Research & Literature

Regulation of hepatic lipase activity by sphingomyelin in plasma lipoproteins.

Yang P, Subbaiah PV

Biochimica et biophysica acta 2015; (1851(10)):1327-36.

Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism.

Kobayashi J, Miyashita K, Nakajima K, Mabuchi H

Journal of atherosclerosis and thrombosis 2015; (22(10)):1001-11 doi:10.5551/jat.31617.

Clinical Study of 224 Patients with Hypertriglyceridemia Pancreatitis.

Zhang XL, Li F, Zhen YM, et al.

Chinese medical journal 2015; (128(15)):2045-9 doi:10.4103/0366-6999.161361.

[Severe hypertriglyceridemia induced acute pancreatitis: a case report and review of the literature].

Herrera Del Águila DD, Garavito Rentería J, Linarez Medina K, Lizarzaburu Rodríguez V

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 2015; (35(2)):159-64.

Primary hypertriglyceridemia in children and adolescents.

Shah AS, Wilson DP

Journal of clinical lipidology 2015; (9(5 Suppl)):S20-8.

Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis.

Andrés-Blasco I, Herrero-Cervera A, Vinué Á, et al.

The Journal of endocrinology 2015; (227(3)):179-91 doi:10.1530/JOE-15-0219.

Long-term follow-up of young adults with familial hypercholesterolemia after participation in clinical trials during childhood.

Langslet G, Bogsrud MP, Halvorsen I, et al.

Journal of clinical lipidology 2015; (9(6)):778-785 doi:10.1016/j.jacl.2015.08.008.

A Chinese patient with recurrent pancreatitis during pregnancy induced by hypertriglyceridemia associated with compound heterozygosity (Glu242Lys and Leu252VaL) in the lipoprotein lipase gene.

Liu Y, Lun Y, Lv W, et al.

Journal of clinical lipidology 2016; (10(1)):199-203.e1.

Hypertriglyceridemic pancreatitis associated with confounding laboratory abnormalities.

Melnick S, Nazir S, Gish D, Aryal MR

Journal of community hospital internal medicine perspectives 2016; (6(3)):31808 doi:10.3402/jchimp.v6.31808.

High-density lipoprotein subpopulation profiles in lipoprotein lipase and hepatic lipase deficiency.

Tani M, Horvath KV, Lamarche B, et al.

Atherosclerosis 2016; (253()):7-14 doi:10.1016/j.atherosclerosis.2016.08.014.

Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans.

Labadzhyan A, Cui J, Péterfy M, et al.

PloS one 2016; (11(11)):e0166263 doi:10.1371/journal.pone.0166263.

Managing Cardiovascular Risk in Lysosomal Acid Lipase Deficiency.

Maciejko JJ

American journal of cardiovascular drugs : drugs, devices, and other interventions 2017; (17(3)):217-231 doi:10.1007/s40256-017-0216-5.

Lysosomal acid lipase deficiency in all siblings of the same parents.

Maciejko JJ, Anne P, Raza S, Lyons HJ

Journal of clinical lipidology 2017; (11(2)):567-574 doi:10.1016/j.jacl.2017.02.006.

Incidental finding of severe hypertriglyceridemia in children. Role of multiple rare variants in genes affecting plasma triglyceride.

Buonuomo PS, Rabacchi C, Macchiaiolo M, et al.

Journal of clinical lipidology 2017; (11(6)):1329-1337.e3 doi:10.1016/j.jacl.2017.08.017.

Severe hypertriglyceridemia in Japan: Differences in causes and therapeutic responses.

Murase T, Okubo M, Ebara T, Mori Y

Journal of clinical lipidology 2017; (11(6)):1383-1392 doi:10.1016/j.jacl.2017.08.006.

PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes.

Hess CN, Low Wang CC, Hiatt WR

Annual review of medicine 2018; (69()):133-145 doi:10.1146/annurev-med-042716-091351.

2017 George Lyman Duff Memorial Lecture: Fat in the Blood, Fat in the Artery, Fat in the Heart: Triglyceride in Physiology and Disease.

Goldberg IJ

Arteriosclerosis, thrombosis, and vascular biology 2018; (38(4)):700-706 doi:10.1161/ATVBAHA.117.309666.

Clinical features and outcomes of severe, very severe, and extreme hypertriglyceridemia in a regional health service.

Zafrir B, Jubran A, Hijazi R, Shapira C

Journal of clinical lipidology 2018; (12(4)):928-936 doi:10.1016/j.jacl.2018.03.086.

Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span.

Williams L, Rhodes KS, Karmally W, et al.

Journal of clinical lipidology 2018; (12(4)):908-919 doi:10.1016/j.jacl.2018.04.010.

Pharmacological treatment options for severe hypertriglyceridemia and familial chylomicronemia syndrome.

Chaudhry R, Viljoen A, Wierzbicki AS

Expert review of clinical pharmacology 2018; (11(6)):589-598 doi:10.1080/17512433.2018.1480368.

Diagnostic Algorithm for Cholesteryl Ester Storage Disease: Clinical Presentation in 19 Polish Patients.

Lipiński P, Ługowska A, Zakharova EY, et al.

Journal of pediatric gastroenterology and nutrition 2018; (67(4)):452-457 doi:10.1097/MPG.0000000000002084.

Familial Chylomicronemia Syndrome: A Clinical Guide For Endocrinologists.

Falko JM

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2018; (24(8)):756-763 doi:10.4158/EP-2018-0157.

Abruptio Placentae Caused by Hypertriglyceridemia-Induced Acute Pancreatitis during Pregnancy: Case Report and Literature Review.

Yalcin Bahat P, Turan G, Aslan Cetin B

Case reports in obstetrics and gynecology 2018; (2018()):3869695 doi:10.1155/2018/3869695.

Triglyceride-Rich Lipoproteins and Novel Targets for Anti-atherosclerotic Therapy.

Reiner Ž

Korean circulation journal 2018; (48(12)):1097-1119 doi:10.4070/kcj.2018.0343.

Aerobic exercise reduces triglycerides by targeting apolipoprotein C3 in patients with coronary heart disease.

Wang Y, Shen L, Xu D

Clinical cardiology 2019; (42(1)):56-61 doi:10.1002/clc.23104.

Severe Hypertriglyceridemia-Related Pancreatitis: Characteristics and Predictors of Recurrence.

Zafrir B, Saliba W, Jubran A, et al.

Pancreas 2019; (48(2)):182-186 doi:10.1097/MPA.0000000000001235.

LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study.

Silbernagel G, Scharnagl H, Kleber ME, et al.

Atherosclerosis 2019; (282()):37-44 doi:10.1016/j.atherosclerosis.2018.12.024.

Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population.

Teng MS, Wu S, Hsu LA, et al.

Lipids in health and disease 2019; (18(1)):111 doi:10.1186/s12944-019-1057-9.

Early diagnosis of infantile-onset lysosomal acid lipase deficiency in the advent of available enzyme replacement therapy.

Cohen JL, Burfield J, Valdez-Gonzalez K, et al.

Orphanet journal of rare diseases 2019; (14(1)):198 doi:10.1186/s13023-019-1129-y.

The Diagnosis and Treatment of Hypertriglyceridemia.

Parhofer KG, Laufs U

Deutsches Arzteblatt international 2019; (116(49)):825-832.

Lipase C, Hepatic Type -250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil.

Zago VHS, Parra ES, Virgínio VWM, et al.

Lipids 2020; (55(3)):225-237 doi:10.1002/lipd.12232.

Can genetic testing help in the management of dyslipidaemias?

Lazarte J, Hegele RA

Current opinion in lipidology 2020; (31(4)):187-193 doi:10.1097/MOL.0000000000000690.

Management of Hypertriglyceridemia: Common Questions and Answers.

Oh RC, Trivette ET, Westerfield KL

American family physician 2020; (102(6)):347-354.

Hyperalphalipoproteinemia and Beyond: The Role of HDL in Cardiovascular Diseases.

Giammanco A, Noto D, Barbagallo CM, et al.

Life (Basel, Switzerland) 2021; (11(6)) doi:10.3390/life11060581.

A Modern Approach to Dyslipidemia.

Berberich AJ, Hegele RA

Endocrine reviews 2022; (43(4)):611-653 doi:10.1210/endrev/bnab037.

Approach to the Patient With Moderate Hypertriglyceridemia.

Subramanian S

The Journal of clinical endocrinology and metabolism 2022; (107(6)):1686-1697 doi:10.1210/clinem/dgac085.

Hypertriglyceridemia Induced Acute Pancreatitis Caused by a Novel LIPC Gene Variant in a Pediatric Patient.

Balanescu L, Cardoneanu A, Stanciu G, et al.

Children (Basel, Switzerland) 2022; (9(2)) doi:10.3390/children9020188.

The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence.

Luna-Castillo KP, Olivares-Ochoa XC, Hernández-Ruiz RG, et al.

Nutrients 2022; (14(5)) doi:10.3390/nu14051104.

Hypertriglyceridemia-Induced Pancreatitis and a Lipemic Blood Sample: A Case Report and Brief Clinical Review.

Ahern BJ, Yi HJ, Somma CL

Journal of emergency nursing 2022; (48(4)):455-459 doi:10.1016/j.jen.2022.02.001.

A case of eruptive xanthomas associated with pregnancy unmasking a G188E heterozygous mutation of the lipoprotein lipase gene: A case report.

Paquette C, Careau AM, Bergeron J, et al.

SAGE open medical case reports 2022; (10()):2050313X221131865 doi:10.1177/2050313X221131865.

Acute pancreatitis secondary to moderate hypertriglyceridemia: A case report.

Nepali A, Kharga S, Jayan M, et al.

Clinical case reports 2024; (12(3)):e8582 doi:10.1002/ccr3.8582.

Severe Hypertriglyceridemia in Patients with Type 2 Diabetes Mellitus Participating in the AMD Annals Initiative.

Russo GT, Manicardi V, Rocca A, et al.

Metabolic syndrome and related disorders 2024; (22(9)):661-668 doi:10.1089/met.2024.0093.

Phenotype in Individuals with Heterozygous Rare Variants in LIPC Encoding Hepatic Lipase.

Jacob EO, Wang J, McIntyre AD, Hegele RA

International journal of molecular sciences 2024; (25(21)) doi:10.3390/ijms252111445.

Identification of a Pathogenic Mutation of the Lipase Maturation Factor 1 (LMF1) Gene Causing Recurrent Pancreatitis and Requiring Critical Care.

Montalvo AF, González-Andrade F, Molestina MJ, et al.

Journal of clinical medicine 2025; (14(6)) doi:10.3390/jcm14061827.

Versatile Functions of Hepatic Lipase in Lipoprotein Metabolism.

Dijk W, Rimbert A, Sotin T, et al.

Arteriosclerosis, thrombosis, and vascular biology 2026; (46(1)):105-118 doi:10.1161/ATVBAHA.125.323051.

Dysbetalipoproteinaemia in genetically predisposed Ghanaians.

Ateko RO, Marais AD, Blom DJ, et al.

Lipids in health and disease 2025; (24(1)):367 doi:10.1186/s12944-025-02787-0.

Prevention and treatment of hypertriglyceridemia-mediated acute pancreatitis: A narrative review.

Subramanian S, Soran H, Sikora Kessler A, et al.

European journal of internal medicine 2025; 106648 doi:10.1016/j.ejim.2025.106648.

Post-heparin plasma lipase activities in patients with severe hypertriglyceridemia treated with evinacumab.

Vitali C, Banerjee P, Pordy R, et al.

Journal of lipid research 2026; (67(4)):101020 doi:10.1016/j.jlr.2026.101020.

Lipid clinics worldwide: harmonization and guidance on how to optimally organize and fund. European Atherosclerosis Society consensus statement across 55 countries and more than 500 lipid clinics.

Bork C, Nordestgaard BG, Hedegaard BS, et al.

Atherosclerosis 2026; (418()):120757 doi:10.1016/j.atherosclerosis.2026.120757.

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.

Ferrandino M, Cerrato Y, Iannuzzo G, et al.

Genes 2026; (17(6)) doi:10.3390/genes17060721.

Silencing Triglycerides: The Clinical Impact of Plozasiran and apoC-III Inhibition in Severe Hypertriglyceridemia.

Kassem BA, Shaik FA, Sorour O, et al.

Journal of cardiovascular pharmacology 2026; (88(2)):123-131 doi:10.1097/FJC.0000000000001846.

Management of complex lipid disorders in a community lipid clinic setting: Implementing a multidisciplinary model.

Miyamoto MI, Ko C, Chiu ST, et al.

Journal of clinical lipidology 2026; doi:10.1016/j.jacl.2026.08.022.