Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
Top Authors
Top Institutions
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The University of Texas MD Anderson Cancer Center
Houston, United States
University of North Carolina at Chapel Hill
Chapel Hill, United States
Dana-Farber Cancer Institute
Boston, United States
Yale Cancer Center
New Haven, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Stanford University
Stanford, United States
American Society of Clinical Oncology
Alexandria, United States
German Breast group
Offenbach, Germany
Sidney Kimmel Comprehensive Cancer Center
Baltimore, United States
University of California, Los Angeles
Los Angeles, United States
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Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial.
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Survival Impact and Cost-Effectiveness of a Multidisciplinary Tumor Board for Breast Cancer in Mozambique, Sub-Saharan Africa.
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Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline.
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Adjuvant Trastuzumab Emtansine Versus Paclitaxel in Combination With Trastuzumab for Stage I HER2-Positive Breast Cancer (ATEMPT): A Randomized Clinical Trial.
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Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies.
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Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors.
Tran TXM, Jung SY, Lee EG, et al.
Cancer research and treatment 2022; (54(4)):1065-1073 doi:10.4143/crt.2021.835.
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How we treat patients with metastatic HER2-positive breast cancer.
Nader-Marta G, Martins-Branco D, de Azambuja E
ESMO open 2022; (7(1)):100343 doi:10.1016/j.esmoop.2021.100343.
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Current and future landscape of targeted therapy in HER2-positive advanced breast cancer: redrawing the lines.
Simmons C, Rayson D, Joy AA, et al.
Therapeutic advances in medical oncology 2022; (14()):17588359211066677 doi:10.1177/17588359211066677.
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Neoadjuvant and adjuvant treatment of patients with HER2-positive early breast cancer.
Harbeck N
Breast (Edinburgh, Scotland) 2022; (62 Suppl 1()):S12-S16 doi:10.1016/j.breast.2022.01.006.
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Multidisciplinary Management of Breast Cancer and Role of the Patient Navigator.
Fenton A, Downes N, Mendiola A, et al.
Obstetrics and gynecology clinics of North America 2022; (49(1)):167-179 doi:10.1016/j.ogc.2021.11.011.
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Multidisciplinary clinical guidance on trastuzumab deruxtecan (T-DXd)-related interstitial lung disease/pneumonitis-Focus on proactive monitoring, diagnosis, and management.
Swain SM, Nishino M, Lancaster LH, et al.
Cancer treatment reviews 2022; (106()):102378 doi:10.1016/j.ctrv.2022.102378.
PMID: 35430509 - 55
Network connectivity between fear of cancer recurrence, anxiety, and depression in breast cancer patients.
Yang Y, Sun H, Luo X, et al.
Journal of affective disorders 2022; (309()):358-367 doi:10.1016/j.jad.2022.04.119.
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Targeted lapatinib anti-HER2/ErbB2 therapy resistance in breast cancer: opportunities to overcome a difficult problem.
Wahdan-Alaswad R, Liu B, Thor AD
Cancer drug resistance (Alhambra, Calif.) 2020; (3(2)):179-198 doi:10.20517/cdr.2019.92.
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Systemic Therapy for Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Guideline Update.
Giordano SH, Franzoi MAB, Temin S, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2022; (40(23)):2612-2635 doi:10.1200/JCO.22.00519.
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The effect of psychological interventions on fear of cancer recurrence in breast cancer survivors: A systematic review and meta-analysis.
Lyu MM, Siah RC, Lam ASL, Cheng KKF
Journal of advanced nursing 2022; (78(10)):3069-3082 doi:10.1111/jan.15321.
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Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial.
Bartsch R, Berghoff AS, Furtner J, et al.
Nature medicine 2022; (28(9)):1840-1847 doi:10.1038/s41591-022-01935-8.
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The role of HER2 alterations in clinicopathological and molecular characteristics of breast cancer and HER2-targeted therapies: a comprehensive review.
Asgari-Karchekani S, Aryannejad A, Mousavi SA, et al.
Medical oncology (Northwood, London, England) 2022; (39(12)):210 doi:10.1007/s12032-022-01817-6.
PMID: 36175719 - 61
Self-Reported Physical Activity, QoL, Cardiac Function, and Cardiorespiratory Fitness in Women With HER2+ Breast Cancer.
Peck SS, Esmaeilzadeh M, Rankin K, et al.
JACC. CardioOncology 2022; (4(3)):387-400 doi:10.1016/j.jaccao.2022.06.006.
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Therapeutic landscape of advanced HER2-positive breast cancer in 2022.
Gupta R, Gupta S, Antonios B, et al.
Medical oncology (Northwood, London, England) 2022; (39(12)):258 doi:10.1007/s12032-022-01849-y.
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A Vanguard Approach to the Design and Delivery of Nurse-Led Survivorship Care.
Sara SAM, Chambers SK, Briggs R, et al.
Seminars in oncology nursing 2023; (39(1)):151366 doi:10.1016/j.soncn.2022.151366.
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The Impact of Tumor Boards on Breast Cancer Care: Evidence from a Systematic Literature Review and Meta-Analysis.
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International journal of environmental research and public health 2022; (19(22)) doi:10.3390/ijerph192214990.
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Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial.
Lin NU, Murthy RK, Abramson V, et al.
JAMA oncology 2023; (9(2)):197-205 doi:10.1001/jamaoncol.2022.5610.
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Diastolic heart failure is a new clinical entity of trastuzumab-induced cardiotoxicity: a case report.
Fujita K, Matsumoto K, Kishi A, Kawasaki S
European heart journal. Case reports 2023; (7(1)):ytac470 doi:10.1093/ehjcr/ytac470.
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Cardiac safety of dual anti-HER2 blockade with pertuzumab plus trastuzumab in early HER2-positive breast cancer in the APHINITY trial.
de Azambuja E, Agostinetto E, Procter M, et al.
ESMO open 2023; (8(1)):100772 doi:10.1016/j.esmoop.2022.100772.
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Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
Tolaney SM, Tarantino P, Graham N, et al.
The Lancet. Oncology 2023; (24(3)):273-285 doi:10.1016/S1470-2045(23)00051-7.
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Risk of Recurrence in Patients With HER2+ Early-Stage Breast Cancer: Literature Analysis of Patient and Disease Characteristics.
O'Shaughnessy J, Gradishar W, O'Regan R, Gadi V
Clinical breast cancer 2023; (23(4)):350-362 doi:10.1016/j.clbc.2023.03.007.
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Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: ASCO-College of American Pathologists Guideline Update.
Wolff AC, Somerfield MR, Dowsett M, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023; (41(22)):3867-3872 doi:10.1200/JCO.22.02864.
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Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer.
Wolff AC, Somerfield MR, Dowsett M, et al.
Archives of pathology & laboratory medicine 2023; (147(9)):993-1000 doi:10.5858/arpa.2023-0950-SA.
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Can You Establish the Cause of This Patient's Shortness of Breath?
Trail A, Rogers J, Ajani J
Journal of the advanced practitioner in oncology 2023; (14(5)):440-443 doi:10.6004/jadpro.2023.14.5.8.
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Managing the Risk of Lung Toxicity with Trastuzumab Deruxtecan (T-DXd): A Canadian Perspective.
Henning JW, Brezden-Masley C, Gelmon K, et al.
Current oncology (Toronto, Ont.) 2023; (30(9)):8019-8038 doi:10.3390/curroncol30090582.
PMID: 37754497 - 74
Treatment with trastuzumab deruxtecan in patients with HER2-positive breast cancer and brain metastases and/or leptomeningeal disease (ROSET-BM).
Niikura N, Yamanaka T, Nomura H, et al.
NPJ breast cancer 2023; (9(1)):82 doi:10.1038/s41523-023-00584-5.
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Successful Trastuzumab-Deruxtecan Rechallenge After Interstitial Lung Disease: A Case Report.
de Weger VA, Schutte T, Konings IRHM, Menke-van der Houven van Oordt CW
Journal of breast cancer 2023; (26(5)):519-523 doi:10.4048/jbc.2023.26.e38.
PMID: 37926069 - 76
Clinicopathologic Features of 2018 American Society of Clinical Oncology/College of American Pathologists Fluorescence In Situ Hybridization Group 3 Breast Carcinoma (Human Epidermal Growth Factor Receptor 2 Chromosome 17 Centromere Ratio <2.0 and Average Human Epidermal Growth Factor Receptor 2 Copy Number ≥6.0).
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Archives of pathology & laboratory medicine 2024; (148(8)):890-897 doi:10.5858/arpa.2023-0275-OA.
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Survivorship Care for People Affected by Advanced or Metastatic Cancer: MASCC-ASCO Standards and Practice Recommendations.
Hart NH, Nekhlyudov L, Smith TJ, et al.
JCO oncology practice 2024; (20(9)):1160-1172 doi:10.1200/OP.23.00716.
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A Comprehensive Review of HER2 in Cancer Biology and Therapeutics.
Cheng X
Genes 2024; (15(7)) doi:10.3390/genes15070903.
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Role of Radiology in the Diagnosis and Treatment of Breast Cancer in Women: A Comprehensive Review.
Arslan M, Asim M, Sattar H, et al.
Cureus 2024; (16(9)):e70097 doi:10.7759/cureus.70097.
PMID: 39449897 - 80
Expert recommendations on treatment sequencing and challenging clinical scenarios in human epidermal growth factor receptor 2-positive (HER2-positive) metastatic breast cancer.
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Cancer treatment reviews 2025; (132()):102853 doi:10.1016/j.ctrv.2024.102853.
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Scanxiety and Fear of Recurrence in Young Adult Female Breast and Gynaecological Cancer Survivors: Investigating Shared Mechanisms.
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Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer.
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The New England journal of medicine 2025; (392(3)):249-257 doi:10.1056/NEJMoa2406070.
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Efficacy of a novel interstitial lung disease monitoring program in breast cancer patients undergoing treatment with trastuzumab-deruxtecan.
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Breast cancer research and treatment 2025; (210(2)):487-491 doi:10.1007/s10549-024-07586-2.
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Association of Surgeon Volume with Adherence to American Society of Breast Surgeons Surgical Quality Measures.
Chan K, Palis BE, Cotler JH, et al.
Annals of surgical oncology 2025; (32(11)):8144-8155 doi:10.1245/s10434-025-17846-0.
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Cardiac function surveillance practices and outcomes in patients with HER2-positive breast cancer treated with trastuzumab: a retrospective cohort study across a safety-net and tertiary care setting.
Huang L, Manthena P, Su M, et al.
Cardio-oncology (London, England) 2025; (11(1)):74 doi:10.1186/s40959-025-00376-9.
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MRI-Based Assessment of Margin Status Determinants, Preoperative Predictors, and Prognostic Outcomes in Breast-Conserving Surgery Following Neoadjuvant Therapy.
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World journal of surgery 2025; (49(10)):2620-2629 doi:10.1002/wjs.70072.
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