Research & Literature

Valproate in the treatment of epilepsy in girls and women of childbearing potential.

Tomson T, Marson A, Boon P, et al.

Epilepsia 2015; (56(7)):1006-19 doi:10.1111/epi.13021.

Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy.

Sarkis RA, Thome-Souza S, Poh MZ, et al.

Epilepsy research 2015; (115()):113-8.

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society.

Glauser T, Shinnar S, Gloss D, et al.

Epilepsy currents 2016; (16(1)):48-61 doi:10.5698/1535-7597-16.1.48.

Efficacy and safety of anti-epileptic drugs in patients with active convulsive seizures when no IV access is available: Systematic review and meta-analysis.

Jain P, Sharma S, Dua T, et al.

Epilepsy research 2016; (122()):47-55.

Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic -Clonic Seizures in Adults - A Randomized Controlled Trial.

Giri VP, Giri OP, Khan FA, et al.

Journal of clinical and diagnostic research : JCDR 2016; (10(7)):FC01-4 doi:10.7860/JCDR/2016/16911.8121.

Prognostic factors in patients with refractory idiopathic generalized epilepsy.

Gomez-Ibañez A, McLachlan RS, Mirsattari SM, et al.

Epilepsy research 2017; (130()):69-73 doi:10.1016/j.eplepsyres.2017.01.011.

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.

Scheffer IE, Berkovic S, Capovilla G, et al.

Epilepsia 2017; (58(4)):512-521 doi:10.1111/epi.13709.

Instruction manual for the ILAE 2017 operational classification of seizure types.

Fisher RS, Cross JH, D'Souza C, et al.

Epilepsia 2017; (58(4)):531-542 doi:10.1111/epi.13671.

Neurological Deficits in Obstructive Sleep Apnea.

Ferini-Strambi L, Lombardi GE, Marelli S, Galbiati A

Current treatment options in neurology 2017; (19(4)):16 doi:10.1007/s11940-017-0451-8.

Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Harden C, Tomson T, Gloss D, et al.

Neurology 2017; (88(17)):1674-1680 doi:10.1212/WNL.0000000000003685.

Long-term outcome in adolescent-onset generalized genetic epilepsies.

Vorderwülbecke BJ, Kowski AB, Kirschbaum A, et al.

Epilepsia 2017; (58(7)):1244-1250 doi:10.1111/epi.13761.

Anticonvulsant drugs for generalized tonic-clonic epilepsy.

Coppola G, Piccorossi A, Operto FF, Verrotti A

Expert opinion on pharmacotherapy 2017; (18(9)):925-936 doi:10.1080/14656566.2017.1328499.

Postictal generalized EEG suppression and respiratory dysfunction following generalized tonic-clonic seizures in sleep and wakefulness.

Peng W, Danison JL, Seyal M

Epilepsia 2017; (58(8)):1409-1414 doi:10.1111/epi.13805.

Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Harden C, Tomson T, Gloss D, et al.

Epilepsy currents 2017; (17(3)):180-187 doi:10.5698/1535-7511.17.3.180.

Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus.

Gaínza-Lein M, Sánchez Fernández I, Jackson M, et al.

JAMA neurology 2018; (75(4)):410-418 doi:10.1001/jamaneurol.2017.4382.

Differentiating motor phenomena in tilt-induced syncope and convulsive seizures.

Shmuely S, Bauer PR, van Zwet EW, et al.

Neurology 2018; (90(15)):e1339-e1346 doi:10.1212/WNL.0000000000005301.

Detection of convulsive seizures using surface electromyography.

Beniczky S, Conradsen I, Wolf P

Epilepsia 2018; (59 Suppl 1()):23-29 doi:10.1111/epi.14048.

Multi-gene panel testing in Korean patients with common genetic generalized epilepsy syndromes.

Lee CG, Lee J, Lee M

PloS one 2018; (13(6)):e0199321 doi:10.1371/journal.pone.0199321.

Two predictors of postictal generalized EEG suppression: Tonic phase duration and postictal immobility period.

Asadollahi M, Noorbakhsh M, Simani L, et al.

Seizure 2018; (61()):135-138 doi:10.1016/j.seizure.2018.08.009.

Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential.

Serafini A, Gerard E, Genton P, et al.

CNS drugs 2019; (33(3)):195-208 doi:10.1007/s40263-018-00602-2.

Childhood-only epilepsy with generalized tonic-clonic seizures: A well-defined epileptic syndrome.

Caraballo R, Silva S, Beltran L, et al.

Epilepsy research 2019; (153()):28-33 doi:10.1016/j.eplepsyres.2019.03.017.

Sleepwalking and Sleep Paralysis: Prevalence in Colombian Families With Genetic Generalized Epilepsy.

Cornejo-Sanchez DM, Carrizosa-Moog J, Cabrera-Hemer D, et al.

Journal of child neurology 2019; (34(9)):491-498 doi:10.1177/0883073819842422.

The utility of an automated and ambulatory device for detecting and differentiating epileptic and psychogenic non-epileptic seizures.

Naganur VD, Kusmakar S, Chen Z, et al.

Epilepsia open 2019; (4(2)):309-317 doi:10.1002/epi4.12327.

Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs.

Blotière PO, Raguideau F, Weill A, et al.

Neurology 2019; (93(2)):e167-e180 doi:10.1212/WNL.0000000000007696.

SUDEP in the North American SUDEP Registry: The full spectrum of epilepsies.

Verducci C, Hussain F, Donner E, et al.

Neurology 2019; (93(3)):e227-e236 doi:10.1212/WNL.0000000000007778.

Discontinuing antiepileptic drugs in long-standing idiopathic generalised epilepsy.

Vorderwülbecke BJ, Kirschbaum A, Merkle H, et al.

Journal of neurology 2019; (266(10)):2554-2559 doi:10.1007/s00415-019-09457-z.

Generalized epilepsies.

Guerrini R, Marini C, Barba C

Handbook of clinical neurology 2019; (161()):3-15 doi:10.1016/B978-0-444-64142-7.00038-2.

Community-informed connectomics of the thalamocortical system in generalized epilepsy.

Wang Z, Larivière S, Xu Q, et al.

Neurology 2019; (93(11)):e1112-e1122 doi:10.1212/WNL.0000000000008096.

Levetiracetam in genetic generalized epilepsy: A prospective unblinded active-controlled trial.

Tabrizi N, Zarvani A, Rezaei P, et al.

Epilepsy research 2019; (157()):106214 doi:10.1016/j.eplepsyres.2019.106214.

Obstructive Sleep Apnea.

Patel SR

Annals of internal medicine 2019; (171(11)):ITC81-ITC96 doi:10.7326/AITC201912030.

Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults.

Stephen LJ, Brodie MJ

CNS drugs 2020; (34(2)):147-161 doi:10.1007/s40263-020-00698-5.

Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.

Ratcliffe C, Wandschneider B, Baxendale S, et al.

Frontiers in neurology 2020; (11()):144 doi:10.3389/fneur.2020.00144.

Differentiation of Epileptic and Psychogenic Nonepileptic Seizures Using Single-Channel Surface Electromyography.

Husain AM, Towne AR, Chen DK, et al.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2021; (38(5)):432-438 doi:10.1097/WNP.0000000000000703.

[Convulsive syncope then convulsive seizure occurred in the long clinical course: a case report].

Sakakibara-Hayashi K, Inoue T, Kuki I, et al.

Rinsho shinkeigaku = Clinical neurology 2020; (60(9)):627-630 doi:10.5692/clinicalneurol.cn-001451.

Recognizing and refuting the myth of tongue swallowing during a seizure.

Rossi KC, Baumgartner AJ, Goldenholz SR, Goldenholz DM

Seizure 2020; (83()):32-37 doi:10.1016/j.seizure.2020.09.023.

Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.

Gesche J, Hjalgrim H, Rubboli G, Beier CP

Epilepsy research 2021; (170()):106547 doi:10.1016/j.eplepsyres.2020.106547.

Levetiracetam as first-line monotherapy for Idiopathic Generalized Epilepsy in women.

Ballvé A, Salas-Puig J, Quintana M, et al.

Acta neurologica Scandinavica 2021; (143(4)):407-412 doi:10.1111/ane.13389.

Can semiology differentiate between bilateral tonic-clonic seizures of focal-onset and generalized-onset? A systematic review.

Christie H, D'Souza W, Cook M, Seneviratne U

Epilepsy & behavior : E&B 2021; (116()):107769 doi:10.1016/j.yebeh.2021.107769.

The probability of sudden unexpected death in epilepsy given postictal prone position.

Esmaeili B, Dworetzky BA, Glynn RJ, Lee JW

Epilepsy & behavior : E&B 2021; (116()):107775 doi:10.1016/j.yebeh.2021.107775.

[SUDEP in brief - knowledge and practice recommendations on sudden unexpected death in epilepsy].

Surges R, Conrad S, Hamer HM, et al.

Der Nervenarzt 2021; (92(8)):809-815 doi:10.1007/s00115-021-01075-3.

Risk of SUDEP during infancy.

Trivisano M, Muccioli L, Ferretti A, et al.

Epilepsy & behavior : E&B 2022; (131(Pt B)):107896 doi:10.1016/j.yebeh.2021.107896.

The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial.

Marson A, Burnside G, Appleton R, et al.

Lancet (London, England) 2021; (397(10282)):1375-1386 doi:10.1016/S0140-6736(21)00246-4.

Sudden Unexpected Death in Epilepsy: A Personalized Prediction Tool.

Jha A, Oh C, Hesdorffer D, et al.

Neurology 2021; (96(21)):e2627-e2638 doi:10.1212/WNL.0000000000011849.

Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures.

Abdelmesih SK, Elkhateeb N, Zakaria M, Girgis MY

Seizure 2021; (91()):263-270 doi:10.1016/j.seizure.2021.06.033.

Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study.

Pottkämper JCM, Verdijk JPAJ, Hofmeijer J, et al.

Epilepsia open 2021; (6(4)):672-684 doi:10.1002/epi4.12532.

Seizure outcome trajectories in a well-defined cohort of newly diagnosed juvenile myoclonic epilepsy patients.

Cerulli Irelli E, Morano A, Orlando B, et al.

Acta neurologica Scandinavica 2022; (145(3)):314-321 doi:10.1111/ane.13556.

Genetic generalized epilepsies in adults - challenging assumptions and dogmas.

Vorderwülbecke BJ, Wandschneider B, Weber Y, Holtkamp M

Nature reviews. Neurology 2022; (18(2)):71-83 doi:10.1038/s41582-021-00583-9.

Sudden unexpected death in epilepsy.

Friedman D

Current opinion in neurology 2022; (35(2)):181-188 doi:10.1097/WCO.0000000000001034.

Pseudoresistance in idiopathic/genetic generalized epilepsies - Definitions, risk factors, and outcome.

Gesche J, Cornwall CD, Delcomyn L, et al.

Epilepsy & behavior : E&B 2022; (130()):108633 doi:10.1016/j.yebeh.2022.108633.

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Nevitt SJ, Sudell M, Cividini S, et al.

The Cochrane database of systematic reviews 2022; (4()):CD011412 doi:10.1002/14651858.CD011412.pub4.

Network connectivity in primary generalized tonic-clonic seizures.

McGuinness I, Abou-Khalil B, Rubinov M, Gallagher MJ

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2022; (138()):97-107 doi:10.1016/j.clinph.2022.02.024.

National compliance with UK wide guidelines for usage of valproate in women of childbearing potential.

Eriksson SH, Tittensor P, Sisodiya SM

Seizure 2022; (98()):8-12 doi:10.1016/j.seizure.2022.03.020.

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions.

Hirsch E, French J, Scheffer IE, et al.

Epilepsia 2022; (63(6)):1475-1499 doi:10.1111/epi.17236.

The recovery position for maintenance of adequate ventilation and the prevention of cardiac arrest: A systematic review.

Douma MJ, Handley AJ, MacKenzie E, et al.

Resuscitation plus 2022; (10()):100236 doi:10.1016/j.resplu.2022.100236.

Contributions of Magnetoencephalography to Understanding Mechanisms of Generalized Epilepsies: Blurring the Boundary Between Focal and Generalized Epilepsies?

Aung T, Tenney JR, Bagić AI

Frontiers in neurology 2022; (13()):831546 doi:10.3389/fneur.2022.831546.

Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.

Bjørk MH, Zoega H, Leinonen MK, et al.

JAMA neurology 2022; (79(7)):672-681 doi:10.1001/jamaneurol.2022.1269.

Semiologic differences between bilateral tonic-clonic seizures of focal onset and generalized onset.

Seneviratne U, Christie H, D'Souza W, Cook M

Epilepsy & behavior : E&B 2022; (134()):108837 doi:10.1016/j.yebeh.2022.108837.

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Lehner J, Frueh JS, Datta AN

Sleep medicine reviews 2022; (65()):101689 doi:10.1016/j.smrv.2022.101689.

The Relationship Between Epilepsy, Obstructive Sleep Apnea, and Treatment Outcome.

Sethi NK

Sleep medicine clinics 2022; (17(4)):639-645 doi:10.1016/j.jsmc.2022.07.012.

Sudden unexpected death in epilepsy in children.

Whitney R, Sharma S, Ramachandrannair R

Developmental medicine and child neurology 2023; (65(9)):1150-1156 doi:10.1111/dmcn.15553.

Pneumocephalus, coma and seizures following lumbar decompression surgery.

Bonome Roel C, Goday Etxebarria M, Domenech Bendaña C, et al.

Revista espanola de anestesiologia y reanimacion 2023; (70(3)):160-164 doi:10.1016/j.redare.2021.10.007.

Focal epilepsies: Update on diagnosis and classification.

Nascimento FA, Friedman D, Peters JM, et al.

Epileptic disorders : international epilepsy journal with videotape 2023; (25(1)):1-17 doi:10.1002/epd2.20045.

Acute Abortive Therapies for Seizure Clusters in Long-Term Care.

Ramsay RE, Becker DA, Vazquez B, et al.

Journal of the American Medical Directors Association 2023; (24(8)):1225-1232 doi:10.1016/j.jamda.2023.04.015.

Non-electroencephalogram-based seizure detection devices: State of the art and future perspectives.

Meritam Larsen P, Beniczky S

Epilepsy & behavior : E&B 2023; (148()):109486 doi:10.1016/j.yebeh.2023.109486.

Epilepsy with generalized tonic-clonic seizures alone: Electroclinical features and prognostic patterns.

Cerulli Irelli E, Gesche J, Schlabitz S, et al.

Epilepsia 2024; (65(1)):84-94 doi:10.1111/epi.17809.

Focal electroclinical features in generalized tonic-clonic seizures: Decision flowchart for a diagnostic challenge.

Vlachou M, Ryvlin P, Armand Larsen S, Beniczky S

Epilepsia 2024; (65(3)):725-738 doi:10.1111/epi.17895.

Benzodiazepines for the Treatment of Seizure Clusters.

Penovich PE, Rao VR, Long L, et al.

CNS drugs 2024; (38(2)):125-140 doi:10.1007/s40263-023-01060-1.

Drug-resistant generalized epilepsies: Revisiting the frontiers of idiopathic generalized epilepsies.

Gauer L, Baer S, Valenti-Hirsch MP, et al.

Revue neurologique 2024; (180(4)):290-297 doi:10.1016/j.neurol.2024.03.001.

Oligoepilepsy and lifelong seizure susceptibility in epilepsy with generalized tonic-clonic seizures alone: Experience at an adult tertiary center.

Peña-Ceballos J, Moloney PB, Kilbride RD, et al.

Epilepsy research 2024; (202()):107362 doi:10.1016/j.eplepsyres.2024.107362.

Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.

Pack AM, Oskoui M, Williams Roberson S, et al.

Neurology 2024; (102(11)):e209279 doi:10.1212/WNL.0000000000209279.

Prospective study of epilepsy with generalized tonic-clonic seizures alone: Clinical features, response to treatment, and likelihood of medication withdrawal.

Jaafar F, Wazne J, Hmaimess G, et al.

Epilepsia open 2024; (9(4)):1426-1436 doi:10.1002/epi4.12981.

Antiseizure Medications and Sudden Unexpected Death in Epilepsy: An Updated Review.

Bosch AT, Sander JW, Thijs RD

CNS drugs 2024; (38(10)):807-817 doi:10.1007/s40263-024-01112-0.

First-aid knowledge and practices towards patients with epileptic seizures among the dental students in Saudi Arabia - A cross-sectional study.

Al-Qahtani Z, Mahmood SE, Alshahrani MS, et al.

Journal of family medicine and primary care 2024; (13(10)):4217-4224 doi:10.4103/jfmpc.jfmpc_153_24.

Diagnosis and management of status epilepticus: improving the status quo.

Gettings JV, Mohammad Alizadeh Chafjiri F, Patel AA, et al.

The Lancet. Neurology 2025; (24(1)):65-76 doi:10.1016/S1474-4422(24)00430-7.

Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia.

Begizew SW, Muluneh BB, Ashine TM, et al.

Scientific reports 2025; (15(1)):3899 doi:10.1038/s41598-025-86268-5.

Treating seizures faster: The Quality Improvement in Time to Treat Status Epilepticus (QuITT-SE) multicenter randomized stepped wedge clinical trial protocol.

Ostendorf AP, Loddenkemper T, Morgan LA, et al.

Contemporary clinical trials 2025; (151()):107831 doi:10.1016/j.cct.2025.107831.

Seizure Detection Devices.

Baumgartner C, Baumgartner J, Lang C, et al.

Journal of clinical medicine 2025; (14(3)) doi:10.3390/jcm14030863.

Seizure freedom and therapy discontinuation in patients with idiopathic generalized epilepsy: retrospective cohort study from a tertiary epilepsy outpatient service.

Curti DG, Bellini A, Cursi M, et al.

Journal of neurology 2025; (272(3)):218 doi:10.1007/s00415-025-12890-y.

Assessment of Seizure Action Plans in Pediatric Convulsive Status Epilepticus: Focus on Benzodiazepine-Responsive and Resistant Cases.

Stredny CM, Rostamian S, Sheehan TA, et al.

Neurology. Clinical practice 2025; (15(3)):e200449 doi:10.1212/CPJ.0000000000200449.

Seizure first aid in the community: current situation, suggestions, and the role of the general practitioner in seizure management.

Sun M, Meng F, Xu ZY, Guo Y

Acta epileptologica 2025; (7(1)):11 doi:10.1186/s42494-025-00202-w.

[Knowledge of first aid for epileptic seizures among the general population and relatives of patients with epilepsy].

Viloria-Alebesque A, Bono-Velilla Á, Bellosta-Diago E, et al.

Anales del sistema sanitario de Navarra 2026; (49(1)).

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 11. First aid.

Woo SH, Lee CH, Kim MY, et al.

Clinical and experimental emergency medicine 2026; (13(Suppl 1)):S185-S194 doi:10.15441/ceem.26.076.

Electroclinical classification of idiopathic generalized epilepsy syndromes at initial evaluation: A prospective multicenter study.

Nawfal O, Samara H, Nasreddine W, et al.

Epilepsia open 2026; doi:10.1002/epi4.70349.