (52(4)):271-278 doi:10.1097/WON.0000000000001188.
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Reproducibility of ultrasound and CEAP classification to describe possible chronic venous disorders in the legs.
Soeder J, Stöfken L, Mendoza E, et al.
Biomedical physics & engineering express 2025; (11(5)) doi:10.1088/2057-1976/adfde8.
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Superficial Vein Thrombosis: A Review.
Piazza G, Krishnathasan D, Hamade N, et al.
JAMA 2025; (334(22)):2020-2030 doi:10.1001/jama.2025.15222.
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Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial.
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Journal of vascular surgery. Venous and lymphatic disorders 2026; (14(1)):102355 doi:10.1016/j.jvsv.2025.102355.
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