Research & Literature

Outcome of surgical treatment of primary aldosteronism.

Citton M, Viel G, Rossi GP, et al.

Langenbeck's archives of surgery 2015; (400(3)):325-31 doi:10.1007/s00423-014-1269-4.

Outcomes of drug-based and surgical treatments for primary aldosteronism.

Steichen O, Lorthioir A, Zinzindohoue F, et al.

Advances in chronic kidney disease 2015; (22(3)):196-203.

[Hypertensive urgency and emergency].

Henny-Fullin K, Buess D, Handschin A, et al.

Therapeutische Umschau. Revue therapeutique 2015; (72(6)):405-11 doi:10.1024/0040-5930/a000693.

Intra-adrenal Aldosterone Secretion: Segmental Adrenal Venous Sampling for Localization.

Satani N, Ota H, Seiji K, et al.

Radiology 2016; (278(1)):265-74 doi:10.1148/radiol.2015142159.

Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands.

Nishimoto K, Tomlins SA, Kuick R, et al.

Proceedings of the National Academy of Sciences of the United States of America 2015; (112(33)):E4591-9 doi:10.1073/pnas.1505529112.

[Hypertensive emergencies and urgencies].

Phan DG, Dreyfuss-Tubiana C, Blacher J

Presse medicale (Paris, France : 1983) 2015; (44(7-8)):737-44.

Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype.

Scholl UI, Healy JM, Thiel A, et al.

Clinical endocrinology 2015; (83(6)):779-89 doi:10.1111/cen.12873.

Potassium Disorders: Hypokalemia and Hyperkalemia.

Viera AJ, Wouk N

American family physician 2015; (92(6)):487-95.

The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline.

Funder JW, Carey RM, Mantero F, et al.

The Journal of clinical endocrinology and metabolism 2016; (101(5)):1889-916 doi:10.1210/jc.2015-4061.

Immunohistochemistry of the adrenal in primary aldosteronism.

Gomez-Sanchez CE, Gomez-Sanchez EP

Current opinion in endocrinology, diabetes, and obesity 2016; (23(3)):242-8 doi:10.1097/MED.0000000000000248.

SFE/SFHTA/AFCE consensus on primary aldosteronism, part 7: Medical treatment of primary aldosteronism.

Pechère-Bertschi A, Herpin D, Lefebvre H

Annales d'endocrinologie 2016; (77(3)):226-34.

Role of ACTH and Other Hormones in the Regulation of Aldosterone Production in Primary Aldosteronism.

El Ghorayeb N, Bourdeau I, Lacroix A

Frontiers in endocrinology 2016; (7()):72 doi:10.3389/fendo.2016.00072.

Lower Extremity Paralysis.

Glancy DL, Subramaniam PN, Rodriguez JF

The American journal of cardiology 2016; (118(10)):1609-1610 doi:10.1016/j.amjcard.2016.08.030.

Effects of Treating Primary Aldosteronism on Renal Function.

Kramers BJ, Kramers C, Lenders JW, Deinum J

Journal of clinical hypertension (Greenwich, Conn.) 2017; (19(3)):290-295 doi:10.1111/jch.12914.

Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance.

Nakamura Y, Yamazaki Y, Tezuka Y, et al.

The Tohoku journal of experimental medicine 2016; (240(3)):183-190 doi:10.1620/tjem.240.183.

Hypertensive crisis: an update on clinical approach and management.

Ipek E, Oktay AA, Krim SR

Current opinion in cardiology 2017; (32(4)):397-406 doi:10.1097/HCO.0000000000000398.

Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort.

Williams TA, Lenders JWM, Mulatero P, et al.

The lancet. Diabetes & endocrinology 2017; (5(9)):689-699 doi:10.1016/S2213-8587(17)30135-3.

A Prospective, Observational Study to Determine the Prevalence and Clinical Profile of Patients of Hypertensive Crisis in a Tertiary Care Hospital.

Salagre SB, Itolikar SM, Gedam K

The Journal of the Association of Physicians of India 2017; (65(6)):14-21.

Electrolytes: Potassium Disorders.

Elliott TL, Braun M

FP essentials 2017; (459()):21-28.

Contralateral suppression of aldosterone at adrenal venous sampling predicts hyperkalemia following adrenalectomy for primary aldosteronism.

Shariq OA, Bancos I, Cronin PA, et al.

Surgery 2018; (163(1)):183-190 doi:10.1016/j.surg.2017.07.034.

Confirmatory Tests for the Diagnosis of Primary Aldosteronism: A Prospective Diagnostic Accuracy Study.

Song Y, Yang S, He W, et al.

Hypertension (Dallas, Tex. : 1979) 2018; (71(1)):118-124 doi:10.1161/HYPERTENSIONAHA.117.10197.

Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.

Heinze B, Fuss CT, Mulatero P, et al.

Hypertension (Dallas, Tex. : 1979) 2018; (71(2)):317-325 doi:10.1161/HYPERTENSIONAHA.117.09975.

Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans.

Nanba K, Omata K, Else T, et al.

The Journal of clinical endocrinology and metabolism 2018; (103(10)):3869-3876 doi:10.1210/jc.2018-01004.

The Expanding Spectrum of Primary Aldosteronism: Implications for Diagnosis, Pathogenesis, and Treatment.

Vaidya A, Mulatero P, Baudrand R, Adler GK

Endocrine reviews 2018; (39(6)):1057-1088 doi:10.1210/er.2018-00139.

Aldosterone level after saline infusion test could predict clinical outcome in primary aldosteronism after adrenalectomy.

Chan CK, Kim JH, Chueh E, et al.

Surgery 2019; (166(3)):362-368 doi:10.1016/j.surg.2019.05.001.

Hypertensive Emergencies: A Review of Common Presentations and Treatment Options.

Brathwaite L, Reif M

Cardiology clinics 2019; (37(3)):275-286 doi:10.1016/j.ccl.2019.04.003.

H-score of 11β-hydroxylase and aldosterone synthase in the histopathological diagnosis of adrenocortical tumors.

Yang Y, Xiao M, Song Y, et al.

Endocrine 2019; (65(3)):683-691 doi:10.1007/s12020-019-02022-8.

Renal damage in primary aldosteronism: a systematic review and meta-analysis.

Monticone S, Sconfienza E, D'Ascenzo F, et al.

Journal of hypertension 2020; (38(1)):3-12 doi:10.1097/HJH.0000000000002216.

Genetic causes of primary aldosteronism.

Seidel E, Schewe J, Scholl UI

Experimental & molecular medicine 2019; (51(11)):1-12 doi:10.1038/s12276-019-0337-9.

Hypokalemia and the Prevalence of Primary Aldosteronism.

Gruber S, Beuschlein F

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2020; (52(6)):347-356 doi:10.1055/a-1134-4980.

Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism.

Gomez-Sanchez CE, Gomez-Sanchez EP, Nishimoto K

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2020; (52(6)):421-426 doi:10.1055/a-1139-2079.

Hypertensive emergencies and urgencies in emergency departments: a systematic review and meta-analysis.

Astarita A, Covella M, Vallelonga F, et al.

Journal of hypertension 2020; (38(7)):1203-1210 doi:10.1097/HJH.0000000000002372.

Hypokalemia Leading to Postoperative Critical Arrhythmias: Case Reports and Literature Review.

Muhammad Ali S, Shaikh N, Shahid F, et al.

Cureus 2020; (12(5)):e8149 doi:10.7759/cureus.8149.

Pathogenesis and treatment of primary aldosteronism.

Zennaro MC, Boulkroun S, Fernandes-Rosa FL

Nature reviews. Endocrinology 2020; (16(10)):578-589 doi:10.1038/s41574-020-0382-4.

Prevalence of Somatic Mutations in Aldosterone-Producing Adenomas in Japanese Patients.

Nanba K, Yamazaki Y, Bick N, et al.

The Journal of clinical endocrinology and metabolism 2020; (105(11)) doi:10.1210/clinem/dgaa595.

Taiwan mini-frontier of primary aldosteronism: Updating detection and diagnosis.

Chang CC, Chen YY, Lai TS, et al.

Journal of the Formosan Medical Association = Taiwan yi zhi 2021; (120(1 Pt 1)):121-129 doi:10.1016/j.jfma.2020.08.001.

11C-metomidate PET in the diagnosis of adrenal masses and primary aldosteronism: a review of the literature.

Chen Cardenas SM, Santhanam P

Endocrine 2020; (70(3)):479-487 doi:10.1007/s12020-020-02474-3.

Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting.

Giordano TJ, Berney D, de Krijger RR, et al.

Human pathology 2021; (110()):50-61 doi:10.1016/j.humpath.2020.10.001.

A case of Williams syndrome with suspected coexisting ectopic aldosterone-producing tumor in the liver.

Baba S, Miyoshi A, Obara S, et al.

Endocrinology, diabetes & metabolism case reports 2020; (2020()).

What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics.

Juhlin CC, Bertherat J, Giordano TJ, et al.

Endocrine pathology 2021; (32(1)):102-133 doi:10.1007/s12022-021-09667-0.

"Double-Down" Adrenal Vein Sampling Results in Patients with Apparent Bilateral Aldosterone Suppression: Utility of Repeat Sampling including Super-Selective Sampling.

DePietro DM, Fraker DL, Wachtel H, et al.

Journal of vascular and interventional radiology : JVIR 2021; (32(5)):656-665 doi:10.1016/j.jvir.2020.12.029.

[Primary aldosteronism: from diagnosis to therapy in clinical practice].

Vetri M, Cassaniti L, Francese GM, Gulizia MM

Giornale italiano di cardiologia (2006) 2021; (22(4)):319-326 doi:10.1714/3574.35578.

Taiwan mini-frontier of primary aldosteronism: Updating treatment and comorbidities detection.

Chan CK, Chang YY, Tsai YC, et al.

Journal of the Formosan Medical Association = Taiwan yi zhi 2021; (120(10)):1811-1820 doi:10.1016/j.jfma.2021.03.032.

Update on Genetics of Primary Aldosteronism.

Itcho K, Oki K, Ohno H, Yoneda M

Biomedicines 2021; (9(4)) doi:10.3390/biomedicines9040409.

Hemodynamic and Non-Hemodynamic Components of Cardiac Remodeling in Primary Aldosteronism.

Pan CT, Wu XM, Tsai CH, et al.

Frontiers in endocrinology 2021; (12()):646097 doi:10.3389/fendo.2021.646097.

Approaches to Gene Mutation Analysis Using Formalin-Fixed Paraffin-Embedded Adrenal Tumor Tissue From Patients With Primary Aldosteronism.

Nanba K, Rainey WE, Udager AM

Frontiers in endocrinology 2021; (12()):683588 doi:10.3389/fendo.2021.683588.

Surgical Outcomes of Aldosterone-Producing Adenoma on the Basis of the Histopathological Findings.

Wang H, Wang F, Zhang Y, et al.

Frontiers in endocrinology 2021; (12()):663096 doi:10.3389/fendo.2021.663096.

Progress on Genetic Basis of Primary Aldosteronism.

Karwacka I, Obołończyk Ł, Kaniuka-Jakubowska S, et al.

Biomedicines 2021; (9(11)) doi:10.3390/biomedicines9111708.

Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism.

Parksook WW, Yozamp N, Hundemer GL, et al.

American journal of hypertension 2022; (35(6)):561-571 doi:10.1093/ajh/hpab189.

False-negative aldosterone-to-renin ratio in a primary aldosteronism patient complicated with primary polydipsia: case report.

Zheng C, Zhao L, Zheng C, et al.

Gland surgery 2022; (11(1)):279-284 doi:10.21037/gs-21-607.

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.

Mete O, Erickson LA, Juhlin CC, et al.

Endocrine pathology 2022; (33(1)):155-196 doi:10.1007/s12022-022-09710-8.

Hypokalemia-Induced Arrhythmia: A Case Series and Literature Review.

Thu Kyaw M, Maung ZM

Cureus 2022; (14(3)):e22940 doi:10.7759/cureus.22940.

Severe hypokalemia in the emergency department: A retrospective, single-center study.

Makinouchi R, Machida S, Matsui K, et al.

Health science reports 2022; (5(3)):e594 doi:10.1002/hsr2.594.

Predictive factors of clinical success after adrenalectomy in primary aldosteronism: A systematic review and meta-analysis.

Manosroi W, Atthakomol P, Phinyo P, Inthaphan P

Frontiers in endocrinology 2022; (13()):925591 doi:10.3389/fendo.2022.925591.

Case report: Area of focus in a case of malignant hypertension.

Bosisio FG, Mingardi D, Moretti E, et al.

Frontiers in cardiovascular medicine 2022; (9()):1108666 doi:10.3389/fcvm.2022.1108666.

International multicenter survey on screening and confirmatory testing in primary aldosteronism.

Naruse M, Murakami M, Katabami T, et al.

European journal of endocrinology 2023; (188(1)) doi:10.1093/ejendo/lvac002.

Duplicated adrenal veins in primary aldosteronism misdiagnosed with ectopic aldosteronoma due to apparent bilateral aldosterone suppression.

Yu J, Fan C, Wei W, et al.

Blood pressure 2023; (32(1)):2209664 doi:10.1080/08037051.2023.2209664.

Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism.

Rege J, Bandulik S, Nanba K, et al.

Nature genetics 2023; (55(10)):1623-1631 doi:10.1038/s41588-023-01498-5.

Cannabis Use: An Uncommon Cause of Hypokalemia-Induced Acute Paralysis.

Singh A, Apostolatos A, Iyer A, et al.

Cureus 2023; (15(8)):e44393 doi:10.7759/cureus.44393.

Recurrence of Primary Aldosteronism After Surgery in Aldosterone-producing Adenoma With KCNJ5 Gene Mutation.

Aiga K, Kometani M, Aono D, Yoneda T

JCEM case reports 2023; (1(1)):luac032 doi:10.1210/jcemcr/luac032.

Primary aldosteronism: Practical recommendations for treatment and follow-up.

Araujo-Castro M, Pascual-Corrales E, Martín Rojas P, Parra Ramírez P

Hipertension y riesgo vascular 2023; (40(4)):215-221 doi:10.1016/j.hipert.2023.08.001.

Clinical and biochemical outcomes after adrenalectomy for primary aldosteronism in tertiary and quaternary referral centers: data from SOPRANO study.

Marzano L, Ronco C

Hypertension research : official journal of the Japanese Society of Hypertension 2024; (47(3)):721-734 doi:10.1038/s41440-023-01554-x.

What We Know about and What Is New in Primary Aldosteronism.

Ekman N, Grossman AB, Dworakowska D

International journal of molecular sciences 2024; (25(2)) doi:10.3390/ijms25020900.

Unilateral Primary Aldosteronism: Long-Term Disease Recurrence After Adrenalectomy.

Tetti M, Brüdgam D, Burrello J, et al.

Hypertension (Dallas, Tex. : 1979) 2024; (81(4)):936-945 doi:10.1161/HYPERTENSIONAHA.123.22281.

Conn´s syndrome after kidney transplantation.

Javorkova M, Bystricanova A, Cirbusova M, et al.

Bratislavske lekarske listy 2024; (125(4)):258-263 doi:10.4149/BLL_2024_39.

Somatic Mutations in MCOLN3 in Aldosterone-Producing Adenomas cause Primary Aldosteronism.

van Rooyen D, Bandulik S, Coon G, et al.

bioRxiv : the preprint server for biology 2024; doi:10.1101/2024.10.20.619295.

Short- and long-term outcomes of adrenalectomy for primary aldosteronism in a single UK center: rear-mirror view.

Abdel-Aziz T, Abdelsalam A, Chung TT, et al.

Hormones (Athens, Greece) 2025; (24(1)):251-258 doi:10.1007/s42000-024-00613-3.

Extra-adrenal adrenocortical cancer associated with multiple endocrine neoplasia type 1.

Green D, Richards K, Doyle B, et al.

Endocrinology, diabetes & metabolism case reports 2024; (2024(4)).

Molecular Imaging Versus Adrenal Vein Sampling for the Detection of Surgically Curable Primary Aldosteronism : A Prospective Within-Patient Trial.

Goodchild E, Wu X, Senanayake R, et al.

Annals of internal medicine 2025; (178(3)):336-347 doi:10.7326/ANNALS-24-00761.

Clinical value of CXCR4-targeted PET-CT in primary aldosteronism: a systematic review and meta-analysis.

Tang R, Pu J, Huang Z

European journal of nuclear medicine and molecular imaging 2025; (52(12)):4706-4716 doi:10.1007/s00259-025-07312-0.

A Rare Case of Primary Hyperaldosteronism Resulting in Severe Hypokalemia.

Sameer S, Qassim AJ, Aqel A, et al.

Cureus 2025; (17(4)):e82069 doi:10.7759/cureus.82069.

Incidental Detection of Renal Cell Carcinoma on 18 F-NOTA-Pentixather PET/CT in a Patient With Aldosterone-producing Adenoma.

Feng L, Wang H, Zhang W

Clinical nuclear medicine 2025; (50(11)):1097-1098 doi:10.1097/RLU.0000000000005945.

Case Report: Anomalous drainage vein sampling for diagnosing aldosterone-producing lesions undetectable by segmental adrenal venous sampling in a two-case series.

Tannai H, Oguro S, Kamada H, et al.

Frontiers in radiology 2025; (5()):1567779 doi:10.3389/fradi.2025.1567779.

The diagnostic utility of the captopril challenge test for primary aldosteronism in a Bangladeshi population: a prospective study.

Jahan S, Lu ZX, Akram M, et al.

Pathology 2025; (57(7)):917-924 doi:10.1016/j.pathol.2025.04.003.

Ectopic Adrenocortical Adenoma Causing Malignant Hypertension and Hypokalemia.

Hu X, Arthur Vithran DT, Yang Z, Li H

The American journal of case reports 2025; (26()):e948022 doi:10.12659/AJCR.948022.

Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain.

Goi J, Paja Fano M, Rizo Gellida A, et al.

European journal of endocrinology 2025; (193(2)):297-309 doi:10.1093/ejendo/lvaf158.

Somatic Mutations in MCOLN3 Are Associated With Aldosterone-Producing Adenomas.

van Rooyen D, Bandulik S, Coon GA, et al.

Hypertension (Dallas, Tex. : 1979) 2025; (82(10)):1778-1788 doi:10.1161/HYPERTENSIONAHA.125.24909.

Factors affecting clinical outcomes of minimally invasive adrenalectomy for unilateral primary aldosteronism: a single-center retrospective cohort study.

Tai Y, Zhou Y, Liu X, Shang J

Gland surgery 2025; (14(9)):1672-1679 doi:10.21037/gs-2025-176.

Post-treatment renin status and cardiovascular, renal, and mortality outcomes in medically treated primary aldosteronism: a systematic review and meta-analysis.

Katsuragawa S, Le MV, Fuller PJ, Yang J

The lancet. Diabetes & endocrinology 2025; (13(12)):1041-1053 doi:10.1016/S2213-8587(25)00263-3.

Primary aldosteronism in South Asia: insights from a tertiary outpatient cohort in Bangladesh.

Jahan S, Akram M, Fariduddin M, et al.

Endocrine connections 2026; (15(1)).

Renin-guided therapy with mineralocorticoid receptor antagonists in primary aldosteronism: feasibility study (RETAME-PA) - a clinical research protocol for a randomised controlled trial.

Merabtine A, Leung AA, Kline GA, et al.

BMJ open 2025; (15(12)):e111167 doi:10.1136/bmjopen-2025-111167.

Clinical manifestations of primary aldosteronism and cardiometabolic risk.

Pascual-Corrales E, Ruiz-Cánovas JM, Peña MMP

Vitamins and hormones 2026; (130()):69-104 doi:10.1016/bs.vh.2025.08.002.

Treatment of Primary Aldosteronism.

Parisien-La Salle S, Hundemer GL, Nehs MA, et al.

Hypertension (Dallas, Tex. : 1979) 2026; (83(5)):e26238 doi:10.1161/HYPERTENSIONAHA.126.26238.

Primary Hyperaldosteronism: Epidemiology, Diagnosis, and Clinical Associations.

Savvidis C, Milionis C, Pachi A, et al.

Epidemiologia (Basel, Switzerland) 2026; (7(2)) doi:10.3390/epidemiologia7020032.

Evaluation and Management of Primary Aldosteronism.

Parisien-La Salle S, Vaidya A

Endocrinology and metabolism clinics of North America 2026; (55(2)):271-284 doi:10.1016/j.ecl.2025.12.002.

Subtyping of Primary Aldosteronism in Partial Adrenal Vein Sampling: The Relative Aldosterone Secretion Index.

Rossi FB, Seccia TM, Rossitto G, Rossi GP

Hypertension (Dallas, Tex. : 1979) 2026; (83(7)):e26988 doi:10.1161/HYPERTENSIONAHA.126.26988.

An unexpected finding of apparent bilateral aldosterone suppression after superselective adrenal venous sampling: a case report.

Pan X, Ma Y, Kang Y, et al.

Blood pressure 2026; (35(1)):2678033 doi:10.1080/08037051.2026.2678033.

Aldosterone-targeted Therapy after Primary Aldosteronism Testing in Resistant Hypertension: A Nationwide Cohort Study.

Tsai CH, Chang YC, Chang CC, et al.

medRxiv : the preprint server for health sciences 2026; doi:10.64898/2026.05.16.26353384.

Severe Hypokalemia and Life-Threatening Ventricular Arrhythmias: A Case of Normotensive Primary Aldosteronism.

Daniel HN, Belleus V, Wang J, Adjovu S

Cureus 2026; (18(5)):e109525 doi:10.7759/cureus.109525.

Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratory.

Sawyer NK, Glendenning P, Schlaich MP, et al.

Pathology 2026; (58(5)):501-506 doi:10.1016/j.pathol.2026.04.003.

Hypertensive crisis in the critically ill.

Demiselle J, Florens N, Garnier-Kepka S, et al.

Annals of intensive care 2026; (16()):100158 doi:10.1016/j.aicoj.2026.100158.