Research & Literature

Review: an update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations.

Lashley T, Rohrer JD, Mead S, Revesz T

Neuropathology and applied neurobiology 2015; (41(7)):858-81 doi:10.1111/nan.12250.

Enhancing caregivers' understanding of dementia and tailoring activities in frontotemporal dementia: two case studies.

O'Connor CM, Clemson L, Brodaty H, et al.

Disability and rehabilitation 2016; (38(7)):704-14 doi:10.3109/09638288.2015.1055375.

The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.

Ossenkoppele R, Pijnenburg YA, Perry DC, et al.

Brain : a journal of neurology 2015; (138(Pt 9)):2732-49 doi:10.1093/brain/awv191.

Frontotemporal Dysfunction and Dementia in Amyotrophic Lateral Sclerosis.

Woolley SC, Strong MJ

Neurologic clinics 2015; (33(4)):787-805.

Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis.

Kansal K, Mareddy M, Sloane KL, et al.

Dementia and geriatric cognitive disorders 2016; (41(1-2)):109-22 doi:10.1159/000443205.

TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation.

Ishiguro A, Kimura N, Watanabe Y, et al.

Genes to cells : devoted to molecular & cellular mechanisms 2016; (21(5)):466-81 doi:10.1111/gtc.12352.

Aphasic variant of Alzheimer disease: Clinical, anatomic, and genetic features.

Rogalski E, Sridhar J, Rader B, et al.

Neurology 2016; (87(13)):1337-43 doi:10.1212/WNL.0000000000003165.

Amyloid Imaging: Poised for Integration into Medical Practice.

Anand K, Sabbagh M

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017; (14(1)):54-61 doi:10.1007/s13311-016-0474-y.

Self-Consciousness Deficits in Alzheimer's Disease and Frontotemporal Dementia.

Arroyo-Anlló EM, Bouston AT, Fargeau MN, et al.

Journal of Alzheimer's disease : JAD 2017; (55(4)):1437-1443 doi:10.3233/JAD-160770.

Pharmacological Management of Psychiatric Symptoms in Frontotemporal Dementia: A Systematic Review.

Buoli M, Serati M, Caldiroli A, et al.

Journal of geriatric psychiatry and neurology 2017; (30(3)):162-169 doi:10.1177/0891988717700506.

Atypical parkinsonian syndromes: a general neurologist's perspective.

Deutschländer AB, Ross OA, Dickson DW, Wszolek ZK

European journal of neurology 2018; (25(1)):41-58 doi:10.1111/ene.13412.

Diagnosing, monitoring and managing behavioural variant frontotemporal dementia.

Piguet O, Kumfor F, Hodges J

The Medical journal of Australia 2017; (207(7)):303-308 doi:10.5694/mja16.01458.

The tailored activity program (TAP) to address behavioral disturbances in frontotemporal dementia: a feasibility and pilot study.

O'Connor CM, Clemson L, Brodaty H, et al.

Disability and rehabilitation 2019; (41(3)):299-310 doi:10.1080/09638288.2017.1387614.

Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.

Watanabe R, Kawakami I, Onaya M, et al.

Neuropathology : official journal of the Japanese Society of Neuropathology 2018; (38(3)):281-287 doi:10.1111/neup.12442.

The Genetics of Monogenic Frontotemporal Dementia.

Takada LT

Dementia & neuropsychologia 2015; (9(3)):219-229 doi:10.1590/1980-57642015DN93000003.

Caregiver burden, sleep quality, depression, and anxiety in dementia caregivers: a comparison of frontotemporal lobar degeneration, dementia with Lewy bodies, and Alzheimer's disease.

Liu S, Liu J, Wang XD, et al.

International psychogeriatrics 2018; (30(8)):1131-1138 doi:10.1017/S1041610217002630.

Anosognosia in degenerative brain diseases: The role of the right hemisphere and of its dominance for emotions.

Gainotti G

Brain and cognition 2018; (127()):13-22 doi:10.1016/j.bandc.2018.08.002.

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.

Bergeron D, Gorno-Tempini ML, Rabinovici GD, et al.

Annals of neurology 2018; (84(5)):729-740 doi:10.1002/ana.25333.

A Review: Mealtime Difficulties following Frontotemporal Lobar Degeneration.

Lewis C, Walterfang M, Velakoulis D, Vogel AP

Dementia and geriatric cognitive disorders 2018; (46(5-6)):285-297 doi:10.1159/000494210.

Genetic screen in a large series of patients with primary progressive aphasia.

Ramos EM, Dokuru DR, Van Berlo V, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2019; (15(4)):553-560 doi:10.1016/j.jalz.2018.10.009.

Pharmacological Management of Dementia with Lewy Bodies.

Hershey LA, Coleman-Jackson R

Drugs & aging 2019; (36(4)):309-319 doi:10.1007/s40266-018-00636-7.

More than words: Social cognition across variants of primary progressive aphasia.

Fittipaldi S, Ibanez A, Baez S, et al.

Neuroscience and biobehavioral reviews 2019; (100()):263-284 doi:10.1016/j.neubiorev.2019.02.020.

A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia.

Ash S, Nevler N, Phillips J, et al.

Brain and language 2019; (194()):46-57 doi:10.1016/j.bandl.2019.04.006.

Understanding Frontotemporal Disease Progression and Management Strategies.

Mulkey M

The Nursing clinics of North America 2019; (54(3)):437-448 doi:10.1016/j.cnur.2019.04.011.

Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.

Miyagawa T, Brushaber D, Syrjanen J, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2020; (16(1)):79-90 doi:10.1016/j.jalz.2019.05.013.

New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.

Boxer AL, Gold M, Feldman H, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2020; (16(1)):131-143 doi:10.1016/j.jalz.2019.06.4956.

Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study.

van der Ende EL, Meeter LH, Poos JM, et al.

The Lancet. Neurology 2019; (18(12)):1103-1111 doi:10.1016/S1474-4422(19)30354-0.

When you hear hoofbeats, think horses and zebras: The importance of a wide differential when it comes to frontotemporal lobar degeneration.

Nathani M, Jaleel V, Turner A, et al.

Asian journal of psychiatry 2020; (47()):101875 doi:10.1016/j.ajp.2019.101875.

Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome.

Jabbari E, Holland N, Chelban V, et al.

JAMA neurology 2020; (77(3)):377-387 doi:10.1001/jamaneurol.2019.4347.

Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.

Miyagawa T, Brushaber D, Syrjanen J, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2020; (16(1)):106-117 doi:10.1002/alz.12033.

Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.

Heuer HW, Wang P, Rascovsky K, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2020; (16(1)):60-70 doi:10.1002/alz.12046.

Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.

Thijssen EH, La Joie R, Wolf A, et al.

Nature medicine 2020; (26(3)):387-397 doi:10.1038/s41591-020-0762-2.

The role of neurofilament light chain in frontotemporal dementia: a meta-analysis.

Karantali E, Kazis D, Chatzikonstantinou S, et al.

Aging clinical and experimental research 2021; (33(4)):869-881 doi:10.1007/s40520-020-01554-8.

Neuropsychiatric Aspects of Frontotemporal Dementia.

Younes K, Miller BL

The Psychiatric clinics of North America 2020; (43(2)):345-360 doi:10.1016/j.psc.2020.02.005.

Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis.

Cajanus A, Katisko K, Kontkanen A, et al.

Annals of clinical and translational neurology 2020; (7(6)):903-910 doi:10.1002/acn3.51041.

Disease Progression in Frontotemporal Dementia and Alzheimer Disease: The Contribution of Staging Scales.

Lima-Silva TB, Mioshi E, Bahia VS, et al.

Journal of geriatric psychiatry and neurology 2021; (34(5)):397-404 doi:10.1177/0891988720944239.

Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants.

Staffaroni AM, Goh SM, Cobigo Y, et al.

JAMA network open 2020; (3(10)):e2022847 doi:10.1001/jamanetworkopen.2020.22847.

Young-onset frontotemporal dementia with FUS pathology.

Gowell M, Baker I, Ansorge O, Husain M

Practical neurology 2020; doi:10.1136/practneurol-2020-002730.

Characteristics and progression of patients with frontotemporal dementia in a regional memory clinic network.

Leroy M, Bertoux M, Skrobala E, et al.

Alzheimer's research & therapy 2021; (13(1)):19 doi:10.1186/s13195-020-00753-9.

The Neuropsychiatric Features of Behavioral Variant Frontotemporal Dementia.

Peet BT, Castro-Suarez S, Miller BL

Advances in experimental medicine and biology 2021; (1281()):17-31 doi:10.1007/978-3-030-51140-1_2.

Predictors of survival in frontotemporal lobar degeneration syndromes.

El-Wahsh S, Finger EC, Piguet O, et al.

Journal of neurology, neurosurgery, and psychiatry 2021; doi:10.1136/jnnp-2020-324349.

Diagnostic value of amyloid-PET and tau-PET: a head-to-head comparison.

Altomare D, Caprioglio C, Assal F, et al.

European journal of nuclear medicine and molecular imaging 2021; (48(7)):2200-2211 doi:10.1007/s00259-021-05246-x.

Differential early subcortical involvement in genetic FTD within the GENFI cohort.

Bocchetta M, Todd EG, Peakman G, et al.

NeuroImage. Clinical 2021; (30()):102646 doi:10.1016/j.nicl.2021.102646.

The natural history of primary progressive aphasia: beyond aphasia.

Ulugut H, Stek S, Wagemans LEE, et al.

Journal of neurology 2022; (269(3)):1375-1385 doi:10.1007/s00415-021-10689-1.

Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.

Duran-Aniotz C, Orellana P, Leon Rodriguez T, et al.

Frontiers in neurology 2021; (12()):663407 doi:10.3389/fneur.2021.663407.

Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology.

Peet BT, Spina S, Mundada N, La Joie R

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021; (18(2)):728-752 doi:10.1007/s13311-021-01101-x.

Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.

Legaz A, Abrevaya S, Dottori M, et al.

Brain : a journal of neurology 2022; (145(3)):1052-1068 doi:10.1093/brain/awab345.

Behavioral and Cognitive Response to Selective Serotonin Reuptake Inhibitors in Frontotemporal Lobar Degeneration: A Systematic Review and Meta-analysis.

Nisar M, Abubaker ZJ, Nizam MA, et al.

Clinical neuropharmacology 2021; (44(5)):175-183 doi:10.1097/WNF.0000000000000469.

Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.

Geraudie A, Battista P, García AM, et al.

Neuroscience and biobehavioral reviews 2021; (131()):1076-1095 doi:10.1016/j.neubiorev.2021.10.015.

In Vivo 18 F-APN-1607 Tau Positron Emission Tomography Imaging in MAPT Mutations: Cross-Sectional and Longitudinal Findings.

Zhou XY, Lu JY, Liu FT, et al.

Movement disorders : official journal of the Movement Disorder Society 2022; (37(3)):525-534 doi:10.1002/mds.28867.

The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.

Silverman HE, Ake JM, Manoochehri M, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2022; (18(9)):1635-1649 doi:10.1002/alz.12494.

Diminished preparatory physiological responses in frontotemporal lobar degeneration syndromes.

Chen KH, Hua AY, Toller G, et al.

Brain communications 2022; (4(2)):fcac075 doi:10.1093/braincomms/fcac075.

Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism.

Jung NY, Park KH, Seo SW, et al.

Journal of clinical medicine 2022; (11(8)) doi:10.3390/jcm11082260.

Biological basis and psychiatric symptoms in frontotemporal dementia.

Mori K, Ikeda M

Psychiatry and clinical neurosciences 2022; (76(8)):351-360 doi:10.1111/pcn.13375.

Advances in Treatment of Frontotemporal Dementia.

Magrath Guimet N, Zapata-Restrepo LM, Miller BL

The Journal of neuropsychiatry and clinical neurosciences 2022; (34(4)):316-327 doi:10.1176/appi.neuropsych.21060166.

Behavioral Variant Frontotemporal Dementia.

Boeve BF

Continuum (Minneapolis, Minn.) 2022; (28(3)):702-725 doi:10.1212/CON.0000000000001105.

Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.

Younes K, Borghesani V, Montembeault M, et al.

Brain : a journal of neurology 2022; (145(11)):4080-4096 doi:10.1093/brain/awac217.

Neuroimmune dysfunction in frontotemporal dementia: Insights from progranulin and C9orf72 deficiency.

Hashimoto K, Jahan N, Miller ZA, Huang EJ

Current opinion in neurobiology 2022; (76()):102599 doi:10.1016/j.conb.2022.102599.

The CBI-R detects early behavioural impairment in genetic frontotemporal dementia.

Nelson A, Russell LL, Peakman G, et al.

Annals of clinical and translational neurology 2022; (9(5)):644-658 doi:10.1002/acn3.51544.

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.

Perry A, Hughes LE, Adams N, et al.

Translational psychiatry 2022; (12(1)):348 doi:10.1038/s41398-022-02114-6.

Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias.

Baiardi S, Quadalti C, Mammana A, et al.

Alzheimer's research & therapy 2022; (14(1)):153 doi:10.1186/s13195-022-01093-6.

White-matter abnormalities in presymptomatic GRN and C9orf72 mutation carriers.

Lee H, Mackenzie IRA, Beg MF, et al.

Brain communications 2023; (5(1)):fcac333 doi:10.1093/braincomms/fcac333.

Bilateral post-traumatic hygromas in patient with frontotemporal dementia.

Scalia G, Marrone S, Costanzo R, et al.

Surgical neurology international 2022; (13()):597 doi:10.25259/SNI_1056_2022.

Behavioral variant frontotemporal dementia in patients with primary psychiatric disorder: A magnetic resonance imaging study.

Tafuri B, Filardi M, Frisullo ME, et al.

Brain and behavior 2023; (13(4)):e2896 doi:10.1002/brb3.2896.

New Approaches to the Treatment of Frontotemporal Dementia.

Neylan KD, Miller BL

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2023; (20(4)):1055-1065 doi:10.1007/s13311-023-01380-6.

Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers.

Bede P, Lulé D, Müller HP, et al.

Journal of neurology 2023; (270(9)):4235-4247 doi:10.1007/s00415-023-11764-5.

Social Cognition in Behavioral Variant Frontotemporal Dementia and Pathological Subtypes: A Narrative Review.

Dilcher R, Malpas CB, O'Brien TJ, Vivash L

Journal of Alzheimer's disease : JAD 2023; (94(1)):19-38 doi:10.3233/JAD-221171.

Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.

Zhang L, Flagan TM, Häkkinen S, et al.

Annals of neurology 2023; (94(4)):632-646 doi:10.1002/ana.26738.

Psychological and social impacts of frontotemporal dementia on caregivers and family members - A systematic review.

Tan YL, Lo YKJ, Ho CSH

General hospital psychiatry 2024; (86()):33-49 doi:10.1016/j.genhosppsych.2023.11.011.

Palliative Care in Neuro-oncology.

Besbris JM, Taylor LP

Seminars in neurology 2024; (44(1)):26-35 doi:10.1055/s-0043-1777703.

Progress in Primary Progressive Aphasia: A Review.

Kertesz A, Finger E, Munoz DG

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 2024; (37(1)):3-12 doi:10.1097/WNN.0000000000000365.

Time to Diagnosis and Its Predictors in Syndromes Associated With Frontotemporal Lobar Degeneration.

Libri I, Altomare D, Bracca V, et al.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2024; (32(8)):1004-1013 doi:10.1016/j.jagp.2024.03.002.

Identifying and Addressing Functional Communication Challenges in Patients With Behavioral Variant Frontotemporal Dementia.

Meade G, Machulda MM, Clark HM, et al.

American journal of speech-language pathology 2024; (33(4)):1573-1589 doi:10.1044/2024_AJSLP-24-00013.

Association of cortical morphology, white matter hyperintensity, and glymphatic function in frontotemporal dementia variants.

Xiao D, Li J, Ren Z, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2024; (20(9)):6045-6059 doi:10.1002/alz.14158.

Trajectories of behavior and social cognition in behavioral variant frontotemporal dementia and primary psychiatric disorders: A call for better operationalization of socioemotional changes.

Fieldhouse JLP, van Engelen ME, Handgraaf D, et al.

European journal of neurology 2024; (31(12)):e16426 doi:10.1111/ene.16426.

RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy.

Burrows DJ, McGown A, Abduljabbar O, et al.

Annals of neurology 2024; (96(6)):1058-1069 doi:10.1002/ana.27068.

Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration.

Ahmad S, Imtiaz MA, Mishra A, et al.

Communications biology 2024; (7(1)):1103 doi:10.1038/s42003-024-06804-3.

Treatment of Alzheimer Disease.

Geldmacher DS

Continuum (Minneapolis, Minn.) 2024; (30(6)):1823-1844 doi:10.1212/CON.0000000000001503.

Musicality and social cognition in dementia: clinical and anatomical associations.

van 't Hooft JJ, Hartog WL, Braun M, et al.

Brain communications 2024; (6(6)):fcae429 doi:10.1093/braincomms/fcae429.

Decoding TDP-43: the molecular chameleon of neurodegenerative diseases.

Zeng J, Luo C, Jiang Y, et al.

Acta neuropathologica communications 2024; (12(1)):205 doi:10.1186/s40478-024-01914-9.

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.

Sheth U, Öijerstedt L, Heckman MG, et al.

Molecular neurodegeneration 2025; (20(1)):30 doi:10.1186/s13024-025-00821-4.

Elements of effective palliative care interventions in advanced heart failure: A narrative review.

Allcroft P, De Pasquale CG, Lim D, et al.

ESC heart failure 2025; (12(3)):1759-1775 doi:10.1002/ehf2.15243.

Diagnostic performance of plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL along the continuum of Alzheimer's disease and non-AD dementias: An international multi-center study.

Doecke JD, Bellomo G, Vermunt L, et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association 2025; (21(6)):e14573 doi:10.1002/alz.14573.

Survival rates in frontotemporal dementia and Alzheimer's disease.

Foxe D, Muggleton J, Cheung SC, et al.

Neurodegenerative disease management 2025; (15(5)):191-197 doi:10.1080/17582024.2025.2527553.

Frontotemporal Lobar degeneration with TDP-43 presenting as progressive supranuclear palsy syndrome.

Murakami A, Koga S, Sekiya H, et al.

Acta neuropathologica communications 2025; (13(1)):151 doi:10.1186/s40478-025-02058-0.

Progressive Supranuclear Palsy and Corticobasal Syndrome.

McFarland NR

Continuum (Minneapolis, Minn.) 2025; (31(4)):1023-1049 doi:10.1212/cont.0000000000001607.

Language and psychiatric symptom overlap in FTD: an SLP perspective.

Masson-Trottier M

International review of psychiatry (Abingdon, England) 2025; (37(8)):781-794 doi:10.1080/09540261.2025.2583258.

The Impact of Caring on Psychological Wellbeing: A Qualitative Study in Carers of People Living With Behavioural-Variant Frontotemporal Dementia.

Ocampo IM, Todd J, Wei G, Kumfor F

Journal of geriatric psychiatry and neurology 2026; (39(4)):534-548 doi:10.1177/08919887251401262.

Second-generation antipsychotics - Cardiac ion channel modulation and QT interval disturbances: A review.

Erkan O, Dai AS, Ozturk N, Ozdemir S

Biomolecules & biomedicine 2025; (26(6)):895-911 doi:10.17305/bb.2025.13405.

A Review of Dementia Caregiver Interventions: Valuing Psychological Well-Being and Economic Impact Through the State-Preference Method.

Consiglio A, Lopez A, Bosco A

International journal of environmental research and public health 2026; (23(1)) doi:10.3390/ijerph23010104.

Timing and outcomes of outpatient palliative care consultations in advanced cancer.

Torres-Tenor JL, Bruera E, Ortí-Hortelano MJ, et al.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026; doi:10.1007/s12094-026-04276-x.