Research & Literature

Multimodal effective connectivity analysis reveals seizure focus and propagation in musicogenic epilepsy.

Klamer S, Rona S, Elshahabi A, et al.

NeuroImage 2015; (113()):70-7.

Valproate in the treatment of epilepsy in girls and women of childbearing potential.

Tomson T, Marson A, Boon P, et al.

Epilepsia 2015; (56(7)):1006-19 doi:10.1111/epi.13021.

Minimally invasive surgical approaches for temporal lobe epilepsy.

Chang EF, Englot DJ, Vadera S

Epilepsy & behavior : E&B 2015; (47()):24-33.

Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus--approach to clinical application.

Leitinger M, Beniczky S, Rohracher A, et al.

Epilepsy & behavior : E&B 2015; (49()):158-63.

Temporal lobe epilepsy in patients with nonlesional MRI and normal memory: an SEEG study.

Suresh S, Sweet J, Fastenau PS, et al.

Journal of neurosurgery 2015; (123(6)):1368-74 doi:10.3171/2015.1.JNS141811.

DEPDC5 mutations are not a frequent cause of familial temporal lobe epilepsy.

Striano P, Serioli E, Santulli L, et al.

Epilepsia 2015; (56(10)):e168-71 doi:10.1111/epi.13094.

Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies.

Wilson RD, , Wilson RD, et al.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 2015; (37(6)):534-52 doi:10.1016/s1701-2163(15)30230-9.

The Utility of Positron Emission Tomography in Epilepsy.

Burneo JG, Poon R, Kellett S, Snead OC

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2015; (42(6)):360-71 doi:10.1017/cjn.2015.279.

Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy.

Ricos MG, Hodgson BL, Pippucci T, et al.

Annals of neurology 2016; (79(1)):120-31 doi:10.1002/ana.24547.

Screening LGI1 in a cohort of 26 lateral temporal lobe epilepsy patients with auditory aura from Turkey detects a novel de novo mutation.

Kesim YF, Uzun GA, Yucesan E, et al.

Epilepsy research 2016; (120()):73-8.

Predictors of and attitudes toward counseling about SUDEP and other epilepsy risk factors among Austrian, German, and Swiss neurologists and neuropediatricians.

Strzelczyk A, Zschebek G, Bauer S, et al.

Epilepsia 2016; (57(4)):612-20 doi:10.1111/epi.13337.

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society.

Glauser T, Shinnar S, Gloss D, et al.

Epilepsy currents 2016; (16(1)):48-61 doi:10.5698/1535-7597-16.1.48.

Steps to prevent SUDEP: the validity of risk factors in the SUDEP and seizure safety checklist: a case control study.

Shankar R, Walker M, McLean B, et al.

Journal of neurology 2016; (263(9)):1840-6 doi:10.1007/s00415-016-8203-3.

Use of Antiepileptic Drugs During Pregnancy: Evolving Concepts.

Pennell PB

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2016; (13(4)):811-820 doi:10.1007/s13311-016-0464-0.

Mesial temporal lobe epilepsy - An overview of surgical techniques.

Muzumdar D, Patil M, Goel A, et al.

International journal of surgery (London, England) 2016; (36(Pt B)):411-419 doi:10.1016/j.ijsu.2016.10.027.

What can we do for people with drug-resistant epilepsy? The 2016 Wartenberg Lecture.

Engel J

Neurology 2016; (87(23)):2483-2489 doi:10.1212/WNL.0000000000003407.

The clinical phenotype of autosomal dominant lateral temporal lobe epilepsy related to reelin mutations.

Michelucci R, Pulitano P, Di Bonaventura C, et al.

Epilepsy & behavior : E&B 2017; (68()):103-107 doi:10.1016/j.yebeh.2016.12.003.

Real-world utility of whole exome sequencing with targeted gene analysis for focal epilepsy.

Perucca P, Scheffer IE, Harvey AS, et al.

Epilepsy research 2017; (131()):1-8 doi:10.1016/j.eplepsyres.2017.02.001.

Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy.

Geller EB, Skarpaas TL, Gross RE, et al.

Epilepsia 2017; (58(6)):994-1004 doi:10.1111/epi.13740.

Memory assessment in patients with temporal lobe epilepsy to predict memory impairment after surgery: A systematic review.

Parra-Díaz P, García-Casares N

Neurologia 2019; (34(9)):596-606 doi:10.1016/j.nrl.2017.02.012.

Familial mesial temporal lobe epilepsy and the borderland of déjà vu.

Perucca P, Crompton DE, Bellows ST, et al.

Annals of neurology 2017; (82(2)):166-176 doi:10.1002/ana.24984.

Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Harden C, Tomson T, Gloss D, et al.

Epilepsy currents 2017; (17(3)):180-187 doi:10.5698/1535-7511.17.3.180.

The usefulness of stereo-electroencephalography (SEEG) in the surgical management of focal epilepsy associated with "hidden" temporal pole encephalocele: a case report and literature review.

de Souza JPSAS, Mullin J, Wathen C, et al.

Neurosurgical review 2018; (41(1)):347-354 doi:10.1007/s10143-017-0922-0.

Potentially high-risk cardiac arrhythmias with focal to bilateral tonic-clonic seizures and generalized tonic-clonic seizures are associated with the duration of periictal hypoxemia.

Park KJ, Sharma G, Kennedy JD, Seyal M

Epilepsia 2017; (58(12)):2164-2171 doi:10.1111/epi.13934.

Brain regions and epileptogenicity influence epileptic interictal spike production and propagation during NREM sleep in comparison with wakefulness.

Lambert I, Roehri N, Giusiano B, et al.

Epilepsia 2018; (59(1)):235-243 doi:10.1111/epi.13958.

Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero.

Bjørk M, Riedel B, Spigset O, et al.

JAMA neurology 2018; (75(2)):160-168 doi:10.1001/jamaneurol.2017.3897.

Verbal learning and memory outcome in selective amygdalohippocampectomy versus temporal lobe resection in patients with hippocampal sclerosis.

Foged MT, Vinter K, Stauning L, et al.

Epilepsy & behavior : E&B 2018; (79()):180-187 doi:10.1016/j.yebeh.2017.12.007.

The incidence and significance of periictal apnea in epileptic seizures.

Lacuey N, Zonjy B, Hampson JP, et al.

Epilepsia 2018; (59(3)):573-582 doi:10.1111/epi.14006.

Efficacy and safety of eslicarbazepine acetate versus controlled-release carbamazepine monotherapy in newly diagnosed epilepsy: A phase III double-blind, randomized, parallel-group, multicenter study.

Trinka E, Ben-Menachem E, Kowacs PA, et al.

Epilepsia 2018; (59(2)):479-491 doi:10.1111/epi.13993.

Epilepsy with auditory features: Long-term outcome and predictors of terminal remission.

Bisulli F, Menghi V, Vignatelli L, et al.

Epilepsia 2018; (59(4)):834-843 doi:10.1111/epi.14033.

Getting the best outcomes from epilepsy surgery.

Vakharia VN, Duncan JS, Witt JA, et al.

Annals of neurology 2018; (83(4)):676-690 doi:10.1002/ana.25205.

Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy.

Anyanwu C, Motamedi GK

Brain sciences 2018; (8(4)) doi:10.3390/brainsci8040049.

Phenotypic spectrum in families with mesial temporal lobe epilepsy probands.

Cvetkovska E, Kuzmanovski I, Babunovska M, et al.

Seizure 2018; (58()):13-16 doi:10.1016/j.seizure.2018.03.019.

Efficacy of antiepileptic drugs in the adjunctive treatment of refractory partial-onset seizures: Meta-analysis of pivotal trials.

Slater J, Chung S, Huynh L, et al.

Epilepsy research 2018; (143()):120-129 doi:10.1016/j.eplepsyres.2017.10.004.

Seizure cluster: Definition, prevalence, consequences, and management.

Jafarpour S, Hirsch LJ, Gaínza-Lein M, et al.

Seizure 2019; (68()):9-15 doi:10.1016/j.seizure.2018.05.013.

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Kanner AM, Ashman E, Gloss D, et al.

Epilepsy currents 2018; (18(4)):260-268 doi:10.5698/1535-7597.18.4.260.

Sudden unexpected death in epilepsy: Risk factors, biomarkers, and prevention.

DeGiorgio CM, Curtis A, Hertling D, Moseley BD

Acta neurologica Scandinavica 2019; (139(3)):220-230 doi:10.1111/ane.13049.

Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP).

Vilella L, Lacuey N, Hampson JP, et al.

Neurology 2019; (92(3)):e171-e182 doi:10.1212/WNL.0000000000006785.

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient.

Ryvlin P, Rheims S, Lhatoo SD

Current opinion in neurology 2019; (32(2)):205-212 doi:10.1097/WCO.0000000000000668.

Epilepsy: a cross-sectional study of paediatricians and general practitioners on their experiences, knowledge and handling of the disease.

Schnabel S, Neininger MP, Bernhard MK, et al.

Epileptic disorders : international epilepsy journal with videotape 2019; (21(2)):197-205 doi:10.1684/epd.2019.1048.

SUDEP in the North American SUDEP Registry: The full spectrum of epilepsies.

Verducci C, Hussain F, Donner E, et al.

Neurology 2019; (93(3)):e227-e236 doi:10.1212/WNL.0000000000007778.

Clinical, semiological, electroencephalographic, and neuropsychological features of "pure" neocortical temporal lobe epilepsy.

Maizuliana H, Usui N, Terada K, et al.

Epileptic disorders : international epilepsy journal with videotape 2020; (22(1)):55-65 doi:10.1684/epd.2020.1132.

Generalized convulsive status epilepticus after retrograde type A aortic dissection surgery.

Li Y, Wu Q, Shi H, et al.

Perfusion 2021; (36(3)):318-321 doi:10.1177/0267659120943158.

Autosomal dominant lateral temporal lobe epilepsy associated with a novel reelin mutation.

Michelucci R, Dazzo E, Volpi L, et al.

Epileptic disorders : international epilepsy journal with videotape 2020; (22(4)):443-448 doi:10.1684/epd.2020.1176.

Epilepsy.

Benson R, Pack A

Handbook of clinical neurology 2020; (172()):155-167 doi:10.1016/B978-0-444-64240-0.00009-X.

Familial mesial temporal lobe epilepsy in Mexico: Inheritance pattern and clinical features.

Guzmán-Jiménez DE, Campos JB, Venegas-Vega CA, et al.

Epilepsy research 2020; (167()):106450 doi:10.1016/j.eplepsyres.2020.106450.

Can We Prevent Sudden Unexpected Death in Epilepsy (SUDEP)?

Bhasin H, Sharma S, Ramachandrannair R

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2021; (48(4)):464-468 doi:10.1017/cjn.2020.221.

Electroencephalographic Seizures in Emergency Department Patients After Treatment for Convulsive Status Epilepticus.

Zehtabchi S, Silbergleit R, Chamberlain JM, et al.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2022; (39(6)):441-445 doi:10.1097/WNP.0000000000000800.

Resistant Temporal Lobe Epilepsy: Initial Steps into a Bigger Epilepsy Surgery Program.

Mehrotra A, Singh S, Kanjilal S, et al.

Journal of neurosciences in rural practice 2021; (12(1)):193-196 doi:10.1055/s-0040-1716796.

[SUDEP in brief - knowledge and practice recommendations on sudden unexpected death in epilepsy].

Surges R, Conrad S, Hamer HM, et al.

Der Nervenarzt 2021; (92(8)):809-815 doi:10.1007/s00115-021-01075-3.

Non-lesional mesial temporal lobe epilepsy requires bilateral invasive evaluation.

Perven G, Podkorytova I, Ding K, et al.

Epilepsy & behavior reports 2021; (15()):100441 doi:10.1016/j.ebr.2021.100441.

Lacosamide add-on therapy for focal epilepsy.

Babar RK, Bresnahan R, Gillespie CS, Michael BD

The Cochrane database of systematic reviews 2021; (5()):CD008841 doi:10.1002/14651858.CD008841.pub3.

Phenotypic and Genotypic Characterization of DEPDC5-Related Familial Focal Epilepsy: Case Series and Literature Review.

Zhang X, Huang Z, Liu J, et al.

Frontiers in neurology 2021; (12()):641019 doi:10.3389/fneur.2021.641019.

Evaluation and management of drug resistant epilepsy in children.

Kumar G

Current problems in pediatric and adolescent health care 2021; (51(7)):101035 doi:10.1016/j.cppeds.2021.101035.

Comparison of T2 relaxometry and PET CT in the evaluation of patients with mesial temporal lobe epilepsy using video EEG as the reference standard.

Varatharajaperumal RK, Arkar R, Arunachalam VK, et al.

Polish journal of radiology 2021; (86()):e601-e607 doi:10.5114/pjr.2021.111058.

Management of status epilepticus: a narrative review.

Migdady I, Rosenthal ES, Cock HR

Anaesthesia 2022; (77 Suppl 1()):78-91 doi:10.1111/anae.15606.

Molecular typing of familial temporal lobe epilepsy.

Liu C, Qiao XZ, Wei ZH, et al.

World journal of psychiatry 2022; (12(1)):98-107 doi:10.5498/wjp.v12.i1.98.

Epilepsy With Auditory Features: From Etiology to Treatment.

Furia A, Licchetta L, Muccioli L, et al.

Frontiers in neurology 2021; (12()):807939 doi:10.3389/fneur.2021.807939.

Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study.

Pennell PB, Karanam A, Meador KJ, et al.

JAMA neurology 2022; (79(4)):370-379 doi:10.1001/jamaneurol.2021.5487.

Neuromodulation for Refractory Epilepsy.

Ryvlin P, Jehi LE

Epilepsy currents 2022; (22(1)):11-17 doi:10.1177/15357597211065587.

Piloting positive psychology resources for caregivers of a child with a genetic developmental and epileptic encephalopathy.

Nevin SM, Wakefield CE, Le Marne F, et al.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2022; (37()):129-138 doi:10.1016/j.ejpn.2022.01.022.

Ictal aphasia in LGI1-related autosomal dominant epilepsy with auditory features.

Moloney PB, McHugh J, O'Byrne J, et al.

Practical neurology 2022; (22(4)):317-320 doi:10.1136/practneurol-2022-003366.

Sleep and Temporal Lobe Epilepsy - Associations, Mechanisms and Treatment Implications.

Garg D, Charlesworth L, Shukla G

Frontiers in human neuroscience 2022; (16()):849899 doi:10.3389/fnhum.2022.849899.

Practical considerations in epilepsy neurostimulation.

Simpson HD, Schulze-Bonhage A, Cascino GD, et al.

Epilepsia 2022; (63(10)):2445-2460 doi:10.1111/epi.17329.

Introduction to use of an acute seizure action plan for seizure clusters and guidance for implementation.

Patel AD, Becker DA

Epilepsia 2022; (63 Suppl 1()):S25-S33 doi:10.1111/epi.17344.

Current Management of Generalized Convulsive Status Epilepticus in Children.

Aulická Š

Children (Basel, Switzerland) 2022; (9(10)) doi:10.3390/children9101586.

Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.

Meng TC, Szaflarski JP, Chen L, et al.

Epilepsy & behavior : E&B 2023; (138()):108989 doi:10.1016/j.yebeh.2022.108989.

Metabolic profiles and correlation with surgical outcomes in mesial versus neocortical temporal lobe epilepsy.

Zhu HY, Tang YX, Xiao L, et al.

CNS neuroscience & therapeutics 2023; (29(9)):2656-2665 doi:10.1111/cns.14209.

Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre cohort study.

Youngerman BE, Banu MA, Khan F, et al.

Journal of neurology, neurosurgery, and psychiatry 2023; (94(11)):879-886 doi:10.1136/jnnp-2022-330979.

Drug resistance in epilepsy.

Perucca E, Perucca P, White HS, Wirrell EC

The Lancet. Neurology 2023; (22(8)):723-734 doi:10.1016/S1474-4422(23)00151-5.

Familial Mesial Temporal Lobe Epilepsy: Clinical Spectrum and Genetic Evidence for a Polygenic Architecture.

Harris RV, Oliver KL, Perucca P, et al.

Annals of neurology 2023; (94(5)):825-835 doi:10.1002/ana.26765.

Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.

Bromley R, Adab N, Bluett-Duncan M, et al.

The Cochrane database of systematic reviews 2023; (8()):CD010224 doi:10.1002/14651858.CD010224.pub3.

Taking a Newer, Faster, Intranasal Route: A Narrative Review of Transitioning to a Less-Invasive Rescue Treatment for Seizure Clusters.

Peters JM, Becker DA, Misra SN, et al.

Patient preference and adherence 2024; (18()):383-389 doi:10.2147/PPA.S447028.

Benzodiazepines for the Treatment of Seizure Clusters.

Penovich PE, Rao VR, Long L, et al.

CNS drugs 2024; (38(2)):125-140 doi:10.1007/s40263-023-01060-1.

A de novo pathogenic variant in MICAL-1 causes epilepsy with auditory features.

Bonanni P, Giorda R, Michelucci R, et al.

Epilepsia open 2024; (9(3)):1083-1087 doi:10.1002/epi4.12937.

DEPDC5 plays a vital role in epilepsy: Genotypic and phenotypic features in cohort and literature.

Gu C, Wei X, Yan D, et al.

Epileptic disorders : international epilepsy journal with videotape 2024; (26(3)):341-349 doi:10.1002/epd2.20223.

Laser Interstitial Thermal Therapy versus Open Surgery for Mesial Temporal Lobe Epilepsy: A Systematic Review and Meta-Analysis.

Ekman FR, Bjellvi J, Ljunggren S, et al.

World neurosurgery 2024; (192()):224-235.e15 doi:10.1016/j.wneu.2024.09.090.

Exploration of epileptic networks in temporal lobe encephaloceles with stereotactic EEG: Electroclinical characteristics and surgical outcomes.

Zillgitt AJ, Mong ER, Manasseh AM, et al.

Epilepsia open 2024; (9(6)):2395-2407 doi:10.1002/epi4.13063.

Investigating the effect of polygenic background on epilepsy phenotype in 'monogenic' families.

Oliver KL, Scheffer IE, Ellis CA, et al.

EBioMedicine 2024; (109()):105404 doi:10.1016/j.ebiom.2024.105404.

Advances in Therapy for Refractory Epilepsy.

Jehi L

Annual review of medicine 2025; (76(1)):389-402 doi:10.1146/annurev-med-050522-034458.

An examination of seizure-free outcome and visual field deficits: Anterior temporal lobectomy versus selective amygdalohippocampectomy for temporal lobe epilepsy-a systematic review and meta-analysis for comprehensive understanding.

Rangwala BS, Rangwala HS, Shafique MA, et al.

Acta neurochirurgica 2024; (166(1)):487 doi:10.1007/s00701-024-06383-6.

Incidence and risk factors of sudden unexpected death in epilepsy in rural Northeast China.

Li R, Zhao D, Hu B, et al.

Seizure 2025; (126()):99-105 doi:10.1016/j.seizure.2025.02.011.

DEPDC5-Related Familial Focal Epilepsy With Variable Foci-1: A Report of a Rare Case.

Itani A, Banjade P, Shrestha U, et al.

Cureus 2025; (17(5)):e84627 doi:10.7759/cureus.84627.

Incomplete penetrance and variable phenotypes of a novel NPRL2 frameshift variant: from familial focal epilepsy with variable foci 2 to neurodevelopmental disorders.

Zhu H, Wang Q, Deng W, et al.

BMC neurology 2025; (25(1)):331 doi:10.1186/s12883-025-04339-6.

Phenotypic variation in a family with GABRG2-related epilepsy caused by a novel missense variant.

Akiba T, Yamoto K, Hiraide T, et al.

Seizure 2025; (131()):340-343 doi:10.1016/j.seizure.2025.08.012.

Crisis-like Seizure Exacerbations in NPRL3-related Epilepsy: Phenotypic Features and Treatment Outcomes.

Thormeyer V, Meyer Z, Polster T, et al.

Neuropediatrics 2026; (57(1)):17-26 doi:10.1055/a-2731-4858.

Long-term predictors of seizure outcome after anterior temporal lobectomy in unilateral hippocampal sclerosis: A 281-patient cohort with mean 10-year follow-up.

Rodrigues TP, Bocca LF, Yacubian EMT, et al.

Epileptic disorders : international epilepsy journal with videotape 2026; (28(1)):84-96 doi:10.1002/epd2.70139.

Seizure control, delivery, and neonatal outcomes in pregnant women with focal epilepsies: a prospective cohort study.

Melikova S, Mammadbayli A

Seizure 2025; (134()):117-125 doi:10.1016/j.seizure.2025.11.018.

Genetic testing for familial epilepsies: Diagnostic yield and genetic findings.

Ellis CA, Copeland J, Velez I, et al.

Epilepsia 2026; (67(6)):3048-3057 doi:10.1002/epi.70160.

Aberrant RNA splicing caused by variant in DEPDC5 identified in a patient with pharmacoresistant epilepsy.

Zhou C, Wei X, Xiang Q, et al.

Neurogenetics 2026; (27(1)).

Does classical semiology ("5As") predict post-operative seizure outcome in patients with temporal lobe epilepsy?

Radhakrishnan A, Sanjay RL, Bharanidharan G, et al.

Epileptic disorders : international epilepsy journal with videotape 2026; (28(4)):1221-1235 doi:10.1002/epd2.70285.

Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy.

Rahimi S, Silvagni F, Matulewicz P, et al.

Frontiers in neuroscience 2026; (20()):1824376 doi:10.3389/fnins.2026.1824376.