Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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Inserm
Paris, France
Assistance Publique – Hôpitaux de Paris
Paris, France
Garvan Institute of Medical Research
Darlinghurst, Australia
University of Pisa
Pisa, Italy
Baylor College of Medicine
Houston, United States
University of California, San Francisco
San Francisco, United States
University of Florence
Florence, Italy
Mayo Clinic
Rochester, United States
Medizinische Hochschule Hannover
Hanover, Germany
Sapienza University of Rome
Rome, Italy
References
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IgG3 subclass: A possible trigger of mixed cryoglobulin cascade in hepatitis C virus chronic infection.
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Achieving Sustained Viral Remission in Patients with Chronic HCV Infection and Cryoglobulinemic Vasculitis Does Not Always Correlate with Normalization of the Serologic Markers.
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Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.
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Interactive Impacts from Hepatitis C Virus Infection and Mixed Cryoglobulinemia on Complement Levels.
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Infective Endocarditis Observed With Cryoglobulinemic Vasculitis.
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Impact of DAA-Based Regimens on HCV-Related Extra-Hepatic Damage: A Narrative Review.
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The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection.
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Direct-acting antiviral therapy improves kidney survival in hepatitis C virus-associated cryoglobulinaemia: the RENALCRYOGLOBULINEMIC study.
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Diagnosis and management of leukocytoclastic vasculitis.
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Internal and emergency medicine 2021; (16(4)):831-841 doi:10.1007/s11739-021-02688-x.
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Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis.
Gragnani L, Lorini S, Marri S, et al.
Hepatology (Baltimore, Md.) 2021; (74(3)):1164-1173 doi:10.1002/hep.31804.
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Impact of direct acting antivirals on hepatitis C virus-related cryoglobulinemic syndrome.
Zignego AL, Marri S, Gragnani L
Minerva gastroenterology 2021; (67(3)):218-226 doi:10.23736/S2724-5985.21.02848-8.
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Polyneuropathy: A Rare and Challenging Presentation of Essential Mixed Cryoglobulinemia.
Taha A, Taha M, Ahmed R, et al.
Journal of investigative medicine high impact case reports 2021; (9()):23247096211026503 doi:10.1177/23247096211026503.
PMID: 34151641 - 54
Noninfectious, Severe Cryoglobulinemic Vasculitis with Renal Involvement - Safety and Efficacy of Long-Term Treatment with Rituximab.
Leśniak K, Rymarz A, Lubas A, Niemczyk S
International journal of nephrology and renovascular disease 2021; (14()):267-277 doi:10.2147/IJNRD.S315388.
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A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia.
Khalid S, Alhankawi D, Kaur K, et al.
Case reports in hepatology 2021; (2021()):8244432 doi:10.1155/2021/8244432.
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Unusual Morphological and Automated Hematology Analyzer Features in 3 Cases of B-cell Malignancy-associated Type I Cryoglobulinemic Vasculitis.
Dave RG, Padiyar S, Mathew J, Nair SC
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 2021; (37(4)):658-663 doi:10.1007/s12288-021-01398-w.
PMID: 34744348 - 57
A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, et al.
Viruses 2021; (13(11)) doi:10.3390/v13112249.
PMID: 34835054 - 58
Letter to the editor: High rate of clinical and immunological response in patients with HCV-associated cryoglobulinemia.
Gavrisheva S, Abdurakhmanov D, Milovanova S, et al.
Hepatology (Baltimore, Md.) 2022; (76(1)):E9-E10 doi:10.1002/hep.32425.
PMID: 35258104 - 59
Evolution of Cryoglobulinemia in Direct-Acting Antiviral-Treated Asian Hepatitis C Patients With Sustained Virological Responses: A 4-Year Prospective Cohort Study.
Chang ML, Cheng JS, Chuang YH, et al.
Frontiers in immunology 2022; (13()):823160 doi:10.3389/fimmu.2022.823160.
PMID: 35371039 - 60
Systemic vasculitis: one year in review 2022.
La Rocca G, Del Frate G, Delvino P, et al.
Clinical and experimental rheumatology 2022; (40(4)):673-687 doi:10.55563/clinexprheumatol/ozhc85.
PMID: 35522544 - 61
Expert perspectives on pathological findings in vasculitis.
Ishizu A, Kawakami T, Kanno H, et al.
Modern rheumatology 2023; (33(1)):1-11 doi:10.1093/mr/roac043.
PMID: 35535676 - 62
Cryoglobulinemia and double-filtration plasmapheresis: Personal experience and literature review.
Naciri Bennani H, Banza AT, Terrec F, et al.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2023; (27(1)):159-169 doi:10.1111/1744-9987.13885.
PMID: 35583180 - 63
A Case of Hepatitis C Related Mixed Cryoglobulinemia Syndrome.
Kayode-Ajala F, Ejikeme C, Picone J, Sanyal A
Journal of community hospital internal medicine perspectives 2022; (12(2)):53-56 doi:10.55729/2000-9666.1041.
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Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients.
Roubertou Y, Mainbourg S, Hot A, et al.
Arthritis research & therapy 2022; (24(1)):167 doi:10.1186/s13075-022-02857-z.
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Plasma exchange in the intensive care unit: a narrative review.
Bauer PR, Ostermann M, Russell L, et al.
Intensive care medicine 2022; (48(10)):1382-1396 doi:10.1007/s00134-022-06793-z.
PMID: 35960275 - 66
Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC).
Quartuccio L, Bortoluzzi A, Scirè CA, et al.
Clinical rheumatology 2023; (42(2)):359-370 doi:10.1007/s10067-022-06391-w.
PMID: 36169798 - 67
Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection.
Ariza Ordoñez N, Sepúlveda VG, Marín AP, et al.
Revista do Instituto de Medicina Tropical de Sao Paulo 2022; (64()):e65 doi:10.1590/S1678-9946202264065.
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Non-hepatitis-associated mixed cryoglobulinemia with polyclonal plasma cells disease and alcoholic cirrhosis: A rare case report.
Luo J, Liu C, Lv QJ, et al.
Frontiers in medicine 2023; (10()):1014261 doi:10.3389/fmed.2023.1014261.
PMID: 36760401 - 69
Leukocytoclastic vasculitis with features of flagellate purpura: a comparison with flagellate erythema.
Ji-Xu A, Mansatta K, Bali R, Moezinia CJ
Dermatology online journal 2022; (28(5)) doi:10.5070/D328559246.
PMID: 36809135 - 70
A Case of Overlap Syndrome of Systemic Sclerosis and Cryoglobulinemic Vasculitis With Central Nervous System Involvement.
Jung Y, Lee EE, Yeo J, et al.
Journal of rheumatic diseases 2021; (28(4)):242-246 doi:10.4078/jrd.2021.28.4.242.
PMID: 37476365 - 71
Recent updates in the diagnosis and management of cryoglobulinemic vasculitis.
Treppo E, Quartuccio L, De Vita S
Expert review of clinical immunology 2023; (19(12)):1457-1467 doi:10.1080/1744666X.2023.2249609.
PMID: 37698547 - 72
Rare manifestations of cryoglobulinemic vasculitis: a case report.
Leleux C, Zerbib Y, Pommerolle P, et al.
Frontiers in immunology 2023; (14()):1271584 doi:10.3389/fimmu.2023.1271584.
PMID: 37901234 - 73
Therapeutic Potential of Rituximab in Managing Hepatitis C-Associated Cryoglobulinemic Vasculitis: A Systematic Review.
Covic A, Caruntu ID, Burlacu A, et al.
Journal of clinical medicine 2023; (12(21)) doi:10.3390/jcm12216806.
PMID: 37959271 - 74
A Case of IgG1-Lambda Multiple Myeloma With Hyperviscosity Syndrome and Cryoglobulinemia: Identification of the Subclass Fraction by Immunoelectrophoresis and Immunofixation Electrophoresis.
Tazoe K, Harada N, Takemura K, et al.
Cureus 2023; (15(11)):e48253 doi:10.7759/cureus.48253.
PMID: 38054160 - 75
Waldenström's Macroglobulinemia and Cryoglobulinemic Glomerulonephritis: An Unusual Case of Monoclonal Gammopathy of Renal Significance.
De La Flor JC, Sulca JM, Rodríguez P, et al.
Medical sciences (Basel, Switzerland) 2023; (11(4)) doi:10.3390/medsci11040077.
PMID: 38132918 - 76
Cryocrystalglobulinemia Leading to Multi-Organ Failure in Chronic Lymphocytic Leukemia Achieving Complete Renal Recovery.
Dunton A, Jain S
Journal of hematology 2023; (12(6)):287-293 doi:10.14740/jh1212.
PMID: 38188472 - 77
Monoclonal gammopathy of renal significance: An atypical presentation of Waldenström's disease.
Rodríguez-Doyágüez P, Motornaya-Morozova , Martínez-Miguel P, et al.
Clinical nephrology. Case studies 2024; (12()):17-21 doi:10.5414/CNCS111200.
PMID: 38352852 - 78
Clinical characteristics, radiological features and outcomes in pulmonary involvement of cryoglobulinemia.
Han HX, Su W, Tian X, et al.
Orphanet journal of rare diseases 2024; (19(1)):185 doi:10.1186/s13023-024-03159-0.
PMID: 38698461 - 79
Cryoglobulinemic vasculitis triggered by Staphylococcus aureus endocarditis with chronic hepatitis C virus co-infection: a case report and literature review.
Reinberg C, Vingerhoets S, Pavlova O, et al.
Frontiers in immunology 2024; (15()):1385086 doi:10.3389/fimmu.2024.1385086.
PMID: 39076993 - 80
Mesenteric ischemia: Recognizing an uncommon disorder and distinguishing among its causes.
Wu T, Nanjundappa A
Cleveland Clinic journal of medicine 2024; (91(9)):545-550 doi:10.3949/ccjm.91a.23094.
PMID: 39227083 - 81
A Rare Presentation of Cryoglobulinemic Vasculitis Associated with Primary Sjögren's Syndrome.
Metyas C, Lee JD, Jun JA, Arkfeld DG
Current rheumatology reviews 2025; (21(4)):480-486 doi:10.2174/0115733971311273240824183333.
PMID: 39313873 - 82
Idiopathic Mixed Cryoglobulinemia: A Diagnostic Challenge.
Rathi H, Patra T, Poojary I, et al.
Cureus 2024; (16(9)):e70069 doi:10.7759/cureus.70069.
PMID: 39449949 - 83
Clinical and Serological Profiles in Cryoglobulinemia: Analysis of Isotypes and Etiologies.
Codes-Méndez H, Jeria S, Park HS, et al.
Journal of clinical medicine 2024; (13(20)) doi:10.3390/jcm13206069.
PMID: 39458019 - 84
Intracapillary monoclonal IgM deposits disease with massive pseudothrombi: A clinicopathologic study of 4 cases and literature review.
Ma L, Liang D, Yao X, et al.
American journal of clinical pathology 2025; (163(2)):187-195 doi:10.1093/ajcp/aqae109.
PMID: 39487722 - 85
Non-infectious mixed cryoglobulinemia as a new clinical presentation of mutation in the gene encoding coatomer subunit alpha: a case report of two adult sisters.
Leśniak K, Płoski R, Rydzanicz M, et al.
Frontiers in immunology 2024; (15()):1450048 doi:10.3389/fimmu.2024.1450048.
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Myopericarditis in a Patient With Cryoglobulinemic Kidney Disease: A Case Report.
Touiti S, Serroukh S, Benyass A, Bouattar T
Cureus 2024; (16(12)):e75550 doi:10.7759/cureus.75550.
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Secondary cryofibrinogenemia is related to more severe microangiopathic involvement in systemic sclerosis: results from a retrospective observational study.
Sandri G, Amati G, Spinella A, et al.
Clinical rheumatology 2025; (44(3)):1173-1185 doi:10.1007/s10067-025-07324-z.
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A Rare Gastrointestinal Manifestation of Cryoglobulinemic Vasculitis: A Case Report.
Gavric L, Tahir MT, Abraham SM
Cureus 2025; (17(3)):e81418 doi:10.7759/cureus.81418.
PMID: 40296981 - 89
Bowel Ischemia From Suspected Non-occlusive Mesenteric Ischemia: A Case Report.
Rehman MA, Abdulrahman R, Awad B, et al.
Cureus 2025; (17(4)):e83175 doi:10.7759/cureus.83175.
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Successful treatment of smoldering multiple myeloma-associated type I cryoglobulinemia with bortezomib and autologous peripheral blood stem cell transplantation.
Hirano D, Iida H, Iwakoshi A, et al.
Journal of clinical and experimental hematopathology : JCEH 2025; (65(2)):121-128 doi:10.3960/jslrt.25001.
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