Research & Literature

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation.

Steffensen AB, Refsgaard L, Andersen MN, et al.

Journal of cardiovascular electrophysiology 2015; (26(7)):715-23 doi:10.1111/jce.12666.

Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.

Hayashi K, Konno T, Tada H, et al.

Circulation. Arrhythmia and electrophysiology 2015; (8(5)):1095-104 doi:10.1161/CIRCEP.114.002519.

An Experience of Landiolol Use for an Advanced Heart Failure Patient With Severe Hypotension.

Nitta D, Kinugawa K, Imamura T, et al.

International heart journal 2015; (56(5)):564-7 doi:10.1536/ihj.15-103.

Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark.

Gundlund A, Christiansen MN, Hansen ML, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2016; (18(5)):658-64 doi:10.1093/europace/euv274.

Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study.

Gundlund A, Olesen JB, Staerk L, et al.

Journal of the American Heart Association 2016; (5(11)).

Association of a Family History of Atrial Fibrillation With Incidence and Outcomes of Atrial Fibrillation: A Population-Based Family Cohort Study.

Chang SH, Kuo CF, Chou IJ, et al.

JAMA cardiology 2017; (2(8)):863-870 doi:10.1001/jamacardio.2017.1855.

Lamin A/C cardiomyopathy: young onset, high penetrance, and frequent need for heart transplantation.

Hasselberg NE, Haland TF, Saberniak J, et al.

European heart journal 2018; (39(10)):853-860 doi:10.1093/eurheartj/ehx596.

Atrial fibrillation progression and outcome in patients with young-onset atrial fibrillation.

De With RR, Marcos EG, Van Gelder IC, Rienstra M

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2018; (20(11)):1750-1757 doi:10.1093/europace/euy028.

Atrial Fibrillation in the ICU.

Bosch NA, Cimini J, Walkey AJ

Chest 2018; (154(6)):1424-1434 doi:10.1016/j.chest.2018.03.040.

A Nurse-Led Limited Risk Factor Modification Program to Address Obesity and Obstructive Sleep Apnea in Atrial Fibrillation Patients.

Yaeger A, Cash NR, Parham T, et al.

Journal of the American Heart Association 2018; (7(23)):e010414 doi:10.1161/JAHA.118.010414.

Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups.

Alzahrani Z, Ornelas-Loredo A, Darbar SD, et al.

JAMA network open 2018; (1(5)):e182497 doi:10.1001/jamanetworkopen.2018.2497.

Association of sex, age and education level with patient reported outcomes in atrial fibrillation.

Gleason KT, Dennison Himmelfarb CR, Ford DE, et al.

BMC cardiovascular disorders 2019; (19(1)):85 doi:10.1186/s12872-019-1059-6.

Patient-Centered Educational Resources for Atrial Fibrillation.

Gallagher C, Rowett D, Nyfort-Hansen K, et al.

JACC. Clinical electrophysiology 2019; (5(10)):1101-1114 doi:10.1016/j.jacep.2019.08.007.

Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.

Choi SH, Jurgens SJ, Weng LC, et al.

Circulation research 2020; (126(2)):200-209 doi:10.1161/CIRCRESAHA.119.315686.

Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration.

Schnabel RB, Haeusler KG, Healey JS, et al.

Circulation 2019; (140(22)):1834-1850 doi:10.1161/CIRCULATIONAHA.119.040267.

Epidemiology and clinical characteristics of atrial fibrillation in patients with inherited heart diseases.

Butters A, Isbister JC, Medi C, et al.

Journal of cardiovascular electrophysiology 2020; (31(2)):465-473 doi:10.1111/jce.14346.

Psychosocial and cognitive multimorbidity and health-related quality of life and symptom burden in older adults with atrial fibrillation: The systematic assessment of geriatric elements in atrial fibrillation (SAGE-AF) cohort study.

Bamgbade BA, Sanghai SR, McManus DD, et al.

Archives of gerontology and geriatrics 2020; (90()):104117 doi:10.1016/j.archger.2020.104117.

Risk predictors in a Spanish cohort with cardiac laminopathies. The REDLAMINA registry.

Barriales-Villa R, Ochoa JP, Larrañaga-Moreira JM, et al.

Revista espanola de cardiologia (English ed.) 2021; (74(3)):216-224 doi:10.1016/j.rec.2020.03.026.

Exploring Depressive Symptoms and Anxiety Among Patients With Atrial Fibrillation and/or Flutter at the Time of Cardioversion or Ablation.

Koleck TA, Mitha SA, Biviano A, et al.

The Journal of cardiovascular nursing 2021; (36(5)):470-481 doi:10.1097/JCN.0000000000000723.

Early Rhythm-Control Therapy in Patients with Atrial Fibrillation.

Kirchhof P, Camm AJ, Goette A, et al.

The New England journal of medicine 2020; (383(14)):1305-1316 doi:10.1056/NEJMoa2019422.

Stroke risk in hypertrophic cardiomyopathy patients with atrial fibrillation: a nationwide database study.

Hsu JC, Huang YT, Lin LY

Aging 2020; (12(23)):24219-24227 doi:10.18632/aging.104133.

Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in 'lone' atrial fibrillation.

Lazarte J, Laksman ZW, Wang J, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2021; (23(6)):844-850 doi:10.1093/europace/euaa421.

Persistent atrial fibrillation ablation in cardiac laminopathy: Electrophysiological findings and clinical outcomes.

Chauvel R, Derval N, Duchateau J, et al.

Heart rhythm 2021; (18(7)):1115-1121 doi:10.1016/j.hrthm.2021.03.040.

Timing of pacemaker and ICD implantation in LMNA mutation carriers.

Ollila LH, Nikus K, Parikka H, et al.

Open heart 2021; (8(1)) doi:10.1136/openhrt-2021-001622.

Early-Onset Atrial Fibrillation and the Prevalence of Rare Variants in Cardiomyopathy and Arrhythmia Genes.

Yoneda ZT, Anderson KC, Quintana JA, et al.

JAMA cardiology 2021; (6(12)):1371-1379 doi:10.1001/jamacardio.2021.3370.

Genetically based atrial fibrillation: Current considerations for diagnosis and management.

Pensa AV, Baman JR, Puckelwartz MJ, Wilcox JE

Journal of cardiovascular electrophysiology 2022; (33(8)):1944-1953 doi:10.1111/jce.15446.

Effect of Occurrence of Lamin A/C (LMNA) Genetic Variants in a Cohort of 101 Consecutive Apparent "Lone AF" Patients: Results and Insights.

Pessente GD, Sacilotto L, Calil ZO, et al.

Frontiers in cardiovascular medicine 2022; (9()):823717 doi:10.3389/fcvm.2022.823717.

Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes.

Yoneda ZT, Anderson KC, Ye F, et al.

JAMA cardiology 2022; (7(7)):733-741 doi:10.1001/jamacardio.2022.0810.

Arrhythmias as Presentation of Genetic Cardiomyopathy.

Lukas Laws J, Lancaster MC, Ben Shoemaker M, et al.

Circulation research 2022; (130(11)):1698-1722 doi:10.1161/CIRCRESAHA.122.319835.

Habitual Alcohol Intake and Risk of Atrial Fibrillation in Young Adults in Korea.

Han M, Lee SR, Choi EK, et al.

JAMA network open 2022; (5(9)):e2229799 doi:10.1001/jamanetworkopen.2022.29799.

Effect of Multifactorial Risk Factor Interventions on Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Liu H, Brobbey A, Ejaredar M, et al.

Current problems in cardiology 2023; (48(4)):101572 doi:10.1016/j.cpcardiol.2022.101572.

Population-Level Prevalence of Rare Variants Associated With Atrial Fibrillation and its Impact on Patient Outcomes.

Kandola MS, Kulm S, Kim LK, et al.

JACC. Clinical electrophysiology 2023; (9(7 Pt 2)):1137-1146 doi:10.1016/j.jacep.2022.11.022.

Genetic Basis of Early Onset Atrial Fibrillation in Patients without Risk Factors.

Rudaka I, Vilne B, Isakova J, et al.

Journal of cardiovascular development and disease 2023; (10(3)) doi:10.3390/jcdd10030104.

Genetic testing in monogenic early-onset atrial fibrillation.

Chalazan B, Freeth E, Mohajeri A, et al.

European journal of human genetics : EJHG 2023; (31(7)):769-775 doi:10.1038/s41431-023-01383-z.

Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy.

Rowin EJ, Link MS, Maron MS, Maron BJ

Circulation 2023; (148(22)):1797-1811 doi:10.1161/CIRCULATIONAHA.123.065037.

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Joglar JA, Chung MK, Armbruster AL, et al.

Circulation 2024; (149(1)):e1-e156 doi:10.1161/CIR.0000000000001193.

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

, Joglar JA, Chung MK, et al.

Journal of the American College of Cardiology 2024; (83(1)):109-279 doi:10.1016/j.jacc.2023.08.017.

The effects of cognitive behavioral therapy on health-related quality of life, anxiety, depression, illness perception, and in atrial fibrillation patients: a six-month longitudinal study.

Minjie Z, Zhijuan X, Xinxin S, et al.

BMC psychology 2023; (11(1)):431 doi:10.1186/s40359-023-01457-z.

Does coping style mediate the relationship between knowledge and psychosocial outcomes in women with atrial fibrillation?

Le Grande MR, Salvacion M, Shwaita L, et al.

Frontiers in psychiatry 2024; (15()):1328111 doi:10.3389/fpsyt.2024.1328111.

Genetic testing in early-onset atrial fibrillation.

Kany S, Jurgens SJ, Rämö JT, et al.

European heart journal 2024; (45(34)):3111-3123 doi:10.1093/eurheartj/ehae298.

Clinical presentation and genetic characterization of early-onset atrial fibrillation in patients affected by long QT syndrome: A single-center experience.

Sarubbi B, Ciriello GD, Barretta F, et al.

Journal of cardiovascular electrophysiology 2024; (35(10)):1941-1951 doi:10.1111/jce.16384.

Diet and risk of atrial fibrillation: a systematic review.

Gawałko M, Middeldorp ME, Saljic A, et al.

European heart journal 2024; (45(40)):4259-4274 doi:10.1093/eurheartj/ehae551.

Clinical Characteristics and Outcomes in Patients With Atrial Fibrillation and Pathogenic TTN Variants.

Virk ZM, El-Harasis MA, Yoneda ZT, et al.

JACC. Clinical electrophysiology 2024; (10(11)):2445-2457 doi:10.1016/j.jacep.2024.07.029.

Atrial Fibrillation: A Review.

Ko D, Chung MK, Evans PT, et al.

JAMA 2025; (333(4)):329-342 doi:10.1001/jama.2024.22451.

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.

Roselli C, Surakka I, Olesen MS, et al.

Nature genetics 2025; (57(3)):539-547 doi:10.1038/s41588-024-02072-3.

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.

Choi SH, Jurgens SJ, Xiao L, et al.

Nature genetics 2025; (57(3)):548-562 doi:10.1038/s41588-025-02074-9.

Cardiovascular benefits of early rhythm control and healthy lifestyle in young atrial fibrillation.

Lee KY, Lee SR, Choi EK, et al.

European journal of clinical investigation 2025; (55(6)):e70018 doi:10.1111/eci.70018.

The Influence of Risk Factor Modification on Atrial Fibrillation Outcomes and Their Impact on the Success of Catheter Ablation.

Chandan N, Ashok V, Hwang T, et al.

Reviews in cardiovascular medicine 2025; (26(3)):27175 doi:10.31083/RCM27175.

The Therapeutic Impact of Genetic Evaluation in an Atrial Fibrillation Precision Medicine Clinic.

Laws JL, Shabani M, Williams HL, et al.

medRxiv : the preprint server for health sciences 2025; doi:10.1101/2025.03.28.25324544.

Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation.

Wijdeveld LFJM, Ajufo E, Challa SP, et al.

JAMA cardiology 2025; (10(6)):564-573 doi:10.1001/jamacardio.2025.0460.

The Role of Cardiac Magnetic Resonance Imaging in the Management of Hypertrophic Cardiomyopathy.

Pugliese L, Luciano A, Chiocchi M

Journal of cardiovascular development and disease 2025; (12(5)) doi:10.3390/jcdd12050189.

Variant-Specific Late Gadolinium Enhancement Patterns Influence Clinical Outcomes in LMNA-Related Cardiomyopathy.

Castrichini M, Garmany R, Siontis KC, et al.

Journal of the American Heart Association 2025; (14(15)):e041230 doi:10.1161/JAHA.124.041230.

Diabetes and Obesity and Treatment Effect of Early Rhythm Control vs Usual Care in Patients With Atrial Fibrillation: A Secondary Analysis of the EAST-AFNET 4 Randomized Clinical Trial.

Metzner A, Willems S, Borof K, et al.

JAMA cardiology 2025; (10(9)):932-941 doi:10.1001/jamacardio.2025.2374.

Age-Dependent Contributions of Rare and Common Genetic Variation in Atrial Fibrillation.

Chen Z, Aziz PF, Greenland P, et al.

Circulation. Genomic and precision medicine 2025; (18(5)):e004958 doi:10.1161/CIRCGEN.124.004958.

Prevalence and severity of atrial cardiomyopathy in patients with recently diagnosed atrial fibrillation and stroke risk factors and its association with early rhythm control: a secondary analysis of EAST-AFNET 4.

Goette A, Lemoine MD, Borof K, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025; (27(10)) doi:10.1093/europace/euaf256.

Long-term prognosis in early-onset atrial fibrillation without overt cardiovascular disease.

Holt A, Strange JE, Gislason GH, et al.

Heart rhythm 2026; (23(1)):e5-e12 doi:10.1016/j.hrthm.2025.09.044.

Genetic evaluation of early-onset atrial fibrillation: impact on patient management.

Laws JL, Shabani M, Williams HL, et al.

European heart journal 2026; (47(13)):1554-1572 doi:10.1093/eurheartj/ehaf829.

New recommendations for rhythm control-What has changed in the 2023 ACC/AHA/ACCP/HRS and 2024 ESC guidelines for atrial fibrillation, and where does dronedarone fit in?

Naccarelli GV, Rackley J, Boriani G

American heart journal plus : cardiology research and practice 2025; (60()):100645 doi:10.1016/j.ahjo.2025.100645.

New Insights in the Diagnosis and Treatment of Atrial Fibrillation in Patients with Hypertrophic Obstructive Cardiomyopathy.

Angelescu CM, Iosifescu TA, Căldăraru CI, et al.

Journal of clinical medicine 2026; (15(8)) doi:10.3390/jcm15083014.

Filamin C Genetic Cardiomyopathy Presenting as Acute Myocardial Injury.

Alexandrino FB, Curtis B, Nguyen C, et al.

JACC. Case reports 2026; (31(26)):108470 doi:10.1016/j.jaccas.2026.108470.

Sex Differences in the Burden of Atrial Fibrillation/Flutter and Associated Heart Failure Stratified by Age at Onset.

Ding Z, Tian X, Zhao J, et al.

Pacing and clinical electrophysiology : PACE 2026; doi:10.1111/pace.70341.

A Review of Cardiomyopathy Gene Variants as Drivers of Early-Onset Atrial Fibrillation: Linking Genotype to Phenotype in Precision Medicine.

Reinhold J, Chrysostomou P, Heck PM, et al.

European heart journal. Quality of care & clinical outcomes 2026; doi:10.1093/ehjqcco/qcag113.

2026 AHA/ACC Clinical Performance and Quality Measures for Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association.

Benjamin EJ, Marcus GM, Hess PL, et al.

Journal of the American College of Cardiology 2026; doi:10.1016/j.jacc.2026.05.032.

Clinical Presentation and Prognosis of Pathogenic Variants in Young-Onset Atrial Fibrillation.

D'Elia N, Dragas M, Bevacqua F, et al.

Journal of cardiovascular electrophysiology 2026; doi:10.1111/jce.70483.

How does genetic susceptibility impact the effectiveness of AF ablation?

Mililis P, Paraskevopoulou D, Saplaouras A, et al.

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2026; doi:10.1016/j.hjc.2026.08.005.

Atrial Fibrillation in Genotyped Dilated Cardiomyopathy: Epidemiology, Risk Factors, and Outcomes: Insights From the SHaRe Registry.

Balakrishnan ID, Heymans ABM, Claggett B, et al.

Circulation. Heart failure 2026; e014322 doi:10.1161/CIRCHEARTFAILURE.125.014322.