Research & Literature

Aromatase inhibitors for short stature in male children and adolescents.

McGrath N, O'Grady MJ

The Cochrane database of systematic reviews 2015; CD010888 doi:10.1002/14651858.CD010888.pub2.

Associations between Psychological Problems and Quality of Life in Pediatric Short Stature from Patients' and Parents' Perspectives.

Quitmann JH, Bullinger M, Sommer R, et al.

PloS one 2016; (11(4)):e0153953 doi:10.1371/journal.pone.0153953.

Ghrelin Receptor Mutations and Human Obesity.

Wang W, Tao YX

Progress in molecular biology and translational science 2016; (140()):131-50.

Ghrelin and Growth.

Perchard R, Clayton PE

Endocrine development 2017; (32()):74-86 doi:10.1159/000475732.

Children's psychosocial functioning and parents' quality of life in paediatric short stature: The mediating role of caregiving stress.

Silva N, Bullinger M, Sommer R, et al.

Clinical psychology & psychotherapy 2018; (25(1)):e107-e118 doi:10.1002/cpp.2146.

Baseline IGFBP - 3 as the Key Element to Predict Growth Response to Growth Hormone and IGF - 1 Therapy in Subjects with Non - GH Deficient Short Stature and IGF - 1 Deficiency.

Perez-Colon S, Lazareva O, Purushothaman R, et al.

International journal of endocrinology and metabolism 2018; (16(3)):e58928 doi:10.5812/ijem.58928.

Efficacy and safety of recombinant human growth hormone in treating Chinese children with idiopathic short stature.

Ying YQ, Hou L, Liang Y, et al.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2018; (42-43()):80-85 doi:10.1016/j.ghir.2018.09.003.

CHALLENGES OF SECURING GROWTH HORMONE COVERAGE FOR IDIOPATHIC SHORT STATURE: REVIEW OF THE 7-YEAR EXPERIENCE AT ONE INSTITUTION.

Chandar MCSR, Kaplowitz PB, Vaidyanathan P

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2019; (25(2)):156-160 doi:10.4158/EP-2018-0271.

Thyroid function in children with growth hormone deficiency during long-term growth hormone replacement therapy.

Witkowska-Sędek E, Borowiec A, Majcher A, et al.

Central-European journal of immunology 2018; (43(3)):255-261 doi:10.5114/ceji.2018.80043.

Factors affecting bone age maturation during 3 years of growth hormone treatment in patients with idiopathic growth hormone deficiency and idiopathic short stature: Analysis of data from the LG growth study.

Kang MJ, Kim EY, Shim YS, et al.

Medicine 2019; (98(14)):e14962 doi:10.1097/MD.0000000000014962.

Towards a Rational and Efficient Diagnostic Approach in Children Referred for Growth Failure to the General Paediatrician.

Wit JM, Kamp GA, Oostdijk W,

Hormone research in paediatrics 2019; (91(4)):223-240 doi:10.1159/000499915.

Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.

Collett-Solberg PF, Ambler G, Backeljauw PF, et al.

Hormone research in paediatrics 2019; (92(1)):1-14 doi:10.1159/000502231.

Clinical and Genetic Characterization of a Constitutional Delay of Growth and Puberty Cohort.

Barroso PS, Jorge AAL, Lerario AM, et al.

Neuroendocrinology 2020; (110(11-12)):959-966 doi:10.1159/000504783.

Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.

Al Shaikh A, Daftardar H, Alghamdi AA, et al.

Acta bio-medica : Atenei Parmensis 2020; (91(1)):29-40 doi:10.23750/abm.v91i1.9182.

Metabolic insights from a GHSR-A203E mutant mouse model.

Torz LJ, Osborne-Lawrence S, Rodriguez J, et al.

Molecular metabolism 2020; (39()):101004 doi:10.1016/j.molmet.2020.101004.

Parental experiences of ultrarapid genomic testing for their critically unwell infants and children.

Brett GR, Martyn M, Lynch F, et al.

Genetics in medicine : official journal of the American College of Medical Genetics 2020; (22(12)):1976-1985 doi:10.1038/s41436-020-0912-4.

Rapid genome-wide sequencing in a neonatal intensive care unit: A retrospective qualitative exploration of parental experiences.

Aldridge CE, Osiovich H, Hal Siden H, et al.

Journal of genetic counseling 2021; (30(2)):616-629 doi:10.1002/jgc4.1353.

Effect of Growth Hormone Secretagogue Receptor Deletion on Growth, Pulsatile Growth Hormone Secretion, and Meal Pattern in Male and Female Mice.

Labarthe A, Zizzari P, Fiquet O, et al.

Neuroendocrinology 2022; (112(3)):215-234 doi:10.1159/000516147.

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions.

Gupta D, Patterson AM, Osborne-Lawrence S, et al.

Molecular metabolism 2021; (53()):101258 doi:10.1016/j.molmet.2021.101258.

Differential Diagnosis of the Short IGF-I-Deficient Child with Apparently Normal Growth Hormone Secretion.

Wit JM, Joustra SD, Losekoot M, et al.

Hormone research in paediatrics 2021; (94(3-4)):81-104 doi:10.1159/000516407.

Ghrelin Gene Deletion Alters Pulsatile Growth Hormone Secretion in Adult Female Mice.

Hassouna R, Fernandez G, Lebrun N, et al.

Frontiers in endocrinology 2021; (12()):754522 doi:10.3389/fendo.2021.754522.

Investigating whether serum IGF-1 and IGFBP-3 levels reflect the height outcome in prepubertal children upon rhGH therapy: LG growth study database.

Kim M, Kim EY, Kim EY, et al.

PloS one 2021; (16(11)):e0259287 doi:10.1371/journal.pone.0259287.

Decreased Thyroxine Levels during rhGH Therapy in Children with Growth Hormone Deficiency.

Witkowska-Sędek E, Kucharska AM, Rumińska M, et al.

Journal of clinical medicine 2021; (10(21)) doi:10.3390/jcm10215100.

Delphi consensus on the diagnosis and treatment of patients with short stature in Spain: GROW-SENS study.

Corripio-Collado R, Fernández-Ramos C, González-Casado I, et al.

Journal of endocrinological investigation 2022; (45(4)):887-897 doi:10.1007/s40618-021-01696-0.

Quality of Life of Children and Adolescents with Short Stature: The Twofold Contribution of Physical Growth and Adaptive Height-Related Cognitive Beliefs.

Mergulhão B, Almeida JP, Moreira H, et al.

Journal of clinical psychology in medical settings 2022; (29(2)):466-475 doi:10.1007/s10880-022-09871-y.

Growth Hormone Stimulation Testing: To Test or Not to Test? That Is One of the Questions.

Yau M, Rapaport R

Frontiers in endocrinology 2022; (13()):902364 doi:10.3389/fendo.2022.902364.

Clinical Indications for Growth Hormone Therapy.

Danowitz M, Grimberg A

Advances in pediatrics 2022; (69(1)):203-217 doi:10.1016/j.yapd.2022.03.005.

International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood.

Hokken-Koelega ACS, van der Steen M, Boguszewski MCS, et al.

Endocrine reviews 2023; (44(3)):539-565 doi:10.1210/endrev/bnad002.

Long-acting PEGylated growth hormone in children with idiopathic short stature: time to reconsider our diagnostic and treatment policy?

Wit JM, Joustra SD

European journal of endocrinology 2023; (188(1)) doi:10.1093/ejendo/lvac005.

A Genetic Approach in the Evaluation of Short Stature.

Turkyilmaz A, Donmez AS, Cayir A

The Eurasian journal of medicine 2022; (54(Suppl1)):179-186 doi:10.5152/eurasianjmed.2022.22171.

Isolated growth hormone deficiency in children with vertically transmitted short stature: What do the genes tell us?

Plachy L, Amaratunga SA, Dusatkova P, et al.

Frontiers in endocrinology 2022; (13()):1102968 doi:10.3389/fendo.2022.1102968.

Effects of early recombinant human growth hormone treatment in young Chinese children with Prader-Willi syndrome.

Gao Y, Yang LL, Dai YL, et al.

Orphanet journal of rare diseases 2023; (18(1)):25 doi:10.1186/s13023-023-02615-7.

Treatment burden, adherence, and quality of life in children with daily GH treatment in France.

Coutant R, Tauber M, Demaret B, et al.

Endocrine connections 2023; (12(4)).

The benefit of rhGH therapy in a Chinese child with 12q14 microdeletion syndrome: a case report.

Ping Y, Luo L, Chen Y, et al.

Journal of pediatric endocrinology & metabolism : JPEM 2023; (36(8)):798-802 doi:10.1515/jpem-2023-0060.

Contribution of Dynamic and Genetic Tests for Short Stature Diagnosing: A Case Report.

Biagetti B, Valenzuela I, Campos-Martorell A, et al.

Diagnostics (Basel, Switzerland) 2023; (13(13)) doi:10.3390/diagnostics13132259.

Characterization of Somatotrope Cell Expansion in Response to GHRH in the Neonatal Mouse Pituitary.

Gonigam RL, Weis KE, Ge X, et al.

Endocrinology 2023; (164(10)) doi:10.1210/endocr/bqad131.

Development of a Minimum Dataset for the Monitoring of Recombinant Human Growth Hormone Therapy in Children with Growth Hormone Deficiency: A GloBE-Reg Initiative.

Chen SC, Bryce J, Chen M, et al.

Hormone research in paediatrics 2024; (97(4)):365-373 doi:10.1159/000533763.

Adherence and quality of life in children receiving rhGH treatment.

Gonzalez-Briceño L, Viaud M, Polak M

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2022; (28(8S1)):8S3-8S8 doi:10.1016/S0929-693X(22)00036-7.

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.

Leggio L, Leko A, Gregory-Flores A, et al.

Research square 2023; doi:10.21203/rs.3.rs-3236045/v1.

Growth hormone treatment in children with short stature: impact of the diagnosis on parents.

Witt S, Bloemeke J, Bullinger M, et al.

Journal of pediatric endocrinology & metabolism : JPEM 2024; (37(4)):326-335 doi:10.1515/jpem-2023-0420.

Children With Idiopathic Short Stature: An Expanding Role for Genetic Investigation in Their Medical Evaluation.

Cohen LE, Rogol AD

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2024; (30(7)):679-686 doi:10.1016/j.eprac.2024.04.009.

Evolving growth hormone deficiency: proof of concept.

Chimatapu SN, Sethuram S, Samuels JG, et al.

Frontiers in endocrinology 2024; (15()):1398171 doi:10.3389/fendo.2024.1398171.

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.

Lékó AH, Gregory-Flores A, Marchette RCN, et al.

Communications biology 2024; (7(1)):632 doi:10.1038/s42003-024-06303-5.

Genetic Findings in Short Turkish Children Born to Consanguineous Parents.

Joustra SD, Joustra SD, Isik E, et al.

Hormone research in paediatrics 2025; (98(5)):532-542 doi:10.1159/000539696.

Response to Recombinant Human Growth Hormone (rhGH) Therapy in Children with Growth Hormone Deficiency.

Riaz M, Ibrahim MN, Rai VR, et al.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2024; (34(8)):932-935 doi:10.29271/jcpsp.2024.08.932.

The role of IGF1 in determining body composition in children and adolescents with growth hormone deficiency and those with idiopathic short stature.

Zaitoon H, Yackobovitch-Gavan M, Midlej E, et al.

Endocrine 2024; (86(3)):1110-1120 doi:10.1007/s12020-024-03992-0.

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I.

Punt LD, Kooijman S, Mutsters NJM, et al.

The Journal of clinical endocrinology and metabolism 2025; (110(5)):e1303-e1314 doi:10.1210/clinem/dgaf010.

Biological effects of recombinant human growth hormone therapy on metabolism in children with growth hormone deficiency: a review.

Dyrka K, Łachut K, Kolesińska Z, et al.

Journal of pediatric endocrinology & metabolism : JPEM 2025; (38(8)):796-806 doi:10.1515/jpem-2025-0057.

Identifying the Impacts, Obstacles and Information Barriers for Parents of Children Living With Genetic Neurodevelopmental Disorders: A Qualitative Study.

Low KJ, , Treneman-Evans G, et al.

Health expectations : an international journal of public participation in health care and health policy 2025; (28(4)):e70340 doi:10.1111/hex.70340.

Insulin Like Growth Factor-1 as a Screening Tool to Differentiate Between Idiopathic Short Stature and Growth Hormone Deficiency.

Khadilkar V, Karguppikar M, Bhalerao A, et al.

Indian journal of pediatrics 2025; (92(10)):1098-1100 doi:10.1007/s12098-025-05687-4.

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants.

Richardson ME, Bishop MFH, Holdren MA, et al.

American journal of human genetics 2025; (112(10)):2266-2280 doi:10.1016/j.ajhg.2025.08.020.

Fathers' and Mothers' support needs and support experiences after rapid genome sequencing.

Dolling H, Rowitch S, Bromham M, et al.

European journal of human genetics : EJHG 2026; (34(2)):260-269 doi:10.1038/s41431-025-01987-7.

Growth hormone treatment outcomes in children with genetic isolated growth hormone deficiency.

Aouchiche K, Castets S, Oliver Petit I, et al.

European journal of pediatrics 2025; (184(12)):812 doi:10.1007/s00431-025-06661-0.

International guideline on genetic testing of children with short stature.

Dauber A, Jorge AAL, Nilsson O, et al.

European journal of endocrinology 2026; (194(2)):R17-R36 doi:10.1093/ejendo/lvag013.

Growth hormone deficiency, bullying victimization, and associations with treatment status: a pediatric case-control study.

Kocabey Sutcu Z, Caliskan Y, Aytaç Kaplan EH

Journal of pediatric psychology 2026; (51(7)):612-620 doi:10.1093/jpepsy/jsag022.

Unraveling the Genetic Heterogeneity of Isolated Growth Hormone Deficiency: Insights from the GENHYPOPIT Cohort.

Aouchiche K, Romanet P, Charnay T, et al.

Hormone research in paediatrics 2026; 1-12 doi:10.1159/000551700.

Predictors of Response to Growth Hormone Therapy in Children with Idiopathic Growth Hormone Deficiency: A Narrative Review.

Cammisa I, De Fortuna G, Rulli E, et al.

Children (Basel, Switzerland) 2026; (13(4)) doi:10.3390/children13040545.

Nutritional Status of Children with Short Stature Is Oppositely Associated with Growth Hormone Peak in Stimulation Tests and Insulin-like Growth Factor-1 Concentration.

Smyczyńska J, Smyczyńska U, Hilczer M, Stawerska R

Journal of clinical medicine 2026; (15(9)) doi:10.3390/jcm15093333.

Phenotypic and genotypic analysis of pediatric patients with congenital isolated growth hormone deficiency resulting from biallelic variants in the GHRHR gene: a Belgian registry study.

Van de Velde S, Boros E, Brunelle C, et al.

European journal of pediatrics 2026; (185(6)).

Pituitary developmental gene defects and their contribution to growth hormone deficiency.

Aouchiche K, Reynaud R, Charnay T, et al.

Annales d'endocrinologie 2026; (87(6)):102581 doi:10.1016/j.ando.2026.102581.

Efficacy of Low Insulin-Like Growth Factor-1 Levels and a Single Insulin Tolerance Test in Diagnosing Growth Hormone Deficiency.

Yuenyong C, Lerdrassameethad W, Srilanchakon K

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2026; (58(10)):399-405 doi:10.1055/a-2930-3751.

Interpretation of genome sequencing results in children with complex neuromotor phenotypes.

Friedman JM, Lehman A, Guimond C, et al.

Med (New York, N.Y.) 2026; 101330 doi:10.1016/j.medj.2026.101330.