Research & Literature

Analysis on therapeutic outcomes and prognostic factors of intracranial ependymoma: a report of 49 clinical cases in a single center.

Ye J, Zhu J, Yan J, et al.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2015; (36(12)):2253-61 doi:10.1007/s10072-015-2347-2.

Psychosocial Late Effects in Pediatric Cancer Survivors: A Report From the Children's Oncology Group.

Bitsko MJ, Cohen D, Dillon R, et al.

Pediatric blood & cancer 2016; (63(2)):337-43 doi:10.1002/pbc.25773.

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Ramaswamy V, Hielscher T, Mack SC, et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016; (34(21)):2468-77 doi:10.1200/JCO.2015.65.7825.

[Pediatric ependymomas: Current diagnosis and therapy].

Frappaz D, Vasiljevic A, Beuriat PA, et al.

Bulletin du cancer 2016; (103(10)):869-879 doi:10.1016/j.bulcan.2016.08.006.

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.

Pajtler KW, Mack SC, Ramaswamy V, et al.

Acta neuropathologica 2017; (133(1)):5-12 doi:10.1007/s00401-016-1643-0.

Aggressive Supratentorial Ependymoma, RELA Fusion-Positive with Extracranial Metastasis: A Case Report.

Kim SI, Lee Y, Kim SK, et al.

Journal of pathology and translational medicine 2017; (51(6)):588-593 doi:10.4132/jptm.2017.08.10.

Outcomes After Reirradiation for Recurrent Pediatric Intracranial Ependymoma.

Tsang DS, Burghen E, Klimo P, et al.

International journal of radiation oncology, biology, physics 2018; (100(2)):507-515 doi:10.1016/j.ijrobp.2017.10.002.

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment.

Witt H, Gramatzki D, Hentschel B, et al.

Neuro-oncology 2018; (20(12)):1616-1624 doi:10.1093/neuonc/noy118.

Pediatric Localized Intracranial Ependymomas: A Multicenter Analysis of the Société Française de lutte contre les Cancers de l'Enfant (SFCE) from 2000 to 2013.

Ducassou A, Padovani L, Chaltiel L, et al.

International journal of radiation oncology, biology, physics 2018; (102(1)):166-173 doi:10.1016/j.ijrobp.2018.05.036.

Pediatric intracranial ependymoma: correlating signs and symptoms at recurrence with outcome in the second prospective AIEOP protocol follow-up.

Massimino M, Barretta F, Modena P, et al.

Journal of neuro-oncology 2018; (140(2)):457-465 doi:10.1007/s11060-018-2974-6.

Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study.

Byun HK, Yi S, Yoon HI, et al.

Journal of neuro-oncology 2018; (140(3)):649-657 doi:10.1007/s11060-018-2995-1.

Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma.

Tsang DS, Murray L, Ramaswamy V, et al.

Neuro-oncology 2019; (21(4)):547-557 doi:10.1093/neuonc/noy191.

Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.

Zapotocky M, Beera K, Adamski J, et al.

Cancer 2019; (125(11)):1867-1876 doi:10.1002/cncr.31995.

Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.

Merchant TE, Bendel AE, Sabin ND, et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019; (37(12)):974-983 doi:10.1200/JCO.18.01765.

Central nervous system ependymoma: clinical implications of the new molecular classification, treatment guidelines and controversial issues.

Delgado-López PD, Corrales-García EM, Alonso-García E, et al.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2019; (21(11)):1450-1463 doi:10.1007/s12094-019-02082-2.

Cerebellopontine angle ependymoma in a young adult: A case report.

Lan Z, Richard SA, Zhang Y

Medicine 2019; (98(14)):e15019 doi:10.1097/MD.0000000000015019.

Depression and anxiety in long-term survivors 5 and 10 years after cancer diagnosis.

Götze H, Friedrich M, Taubenheim S, et al.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2020; (28(1)):211-220 doi:10.1007/s00520-019-04805-1.

Predicting late magnetic resonance image changes in glioma patients after proton therapy.

Eulitz J, Troost EGC, Raschke F, et al.

Acta oncologica (Stockholm, Sweden) 2019; (58(10)):1536-1539 doi:10.1080/0284186X.2019.1631477.

Current and Emerging Methods of Management of Ependymoma.

Toescu SM, Aquilina K

Current oncology reports 2019; (21(9)):78 doi:10.1007/s11912-019-0826-y.

MYCN amplification drives an aggressive form of spinal ependymoma.

Ghasemi DR, Sill M, Okonechnikov K, et al.

Acta neuropathologica 2019; (138(6)):1075-1089 doi:10.1007/s00401-019-02056-2.

Clinical characteristics and surgical outcomes of spinal myxopapillary ependymomas.

Liu T, Yang C, Deng X, et al.

Neurosurgical review 2020; (43(5)):1351-1356 doi:10.1007/s10143-019-01150-z.

Long-Term Surgical Resection Outcomes of Pediatric Myxopapillary Ependymoma: Experience of Two Centers and Brief Literature Review.

Abdallah A, Emel E, Gündüz HB, et al.

World neurosurgery 2020; (136()):e245-e261 doi:10.1016/j.wneu.2019.12.128.

Extent of re-excision, sequence/timing of salvage re-irradiation, and disease-free interval impact upon clinical outcomes in recurrent/progressive ependymoma.

Gupta T, Maitre M, Gupta P, et al.

Journal of neuro-oncology 2020; (147(2)):405-415 doi:10.1007/s11060-020-03434-7.

cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors.

Ellison DW, Aldape KD, Capper D, et al.

Brain pathology (Zurich, Switzerland) 2020; (30(5)):863-866 doi:10.1111/bpa.12866.

Clinical outcomes in a large pediatric cohort of patients with ependymoma treated with proton radiotherapy.

Patteson BE, Baliga S, Bajaj BVM, et al.

Neuro-oncology 2021; (23(1)):156-166 doi:10.1093/neuonc/noaa139.

Understanding the Deadly Silence of Posterior Fossa A Ependymoma.

Lin GL, Monje M

Molecular cell 2020; (78(6)):999-1001 doi:10.1016/j.molcel.2020.05.020.

The effect of adjuvant radiotherapy on overall survival in adults with intracranial ependymoma.

Prabhu RS, Corso CD, Ward MC, et al.

Neuro-oncology practice 2020; (7(4)):391-399 doi:10.1093/nop/npz070.

Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.

Zhang C, Ostrom QT, Semmes EC, et al.

Acta neuropathologica communications 2020; (8(1)):173 doi:10.1186/s40478-020-01038-w.

Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role.

Ahn JS, Petersen M, Friedman AH, et al.

Ultrastructural pathology 2020; (44(4-6)):511-518 doi:10.1080/01913123.2020.1843578.

Proton beam radiotherapy for esophagus cancer: state of the art.

Gergelis KR, Jethwa KR, Tryggestad EJ, et al.

Journal of thoracic disease 2020; (12(11)):7002-7010 doi:10.21037/jtd-2019-cptn-06.

Outcomes after first relapse of childhood intracranial ependymoma.

Tsai JW, Manoharan N, Alexandrescu S, et al.

Pediatric blood & cancer 2021; (68(8)):e28930 doi:10.1002/pbc.28930.

Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines.

Mizumoto M, Fuji H, Miyachi M, et al.

Cancer treatment reviews 2021; (98()):102209 doi:10.1016/j.ctrv.2021.102209.

Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.

Tauziède-Espariat A, Siegfried A, Nicaise Y, et al.

Acta neuropathologica communications 2021; (9(1)):135 doi:10.1186/s40478-021-01238-y.

Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies.

Adolph JE, Fleischhack G, Gaab C, et al.

Journal of neuro-oncology 2021; (155(2)):193-202 doi:10.1007/s11060-021-03867-8.

Pediatric Extraspinal Subcutaneous Sacrococcygeal Myxopapillary Ependymoma: Case Report and Minireview.

Liu Y, Peng Y, Wang X, et al.

The American Journal of dermatopathology 2021; (43(12)):e273-e276 doi:10.1097/DAD.0000000000002043.

Reevaluating surgery and re-irradiation for locally recurrent pediatric ependymoma-a multi-institutional study.

Mak DY, Laperriere N, Ramaswamy V, et al.

Neuro-oncology advances 2021; (3(1)):vdab158 doi:10.1093/noajnl/vdab158.

Descriptive Epidemiology of Ependymal Tumors in Gironde, France: Results from the Gironde Registry for the 2000-2018 Period.

Laine G, Baldi I, Jecko V, et al.

Neuroepidemiology 2022; (56(4)):250-260 doi:10.1159/000523954.

Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol.

Leblond P, Massimino M, English M, et al.

Frontiers in neurology 2022; (13()):887544 doi:10.3389/fneur.2022.887544.

Redefining germline predisposition in children with molecularly characterized ependymoma: a population-based 20-year cohort.

Foss-Skiftesvik J, Stoltze UK, van Overeem Hansen T, et al.

Acta neuropathologica communications 2022; (10(1)):123 doi:10.1186/s40478-022-01429-1.

The Knosp Criteria Revisited: 3-Dimensional Volumetric Analysis as a Predictive Tool for Extent of Resection in Complex Endoscopic Pituitary Surgery.

DiRisio AC, Feng R, Shuman WH, et al.

Neurosurgery 2023; (92(1)):179-185 doi:10.1227/neu.0000000000002170.

Delineation of molecular characteristics in pediatric PFA ependymoma involving rare osseous and pulmonary metastases: A case report and literature review.

Zhou M, Wang L, Sun P, et al.

Frontiers in oncology 2022; (12()):1001118 doi:10.3389/fonc.2022.1001118.

[Pediatric Intracranial Ependymoma - Recommendations for First-Line Treatment from the German HIT-MED study group].

Obrecht D, Mynarek M, Stickan-Verfürth M, et al.

Klinische Padiatrie 2023; (235(3)):167-177 doi:10.1055/a-2070-7572.

Posterior fossa ependymoma in children: A long-term single-center experience.

Boukaka RG, Szathmari A, Di Rocco F, et al.

Neuro-Chirurgie 2023; (69(4)):101459 doi:10.1016/j.neuchi.2023.101459.

[Ependymoma in WHO Classification of Tumours 5th Edition].

Saito R

No shinkei geka. Neurological surgery 2023; (51(5)):867-875 doi:10.11477/mf.1436204828.

Complications following resection of primary and recurrent pediatric posterior fossa ependymoma.

Malhotra AK, Nobre L, Ibrahim GM, et al.

Journal of neurosurgery. Pediatrics 2024; (33(4)):367-373 doi:10.3171/2023.11.PEDS23364.

Clinical presentation and extent of resection impacts progression-free survival in spinal ependymomas.

Davison MA, Lilly DT, Patel AA, et al.

Journal of neuro-oncology 2024; (167(3)):437-446 doi:10.1007/s11060-024-04623-4.

Ependymal Tumors: Overview of the Recent World Health Organization Histopathologic and Genetic Updates with an Imaging Characteristic.

Soni N, Ora M, Bathla G, et al.

AJNR. American journal of neuroradiology 2024; (45(11)):1624-1634 doi:10.3174/ajnr.A8237.

Clinicopathological profile of ependymomas with special reference to survival data - Experiences of a tertiary care center'.

Basu T, Das M, Debnath R, et al.

Indian journal of pathology & microbiology 2025; (68(1)):118-124 doi:10.4103/ijpm.ijpm_814_23.

Supra-tentorial Ependymomas with ZFTA Fusion, YAP1 Fusion, and Astroblastomas, MN1-altered: Characteristic Imaging Features.

Perrod V, Levy R, Tauziède-Espariat A, et al.

Clinical neuroradiology 2024; (34(4)):939-950 doi:10.1007/s00062-024-01444-w.

The medical and functional burden of surviving childhood ependymoma: A population-based study in Ontario, Canada.

Coltin H, Pequeno P, Liu N, et al.

Pediatric blood & cancer 2024; (71(11)):e31275 doi:10.1002/pbc.31275.

Proton therapy for pediatric malignancies: Indications and challenges focusing on the oncological landscape.

Vennarini S, Colombo F, Filippi AR, Orlandi E

Tumori 2024; (110(6)):416-421 doi:10.1177/03008916241287016.

Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology Consensus Review on diagnosis, management, and future directions.

Lim-Fat MJ, Bennett J, Ostrom Q, et al.

Neuro-oncology 2025; (27(1)):13-32 doi:10.1093/neuonc/noae186.

Spheno-Orbital Meningiomas: A Systematic Review of Treatment Modalities, Adjuvant Therapies, and Recurrence Risk.

Sulaiman II, Hassan Baker A, Shafeeq A, Ismail M

Cureus 2024; (16(11)):e73908 doi:10.7759/cureus.73908.

Evaluation of pediatric spinal ependymomas: A 25-year retrospective observational study.

Narin F, Bahadir S, Hanalioğlu Ş, et al.

Medicine 2024; (103(51)):e40986 doi:10.1097/MD.0000000000040986.

Advances in molecular prognostication and treatments in ependymoma.

Bakes E, Cheng R, Mañucat-Tan N, et al.

Journal of neuro-oncology 2025; (172(2)):317-326 doi:10.1007/s11060-024-04923-9.

MYCN-amplified spinal ependymomas: a rare aggressive subtype. Illustrative cases.

Zhou MH, Cha S

Journal of neurosurgery. Case lessons 2025; (9(1)).

Longitudinal Psychological Distress After Malignant Brain Tumor Diagnosis: A Multilevel Analysis of Patients and Their Caregivers.

Karger A, Kisić AM, Quente C, et al.

Psycho-oncology 2025; (34(1)):e70064 doi:10.1002/pon.70064.

Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma.

Ren J, Amoozgar Z, Uccello TP, et al.

Proceedings of the National Academy of Sciences of the United States of America 2025; (122(4)):e2319474122 doi:10.1073/pnas.2319474122.

Recurrence patterns in pediatric intracranial ependymal neoplasm: a systematic imaging work-up.

Stock A, Krumma J, Fleischhack G, et al.

Neuroradiology 2025; (67(3)):767-781 doi:10.1007/s00234-025-03553-w.

The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers: A Review.

DeVine A, Landier W, Hudson MM, et al.

JAMA oncology 2025; (11(5)):544-553 doi:10.1001/jamaoncol.2024.6812.

The association between postoperative photon radiotherapy dose and disease control and salvage treatment in pediatric and adolescent ependymoma: a multi-institutional investigation.

Liu KX, Salans M, Easwaran TP, et al.

Journal of neuro-oncology 2025; (173(1)):167-177 doi:10.1007/s11060-025-04975-5.

How long should survivors of pediatric medulloblastoma and ependymoma be screened for recurrence? A retrospective cohort study.

Meulendijks TFC, Kaspers GJL, Ramaswamy V, et al.

International journal of cancer 2025; (157(10)):2114-2123 doi:10.1002/ijc.70016.

Optimizing outcomes in intracranial ependymoma: a contemporary review.

Pan Z, Bao J, Wei S

Frontiers in oncology 2025; (15()):1617169 doi:10.3389/fonc.2025.1617169.

Nationwide Brain Tumor Registry-based Study of Adult Intracranial Ependymoma in Japan.

Yamazawa E, Tanaka S, Takayanagi S, et al.

Neurologia medico-chirurgica 2025; (65(9)):373-379 doi:10.2176/jns-nmc.2025-0037.

Selection of the Most Appropriate Radiation Treatment Modality for Children's Cancers: A Paediatric Radiation Oncology Society (PROS) Position Paper on the Ethical Utilization of Proton Therapy.

Esiashvili N, Indelicato DJ, Mahajan A, et al.

Pediatric blood & cancer 2025; e32155 doi:10.1002/pbc.32155.

Ependymal Tumors.

Thomas AG, Chattopadhyay A, Dineen RA

Neuroimaging clinics of North America 2026; (36(1)):69-83 doi:10.1016/j.nic.2025.08.008.

Phase 3 randomized trial of postirradiation chemotherapy in patients with newly diagnosed ependymoma: A report from the Children's Oncology Group.

Smith AA, Onar-Thomas A, Lensing S, et al.

Neuro-oncology 2026; (28(5)):1286-1297 doi:10.1093/neuonc/noaf285.

Unraveling the miRNA-EMT-stemness interplay in fusion-positive supratentorial ependymomas: Identifying therapeutic vulnerabilities.

Sharma A, Kulshreshtha R, Chauhan SS, et al.

Biochemical and biophysical research communications 2026; (804()):153349 doi:10.1016/j.bbrc.2026.153349.

Influence of subgroup, location, and tumor volume in medulloblastoma surgery and consideration for second look surgery: a single institution experience.

Power EA, Pumford AD, Futso-Kamga L, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2026; (42(1)):67 doi:10.1007/s00381-026-07141-y.