Research & Literature

Diagnostic and Treatment Approaches for Refractory Peptic Ulcers.

Kim HU

Clinical endoscopy 2015; (48(4)):285-90 doi:10.5946/ce.2015.48.4.285.

Gastric Hypersecretory States: Investigation and Management.

Phan J, Benhammou JN, Pisegna JR

Current treatment options in gastroenterology 2015; (13(4)):386-97 doi:10.1007/s11938-015-0065-8.

Upper non-variceal gastrointestinal bleeding - review the effectiveness of endoscopic hemostasis methods.

Szura M, Pasternak A

World journal of gastrointestinal endoscopy 2015; (7(13)):1088-95 doi:10.4253/wjge.v7.i13.1088.

Impact of Delay in Diagnosis in Outcomes in MEN1: Results From the Dutch MEN1 Study Group.

van Leeuwaarde RS, van Nesselrooij BP, Hermus AR, et al.

The Journal of clinical endocrinology and metabolism 2016; (101(3)):1159-65 doi:10.1210/jc.2015-3766.

Recent Updates on Neuroendocrine Tumors From the Gastrointestinal and Pancreatobiliary Tracts.

Kim JY, Hong SM

Archives of pathology & laboratory medicine 2016; (140(5)):437-48 doi:10.5858/arpa.2015-0314-RA.

Assessing for Multiple Endocrine Neoplasia Type 1 in Patients Evaluated for Zollinger-Ellison Syndrome-Clues to a Safer Diagnostic Process.

Singh Ospina N, Donegan D, Rodriguez-Gutierrez R, et al.

The American journal of medicine 2017; (130(5)):603-605 doi:10.1016/j.amjmed.2016.11.035.

Zollinger-Ellison Syndrome: A Rare Case of Chronic Diarrhea.

Aamar A, Madhani K, Virk H, Butt Z

Gastroenterology research 2016; (9(6)):103-104 doi:10.14740/gr734w.

Multiple endocrine neoplasia syndrome type 1: institution, management, and data analysis of a nationwide multicenter patient database.

Giusti F, Cianferotti L, Boaretto F, et al.

Endocrine 2017; (58(2)):349-359 doi:10.1007/s12020-017-1234-4.

Perforated peptic ulcer - an update.

Chung KT, Shelat VG

World journal of gastrointestinal surgery 2017; (9(1)):1-12 doi:10.4240/wjgs.v9.i1.1.

Genetics of multiple endocrine neoplasia type 1 syndrome: what's new and what's old.

Falchetti A

F1000Research 2017; (6()) doi:10.12688/f1000research.7230.1.

A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.

Matsubayashi H, Kawata N, Kakushima N, et al.

BMC gastroenterology 2017; (17(1)):37 doi:10.1186/s12876-017-0597-6.

A Perplexing Case of Abdominal Pain That Led to the Diagnosis of Zollinger-Ellison Syndrome.

Lenhart A, Hassan M, Meighani A, et al.

Case reports in gastrointestinal medicine 2017; (2017()):7636952 doi:10.1155/2017/7636952.

The future: genetics advances in MEN1 therapeutic approaches and management strategies.

Agarwal SK

Endocrine-related cancer 2017; (24(10)):T119-T134 doi:10.1530/ERC-17-0199.

The Zollinger-Ellison syndrome: is there a role for somatostatin analogues in the treatment of the gastrinoma?

Guarnotta V, Martini C, Davì MV, et al.

Endocrine 2018; (60(1)):15-27 doi:10.1007/s12020-017-1420-4.

Optimizing Somatostatin Receptor Imaging in Patients With Neuroendocrine Tumors: The Impact of 99mTc-HYNICTOC SPECT/SPECT/CT Versus 68Ga-DOTATATE PET/CT Upon Clinical Management.

Kunikowska J, Lewington V, Krolicki L

Clinical nuclear medicine 2017; (42(12)):905-911 doi:10.1097/RLU.0000000000001877.

Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.

Metz DC, Cadiot G, Poitras P, et al.

International journal of endocrine oncology 2017; (4(4)):167-185 doi:10.2217/ije-2017-0018.

Proton Pump Inhibitors: Review of Emerging Concerns.

Nehra AK, Alexander JA, Loftus CG, Nehra V

Mayo Clinic proceedings 2018; (93(2)):240-246 doi:10.1016/j.mayocp.2017.10.022.

Old and New Gut Hormone, Gastrin and Acid Suppressive Therapy.

Haruma K, Kamada T, Manabe N, et al.

Digestion 2018; (97(4)):340-344 doi:10.1159/000485734.

Lu-177-Based Peptide Receptor Radionuclide Therapy for Advanced Neuroendocrine Tumors.

Kim K, Kim SJ

Nuclear medicine and molecular imaging 2018; (52(3)):208-215 doi:10.1007/s13139-017-0505-6.

Heterogeneity of Duodenal Neuroendocrine Tumors: An Italian Multi-center Experience.

Massironi S, Campana D, Partelli S, et al.

Annals of surgical oncology 2018; (25(11)):3200-3206 doi:10.1245/s10434-018-6673-5.

Diagnosing Nonfunctional Pancreatic NETs in MEN1: The Evidence Base.

van Treijen MJC, van Beek DJ, van Leeuwaarde RS, et al.

Journal of the Endocrine Society 2018; (2(9)):1067-1088 doi:10.1210/js.2018-00087.

Multiple Endocrine Neoplasia Type 1: A Case Report With Review of Imaging Findings.

Keller HR, Record JL, Lall NU

Ochsner journal 2018; (18(2)):170-175 doi:10.31486/toj.17.0019.

Intraoperative Decision-Making and Technical Aspects of Parathyroidectomy in Young Patients With MEN1 Related Hyperparathyroidism.

Nobecourt PF, Zagzag J, Asare EA, Perrier ND

Frontiers in endocrinology 2018; (9()):618 doi:10.3389/fendo.2018.00618.

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Poly TN, Islam MM, Yang HC, et al.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2019; (30(1)):103-114 doi:10.1007/s00198-018-4788-y.

Symptomatic and Radiological Response to 177Lu-DOTATATE for the Treatment of Functioning Pancreatic Neuroendocrine Tumors.

Zandee WT, Brabander T, Blažević A, et al.

The Journal of clinical endocrinology and metabolism 2019; (104(4)):1336-1344 doi:10.1210/jc.2018-01991.

Zollinger Ellison Syndrome in a Patient with Multiple Endocrine Neoplasia Type 1: A Classic Presentation.

Shah I, Vyas N, Kadkhodayan KS

Case reports in gastrointestinal medicine 2019; (2019()):9605769 doi:10.1155/2019/9605769.

Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1.

Albers MB, Manoharan J, Bartsch DK

Best practice & research. Clinical endocrinology & metabolism 2019; (33(5)):101318 doi:10.1016/j.beem.2019.101318.

Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies.

Shao QQ, Zhao BB, Dong LB, et al.

World journal of gastroenterology 2019; (25(32)):4673-4681 doi:10.3748/wjg.v25.i32.4673.

Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.

Lee L, Ramos-Alvarez I, Ito T, Jensen RT

International journal of molecular sciences 2019; (20(20)) doi:10.3390/ijms20205128.

[Multiple endocrine neoplasia type 1: about a case].

Anguezomo G, El Mghari G, El Ansari N

The Pan African medical journal 2019; (33()):238 doi:10.11604/pamj.2019.33.238.18053.

Nuclear Imaging of Neuroendocrine Tumors.

Pollard J, McNeely P, Menda Y

Surgical oncology clinics of North America 2020; (29(2)):209-221 doi:10.1016/j.soc.2019.11.007.

De novo Gastrinoma: A Case Report.

Barbosa A, Gomes F, Fonseca L, et al.

GE Portuguese journal of gastroenterology 2020; (27(3)):192-196 doi:10.1159/000503073.

Delayed Management of Zollinger-Ellison Syndrome in a Noncompliant Patient.

Klimko A, Plotogea O, Constantinescu A, Constantinescu G

Cureus 2020; (12(6)):e8471 doi:10.7759/cureus.8471.

Gastrointestinal neuroendocrine tumors in 2020.

Ahmed M

World journal of gastrointestinal oncology 2020; (12(8)):791-807 doi:10.4251/wjgo.v12.i8.791.

Total gastrectomy for severe proton pump inhibitor-induced hypomagnesemia in a MEN1/Zollinger Ellison syndrome patient.

Perrier M, Delemer B, Deguelte S, et al.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021; (21(1)):236-239 doi:10.1016/j.pan.2020.12.002.

A subcentimeter duodenal neuroendocrine neoplasm with a liver metastasis upgraded to G3: a case report.

Kitada T, Masui T, Kasai Y, et al.

Surgical case reports 2021; (7(1)):72 doi:10.1186/s40792-021-01155-1.

Hypertrophic Gastric folds with Hypomagnesemia, linking the dots.

Zafar M, Muhammad T, Saher NU, Toqeer M

Pakistan journal of medical sciences 2021; (37(4)):1237-1240 doi:10.12669/pjms.37.4.3984.

Benign Oesophageal Stricture and Chronic Diarrhoea As Atypical Presenting Symptoms of an Advanced Metastatic Pancreatic Gastrinoma: A Case Report and Review of Literature.

Kamarul Bahrin MH, Hagag R, Ali A, et al.

Cureus 2021; (13(7)):e16593 doi:10.7759/cureus.16593.

Validity of Secretin Stimulation Testing on Proton Pump Inhibitor Therapy for Diagnosis of Zollinger-Ellison Syndrome.

Bhattacharya S, Blau JE, Cochran C, et al.

The American journal of gastroenterology 2021; (116(11)):2216-2221 doi:10.14309/ajg.0000000000001487.

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, et al.

World journal of gastroenterology 2021; (27(35)):5890-5907 doi:10.3748/wjg.v27.i35.5890.

Secretin Stimulation Test and Early Diagnosis of Gastrinoma in MEN1 Syndrome: Survey on the MEN1 Florentine Database.

Giusti F, Cioppi F, Fossi C, et al.

The Journal of clinical endocrinology and metabolism 2022; (107(5)):e2110-e2123 doi:10.1210/clinem/dgab903.

The Importance of Periodical Screening for Primary Hyperparathyroidism in a Pituitary Tumor Cohort in Searching Patients With MEN1 and Its Genetic Profile.

Damianse SSP, Nascimento GC, Rocha VCC, et al.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2022; (28(5)):509-514 doi:10.1016/j.eprac.2022.02.010.

Update on the clinical management of multiple endocrine neoplasia type 1.

Pieterman CRC, Valk GD

Clinical endocrinology 2022; (97(4)):409-423 doi:10.1111/cen.14727.

Pancreaticoduodenectomy Is the Best Surgical Procedure for Zollinger-Ellison Syndrome Associated with Multiple Endocrine Neoplasia Type 1.

Kong W, Albers MB, Manoharan J, et al.

Cancers 2022; (14(8)) doi:10.3390/cancers14081928.

Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review.

Teresa Selvin S, Thomas S, Bikeyeva V, et al.

Cureus 2022; (14(7)):e27188 doi:10.7759/cureus.27188.

Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice.

van Beek DJ, Pieterman CRC, Wessels FJ, et al.

Frontiers in endocrinology 2022; (13()):926491 doi:10.3389/fendo.2022.926491.

Sporadic and MEN1-related gastrinoma and Zollinger-Ellison syndrome: differences in clinical characteristics and survival outcomes.

Massironi S, Rossi RE, Laffusa A, et al.

Journal of endocrinological investigation 2023; (46(5)):957-965 doi:10.1007/s40618-022-01961-w.

How to treat gastrinomas in patients with multiple endocrine neoplasia type1: surgery or long-term proton pump inhibitors?

Imamura M, Komoto I, Taki Y

Surgery today 2023; (53(12)):1325-1334 doi:10.1007/s00595-022-02627-z.

Recurrence after surgical resection of nonmetastatic sporadic gastrinoma: Which prognostic factors and surgical procedure?

Robin L, Sauvanet A, Walter T, et al.

Surgery 2023; (173(5)):1144-1152 doi:10.1016/j.surg.2022.12.030.

Successful Lifetime/Long-Term Medical Treatment of Acid Hypersecretion in Zollinger-Ellison Syndrome (ZES): Myth or Fact? Insights from an Analysis of Results of NIH Long-Term Prospective Studies of ZES.

Ito T, Ramos-Alvarez I, Jensen RT

Cancers 2023; (15(5)) doi:10.3390/cancers15051377.

All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update.

Chatzipanagiotou O, Schizas D, Vailas M, et al.

Journal of neuroendocrinology 2023; (35(4)):e13267 doi:10.1111/jne.13267.

Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors.

Maideen NMP

Chonnam medical journal 2023; (59(2)):115-127 doi:10.4068/cmj.2023.59.2.115.

Imaging surveillance in multiple endocrine neoplasia type 1: Ten years of experience with somatostatin receptor positron emission tomography.

Said M, Krogh J, Feldt-Rasmussen U, et al.

Journal of neuroendocrinology 2023; (35(8)):e13322 doi:10.1111/jne.13322.

A Rare Case of Hepatic Gastrinoma.

Zaher EA, Eshan SH, Patel P, et al.

Cureus 2023; (15(8)):e43383 doi:10.7759/cureus.43383.

Sporadic Zollinger-Ellison syndrome in a patient with isolated mesenteric gastrinoma.

Efared B, Tassiou EIM, Bako ABA, et al.

International journal of surgery case reports 2024; (116()):109474 doi:10.1016/j.ijscr.2024.109474.

Digital image analysis of Ki67 hotspot detection and index counting in gastroenteropancreatic neuroendocrine neoplasms.

Saetiew K, Angkathunyakul N, Hunnangkul S, Pongpaibul A

Annals of diagnostic pathology 2024; (71()):152295 doi:10.1016/j.anndiagpath.2024.152295.

Severe Hypomagnesemia Caused by Proton-Pump Inhibitors in a Patient With an Ostomy.

Ali K, Ali AA, Jaikaransingh V

Cureus 2024; (16(3)):e55856 doi:10.7759/cureus.55856.

Long-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B12 Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.

Ito T, Ramos-Alvarez I, Jensen RT

International journal of molecular sciences 2024; (25(13)) doi:10.3390/ijms25137286.

Screening and surveillance practices for Multiple Endocrine Neoplasia type 1-related Neuroendocrine Tumours in European Neuroendocrine Tumor Society Centers of Excellence (ENETS CoE)-An ENETS MEN1 task force questionnaire study.

Pieterman CRC, Grozinsky-Glasberg S, O'Toole D, et al.

Journal of neuroendocrinology 2025; (37(1)):e13468 doi:10.1111/jne.13468.

American Association of Clinical Endocrinology Consensus Statement on Management of Multiple Endocrine Neoplasia Type 1.

Del Rivero J, Gangi A, Annes JP, et al.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2025; doi:10.1016/j.eprac.2025.02.001.

Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline.

Perez K, Del Rivero J, Kennedy EB, et al.

JCO oncology practice 2025; OP2500133 doi:10.1200/OP-25-00133.

Case Report: PRRT in a patient with Zollinger-Ellison syndrome. The management of gastrointestinal complications.

Di Franco M, Durmo R, Di Paolo ML, et al.

Frontiers in oncology 2025; (15()):1590478 doi:10.3389/fonc.2025.1590478.

Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice.

Brandi ML, Pieterman CRC, English KA, et al.

The lancet. Diabetes & endocrinology 2025; (13(8)):699-721 doi:10.1016/S2213-8587(25)00119-6.

Gastrointestinal surveillance in patients with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome.

Schueler SA, Sharma SLT, Kamal N, et al.

Scandinavian journal of gastroenterology 2025; (60(10)):966-971 doi:10.1080/00365521.2025.2541209.

Efficacy and Safety of Non-Surgical Treatments for Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis.

AlQahtani MS, Miutescu B, Domilescu I, et al.

Pharmaceuticals (Basel, Switzerland) 2025; (18(11)) doi:10.3390/ph18111650.

Clinicopathological characteristics and prognosis analysis of gastrinoma based on the SEER database.

Qiu C, Hu C, Lu C, et al.

PloS one 2025; (20(12)):e0337940 doi:10.1371/journal.pone.0337940.

Severe Recurrent Gastrointestinal Bleeding and Diagnostic Dilemmas in Zollinger-Ellison Syndrome: A Case Report.

Bragança S, Figueiredo LM, Oliveira AM, et al.

GE Portuguese journal of gastroenterology 2025; doi:10.1159/000550071.

Primary hepatic gastrinoma as a clinical mimic: Favorable clinical outcomes.

Sanchis-Pascual D, de Miguel-Rodríguez L, Morillas-Amat P, et al.

Endocrinologia, diabetes y nutricion 2026; (73(6)):501769 doi:10.1016/j.endien.2026.501769.

The Use of Adjunct Therapies with Surgery for Gastroenteropancreatic Neuroendocrine Tumors: Indications, Timing, and Outcomes.

Cavallo K, Nilubol N

Biomedicines 2026; (14(9)) doi:10.3390/biomedicines14092105.