Research & Literature

Gastrointestinal Stromal Tumors: A Clinicopathologic and Risk Stratification Study of 255 Cases from Pakistan and Review of Literature.

Ud Din N, Ahmad Z, Arshad H, et al.

Asian Pacific journal of cancer prevention : APJCP 2015; (16(12)):4873-80 doi:10.7314/apjcp.2015.16.12.4873.

Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future Directions.

Bauer S, Joensuu H

Drugs 2015; (75(12)):1323-34 doi:10.1007/s40265-015-0440-8.

Extragastrointestinal stromal tumor of lesser omentum: a challenging radiological and histological diagnosis.

Trombatore C, Palmucci S, Angelico G, et al.

Clinical imaging 2015; (39(6)):1123-7.

The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines.

Nishida T, Blay JY, Hirota S, et al.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2016; (19(1)):3-14 doi:10.1007/s10120-015-0526-8.

Two cases of gastrointestinal stromal tumor of the small intestine with liver and bone metastasis.

Aktan M, Koc M, Yavuz BB, Kanyilmaz G

Annals of translational medicine 2015; (3(17)):259 doi:10.3978/j.issn.2305-5839.2015.09.46.

Analysis of mutation of the c-Kit gene and PDGFRA in gastrointestinal stromal tumors.

Xu CW, Lin S, Wang WL, et al.

Experimental and therapeutic medicine 2015; (10(3)):1045-1051 doi:10.3892/etm.2015.2613.

Gene expression identifies heterogeneity of metastatic behavior among gastrointestinal stromal tumors.

Skubitz KM, Geschwind K, Xu WW, et al.

Journal of translational medicine 2016; (14()):51 doi:10.1186/s12967-016-0802-3.

Targeting gastrointestinal stromal tumors: the role of regorafenib.

Schroeder B, Li Z, Cranmer LD, et al.

OncoTargets and therapy 2016; (9()):3009-16 doi:10.2147/OTT.S104081.

An Unusual Case of Central Retinal Vein Occlusion and Review of the Toxicity Profile of Regorafenib in GIST Patients.

Schvartsman G, Wagner MJ, Zobniw CM, et al.

Current oncology reports 2016; (18(8)):49 doi:10.1007/s11912-016-0536-7.

Changes from imatinib mesylate to second generation tyrosine kinase inhibitors improve renal impairment with imatinib mesylate in chronic myelogenous leukemia.

Hino A, Yoshida H, Tada Y, et al.

International journal of hematology 2016; (104(5)):605-611 doi:10.1007/s12185-016-2071-6.

Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells.

Sanders KM, Kito Y, Hwang SJ, Ward SM

Physiology (Bethesda, Md.) 2016; (31(5)):316-26 doi:10.1152/physiol.00006.2016.

Risk of arterial and venous occlusive events in chronic myeloid leukemia patients treated with new generation BCR-ABL tyrosine kinase inhibitors: a systematic review and meta-analysis.

Haguet H, Douxfils J, Mullier F, et al.

Expert opinion on drug safety 2017; (16(1)):5-12 doi:10.1080/14740338.2017.1261824.

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia.

Hochhaus A, Larson RA, Guilhot F, et al.

The New England journal of medicine 2017; (376(10)):917-927 doi:10.1056/NEJMoa1609324.

Malignant gastrointestinal neuroectodermal tumor: a case report and review of the literature.

Alyousef MJ, Alratroot JA, ElSharkawy T, et al.

Diagnostic pathology 2017; (12(1)):29 doi:10.1186/s13000-017-0620-9.

Phase III Clinical Trial (RERISE study) Results of Efficacy and Safety of Radotinib Compared with Imatinib in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia.

Kwak JY, Kim SH, Oh SJ, et al.

Clinical cancer research : an official journal of the American Association for Cancer Research 2017; (23(23)):7180-7188 doi:10.1158/1078-0432.CCR-17-0957.

A precision therapy against cancers driven by KIT/PDGFRA mutations.

Evans EK, Gardino AK, Kim JL, et al.

Science translational medicine 2017; (9(414)) doi:10.1126/scitranslmed.aao1690.

Gastrointestinal Stromal Tumors.

von Mehren M, Joensuu H

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018; (36(2)):136-143 doi:10.1200/JCO.2017.74.9705.

Gastrointestinal stromal tumor of unusual phenotype after imatinib treatment: A case report and diagnostic utility of ETV1 mRNA in situ hybridization.

Jung M, Park SH, Jeon YK, et al.

Medicine 2017; (96(49)):e9031 doi:10.1097/MD.0000000000009031.

Management of liver metastases from gastrointestinal stromal tumors: where do we stand?

Machairas N, Prodromidou A, Molmenti E, et al.

Journal of gastrointestinal oncology 2017; (8(6)):1100-1108 doi:10.21037/jgo.2017.08.08.

Micromanagement of drug-resistant advanced gastrointestinal stromal tumors: regorafenib-new ammunition in battling exon 17 mutations.

Eckardt AJ, Klein O

Translational gastroenterology and hepatology 2018; (3()):12 doi:10.21037/tgh.2018.02.01.

Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib.

Serrano C, García-Del-Muro X, Valverde C, et al.

The oncologist 2019; (24(5)):680-687 doi:10.1634/theoncologist.2018-0032.

Gastrointestinal Stromal Tumors of the Distal Gastrointestinal Tract.

Kelley KA, Byrne R, Lu KC

Clinics in colon and rectal surgery 2018; (31(5)):295-300 doi:10.1055/s-0038-1642053.

Renal dysfunction and anemia associated with long-term imatinib treatment in patients with chronic myelogenous leukemia.

Sakurai M, Kikuchi T, Karigane D, et al.

International journal of hematology 2019; (109(3)):292-298 doi:10.1007/s12185-019-02596-z.

Defining Tumor Rupture in Gastrointestinal Stromal Tumor.

Nishida T, Hølmebakk T, Raut CP, Rutkowski P

Annals of surgical oncology 2019; (26(6)):1669-1675 doi:10.1245/s10434-019-07297-9.

Resection of GIST in the duodenum and proximal jejunum: A retrospective analysis of outcomes.

Huang Y, Chen G, Lin L, et al.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2019; (45(10)):1950-1956 doi:10.1016/j.ejso.2019.05.002.

Assessment of chronic renal injury in patients with chronic myeloid leukemia in the chronic phase receiving tyrosine kinase inhibitors.

Ren X, Qin Y, Huang X, et al.

Annals of hematology 2019; (98(7)):1627-1640 doi:10.1007/s00277-019-03690-2.

The prognostic value of gastrointestinal bleeding in gastrointestinal stromal tumor: A propensity score matching analysis.

Wan W, Xiong Z, Zeng X, et al.

Cancer medicine 2019; (8(9)):4149-4158 doi:10.1002/cam4.2328.

Frequent rectal gastrointestinal stromal tumor recurrences in the imatinib era: Retrospective analysis of an International Patient Registry.

Stuart E, Banerjee S, de la Torre J, et al.

Journal of surgical oncology 2019; (120(4)):715-721 doi:10.1002/jso.25621.

Rectal adenocarcinoma coexisting with incidentally found microscopic gastrointestinal stromal tumor: A case report.

Xue W, Li Y, Wang S, et al.

Medicine 2019; (98(31)):e16644 doi:10.1097/MD.0000000000016644.

Gastrointestinal Stromal Tumors of Small Intestine.

Huda T, Singh MP

Surgery journal (New York, N.Y.) 2019; (5(3)):e92-e95 doi:10.1055/s-0039-1694704.

Gastric glomus tumor: clinical conundrums and potential mimic of gastrointestinal stromal tumor (GIST).

Duan K, Chetty R

International journal of clinical and experimental pathology 2017; (10(7)):7905-7912.

Gastrointestinal stromal tumor of the rectum resected by transanal total mesorectal excision after neoadjuvant imatinib treatment: A case report.

Yano T, Nakahara M, Okuda H, et al.

Asian journal of endoscopic surgery 2020; (13(4)):574-577 doi:10.1111/ases.12782.

Pretreatment Tumor DNA Sequencing of KIT and PDGFRA in Endosonography-Guided Biopsies Optimizes the Preoperative Management of Gastrointestinal Stromal Tumors.

Hedenström P, Andersson C, Sjövall H, et al.

Molecular diagnosis & therapy 2020; (24(2)):201-214 doi:10.1007/s40291-020-00451-0.

Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial.

Blay JY, Serrano C, Heinrich MC, et al.

The Lancet. Oncology 2020; (21(7)):923-934 doi:10.1016/S1470-2045(20)30168-6.

Avapritinib in the treatment of PDGFRA exon 18 mutated gastrointestinal stromal tumors.

Smrke A, Gennatas S, Huang P, Jones RL

Future oncology (London, England) 2020; (16(22)):1639-1646 doi:10.2217/fon-2020-0348.

Prognostic Indicators for Gastrointestinal Stromal Tumors: A Review.

Zhang H, Liu Q

Translational oncology 2020; (13(10)):100812 doi:10.1016/j.tranon.2020.100812.

Adjuvant systemic therapy for small bowel gastrointestinal stromal tumor (GIST): Is there a survival benefit after R0 resection?

Patel DJ, Lutfi W, Eguia E, et al.

Surgery 2020; (168(4)):695-700 doi:10.1016/j.surg.2020.04.069.

Recent advances in the management of gastrointestinal stromal tumor.

Ahmed M

World journal of clinical cases 2020; (8(15)):3142-3155 doi:10.12998/wjcc.v8.i15.3142.

Shifting into high gear: how interstitial cells of Cajal change the motility pattern of the developing intestine.

Chevalier NR, Ammouche Y, Gomis A, et al.

American journal of physiology. Gastrointestinal and liver physiology 2020; (319(4)):G519-G528 doi:10.1152/ajpgi.00112.2020.

Gastrointestinal Stromal Tumor (GIST) Causing Obscure Gastrointestinal Bleeding: An Uncommon Way of Diagnosing An Uncommon Disease.

Dziadkowiec KN, Stawinski P, Sánchez-Luna SA, Katz A

Cureus 2020; (12(8)):e9558 doi:10.7759/cureus.9558.

Small bowel gastrointestinal stromal tumor presenting with involvement of the adjacent small bowel and hemoperitoneum case report.

Makkapati B, Nanda AK

Annals of medicine and surgery (2012) 2020; (59()):17-20 doi:10.1016/j.amsu.2020.08.024.

Multiple Primary Malignancies of the Colon, Stomach, and Kidney in a Patient with Bowel Obstruction Requiring Emergency Surgery: A Case Report.

AlBaqmi KH, AlMudaiheem FA, Boghdadly S, et al.

The American journal of case reports 2020; (21()):e926472 doi:10.12659/AJCR.926472.

[A Case of the Large Rectal GIST Treated by Laparoscopic Anus Preserving Operation after Neoadjuvant Therapy with Imatinib Mesylate].

Matsuzuka S, Iseki Y, Fukuoka T, et al.

Gan to kagaku ryoho. Cancer & chemotherapy 2021; (48(3)):385-387.

Gastric and Small Intestine Gist: Results of 156 Cases in 20 Years.

Lopez Gordo S, Bettonica C, Miró M, et al.

Journal of gastrointestinal cancer 2022; (53(2)):451-459 doi:10.1007/s12029-021-00641-x.

Ripretinib for the treatment of advanced gastrointestinal stromal tumor.

Zalcberg JR

Therapeutic advances in gastroenterology 2021; (14()):17562848211008177 doi:10.1177/17562848211008177.

Gastrointestinal stromal tumor metastasis to the ovary: A case report.

Yamaguchi T, Kinoshita J, Saito H, et al.

SAGE open medical case reports 2021; (9()):2050313X211012511 doi:10.1177/2050313X211012511.

A case of KIT negative extra-gastrointestinal stromal tumor arising in the greater omentum with predominant cystic formation.

Nanjo K, Nishimuta Y, Miyasaka M, et al.

Radiology case reports 2021; (16(8)):2315-2318 doi:10.1016/j.radcr.2021.05.061.

Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor.

Bauer S, George S, von Mehren M, Heinrich MC

Frontiers in oncology 2021; (11()):672500 doi:10.3389/fonc.2021.672500.

Prognostic Value of Bleeding in Gastrointestinal Stromal Tumors: A Meta-Analysis.

Fan X, Han H, Sun Z, et al.

Technology in cancer research & treatment 2021; (20()):15330338211034259 doi:10.1177/15330338211034259.

Avapritinib in unresectable or metastatic gastrointestinal stromal tumor with PDGFRA exon 18 mutation: safety and efficacy.

Henriques-Abreu M, Serrano C

Expert review of anticancer therapy 2021; (21(10)):1081-1088 doi:10.1080/14737140.2021.1963235.

Gastrointestinal Stromal Tumors-A Mini Review.

Gheorghe G, Bacalbasa N, Ceobanu G, et al.

Journal of personalized medicine 2021; (11(8)) doi:10.3390/jpm11080694.

Gastrointestinal stromal tumors of the stomach: A 10-year experience of a single-center.

Uzunoglu H, Tosun Y, Akinci O, Baris B

Nigerian journal of clinical practice 2021; (24(12)):1785-1792 doi:10.4103/njcp.njcp_558_20.

Epithelioid Gastrointestinal Stromal Tumor of Duodenum Mimicking Adenocarcinoma: A Case Report.

Tiwari SB, Karki S

JNMA; journal of the Nepal Medical Association 2021; (59(244)):1310-1312 doi:10.31729/jnma.6104.

Comparison of Computed Tomography Features of Gastric and Small Bowel Gastrointestinal Stromal Tumors With Different Risk Grades.

Tang B, Feng QX, Liu XS

Journal of computer assisted tomography 2022; (46(2)):175-182 doi:10.1097/RCT.0000000000001262.

Gastrointestinal stromal tumor as mimicking gynecological mass finding on CT scan imaging: A case report.

Rahma DY, Atmaja MHS

International journal of surgery case reports 2022; (94()):107092 doi:10.1016/j.ijscr.2022.107092.

Gastrointestinal stromal tumors: a comprehensive radiological review.

Inoue A, Ota S, Yamasaki M, et al.

Japanese journal of radiology 2022; (40(11)):1105-1120 doi:10.1007/s11604-022-01305-x.

Risk Factors and Prognostic Analysis of Gastrointestinal Stromal Tumor Recurrence-Metastasis.

Chen S, Sang K, Chen W, et al.

Computational and mathematical methods in medicine 2022; (2022()):1127146 doi:10.1155/2022/1127146.

Systemic Therapy for Gastrointestinal Stromal Tumor: Current Standards and Emerging Challenges.

Huang WK, Wu CE, Wang SY, et al.

Current treatment options in oncology 2022; (23(9)):1303-1319 doi:10.1007/s11864-022-00996-8.

Might Patients with Metastatic Gastrointestinal Stromal Tumors Benefit from Operative Management? A Population-Based Retrospective Study.

Yue L, Sun Y, Hu M, Hu W

BioMed research international 2022; (2022()):9432410 doi:10.1155/2022/9432410.

A literature review and database of how the primary KIT/PDGFRA variant of a gastrointestinal stromal tumour predicts for sensitivity to imatinib.

Wong NACS, Garcia-Petit C, Dangoor A, Andrew N

Cancer genetics 2022; (268-269()):46-54 doi:10.1016/j.cancergen.2022.09.002.

Clinicopathological and therapeutic analysis of PDGFRA mutated gastrointestinal stromal tumor.

Huang W, Yuan W, Ren L, et al.

Pathology, research and practice 2022; (239()):154138 doi:10.1016/j.prp.2022.154138.

NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022.

von Mehren M, Kane JM, Riedel RF, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2022; (20(11)):1204-1214 doi:10.6004/jnccn.2022.0058.

[A Case Report of a Giant GIST Markedly Responsive to Neoadjuvant Chemotherapy with Imatinib Mesylate].

Irie T, Kawai M, Takahashi H, et al.

Gan to kagaku ryoho. Cancer & chemotherapy 2022; (49(13)):1983-1985.

Scanxiety among Adults with Cancer: A Scoping Review to Guide Research and Interventions.

Derry-Vick HM, Heathcote LC, Glesby N, et al.

Cancers 2023; (15(5)) doi:10.3390/cancers15051381.

Coping With 'Scanxiety': Within-Person Processes in Lung Cancer.

Dunsmore VJ, Neupert SD

Psychological reports 2025; (128(2)):702-722 doi:10.1177/00332941231164336.

Predictive Value of a Radiomics Nomogram Model Based on Contrast-Enhanced Computed Tomography for KIT Exon 9 Gene Mutation in Gastrointestinal Stromal Tumors.

Wei Y, Lu Z, Ren Y

Technology in cancer research & treatment 2023; (22()):15330338231181260 doi:10.1177/15330338231181260.

Management of Patients With Advanced Gastrointestinal Stromal Tumor: Emphasis on Fourth-Line Treatment With Ripretinib.

Brackert S, Polson K

Journal of the advanced practitioner in oncology 2023; (14(4)):317-328 doi:10.6004/jadpro.2023.14.4.6.

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.

Teuber A, Schulz T, Fletcher BS, et al.

Nature communications 2024; (15(1)):63 doi:10.1038/s41467-023-44376-8.

Scanxiety and quality of life around follow-up imaging in patients with unruptured intracranial aneurysms: a prospective cohort study.

Kamphuis MJ, van der Kamp LT, van Eijk RPA, et al.

European radiology 2024; (34(9)):6018-6025 doi:10.1007/s00330-024-10602-0.

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature.

Mirovic M, Stojanovic MD, Jovanovic M, et al.

Current issues in molecular biology 2024; (46(2)):1192-1207 doi:10.3390/cimb46020076.

Treatment of BRAF V600E mutant gastrointestinal stromal tumor with dabrafenib: a case report.

Gowda S, Sandow L, Heinrich MC

Journal of gastrointestinal oncology 2024; (15(2)):788-793 doi:10.21037/jgo-23-767.

Pan-Canadian consensus recommendations for GIST management in high- and low-throughput centres across Canada.

Beecroft JR, Brar S, Feng X, et al.

Therapeutic advances in medical oncology 2024; (16()):17588359241266179 doi:10.1177/17588359241266179.

Impact of Gastrointestinal Bleeding on Prognosis and Associated Risk Factors in Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis.

Bai S, Sun Y, Xu H

The American surgeon 2025; (91(3)):434-443 doi:10.1177/00031348241307402.

[A Case of a Giant Rectal GIST Markedly Responsive to Neoadjuvant Chemotherapy with Imatinib Mesylate].

Yamamoto M, Kato K, Hayashi K, et al.

Gan to kagaku ryoho. Cancer & chemotherapy 2024; (51(13)):1564-1566.

Acute abdomen due to a perforated giant GIST of the small intestine evolving slowly for 6 years: A case report.

Ben Mahmoud A, Hammami M, Atri S, et al.

International journal of surgery case reports 2025; (129()):111207 doi:10.1016/j.ijscr.2025.111207.

Gastrointestinal Stromal Tumor: Current Approaches and Future Directions in the Treatment of Advanced Disease.

Cicala CM, Bauer S, Heinrich MC, Serrano C

Hematology/oncology clinics of North America 2025; (39(4)):773-784 doi:10.1016/j.hoc.2025.04.006.

Giant gastric gastrointestinal stromal tumor: A case report.

Neupane D, Pandit N

International journal of surgery case reports 2025; (131()):111420 doi:10.1016/j.ijscr.2025.111420.

Case Report: Dramatic response to entritinib in a patient with gastrointestinal stromal tumor positive for NTRK3 fusion.

Dong G, Han P, Zhang Z, et al.

Frontiers in oncology 2025; (15()):1588950 doi:10.3389/fonc.2025.1588950.

Prevalence, severity, and modifiable predictors of scanxiety in patients undergoing routine oncologic imaging: a prospective longitudinal study.

Shah MS, Memon JA, Malik U, et al.

Clinical imaging 2025; (128()):110634 doi:10.1016/j.clinimag.2025.110634.

Hemoglobin changes during long-lasting frontline treatment with Tyrosine-Kinase inhibitors in patients with chronic myeloid leukemia.

Latagliata R, Carmosino I, Di Veroli A, et al.

Leukemia & lymphoma 2026; (67(2)):349-354 doi:10.1080/10428194.2025.2586816.

Succinate dehydrogenase deficient GIST: Case series and review of literature from a tertiary care center in India.

Santhosh AP, Rastogi S, Shamim SA, et al.

Indian journal of cancer 2025; (62(3)):408-415 doi:10.4103/ijc.ijc_500_24.