Research & Literature

Predictive genetic testing in minors for Myocilin juvenile onset open angle glaucoma.

Souzeau E, Glading J, Ridge B, et al.

Clinical genetics 2015; (88(6)):584-8 doi:10.1111/cge.12558.

Evaluation of corneal endothelium in adolescents with juvenile glaucoma.

Urban B, Bakunowicz-Łazarczyk A, Michalczuk M, Krętowska M

Journal of ophthalmology 2015; (2015()):895428 doi:10.1155/2015/895428.

Long-Term Bleb-Related Infections After Trabeculectomy: Incidence, Risk Factors, and Influence of Bleb Revision.

Kim EA, Law SK, Coleman AL, et al.

American journal of ophthalmology 2015; (159(6)):1082-91.

Risk of Visual Field Progression in Glaucoma Patients with Progressive Retinal Nerve Fiber Layer Thinning: A 5-Year Prospective Study.

Yu M, Lin C, Weinreb RN, et al.

Ophthalmology 2016; (123(6)):1201-10.

A novel de novo Myocilin variant in a patient with sporadic juvenile open angle glaucoma.

Souzeau E, Burdon KP, Ridge B, et al.

BMC medical genetics 2016; (17()):30 doi:10.1186/s12881-016-0291-5.

Late-onset Hypotony Maculopathy After Trabeculectomy in a Highly Myopic Patient With Juvenile Open-angle Glaucoma.

Kao ST, Lee SH, Chen YC

Journal of glaucoma 2017; (26(4)):e137-e141 doi:10.1097/IJG.0000000000000485.

Primary open-angle glaucoma.

Weinreb RN, Leung CK, Crowston JG, et al.

Nature reviews. Disease primers 2016; (2()):16067 doi:10.1038/nrdp.2016.67.

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.

Kasetti RB, Phan TN, Millar JC, Zode GS

Investigative ophthalmology & visual science 2016; (57(14)):6058-6069 doi:10.1167/iovs.16-19610.

Genetics and genetic testing for glaucoma.

Miller MA, Fingert JH, Bettis DI

Current opinion in ophthalmology 2017; (28(2)):133-138 doi:10.1097/ICU.0000000000000344.

Identification of Mutations in Myocilin and Beta-1,4-galactosyltransferase 3 Genes in a Chinese Family with Primary Open-angle Glaucoma.

Liao RF, Zhong ZL, Ye MJ, et al.

Chinese medical journal 2016; (129(23)):2810-2815 doi:10.4103/0366-6999.194641.

Myocilin Predictive Genetic Testing for Primary Open-Angle Glaucoma Leads to Early Identification of At-Risk Individuals.

Souzeau E, Tram KH, Witney M, et al.

Ophthalmology 2017; (124(3)):303-309 doi:10.1016/j.ophtha.2016.11.011.

Evaluation of the Myocilin Mutation Gln368Stop Demonstrates Reduced Penetrance for Glaucoma in European Populations.

Nag A, Lu H, Arno M, et al.

Ophthalmology 2017; (124(4)):547-553 doi:10.1016/j.ophtha.2016.11.018.

Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma.

Lu LJ, Tsai JC, Liu J

The Yale journal of biology and medicine 2017; (90(1)):111-118.

Genetics of glaucoma.

Wiggs JL, Pasquale LR

Human molecular genetics 2017; (26(R1)):R21-R27 doi:10.1093/hmg/ddx184.

Ganglion Cell-Inner Plexiform Layer Change Detected by Optical Coherence Tomography Indicates Progression in Advanced Glaucoma.

Shin JW, Sung KR, Lee GC, et al.

Ophthalmology 2017; (124(10)):1466-1474 doi:10.1016/j.ophtha.2017.04.023.

A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients.

Hamanaka T, Kimura M, Sakurai T, et al.

Investigative ophthalmology & visual science 2017; (58(5)):2818-2831 doi:10.1167/iovs.16-20646.

Glaucoma.

Jonas JB, Aung T, Bourne RR, et al.

Lancet (London, England) 2017; (390(10108)):2183-2193 doi:10.1016/S0140-6736(17)31469-1.

CRISPR-Cas9-based treatment of myocilin-associated glaucoma.

Jain A, Zode G, Kasetti RB, et al.

Proceedings of the National Academy of Sciences of the United States of America 2017; (114(42)):11199-11204 doi:10.1073/pnas.1706193114.

In Vivo Analysis of Angle Dysgenesis in Primary Congenital, Juvenile, and Adult-Onset Open Angle Glaucoma.

Gupta V, Chaurasia AK, Gupta S, et al.

Investigative ophthalmology & visual science 2017; (58(13)):6000-6005 doi:10.1167/iovs.17-22695.

Methods for Analyzing Endoplasmic Reticulum Stress in the Trabecular Meshwork of Glaucoma Models.

Maddineni P, Kasetti RB, Zode GS

Methods in molecular biology (Clifton, N.J.) 2018; (1695()):121-134 doi:10.1007/978-1-4939-7407-8_12.

Selective laser trabeculoplasty for primary open-angle glaucoma patients younger than 40 years.

Gupta V, Ghosh S, Sujeeth M, et al.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 2018; (53(1)):81-85 doi:10.1016/j.jcjo.2017.07.023.

Integrating Macular Ganglion Cell Inner Plexiform Layer and Parapapillary Retinal Nerve Fiber Layer Measurements to Detect Glaucoma Progression.

Hou HW, Lin C, Leung CK

Ophthalmology 2018; (125(6)):822-831 doi:10.1016/j.ophtha.2017.12.027.

Simplifying "target" intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma.

Sihota R, Angmo D, Ramaswamy D, Dada T

Indian journal of ophthalmology 2018; (66(4)):495-505 doi:10.4103/ijo.IJO_1130_17.

A recurrent G367R mutation in MYOC associated with juvenile open angle glaucoma in a large Chinese family.

Yao YH, Wang YQ, Fang WF, et al.

International journal of ophthalmology 2018; (11(3)):369-374 doi:10.18240/ijo.2018.03.04.

Visual Subfield Progression in Glaucoma Subtypes.

Su WW, Hsieh SS, Cheng ST, et al.

Journal of ophthalmology 2018; (2018()):7864219 doi:10.1155/2018/7864219.

The Association of Socioeconomic Status with Severity of Glaucoma and the Impacts of Both Factors on the Costs of Glaucoma Medications: A Cross-Sectional Study in West Bengal, India.

Chakravarti T

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2018; (34(6)):442-451 doi:10.1089/jop.2017.0135.

Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies.

Han X, Souzeau E, Ong JS, et al.

JAMA ophthalmology 2019; (137(1)):28-35 doi:10.1001/jamaophthalmol.2018.4477.

[Primary open-angle glaucoma].

Bertaud S, Aragno V, Baudouin C, Labbé A

La Revue de medecine interne 2019; (40(7)):445-452 doi:10.1016/j.revmed.2018.12.001.

The clinical feature of myocilin Y437H mutation in a Chinese family with primary open-angle glaucoma.

Lei L, Li S, Liu X, Zhang C

The British journal of ophthalmology 2019; (103(10)):1524-1529 doi:10.1136/bjophthalmol-2018-313069.

Impact of acute intraocular pressure elevation on the visual acuity of non-human primates.

Li M, Yuan N, Chen X, et al.

EBioMedicine 2019; (44()):554-562 doi:10.1016/j.ebiom.2019.05.059.

Mendelian genes in primary open angle glaucoma.

Sears NC, Boese EA, Miller MA, Fingert JH

Experimental eye research 2019; (186()):107702 doi:10.1016/j.exer.2019.107702.

Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation.

Huard DJE, Jonke AP, Torres MP, Lieberman RL

Scientific reports 2019; (9(1)):12769 doi:10.1038/s41598-019-48751-8.

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

, Hauser MA, Allingham RR, et al.

JAMA 2019; (322(17)):1682-1691 doi:10.1001/jama.2019.16161.

Ganglion Cell-Inner Plexiform Layer and Retinal Nerve Fiber Layer Changes in Glaucoma Suspects Enable Prediction of Glaucoma Development.

Shin JW, Sung KR, Song MK

American journal of ophthalmology 2020; (210()):26-34 doi:10.1016/j.ajo.2019.11.002.

The importance of corneal assessment in a glaucoma suspect - a review.

Potop V, Corbu C, Coviltir V, et al.

Romanian journal of ophthalmology 2019; (63(4)):321-326.

Does TRABECULECTOMY meet the 10-10-10 challenge in PACG, POAG, JOAG and Secondary glaucomas?

Sihota R, Shakrawal J, Sidhu T, et al.

International ophthalmology 2020; (40(5)):1233-1243 doi:10.1007/s10792-020-01289-5.

The mutational spectrum of Myocilin gene among familial versus sporadic cases of Juvenile onset open angle glaucoma.

Gupta V, Somarajan BI, Gupta S, et al.

Eye (London, England) 2021; (35(2)):400-408 doi:10.1038/s41433-020-0850-z.

Accumulation of Asn450Tyr mutant myocilin in ER promotes apoptosis of human trabecular meshwork cells.

Yan X, Wu S, Liu Q, et al.

Molecular vision 2020; (26()):563-573.

Longitudinal Macular Ganglion Cell-Inner Plexiform Layer Measurements to Detect Glaucoma Progression in High Myopia.

Shin JW, Song MK, Sung KR

American journal of ophthalmology 2021; (223()):9-20 doi:10.1016/j.ajo.2020.09.039.

Ahmed and Baerveldt Drainage Implants in the Treatment of Juvenile Open-angle Glaucoma.

Le PH, Nguyen M, Humphrey KA, Klifto MR

Journal of glaucoma 2021; (30(3)):276-280 doi:10.1097/IJG.0000000000001732.

Anterior Chamber Angle Assessment Techniques: A Review.

Riva I, Micheletti E, Oddone F, et al.

Journal of clinical medicine 2020; (9(12)) doi:10.3390/jcm9123814.

Recent developments in the use of optical coherence tomography for glaucoma.

Vazquez LE, Bye A, Aref AA

Current opinion in ophthalmology 2021; (32(2)):98-104 doi:10.1097/ICU.0000000000000733.

Ocular hypertension in Axenfeld-Rieger Syndrome.

Espinosa-Barberi G, Galván González JF, Antón A

Romanian journal of ophthalmology 2020; (64(4)):455-458 doi:10.22336/rjo.2020.70.

Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.

Stein JD, Khawaja AP, Weizer JS

JAMA 2021; (325(2)):164-174 doi:10.1001/jama.2020.21899.

Pigment dispersion syndrome and its implications for glaucoma.

Bustamante-Arias A, Ruiz-Lozano RE, Carlos Alvarez-Guzman J, et al.

Survey of ophthalmology 2021; (66(5)):743-760 doi:10.1016/j.survophthal.2021.01.002.

The role of clinical examination of the optic nerve head in glaucoma today.

Sihota R, Sidhu T, Dada T

Current opinion in ophthalmology 2021; (32(2)):83-91 doi:10.1097/ICU.0000000000000734.

Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank.

Zebardast N, Sekimitsu S, Wang J, et al.

Ophthalmology 2021; (128(9)):1300-1311 doi:10.1016/j.ophtha.2021.03.007.

Systemic Genotype-Phenotype Analysis of MYOC Variants Based on Exome Sequencing and Literature Review.

Li X, Xiao X, Li S, et al.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2021; (10(2)):173-182 doi:10.1097/APO.0000000000000382.

Molecular Insights into Myocilin and Its Glaucoma-Causing Misfolded Olfactomedin Domain Variants.

Lieberman RL, Ma MT

Accounts of chemical research 2021; (54(9)):2205-2215 doi:10.1021/acs.accounts.1c00060.

In Vivo Imaging of the Schlemm's Canal and the Response to Selective Laser Trabeculoplasty.

Varshney T, Azmira K, Gupta S, et al.

American journal of ophthalmology 2022; (234()):126-137 doi:10.1016/j.ajo.2021.07.002.

Juvenile-onset open-angle glaucoma - A clinical and genetic update.

Selvan H, Gupta S, Wiggs JL, Gupta V

Survey of ophthalmology 2022; (67(4)):1099-1117 doi:10.1016/j.survophthal.2021.09.001.

Communication processes about predictive genetic testing within high-risk breast cancer families: a two-phase study design.

Blomen CL, Pott A, Volk AE, et al.

Scientific reports 2021; (11(1)):20178 doi:10.1038/s41598-021-98737-8.

A Prospective Study of Intraocular Pressure Spike and Failure After Gonioscopy-Assisted Transluminal Trabeculotomy in Juvenile Open-Angle Glaucoma: A Prospective Study of GATT in JOAG.

Shi Y, Wang H, Oatts JT, et al.

American journal of ophthalmology 2022; (236()):79-88 doi:10.1016/j.ajo.2021.10.009.

Gonioscopy-assisted transluminal trabeculotomy versus goniotomy with Kahook dual blade in patients with uncontrolled juvenile open-angle glaucoma: a retrospective study.

Qiao Y, Tan C, Chen X, et al.

BMC ophthalmology 2021; (21(1)):395 doi:10.1186/s12886-021-02159-z.

Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Associations with Polymorphisms in Protein Stabilities.

Tanji T, Cohen E, Shen D, et al.

Genes 2021; (12(11)) doi:10.3390/genes12111802.

Penetrance of MYOC gene mutation in primary open-angle glaucoma: A systematic review and meta-analysis.

Xie JJ, Zhang GW, Cui HY, et al.

Ophthalmic genetics 2022; (43(2)):240-247 doi:10.1080/13816810.2021.2021427.

Approach to childhood glaucoma: A review.

Karaconji T, Zagora S, Grigg JR

Clinical & experimental ophthalmology 2022; (50(2)):232-246 doi:10.1111/ceo.14039.

PRIMARY OPEN-ANGLE GLAUCOMA DUE TO MUTATIONS IN THE MYOC GENE.

Vergaro A, Rezková L, Fichtl M, et al.

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 2022; (78(5)):242-248 doi:10.31348/2022/25.

Structure‒function‒pathogenicity analysis of C-terminal myocilin missense variants based on experiments and 3D models.

Zhou B, Lin X, Li Z, et al.

Frontiers in genetics 2022; (13()):1019208 doi:10.3389/fgene.2022.1019208.

Surgical Outcomes of Glaucoma Drainage Device Implantation in Refractory Glaucoma Patients in Thailand.

Rojananuangnit K, Jiaranaisilawong P, Rattanaphaithun O, Sathim W

Clinical ophthalmology (Auckland, N.Z.) 2022; (16()):4163-4178 doi:10.2147/OPTH.S393730.

TUBE VERSUS TRABECULECTOMY IN JUVENILE-ONSET OPEN ANGLE GLAUCOMA - TREATMENT OUTCOMES IN TERTIARY HOSPITALS IN MALAYSIA.

Abd H, Ang , Raja N, et al.

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 2022; (78(6)):298-303 doi:10.31348/2022/29.

A novel heterozygous c.733 T > G MYOC mutation associated with juvenile-onset open-angle glaucoma in a Chinese family.

Dai A, Cheng X, Wang W, et al.

Eye (London, England) 2023; (37(12)):2488-2493 doi:10.1038/s41433-022-02359-x.

Ganglion Cell Complex Analysis: Correlations with Retinal Nerve Fiber Layer on Optical Coherence Tomography.

Ghita AM, Iliescu DA, Ghita AC, et al.

Diagnostics (Basel, Switzerland) 2023; (13(2)) doi:10.3390/diagnostics13020266.

Glaucoma: Diagnosis and Management.

Michels TC, Ivan O

American family physician 2023; (107(3)):253-262.

Analysis of glaucoma genes in Finnish patients with juvenile open-angle glaucoma.

Liuska PJ, Tadji A, Repo P, et al.

Acta ophthalmologica 2023; (101(7)):797-806 doi:10.1111/aos.15670.

Myocilin misfolding and glaucoma: A 20-year update.

Saccuzzo EG, Youngblood HA, Lieberman RL

Progress in retinal and eye research 2023; (95()):101188 doi:10.1016/j.preteyeres.2023.101188.

Myocilin Mutation N480K Leads to Early Onset Juvenile and Adult-onset Primary Open Angle Glaucoma in a Six Generation Family.

Kader MA, Devarajan B, Vijayan S, et al.

Journal of glaucoma 2024; (33(3)):218-224 doi:10.1097/IJG.0000000000002286.

Treatment Outcomes for Juvenile Open Angle Glaucoma in Thailand.

Seresirikachorn K, Thiamthat W, Annopawong K, et al.

Journal of glaucoma 2023; (32(11)):976-982 doi:10.1097/IJG.0000000000002309.

Universal slit-lamp mounted indentation gonioscopy tool for angle evaluation: An innovative device.

Bhirud A, Tripathi A, Agarwal M, Mishra A

Indian journal of ophthalmology 2024; (72(7)):928-930 doi:10.4103/IJO.IJO_3035_23.

Selective laser trabeculoplasty in the treatment of juvenile open angle glaucoma patients under 25 years of age.

Kurnaz E

International ophthalmology 2024; (44(1)):201 doi:10.1007/s10792-024-03108-7.

Outcomes of Second Trabeculectomy Versus Glaucoma Drainage Device in Juvenile Open Angle Glaucoma After Primary Trabeculectomy Failure.

Seresirikachorn K, Annopawong K, Parivisutt N, et al.

Journal of glaucoma 2025; (34(4)):297-303 doi:10.1097/IJG.0000000000002525.

Monitoring mutant myocilin secretion and localization in trabecular meshwork cell cultures using a protein complementation-based luminescence assay.

Youngblood HA, Harris EF, Lankford KP, et al.

Experimental eye research 2025; (255()):110333 doi:10.1016/j.exer.2025.110333.

Three-year outcomes of gonioscopy-assisted transluminal trabeculotomy for juvenile-onset primary open-angle glaucoma: a retrospective study.

Hu B, Liu S, Fan H, Zeng L

BMC ophthalmology 2025; (25(1)):170 doi:10.1186/s12886-025-03930-2.

Gonioscopy-Assisted Transluminal Trabeculotomy for Myocilin-Associated Juvenile Open-Angle Glaucoma: A Case Series of 8 Eyes Over 2.2 to 4.1 Years.

Boese EA, Alward WLM, Fingert JH

Ophthalmology. Glaucoma 2025; (8(5)):466-473 doi:10.1016/j.ogla.2025.03.011.

Increased intraocular pressure as the first presenting sign of Miller Fisher syndrome.

Chen G, Li C, Peng J, et al.

BMC ophthalmology 2025; (25(1)):259 doi:10.1186/s12886-025-04088-7.

Early outcomes of 5-0 prolene gonioscopy-assisted transluminal trabeculotomy in juvenile open-angle glaucoma.

Maheshwari D, Gupta S, Pillai MR, et al.

Indian journal of ophthalmology 2025; (73(Suppl 3)):S449-S453 doi:10.4103/IJO.IJO_1864_24.

Visual Outcomes and Risk Factors for Progression in Juvenile Open-Angle Glaucoma.

Seresirikachorn K, Vu DM, Narayana A, et al.

Ophthalmology. Glaucoma 2025; (8(6)):627-633 doi:10.1016/j.ogla.2025.06.003.

Evaluation of prolonged use of topical glaucoma medications on gonioscopy-assisted transluminal trabeculotomy outcomes in juvenile open-angle glaucoma.

Wang Z, Yang Z, Liu S, et al.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2025; (14(6)):100240 doi:10.1016/j.apjo.2025.100240.

Therapeutic mRNA delivery of CRISPR-Cas9 to the trabecular meshwork reverses ocular hypertension in myocilin glaucoma.

Yacoub S, Kaipa BR, Li L, et al.

Molecular therapy. Methods & clinical development 2025; (33(4)):101614 doi:10.1016/j.omtm.2025.101614.

Juvenile open-angle glaucoma: a clinicopathological update and review.

Nadeem S

International ophthalmology 2026; (46(1)).

Glaucoma.

Bair H, Djulbegovic M, Schuman JS

Handbook of clinical neurology 2026; (218()):219-239 doi:10.1016/B978-0-443-22212-2.00010-0.