Research & Literature

External prolonged electrocardiogram monitoring in unexplained syncope and palpitations: results of the SYNARR-Flash study.

Locati ET, Moya A, Oliveira M, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2016; (18(8)):1265-72 doi:10.1093/europace/euv311.

Cardiac Abnormalities in First-Degree Relatives of Unexplained Cardiac Arrest Victims: A Report From the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry.

Steinberg C, Padfield GJ, Champagne J, et al.

Circulation. Arrhythmia and electrophysiology 2016; (9(9)).

Mechanism of syncope without prodromes with normal heart and normal electrocardiogram.

Brignole M, Guieu R, Tomaino M, et al.

Heart rhythm 2017; (14(2)):234-239 doi:10.1016/j.hrthm.2016.08.046.

Relationships of Measured and Genetically Determined Height With the Cardiac Conduction System in Healthy Adults.

Kofler T, Thériault S, Bossard M, et al.

Circulation. Arrhythmia and electrophysiology 2017; (10(1)) doi:10.1161/CIRCEP.116.004735.

Implantable cardioverter-defibrillator implantation for primary and secondary prevention: indications and outcomes.

Pick JM, Batra AS

Cardiology in the young 2017; (27(S1)):S126-S131 doi:10.1017/S1047951116002365.

Noninvasive Determination of HV Interval Using Magnetocardiography.

Senthilnathan S, Selvaraj RJ, Patel R, et al.

Pacing and clinical electrophysiology : PACE 2017; (40(5)):568-577 doi:10.1111/pace.13067.

Syncope: Evaluation and Differential Diagnosis.

Runser LA, Gauer RL, Houser A

American family physician 2017; (95(5)):303-312.

The normal variants in the left bundle branch system.

Elizari MV

Journal of electrocardiology 2017; (50(4)):389-399 doi:10.1016/j.jelectrocard.2017.03.004.

Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy.

Hayano M, Makiyama T, Kamakura T, et al.

Circulation journal : official journal of the Japanese Circulation Society 2017; (81(12)):1783-1791 doi:10.1253/circj.CJ-17-0064.

Arrhythmias Originating in the Atria.

Leonelli F, Bagliani G, Boriani G, Padeletti L

Cardiac electrophysiology clinics 2017; (9(3)):383-409 doi:10.1016/j.ccep.2017.05.002.

The QRS Complex: Normal Activation of the Ventricles.

Bagliani G, De Ponti R, Gianni C, Padeletti L

Cardiac electrophysiology clinics 2017; (9(3)):453-460 doi:10.1016/j.ccep.2017.05.005.

Cardiac Arrhythmias Related to Sodium Channel Dysfunction.

Savio-Galimberti E, Argenziano M, Antzelevitch C

Handbook of experimental pharmacology 2018; (246()):331-354 doi:10.1007/164_2017_43.

Lamin A/C cardiomyopathy: young onset, high penetrance, and frequent need for heart transplantation.

Hasselberg NE, Haland TF, Saberniak J, et al.

European heart journal 2018; (39(10)):853-860 doi:10.1093/eurheartj/ehx596.

Transient receptor potential melastatin 4 cation channel in pediatric heart block.

Tian J, An XJ, Fu MY

European review for medical and pharmacological sciences 2017; (21(4 Suppl)):79-84.

Lamin and the heart.

Captur G, Arbustini E, Bonne G, et al.

Heart (British Cardiac Society) 2018; (104(6)):468-479 doi:10.1136/heartjnl-2017-312338.

Contemporary genetic testing in inherited cardiac disease: tools, ethical issues, and clinical applications.

Girolami F, Frisso G, Benelli M, et al.

Journal of cardiovascular medicine (Hagerstown, Md.) 2018; (19(1)):1-11 doi:10.2459/JCM.0000000000000589.

Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers.

Nishiuchi S, Makiyama T, Aiba T, et al.

Circulation. Cardiovascular genetics 2017; (10(6)) doi:10.1161/CIRCGENETICS.116.001603.

Cardiac manifestations of PRKAG2 mutation.

Banankhah P, Fishbein GA, Dota A, Ardehali R

BMC medical genetics 2018; (19(1)):1 doi:10.1186/s12881-017-0512-6.

Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells.

Zhan Y, Sun X, Li B, et al.

Journal of molecular and cellular cardiology 2018; (117()):49-61 doi:10.1016/j.yjmcc.2018.02.007.

Human γ2-AMPK Mutations.

Yavari A, Sarma D, Sternick EB

Methods in molecular biology (Clifton, N.J.) 2018; (1732()):581-619 doi:10.1007/978-1-4939-7598-3_37.

Genotype-phenotype relationship and risk stratification in loss-of-function SCN5A mutation carriers.

Robyns T, Nuyens D, Vandenberk B, et al.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2018; (23(5)):e12548 doi:10.1111/anec.12548.

Atrial Flutter With Exercise-Induced 1:1 Atrioventricular Conduction.

Burkhart R, Gerasimon G

The Journal of the American Osteopathic Association 2018; (118(5)):337-340 doi:10.7556/jaoa.2018.065.

Clinical Spectrum of SCN5A Mutations: Long QT Syndrome, Brugada Syndrome, and Cardiomyopathy.

Wilde AAM, Amin AS

JACC. Clinical electrophysiology 2018; (4(5)):569-579 doi:10.1016/j.jacep.2018.03.006.

Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).

Hershberger RE, Givertz MM, Ho CY, et al.

Genetics in medicine : official journal of the American College of Medical Genetics 2018; (20(9)):899-909 doi:10.1038/s41436-018-0039-z.

Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys).

Podliesna S, Delanne J, Miller L, et al.

Heart rhythm 2019; (16(1)):98-105 doi:10.1016/j.hrthm.2018.07.015.

[Syncope in prehospital emergency medicine].

Kill C, Betz S, Bösl E

Medizinische Klinik, Intensivmedizin und Notfallmedizin 2020; (115(2)):88-93 doi:10.1007/s00063-018-0458-2.

SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups.

Baruteau AE, Kyndt F, Behr ER, et al.

European heart journal 2018; (39(31)):2879-2887 doi:10.1093/eurheartj/ehy412.

Unsolved Questions on the Anatomy of the Ventricular Conduction System.

Oh IY, Cha MJ, Lee TH, et al.

Korean circulation journal 2018; (48(12)):1081-1096 doi:10.4070/kcj.2018.0335.

Aggravation of atrial arrhythmia by amiodarone during the perinatal period: A case report.

Ye F, Jiang W, Wang Y, et al.

Medicine 2019; (98(7)):e14466 doi:10.1097/MD.0000000000014466.

Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Mark DB, Anstrom KJ, Sheng S, et al.

JAMA 2019; (321(13)):1275-1285 doi:10.1001/jama.2019.0692.

Importance of Risk Reassessment in Patients With Atrial Fibrillation in Guidelines: Assessing Risk as a Dynamic Process.

Chang TY, Lip GYH, Chen SA, Chao TF

The Canadian journal of cardiology 2019; (35(5)):611-618 doi:10.1016/j.cjca.2019.01.018.

Molecular and genetic insights into progressive cardiac conduction disease.

Asatryan B, Medeiros-Domingo A

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2019; (21(8)):1145-1158 doi:10.1093/europace/euz109.

Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies.

Wahbi K, Ben Yaou R, Gandjbakhch E, et al.

Circulation 2019; (140(4)):293-302 doi:10.1161/CIRCULATIONAHA.118.039410.

Risk Stratification for Sudden Cardiac Death in Non-Ischaemic Dilated Cardiomyopathy.

Akhtar M, Elliott PM

Current cardiology reports 2019; (21(12)):155 doi:10.1007/s11886-019-1236-3.

Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms.

Rivaud MR, Delmar M, Remme CA

Cardiovascular research 2020; (116(9)):1557-1570 doi:10.1093/cvr/cvaa082.

Identification, clinical manifestation and structural mechanisms of mutations in AMPK associated cardiac glycogen storage disease.

Hu D, Hu D, Liu L, et al.

EBioMedicine 2020; (54()):102723 doi:10.1016/j.ebiom.2020.102723.

Diagnosis and Management of 1:1 Atrial Flutter in the Setting of Aortic Valve Endocarditis and Embolic Stroke.

Nigussie B, Abaleka FI, Suhail M, et al.

Cureus 2020; (12(6)):e8739 doi:10.7759/cureus.8739.

Fascicular Blocks: Update 2019.

Elizari MV

Current cardiology reviews 2021; (17(1)):31-40 doi:10.2174/1573403X16666200708111928.

Clinical Features and Natural History of PRKAG2 Variant Cardiac Glycogenosis.

Lopez-Sainz A, Dominguez F, Lopes LR, et al.

Journal of the American College of Cardiology 2020; (76(2)):186-197 doi:10.1016/j.jacc.2020.05.029.

Familial Atrial Enlargement, Conduction Disorder and Symmetric Cardiac Hypertrophy Are Early Signs of PRKAG2 R302Q.

Hu J, Tang B, Wang J, et al.

Current medical science 2020; (40(3)):486-492 doi:10.1007/s11596-020-2207-z.

Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1.

Itoh H, Hisamatsu T, Tamura T, et al.

Journal of the American Heart Association 2020; (9(17)):e015709 doi:10.1161/JAHA.119.015709.

Late gadolinium enhancement role in arrhythmic risk stratification of patients with LMNA cardiomyopathy: results from a long-term follow-up multicentre study.

Peretto G, Barison A, Forleo C, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2020; (22(12)):1864-1872 doi:10.1093/europace/euaa171.

Catheter ablation for atrial fibrillation: current indications and evolving technologies.

Parameswaran R, Al-Kaisey AM, Kalman JM

Nature reviews. Cardiology 2021; (18(3)):210-225 doi:10.1038/s41569-020-00451-x.

Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation.

Andrade JG, Wells GA, Deyell MW, et al.

The New England journal of medicine 2021; (384(4)):305-315 doi:10.1056/NEJMoa2029980.

Diagnosis, family screening, and treatment of inherited arrhythmogenic diseases in Europe: results of the European Heart Rhythm Association Survey.

Conte G, Scherr D, Lenarczyk R, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2020; (22(12)):1904-1910 doi:10.1093/europace/euaa223.

Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies.

Amarouch MY, El Hilaly J

Cardiovascular therapeutics 2020; (2020()):6615038 doi:10.1155/2020/6615038.

A Normal Electrocardiogram Does Not Exclude Infra-Hisian Conduction Disease in Patients With Myotonic Dystrophy Type 1.

Creta A, Providência R, Gossios T, et al.

JACC. Clinical electrophysiology 2021; (7(8)):1038-1048 doi:10.1016/j.jacep.2021.01.017.

[Arrhythmogenic right ventricular cardiomyopathy associated with arrhythmia-induced cardiomyopathy: A case report].

Chen SM, Sun C, Wang XY, et al.

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2021; (53(5)):1002-1006.

Clinical Features of LMNA-Related Cardiomyopathy in 18 Patients and Characterization of Two Novel Variants.

Ferradini V, Cosma J, Romeo F, et al.

Journal of clinical medicine 2021; (10(21)) doi:10.3390/jcm10215075.

Echocardiographic characteristics of PRKAG2 syndrome: a research using three-dimensional speckle tracking echocardiography compared with sarcomeric hypertrophic cardiomyopathy.

Tang L, Li X, Zhou N, et al.

Cardiovascular ultrasound 2022; (20(1)):14 doi:10.1186/s12947-022-00284-3.

The role of landiolol in the management of atrial tachyarrhythmias in patients with acute heart failure and cardiogenic shock: case reports and review of literature.

Bezati S, Velliou M, Polyzogopoulou E, et al.

European heart journal supplements : journal of the European Society of Cardiology 2022; (24(Suppl D)):D22-D33 doi:10.1093/eurheartjsupp/suac024.

Intrafamilial Phenotypical Variability Linked to PRKAG2 Mutation-Family Case Report and Review of the Literature.

Marcu AS, Vătăşescu R, Onciul S, et al.

Life (Basel, Switzerland) 2022; (12(12)) doi:10.3390/life12122136.

Incidence and management of atrioventricular conduction disorders in new-onset left bundle branch block after TAVI: A prospective multicenter study.

Massoullié G, Ploux S, Souteyrand G, et al.

Heart rhythm 2023; (20(5)):699-706 doi:10.1016/j.hrthm.2023.01.013.

Genetic Burden of TNNI3K in Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias.

Pham C, Andrzejczyk K, Jurgens SJ, et al.

Circulation. Genomic and precision medicine 2023; (16(4)):328-336 doi:10.1161/CIRCGEN.122.003975.

A method for noninvasive beat-by-beat visualization of His bundle signals.

Sengottuvel S, Shenbaga Devi S, Sasikala M, et al.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2023; (28(5)):e13076 doi:10.1111/anec.13076.

LMNA Cardiomyopathy: Important Considerations for the Heart Failure Clinician.

Rosario KF, Karra R, Amos K, et al.

Journal of cardiac failure 2023; (29(12)):1657-1666 doi:10.1016/j.cardfail.2023.08.016.

Chinese experts' consensus guideline on preimplantation genetic testing of monogenic disorders.

Yan L, Cao Y, Chen ZJ, et al.

Human reproduction (Oxford, England) 2023; (38(38 Suppl 2)):ii3-ii13 doi:10.1093/humrep/dead112.

SCN5A-L256del and L1621F exhibit loss-of-function properties related to autosomal recessive congenital cardiac disorders presenting as sick sinus syndrome, dilated cardiomyopathy, and sudden cardiac death.

Shi J, Pan X, Wang Z, et al.

Gene 2024; (898()):148093 doi:10.1016/j.gene.2023.148093.

Tips for Testing Adults With Suspected Genetic Kidney Disease.

Savige J

American journal of kidney diseases : the official journal of the National Kidney Foundation 2024; (83(6)):816-824 doi:10.1053/j.ajkd.2023.10.011.

Predictors of pacemaker requirement in patients with implantable loop recorder and unexplained syncope: A systematic review and meta-analysis.

Zangiabadian M, Soltani K, Gholinejad Y, et al.

Clinical cardiology 2024; (47(2)):e24221 doi:10.1002/clc.24221.

Prevalence and clinical significance of electrocardiographic complete right bundle branch block in young individuals.

MacLachlan H, Antonakaki D, Bhatia R, et al.

European journal of preventive cardiology 2025; (32(12)):1054-1061 doi:10.1093/eurjpc/zwae082.

Biophysical mechanisms of myocardium sodium channelopathies.

Zaytseva AK, Kulichik OE, Kostareva AA, Zhorov BS

Pflugers Archiv : European journal of physiology 2024; (476(5)):735-753 doi:10.1007/s00424-024-02930-3.

Cardiac conduction disorders in young adults: Clinical characteristics and genetic background of an underestimated population.

Balla C, Margutti A, De Carolis B, et al.

Heart rhythm 2024; (21(8)):1363-1369 doi:10.1016/j.hrthm.2024.03.008.

Genetic testing in early-onset atrial fibrillation.

Kany S, Jurgens SJ, Rämö JT, et al.

European heart journal 2024; (45(34)):3111-3123 doi:10.1093/eurheartj/ehae298.

Genetic testing for inherited arrhythmia syndromes and cardiomyopathies: results of the European Heart Rhythm Association survey.

Zeljkovic I, Gauthey A, Manninger M, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2024; (26(9)) doi:10.1093/europace/euae216.

aTrial arrhythmias in inhEriTed aRrhythmIa Syndromes: results from the TETRIS study.

Conte G, Bergonti M, Probst V, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2024; (26(12)) doi:10.1093/europace/euae288.

Leucocyte telomere length and conduction system ageing.

van Duijvenboden S, Nelson CP, Raisi-Estabragh Z, et al.

Heart (British Cardiac Society) 2025; (111(7)):314-320 doi:10.1136/heartjnl-2024-324875.

Atypical Wenckebach AV Block in the Infra-Hisian Region: Clinical Implications and Management.

Kaushik A, Jeewooth A, Jaswal A, et al.

The American journal of case reports 2024; (25()):e946186 doi:10.12659/AJCR.946186.

Phenotypic expression of rare progressive cardiac conduction disease variants in the general population.

Shah RA, Ramírez J, Kirkby C, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025; (27(6)) doi:10.1093/europace/euaf103.

The Cardiovascular Magnetic Resonance Phenotype of Lamin Heart Disease.

Topriceanu CC, Al-Farih M, Joy G, et al.

JACC. Cardiovascular imaging 2025; (18(6)):644-660 doi:10.1016/j.jcmg.2025.01.004.

Clinical care of family members of patients with dilated cardiomyopathy.

Verdonschot JAJ, Kaski JP, Asselbergs FW, et al.

European heart journal 2025; (46(43)):4569-4582 doi:10.1093/eurheartj/ehaf571.

Electrocardiogram vs Electrophysiological Study and Major Conduction Delays in Myotonic Dystrophy Type 1.

Clementy N, Labombarda F, Grolleau F, et al.

JAMA cardiology 2025; (10(11)):1121-1129 doi:10.1001/jamacardio.2025.3055.

Clinical Spectrum of Arrhythmogenic Entities in Spanish Children Carrying Deleterious SCN5A Variants.

Martínez-Barrios E, Cruzalegui J, Hidalgo-Sanuy M, et al.

International journal of molecular sciences 2026; (27(2)) doi:10.3390/ijms27020880.

Bridging the Gap Between Genetic Cardiomyopathies and Pregnancy.

Flores Rosario K, Hussien M, Grover P, et al.

JACC. Advances 2026; (5(6 Pt 1)):102784 doi:10.1016/j.jacadv.2026.102784.

Practical Recommendations for Anticoagulation in Patients With Atrial Fibrillation.

Johner N, Gencer B

European journal of clinical investigation 2026; (56(5)):e70224 doi:10.1111/eci.70224.

Sequential Electrocardiographic Progression of Alternating Bundle Branch Block Culminating in Complete Atrioventricular Block.

Goodwin AS, Martinez-Parachini JR, Engels MC, et al.

JACC. Case reports 2026; (31(20)):107832 doi:10.1016/j.jaccas.2026.107832.

Current Topics of Progressive Cardiac Conduction Disease.

Sumitomo N, Mori H, Kumamoto T, et al.

Journal of arrhythmia 2026; (42(3)):e70383 doi:10.1002/joa3.70383.

LMNA Deficiency Reveals a Role for SK3 Channel Dysfunction in Atrioventricular Block.

Li T, Wang X, Song J, et al.

JACC. Clinical electrophysiology 2026; doi:10.1016/j.jacep.2026.06.035.

How does genetic susceptibility impact the effectiveness of AF ablation?

Mililis P, Paraskevopoulou D, Saplaouras A, et al.

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2026; doi:10.1016/j.hjc.2026.08.005.

Diagnosis and management of very rare primary arrhythmia syndromes in children and adults: a Clinical Consensus Statement of the European Heart Rhythm Association of the ESC and the Association of Cardiovascular Nursing & Allied Professions of the ESC, endorsed by the Association for European Paediatric and Congenital Cardiology.

Sarquella-Brugada G, Mazzanti A, Baban A, et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2026; (28(8)) doi:10.1093/europace/euag184.

High-density mapping of his-ventricular intervals: impact of recording site and sex-specific differences.

Serban T, du Fay de Lavallaz J, Knecht S, et al.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2026; (69(6)):1493-1501 doi:10.1007/s10840-026-02438-z.

A reassuring ECG is not enough in myotonic dystrophy type 1: A systematic review and meta-analysis.

Shatarat F, Bdarnh O, Alomari AA, et al.

Indian pacing and electrophysiology journal 2026; doi:10.1016/j.ipej.2026.09.012.

Ventricular Fibrillation in PRKAG2 Cardiomyopathy: A Genetic Arrhythmia Substrate Beyond Wolff-Parkinson-White.

Visch J, Hopman LHGA, Holtus D, et al.

JACC. Case reports 2026; 110634 doi:10.1016/j.jaccas.2026.110634.