Research & Literature

Resective epilepsy surgery for drug-resistant focal epilepsy: a review.

Jobst BC, Cascino GD

JAMA 2015; (313(3)):285-93 doi:10.1001/jama.2014.17426.

Efficacy of low to moderate doses of oxcarbazepine in adult patients with newly diagnosed partial epilepsy.

Zou XM, Chen JN, An DM, et al.

Seizure 2015; (29()):81-5.

Migraine aura symptoms: Duration, succession and temporal relationship to headache.

Viana M, Linde M, Sances G, et al.

Cephalalgia : an international journal of headache 2016; (36(5)):413-21 doi:10.1177/0333102415593089.

The role of sleep electroencephalography in patients with new onset epilepsy.

Delil S, Senel GB, Demiray DY, Yeni N

Seizure 2015; (31()):80-3.

Diagnosis of Epilepsy and Related Episodic Disorders.

St Louis EK, Cascino GD

Continuum (Minneapolis, Minn.) 2016; (22(1 Epilepsy)):15-37 doi:10.1212/CON.0000000000000284.

Treatment of Convulsive Status Epilepticus.

Grover EH, Nazzal Y, Hirsch LJ

Current treatment options in neurology 2016; (18(3)):11 doi:10.1007/s11940-016-0394-5.

Widespread changes in network activity allow non-invasive detection of mesial temporal lobe seizures.

Lam AD, Zepeda R, Cole AJ, Cash SS

Brain : a journal of neurology 2016; (139(Pt 10)):2679-2693 doi:10.1093/brain/aww198.

Outcome of initial antiepileptic drug treatment in elderly patients with newly diagnosed epilepsy.

Bruun E, Kälviäinen R, Keränen T

Epilepsy research 2016; (127()):60-65 doi:10.1016/j.eplepsyres.2016.08.023.

Discussing sudden unexpected death in epilepsy: Are we empowering our patients? A questionnaire survey.

Keddie S, Angus-Leppan H, Parker T, et al.

JRSM open 2016; (7(9)):2054270416654358 doi:10.1177/2054270416654358.

Efficacy and Tolerability of Antiepileptic Drugs in Patients with Focal Epilepsy: Systematic Review and Network Meta-analyses.

Campos MS, Ayres LR, Morelo MR, et al.

Pharmacotherapy 2016; (36(12)):1255-1271 doi:10.1002/phar.1855.

Epilepsy treatment in adults and adolescents: Expert opinion, 2016.

Shih JJ, Whitlock JB, Chimato N, et al.

Epilepsy & behavior : E&B 2017; (69()):186-222 doi:10.1016/j.yebeh.2016.11.018.

Instruction manual for the ILAE 2017 operational classification of seizure types.

Fisher RS, Cross JH, D'Souza C, et al.

Epilepsia 2017; (58(4)):531-542 doi:10.1111/epi.13671.

Most Children With Epilepsy Experience Postictal Phenomena, Often Preventing a Return to Normal Activities of Childhood.

MacEachern SJ, D'Alfonso S, McDonald RJ, et al.

Pediatric neurology 2017; (72()):42-50.e3 doi:10.1016/j.pediatrneurol.2017.03.002.

Psychiatric side effects and antiepileptic drugs: Observations from prospective audits.

Stephen LJ, Wishart A, Brodie MJ

Epilepsy & behavior : E&B 2017; (71(Pt A)):73-78 doi:10.1016/j.yebeh.2017.04.003.

Association of sleep with sudden unexpected death in epilepsy.

Ali A, Wu S, Issa NP, et al.

Epilepsy & behavior : E&B 2017; (76()):1-6 doi:10.1016/j.yebeh.2017.08.021.

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study.

Chen Z, Brodie MJ, Liew D, Kwan P

JAMA neurology 2018; (75(3)):279-286 doi:10.1001/jamaneurol.2017.3949.

Lacosamide: A Review in Focal-Onset Seizures in Patients with Epilepsy.

Hoy SM

CNS drugs 2018; (32(5)):473-484 doi:10.1007/s40263-018-0523-7.

Antiepileptic monotherapy in newly diagnosed focal epilepsy. A network meta-analysis.

Lattanzi S, Zaccara G, Giovannelli F, et al.

Acta neurologica Scandinavica 2019; (139(1)):33-41 doi:10.1111/ane.13025.

Putting it all together: Options for intractable epilepsy: An updated algorithm on the use of epilepsy surgery and neurostimulation.

Benbadis SR, Geller E, Ryvlin P, et al.

Epilepsy & behavior : E&B 2018; (88S()):33-38 doi:10.1016/j.yebeh.2018.05.030.

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Kanner AM, Ashman E, Gloss D, et al.

Epilepsy currents 2018; (18(4)):260-268 doi:10.5698/1535-7597.18.4.260.

Focal epilepsy without interictal spikes on scalp EEG: A common finding of uncertain significance.

Basiri R, Shariatzadeh A, Wiebe S, Aghakhani Y

Epilepsy research 2019; (150()):1-6 doi:10.1016/j.eplepsyres.2018.12.009.

Validated outcome of treatment changes according to International League Against Epilepsy criteria in adults with drug-resistant focal epilepsy.

Mula M, Zaccara G, Galimberti CA, et al.

Epilepsia 2019; (60(6)):1114-1123 doi:10.1111/epi.14685.

7T MRI in epilepsy patients with previously normal clinical MRI exams compared against healthy controls.

Feldman RE, Delman BN, Pawha PS, et al.

PloS one 2019; (14(3)):e0213642 doi:10.1371/journal.pone.0213642.

Signs and symptoms of the postictal period in epilepsy: A systematic review and meta-analysis.

Subota A, Khan S, Josephson CB, et al.

Epilepsy & behavior : E&B 2019; (94()):243-251 doi:10.1016/j.yebeh.2019.03.014.

Comparison and Selection of Current Implantable Anti-Epileptic Devices.

Wong S, Mani R, Danish S

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2019; (16(2)):369-380 doi:10.1007/s13311-019-00727-2.

Epilepsy surgery.

Rugg-Gunn F, Miserocchi A, McEvoy A

Practical neurology 2020; (20(1)):4-14 doi:10.1136/practneurol-2019-002192.

Oxcarbazepine add-on for drug-resistant focal epilepsy.

Bresnahan R, Atim-Oluk M, Marson AG

The Cochrane database of systematic reviews 2020; (3()):CD012433 doi:10.1002/14651858.CD012433.pub2.

Efficacy and safety of perampanel monotherapy in patients with focal-onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period of remission: The open-label Study 342 (FREEDOM Study).

Yamamoto T, Lim SC, Ninomiya H, et al.

Epilepsia open 2020; (5(2)):274-284 doi:10.1002/epi4.12398.

Hyperkinetic Seizures with Ictal Fear as Localizing Ictal Signs in MRI-Negative Medial Frontal Lobe Epilepsy.

Cloppenborg T, Albers K, Kalbhenn T, et al.

Neuropediatrics 2021; (52(1)):44-47 doi:10.1055/s-0040-1715630.

The Sensitivity of Scalp EEG at Detecting Seizures-A Simultaneous Scalp and Stereo EEG Study.

Casale MJ, Marcuse LV, Young JJ, et al.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2022; (39(1)):78-84 doi:10.1097/WNP.0000000000000739.

Experiential seizures related to the hippocampal-parahippocampal spatial representation system.

Revdal E, Arntsen V, Doan TP, et al.

Epilepsy & behavior reports 2020; (14()):100386 doi:10.1016/j.ebr.2020.100386.

Can We Prevent Sudden Unexpected Death in Epilepsy (SUDEP)?

Bhasin H, Sharma S, Ramachandrannair R

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2021; (48(4)):464-468 doi:10.1017/cjn.2020.221.

Diagnostic yield of seizure recordings and neuroimaging in patients with focal epilepsy without interictal epileptiform discharges.

Suzuki M, Jin K, Kitazawa Y, et al.

Epilepsy & behavior : E&B 2020; (112()):107468 doi:10.1016/j.yebeh.2020.107468.

[SUDEP in brief - knowledge and practice recommendations on sudden unexpected death in epilepsy].

Surges R, Conrad S, Hamer HM, et al.

Der Nervenarzt 2021; (92(8)):809-815 doi:10.1007/s00115-021-01075-3.

The SANTÉ study at 10 years of follow-up: Effectiveness, safety, and sudden unexpected death in epilepsy.

Salanova V, Sperling MR, Gross RE, et al.

Epilepsia 2021; (62(6)):1306-1317 doi:10.1111/epi.16895.

Response to first antiseizure medication in patients diagnosed with epilepsy.

Hersi H, Saarinen JT, Raitanen J, Peltola J

Acta neurologica Scandinavica 2021; (144(1)):67-75 doi:10.1111/ane.13426.

Phase-amplitude coupling of ripple activities during seizure evolution with theta phase.

Hashimoto H, Khoo HM, Yanagisawa T, et al.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2021; (132(6)):1243-1253 doi:10.1016/j.clinph.2021.03.007.

Sudden Unexpected Death in Epilepsy: A Personalized Prediction Tool.

Jha A, Oh C, Hesdorffer D, et al.

Neurology 2021; (96(21)):e2627-e2638 doi:10.1212/WNL.0000000000011849.

Electroclinical markers to differentiate between focal and generalized epilepsies.

Raga S, Rheims S, Specchio N, Wilmshurst JM

Epileptic disorders : international epilepsy journal with videotape 2021; (23(3)):437-458 doi:10.1684/epd.2021.1291.

In the pursuit of the epileptogenic zone - listen carefully and look deeply.

Nascimento FA, Srinivasan VM, Sheth SA, Gavvala JR

Epileptic disorders : international epilepsy journal with videotape 2021; (23(4)):667-673 doi:10.1684/epd.2021.1297.

Clinical Management of Drug Resistant Epilepsy: A Review on Current Strategies.

Guery D, Rheims S

Neuropsychiatric disease and treatment 2021; (17()):2229-2242 doi:10.2147/NDT.S256699.

Arousal and Consciousness in Focal Seizures.

Blumenfeld H

Epilepsy currents 2021; (21(5)):353-359 doi:10.1177/15357597211029507.

Diagnostic value of MRI in the presurgical evaluation of patients with epilepsy: influence of field strength and sequence selection: a systematic review and meta-analysis from the E-PILEPSY Consortium.

Rados M, Mouthaan B, Barsi P, et al.

Epileptic disorders : international epilepsy journal with videotape 2022; (24(2)):323-342 doi:10.1684/epd.2021.1399.

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Nevitt SJ, Sudell M, Cividini S, et al.

The Cochrane database of systematic reviews 2022; (4()):CD011412 doi:10.1002/14651858.CD011412.pub4.

Antiseizure Medications for Adults With Epilepsy: A Review.

Kanner AM, Bicchi MM

JAMA 2022; (327(13)):1269-1281 doi:10.1001/jama.2022.3880.

Surgical Treatments for Epilepsy.

Culler GW, Jobst BC

Continuum (Minneapolis, Minn.) 2022; (28(2)):536-558 doi:10.1212/CON.0000000000001106.

Auditory verbal hallucinations as ictal phenomena in a patient with drug-resistant epilepsy.

Perez JT, Burneo JG, Macdougall K, et al.

Clinical neurology and neurosurgery 2022; (216()):107223 doi:10.1016/j.clineuro.2022.107223.

Seizure semiology: ILAE glossary of terms and their significance.

Beniczky S, Tatum WO, Blumenfeld H, et al.

Epileptic disorders : international epilepsy journal with videotape 2022; (24(3)):447-495 doi:10.1684/epd.2022.1430.

Diagnostic Puzzle of Acute Ischemic Stroke Mimics - Seizure Versus Post-Stroke Recrudescence: A Case Report.

Akintomide FA, Hosseini R, Candale-Radu C, Khan K

The American journal of case reports 2022; (23()):e936826 doi:10.12659/AJCR.936826.

"Temporal" intermittent rhythmic delta activity: the true localizing nature of TIRDA

Freund BE, Mheir-Al-Saadi Z, Brinkmann BH, Tatum WO

Epileptic disorders : international epilepsy journal with videotape 2022; (24(5)):947-951 doi:10.1684/epd.2022.1459.

Temporal encephalocele: a rare but treatable cause of temporal lobe epilepsy

Jagtap SA, Kurwale N, Patil S, et al.

Epileptic disorders : international epilepsy journal with videotape 2022; (24(6)):1073-1080 doi:10.1684/epd.2022.1487.

Opportunities for Community Pharmacists to Counsel Patients With Epilepsy and Seizure Clusters to Overcome Barriers and Foster Appropriate Treatment.

Gidal B, Welty T, Cokley J, et al.

Journal of pharmacy practice 2024; (37(1)):190-197 doi:10.1177/08971900221126570.

Migraine aura-like symptoms at onset of stroke and stroke-like symptoms in migraine with aura.

Scutelnic A, Kreis LA, Beyeler M, et al.

Frontiers in neurology 2022; (13()):1004058 doi:10.3389/fneur.2022.1004058.

Rescue Treatments for Seizure Clusters.

Kotloski RJ, Gidal BE

Neurologic clinics 2022; (40(4)):927-937 doi:10.1016/j.ncl.2022.03.016.

Implications of Seizure-Cluster Treatment on Healthcare Utilization: Use of Approved Rescue Medications.

Rabinowicz AL, Faught E, Cook DF, Carrazana E

Neuropsychiatric disease and treatment 2022; (18()):2431-2441 doi:10.2147/NDT.S376104.

Response to subsequent antiseizure medications after first antiseizure medication failure in newly diagnosed epilepsy.

Hersi H, Saarinen JT, Raitanen J, Peltola J

Frontiers in neurology 2022; (13()):1042168 doi:10.3389/fneur.2022.1042168.

Symptoms and patterns of symptom propagation in incipient ischemic stroke and migraine aura.

Scutelnic A, Bracher J, Kreis LA, et al.

Frontiers in human neuroscience 2022; (16()):1077737 doi:10.3389/fnhum.2022.1077737.

Focal epilepsies: Update on diagnosis and classification.

Nascimento FA, Friedman D, Peters JM, et al.

Epileptic disorders : international epilepsy journal with videotape 2023; (25(1)):1-17 doi:10.1002/epd2.20045.

SUDEP counseling: Where do we stand?

Whitney R, Jones KC, Sharma S, RamachandranNair R

Epilepsia 2023; (64(6)):1424-1431 doi:10.1111/epi.17617.

Acute Abortive Therapies for Seizure Clusters in Long-Term Care.

Ramsay RE, Becker DA, Vazquez B, et al.

Journal of the American Medical Directors Association 2023; (24(8)):1225-1232 doi:10.1016/j.jamda.2023.04.015.

[Cingulate seizure as a clinical manifestation of anti-myelin oligodendrocyte glycoprotein antibody-positive cerebral cortical encephalitis of two cases].

Tanaka T, Togo M, Okayama K, et al.

Rinsho shinkeigaku = Clinical neurology 2023; (63(7)):441-449 doi:10.5692/clinicalneurol.cn-001724.

Localizing and lateralizing value of auditory phenomena in seizures.

Cossette-Roberge H, Li J, Citherlet D, Nguyen DK

Epilepsy & behavior : E&B 2023; (145()):109327 doi:10.1016/j.yebeh.2023.109327.

A new strategy for treating drug-resistant focal aware seizures: thalamic specific nuclei deep brain stimulation. Illustrative case.

Vilela-Filho O, Silva-Filho HF, Goulart LC, et al.

Journal of neurosurgery. Case lessons 2023; (6(8)).

Focal aware somatosensory seizures with paresis as a complication of surgery for chronic subdural hematoma.

Ishida S, Nitta N, Yoshida K

Epilepsy & behavior reports 2023; (24()):100621 doi:10.1016/j.ebr.2023.100621.

Measuring quality and safety of epilepsy monitoring units in Brazil: Adoption of quality indicators.

de Albuquerque LCP, Torres CM, Batista CEA, et al.

Seizure 2024; (115()):68-74 doi:10.1016/j.seizure.2023.12.021.

Benzodiazepines for the Treatment of Seizure Clusters.

Penovich PE, Rao VR, Long L, et al.

CNS drugs 2024; (38(2)):125-140 doi:10.1007/s40263-023-01060-1.

The role of neuromodulation in the management of drug-resistant epilepsy.

Salama H, Salama A, Oscher L, et al.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2024; (45(9)):4243-4268 doi:10.1007/s10072-024-07513-9.

Outpatient management of prolonged seizures and seizure clusters to prevent progression to a higher-level emergency: Consensus recommendations of an expert working group.

Pina-Garza JE, Chez M, Cloyd J, et al.

Epileptic disorders : international epilepsy journal with videotape 2024; (26(4)):484-497 doi:10.1002/epd2.20243.

Therapeutic strategies during cenobamate treatment initiation: Delphi panel recommendations.

Steinhoff BJ, Ben-Menachem E, Klein P, et al.

Therapeutic advances in neurological disorders 2024; (17()):17562864241256733 doi:10.1177/17562864241256733.

Anti-LGI-1 Limbic Encephalitis and Autoimmune Epilepsy Following a Third Dose of COVID-19 Vaccination: A Case Report.

Mullan G, Kinney M

The Neurohospitalist 2024; (14(3)):332-335 doi:10.1177/19418744241234100.

Short-Term Impact of Seizures and Mitigation Opportunities.

Glauser T, Becker DA, Long L, et al.

Current neurology and neuroscience reports 2024; (24(8)):303-314 doi:10.1007/s11910-024-01350-1.

Network signatures define consciousness state during focal seizures.

Doss DJ, Johnson GW, Makhoul GS, et al.

Epilepsia 2024; (65(9)):2686-2699 doi:10.1111/epi.18074.

Antiseizure Medications and Sudden Unexpected Death in Epilepsy: An Updated Review.

Bosch AT, Sander JW, Thijs RD

CNS drugs 2024; (38(10)):807-817 doi:10.1007/s40263-024-01112-0.

Treatment of prolonged seizure with diazepam nasal spray: An exploratory post hoc cohort analysis.

Jarrar R, Stern JM, Becker DA, et al.

Epilepsy & behavior : E&B 2024; (159()):109987 doi:10.1016/j.yebeh.2024.109987.

The Adverse Effects of Commonly Prescribed Antiseizure Medications in Adults With Newly Diagnosed Focal Epilepsy.

Barnard SN, Chen Z, Kanner AM, et al.

Neurology 2024; (103(7)):e209821 doi:10.1212/WNL.0000000000209821.

Ictal Involvement of the Pulvinar and the Anterior Nucleus of the Thalamus in Patients With Refractory Epilepsy.

McGinn R, Von Stein EL, Datta A, et al.

Neurology 2024; (103(11)):e210039 doi:10.1212/WNL.0000000000210039.

First Seizures, Acute Repetitive Seizures, and Status Epilepticus.

Vossler DG

Continuum (Minneapolis, Minn.) 2025; (31(1)):95-124 doi:10.1212/CON.0000000000001530.

Seizure Detection Devices.

Baumgartner C, Baumgartner J, Lang C, et al.

Journal of clinical medicine 2025; (14(3)) doi:10.3390/jcm14030863.

Harmonization of MRI sequences across ERN EpiCARE centers.

Adler S, D'Arco F, Mankad K, et al.

Epilepsia open 2025; (10(2)):587-592 doi:10.1002/epi4.13115.

Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy.

Beniczky S, Trinka E, Wirrell E, et al.

Epilepsia 2025; (66(6)):1804-1823 doi:10.1111/epi.18338.

Early Introduction of Cenobamate in Uncontrolled Focal Epilepsy: Insights from a Structured Controversy.

Labate A, Liguori C, Tartara E, et al.

Neurology and therapy 2025; (14(4)):1671-1684 doi:10.1007/s40120-025-00781-3.

Mapping Postictal Aphasia through Signal Complexity: A Stereo-Electroencephalography Study.

Bratu IF, Bénar CG, Villalon SM, et al.

Annals of neurology 2025; (98(5)):1080-1095 doi:10.1002/ana.27307.

Clinical features, including atypical symptoms, associated with acute cerebral ischaemia on DWI-MRI in suspected TIA and minor stroke.

Gallogly PC, Hassan J, Lee C, et al.

International journal of stroke : official journal of the International Stroke Society 2026; (21(3)):353-361 doi:10.1177/17474930251368895.

Treatment Response to Antiseizure Medications in People With Newly Diagnosed Focal Epilepsy.

Barnard SN, Chen Z, Holmes M, et al.

JAMA neurology 2025; (82(10)):1022-1030 doi:10.1001/jamaneurol.2025.2949.

Postictal status and clinical variables in adults with epilepsy.

Agostinho CF, Tedrus GMAS

Arquivos de neuro-psiquiatria 2025; (83(9)):1-6 doi:10.1055/s-0045-1811625.

Lateral septal inhibition of nucleus basalis through direct and indirect pathways in focal limbic seizures.

Liu J, Sieu LA, Shi I, et al.

bioRxiv : the preprint server for biology 2025; doi:10.1101/2025.09.17.676820.

Efficacy and safety of perampanel monotherapy in Chinese children with newly diagnosed focal epilepsy: a single-center prospective study.

Hong Y, Lu Y, Chen H, Liu Z

Translational pediatrics 2025; (14(10)):2758-2764 doi:10.21037/tp-2025-396.

Multi-unit activity and high-gamma patterns dissociate in the seizure onset zone during focal to bilateral tonic-clonic seizures.

Gorska-Klimowska U, Mat B, Denis C, et al.

medRxiv : the preprint server for health sciences 2025; doi:10.1101/2025.11.03.25339320.

Human Mediodorsal Thalamus in Seizure Propagation.

Marais O, Lozano C, Risman A, et al.

bioRxiv : the preprint server for biology 2025; doi:10.64898/2025.12.01.691640.

Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) and insights into the role of invasive monitoring.

Khoury J, Blümcke I, Busch RM, et al.

Epilepsia 2026; (67(5)):2227-2240 doi:10.1002/epi.70118.

Current perspectives in sudden unexpected death in epilepsy (SUDEP): epidemiology, research approaches and pathways to prevention.

Mann C, Schubert-Bast S, Rosenow F, Strzelczyk A

Neurological research and practice 2026; (8(1)).

Thalamocortical network dynamics in focal epilepsy: SEEG investigation.

Nester EM, Jayaram MA, Umesh T, et al.

bioRxiv : the preprint server for biology 2026; doi:10.64898/2026.03.05.709626.

Postictal Todd's Paralysis Mimicking Acute Ischemic Stroke in Medullary Melanocytoma: A Multimodal Diagnostic Challenge.

Ali S, Memari K, Lazo LP, et al.

Cureus 2026; (18(3)):e104991 doi:10.7759/cureus.104991.

Navigating safety and sudden unexpected death in epilepsy (SUDEP) discussions in adolescents with epilepsy: short-term outcomes of a structured counselling intervention.

Kumar S, Elwadhi A, Chowdhury SR, et al.

Epilepsy & behavior : E&B 2026; (182()):111134 doi:10.1016/j.yebeh.2026.111134.

Comparison of volume- and surface-based magnetic resonance imaging morphometry algorithms in the detection of focal cortical dysplasia.

Bücheler L, Reisert M, Demerath T, et al.

Epilepsia 2026; doi:10.1002/epi.70326.