Research & Literature

Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris.

Berki DM, Liu L, Choon SE, et al.

The Journal of investigative dermatology 2015; (135(12)):2964-2970 doi:10.1038/jid.2015.288.

CARD14 alterations in Tunisian patients with psoriasis and further characterization in European cohorts.

Ammar M, Jordan CT, Cao L, et al.

The British journal of dermatology 2016; (174(2)):330-7 doi:10.1111/bjd.14158.

A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia.

Guerreiro de Moura CA, de Assis LH, Góes P, et al.

Case reports in dermatology 2015; (7(3)):345-51 doi:10.1159/000442380.

IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases.

Tauber M, Bal E, Pei XY, et al.

The Journal of investigative dermatology 2016; (136(9)):1811-1819 doi:10.1016/j.jid.2016.04.038.

Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA.

Shibata A, Sugiura K, Furuta Y, et al.

Journal of autoimmunity 2017; (80()):28-38 doi:10.1016/j.jaut.2017.01.007.

Internalized stigma in psoriasis: A multicenter study.

Alpsoy E, Polat M, FettahlıoGlu-Karaman B, et al.

The Journal of dermatology 2017; (44(8)):885-891 doi:10.1111/1346-8138.13841.

European consensus statement on phenotypes of pustular psoriasis.

Navarini AA, Burden AD, Capon F, et al.

Journal of the European Academy of Dermatology and Venereology : JEADV 2017; (31(11)):1792-1799 doi:10.1111/jdv.14386.

Clinical features of von Zumbusch type of generalized pustular psoriasis in children: a retrospective study of 26 patients in southwestern China.

Wang Q, Liu W, Zhang L

Anais brasileiros de dermatologia 2017; (92(3)):319-322 doi:10.1590/abd1806-4841.20175536.

Pustular psoriasis of pregnancy: current perspectives.

Trivedi MK, Vaughn AR, Murase JE

International journal of women's health 2018; (10()):109-115 doi:10.2147/IJWH.S125784.

Generalized pustular psoriasis: a review and update on treatment.

Hoegler KM, John AM, Handler MZ, Schwartz RA

Journal of the European Academy of Dermatology and Venereology : JEADV 2018; (32(10)):1645-1651 doi:10.1111/jdv.14949.

Genetic polymorphism of IL36RN in Han patients with generalized pustular psoriasis in Sichuan region of China: A case-control study.

Li Z, Yang Q, Wang S

Medicine 2018; (97(31)):e11741 doi:10.1097/MD.0000000000011741.

Long-term efficacy and safety of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis: subgroup analyses of an open-label, phase 3 study (UNCOVER-J).

Okubo Y, Mabuchi T, Iwatsuki K, et al.

Journal of the European Academy of Dermatology and Venereology : JEADV 2019; (33(2)):325-332 doi:10.1111/jdv.15287.

Distinguishing pustular psoriasis and acute generalized exanthematous pustulosis on the basis of plasmacytoid dendritic cells and MxA protein.

Vyas NS, Charifa A, Desman GT, McNiff JM

Journal of cutaneous pathology 2019; (46(5)):317-326 doi:10.1111/cup.13430.

Diagnosis and screening of patients with generalized pustular psoriasis.

Ly K, Beck KM, Smith MP, et al.

Psoriasis (Auckland, N.Z.) 2019; (9()):37-42 doi:10.2147/PTT.S181808.

Review of treatments for generalized pustular psoriasis.

Kearns DG, Chat VS, Zang PD, et al.

The Journal of dermatological treatment 2021; (32(5)):492-494 doi:10.1080/09546634.2019.1682502.

Interleukin-36: Structure, Signaling and Function.

Zhou L, Todorovic V

Advances in experimental medicine and biology 2021; (21()):191-210 doi:10.1007/5584_2020_488.

Clinical presentation and management of atypical and recalcitrant acute generalized exanthematous pustulosis.

Hadavand MA, Kaffenberger B, Cartron AM, Trinidad JCL

Journal of the American Academy of Dermatology 2022; (87(3)):632-639 doi:10.1016/j.jaad.2020.09.024.

A brief guide to pustular psoriasis for primary care providers.

Crowley JJ, Pariser DM, Yamauchi PS

Postgraduate medicine 2021; (133(3)):330-344 doi:10.1080/00325481.2020.1831315.

Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease.

Iznardo H, Puig L

International journal of molecular sciences 2021; (22(9)) doi:10.3390/ijms22094344.

Treatment of Generalized Pustular Psoriasis of Pregnancy With Infliximab.

Beksac B, Adisen E, Gurer MA

Cutis 2021; (107(3)):E2-E5 doi:10.12788/cutis.0210.

Clinical analysis of generalized pustular psoriasis in Chinese patients: A retrospective study of 110 patients.

Zheng J, Chen W, Gao Y, et al.

The Journal of dermatology 2021; (48(9)):1336-1342 doi:10.1111/1346-8138.15958.

Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasis.

Baum P, Visvanathan S, Garcet S, et al.

The Journal of allergy and clinical immunology 2022; (149(4)):1402-1412 doi:10.1016/j.jaci.2021.09.035.

Trial of Spesolimab for Generalized Pustular Psoriasis.

Bachelez H, Choon SE, Marrakchi S, et al.

The New England journal of medicine 2021; (385(26)):2431-2440 doi:10.1056/NEJMoa2111563.

Clinical Course and Characteristics of Generalized Pustular Psoriasis.

Choon SE, Navarini AA, Pinter A

American journal of clinical dermatology 2022; (23(Suppl 1)):21-29 doi:10.1007/s40257-021-00654-z.

Impact of Generalized Pustular Psoriasis from the Perspective of People Living with the Condition: Results of an Online Survey.

Reisner DV, Johnsson FD, Kotowsky N, et al.

American journal of clinical dermatology 2022; (23(Suppl 1)):65-71 doi:10.1007/s40257-021-00663-y.

Pustular psoriasis of pregnancy: Clinical and genetic characteristics in a series of eight patients and review of the literature.

Ennouri M, Bahloul E, Sellami K, et al.

Dermatologic therapy 2022; (35(8)):e15593 doi:10.1111/dth.15593.

Generalized Pustular Psoriasis in Pregnancy: Current and Future Treatments.

Seishima M, Fujii K, Mizutani Y

American journal of clinical dermatology 2022; (23(5)):661-671 doi:10.1007/s40257-022-00698-9.

Real-world data on the use of secukinumab and acitretin in pediatric generalized pustular psoriasis.

Miao C, Chen Y, Wang Z, et al.

The Journal of dermatology 2023; (50(2)):258-261 doi:10.1111/1346-8138.16551.

Generalized Pustular Psoriasis: A Review of the Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment.

Reynolds KA, Pithadia DJ, Lee EB, et al.

Cutis 2022; (110(2 Suppl)):19-25 doi:10.12788/cutis.0579.

An analysis of psoriasis hospitalisation in Thailand.

Chaiyabutr C, Silpa-Archa N, Wongpraprarut C, et al.

Archives of dermatological research 2023; (315(4)):779-786 doi:10.1007/s00403-022-02429-w.

Case report: Successful treatment of acute generalized pustular psoriasis of puerperium with secukinumab.

Xue G, Lili M, Yimiao F, et al.

Frontiers in medicine 2022; (9()):1072039 doi:10.3389/fmed.2022.1072039.

Current management of generalized pustular psoriasis.

Kodali N, Blanchard I, Kunamneni S, Lebwohl MG

Experimental dermatology 2023; (32(8)):1204-1218 doi:10.1111/exd.14765.

Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia.

Choon SE, Tok PSK, Wong KW, et al.

Experimental dermatology 2023; (32(8)):1263-1271 doi:10.1111/exd.14776.

Psychometric validation of the generalized pustular psoriasis physician global assessment (GPPGA) and generalized pustular psoriasis area and severity index (GPPASI).

Burden AD, Bissonnette R, Lebwohl MG, et al.

Journal of the European Academy of Dermatology and Venereology : JEADV 2023; (37(7)):1327-1335 doi:10.1111/jdv.18999.

Rapid and sustained improvements in Generalized Pustular Psoriasis Physician Global Assessment scores with spesolimab for treatment of generalized pustular psoriasis flares in the randomized, placebo-controlled Effisayil 1 study.

Elewski BE, Lebwohl MG, Anadkat MJ, et al.

Journal of the American Academy of Dermatology 2023; (89(1)):36-44 doi:10.1016/j.jaad.2023.02.040.

Characteristics of Patients Experiencing a Flare of Generalized Pustular Psoriasis: A Multicenter Observational Study.

Bellinato F, Gisondi P, Marzano AV, et al.

Vaccines 2023; (11(4)) doi:10.3390/vaccines11040740.

Imsidolimab, an anti-interleukin-36 receptor monoclonal antibody, for the treatment of generalized pustular psoriasis: results from the phase II GALLOP trial.

Warren RB, Reich A, Kaszuba A, et al.

The British journal of dermatology 2023; (189(2)):161-169 doi:10.1093/bjd/ljad083.

Incidence and prevalence of generalized pustular psoriasis in multiethnic Johor Bahru, Malaysia: a population-based cohort study using routinely captured electronic health records in the Teleprimary Care (TPC®) clinical information system from 2010 to 2020.

Choon SE, Wright AK, Griffiths CEM, et al.

The British journal of dermatology 2023; (189(4)):410-418 doi:10.1093/bjd/ljad158.

Exploring the Clinical Features, Immunopathogenesis and Approach to Diagnosis for Generalized Pustular Psoriasis [Podcast].

Bhutani T, Hawkes JE

Clinical, cosmetic and investigational dermatology 2023; (16()):1553-1558 doi:10.2147/CCID.S424073.

Use of Biological Therapies for the Management of Pustular Psoriasis: A New Era?

Megna M, Camela E, Ruggiero A, et al.

Clinical, cosmetic and investigational dermatology 2023; (16()):1677-1690 doi:10.2147/CCID.S407812.

Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial.

Morita A, Strober B, Burden AD, et al.

Lancet (London, England) 2023; (402(10412)):1541-1551 doi:10.1016/S0140-6736(23)01378-8.

Mature IL-36γ Induces Stratum Corneum Exfoliation in Generalized Pustular Psoriasis by Suppressing Corneodesmosin.

Sato E, Imayoshi H, Tsutsui Y, et al.

The Journal of investigative dermatology 2024; (144(4)):764-773.e4 doi:10.1016/j.jid.2023.09.267.

Generalized pustular psoriasis: practical recommendations for Spanish primary care and emergency physicians.

Rivera-Diaz R, Epelde F, Heras-Hitos JA, et al.

Postgraduate medicine 2023; (135(8)):766-774 doi:10.1080/00325481.2023.2285730.

Generalized pustular psoriasis successfully treated with spesolimab: A case report.

Brigenti N, Gisondi P, Bellinato F, Girolomoni G

SAGE open medical case reports 2024; (12()):2050313X241235451 doi:10.1177/2050313X241235451.

Exploring the Clinical Presentation, Course, and Burden of Disease in Generalized Pustular Psoriasis [Podcast].

Merola JF, Amin AZ

Clinical, cosmetic and investigational dermatology 2024; (17()):539-545 doi:10.2147/CCID.S444221.

Successful treatment of generalized pustular psoriasis with guselkumab.

Part M

The Journal of dermatological treatment 2024; (35(1)):2331807 doi:10.1080/09546634.2024.2331807.

Successful treatment of recalcitrant generalized pustular psoriasis of pregnancy with spesolimab.

Yang C, Wang Y, Li R, et al.

The Journal of dermatological treatment 2024; (35(1)):2334791 doi:10.1080/09546634.2024.2334791.

Rapid and sustained resolution in generalized pustular psoriasis with IL-17A inhibitors required high adherence: a 96-week analysis in a real-life setting.

Hu K, Liu Y, Liu Y, et al.

International journal of dermatology 2024; (63(11)):1551-1557 doi:10.1111/ijd.17163.

International Consensus Definition and Diagnostic Criteria for Generalized Pustular Psoriasis From the International Psoriasis Council.

Choon SE, van de Kerkhof P, Gudjonsson JE, et al.

JAMA dermatology 2024; (160(7)):758-768 doi:10.1001/jamadermatol.2024.0915.

A Non-Interventional, Multicenter Study to Characterize the Socio-Demographics, Clinical Characteristics, and Management of Generalized Pustular Psoriasis Patients in Spain: IMPULSE Study.

Puig L, Izu Belloso R, Rivera-Díaz R, et al.

Dermatology (Basel, Switzerland) 2024; (240(5-6)):778-792 doi:10.1159/000540019.

Acute Respiratory Distress Syndrome in a Carrier of an Interleukin-36 Receptor Antagonist Mutation With Generalized Pustular Psoriasis.

Baniel A, Bar-Ilan E, Hilerowicz Y, et al.

Journal of psoriasis and psoriatic arthritis 2022; (7(1)):9-12 doi:10.1177/24755303211051724.

The Disease Burden of Generalized Pustular Psoriasis: Real-World Evidence From CorEvitas' Psoriasis Registry.

Lebwohl M, Medeiros RA, Mackey RH, et al.

Journal of psoriasis and psoriatic arthritis 2022; (7(2)):71-78 doi:10.1177/24755303221079814.

2023 guidelines on the management of psoriasis by the Dermatological Society of Singapore.

Oon HH, Tan C, Aw DCW, et al.

Annals of the Academy of Medicine, Singapore 2024; (53(9)):562-577 doi:10.47102/annals-acadmedsg.2023367.

Successful treatment of generalized pustular psoriasis with chronic hepatitis B using spesolimab: A case report.

Ming R, Zhang L, Xiong X

Medicine 2025; (104(17)):e41979 doi:10.1097/MD.0000000000041979.

A Global Assessment of Patient Experience and Quality of Life in Generalized Pustular Psoriasis: Results from Interviews and Online Surveys.

Kole LCS, Tada Y, Gerdes S, et al.

Dermatology and therapy 2025; (15(10)):3037-3053 doi:10.1007/s13555-025-01483-2.

Generalized Pustular Psoriasis as a Systemic Inflammatory Disease: Experience With 38 Japanese Cases Over 15 Years at a Single Institution.

Kikuchi N, Kusano M, Yamamoto T

Cureus 2025; (17(7)):e88108 doi:10.7759/cureus.88108.

A prospective, observational study of the epidemiology, disease characteristics and treatment outcomes of generalized pustular psoriasis in India.

Dogra S, Sharma A, Narang T, Handa S

Clinical and experimental dermatology 2026; (51(4)):571-577 doi:10.1093/ced/llaf507.

Patient Experiences on the Diagnosis, Management, and Burden of Generalized Pustular Psoriasis: An International Web Survey and Qualitative Interview Study.

Lebwohl M, Fujita H, Eyerich K, et al.

Journal of psoriasis and psoriatic arthritis 2025; 24755303251401112 doi:10.1177/24755303251401112.

Generalized Pustular Psoriasis: Review and Consensus of the Psoriasis Group of the Spanish Academy of Dermatology and Venereology.

Puig L, Carrascosa JM, Rivera R, et al.

Actas dermo-sifiliograficas 2026; (117(3)):104544 doi:10.1016/j.ad.2025.104544.

The IL-36 cytokine family: From barrier immunity to therapeutic target in inflammatory diseases.

Satoh TK, Mellett M, French LE

Allergology international : official journal of the Japanese Society of Allergology 2026; (75(3)):366-379 doi:10.1016/j.alit.2026.01.006.

Comparison of Severity Assessment Methods in Generalized Pustular Psoriasis: A Single-Center Study.

Ozaki M, Hayama K, Fujita H

The Journal of dermatology 2026; (53(5)):851-855 doi:10.1111/1346-8138.70232.

Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis.

Smieszek S, Przychodzen B, Tyner C, et al.

NEJM evidence 2026; (5(5)):EVIDoa2500272 doi:10.1056/EVIDoa2500272.

RSV infection-associated pediatric generalized pustular psoriasis with innate immune activation: a case report.

Zhou X, An R, Qu P, et al.

Frontiers in immunology 2026; (17()):1808692 doi:10.3389/fimmu.2026.1808692.

Monotherapy with Biologics for Generalized Pustular Psoriasis: A Systematic Review of Comparative Interventional Studies with an Exploratory Network Meta-Analysis.

Gupta AK, Bamimore MA, Wang T, et al.

Medical sciences (Basel, Switzerland) 2026; (14(2)) doi:10.3390/medsci14020307.

Clinical Practice Recommendations for Non-Dermatologists on the Diagnostic Suspicion of GPP.

Di Cesare A, Rosi E, Cavallo A, et al.

Journal of clinical medicine 2026; (15(15)) doi:10.3390/jcm15156087.

Spesolimab for treatment of generalized pustular psoriasis of pregnancy.

Bunn J, Henricks C, Azhar A, et al.

Pregnancy (Hoboken, N.J.) 2026; (2(1)):e70196 doi:10.1002/pmf2.70196.