Research & Literature

The complex pathophysiology of acquired aplastic anaemia.

Zeng Y, Katsanis E

Clinical and experimental immunology 2015; (180(3)):361-70 doi:10.1111/cei.12605.

Successful desensitization of a patient with aplastic anemia to antithymocyte globulin.

Wolanin SA, Demain JG, Meier EA

Allergy & rhinology (Providence, R.I.) 2015; (6(1)):64-7 doi:10.2500/ar.2015.6.0110.

Immunosuppressive therapy in patients with aplastic anemia: a single-center retrospective study.

Jalaeikhoo H, Khajeh-Mehrizi A

PloS one 2015; (10(5)):e0126925 doi:10.1371/journal.pone.0126925.

Diagnosis and management of acquired aplastic anemia in childhood. Guidelines from the Marrow Failure Study Group of the Pediatric Haemato-Oncology Italian Association (AIEOP).

Barone A, Lucarelli A, Onofrillo D, et al.

Blood cells, molecules & diseases 2015; (55(1)):40-7.

[Hepatitis E virus-associated aplastic anemia. Report of a case].

Zylberman M, Turdó K, Odzak A, et al.

Medicina 2015; (75(3)):175-7.

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

Yoshizato T, Dumitriu B, Hosokawa K, et al.

The New England journal of medicine 2015; (373(1)):35-47 doi:10.1056/NEJMoa1414799.

Endometrial Ablation for Aplastic Anemia-Associated Menorrhagia.

Jacob S, Abdullah A, Hurwitz J, et al.

Connecticut medicine 2015; (79(5)):289-90.

[Outcomes of very severe aplastic anemia patients with different absolute neutrophil counts after frontline immnunosuppressive therapy].

Li Y, Wu Z, Zhao X, et al.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2016; (37(4)):329-33 doi:10.3760/cma.j.issn.0253-2727.2016.04.016.

Bone marrow transplantation versus immunosuppressive therapy in patients with acquired severe aplastic anemia.

Bacigalupo A, Giammarco S, Sica S

International journal of hematology 2016; (104(2)):168-74 doi:10.1007/s12185-016-2037-8.

Comparable outcomes between younger (⩽40 years) and older (>40 years) adult patients with severe aplastic anemia after HLA-matched sibling stem cell transplantation using fludarabine-based conditioning.

Shin SH, Jeon YW, Yoon JH, et al.

Bone marrow transplantation 2016; (51(11)):1456-1463 doi:10.1038/bmt.2016.171.

Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

Keel SB, Scott A, Sanchez-Bonilla M, et al.

Haematologica 2016; (101(11)):1343-1350 doi:10.3324/haematol.2016.149476.

Outcome of severe infections in afebrile neutropenic cancer patients.

Strojnik K, Mahkovic-Hergouth K, Novakovic BJ, Seruga B

Radiology and oncology 2016; (50(4)):442-448 doi:10.1515/raon-2016-0011.

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

Townsley DM, Scheinberg P, Winkler T, et al.

The New England journal of medicine 2017; (376(16)):1540-1550 doi:10.1056/NEJMoa1613878.

Resolution of acute hepatitis B-associated aplastic anaemia with antiviral therapy.

Hendren N, Moore J, Hofmann S, Rambally S

BMJ case reports 2017; (2017()) doi:10.1136/bcr-2017-221503.

Diagnosis and Treatment of Aplastic Anemia.

Peslak SA, Olson T, Babushok DV

Current treatment options in oncology 2017; (18(12)):70 doi:10.1007/s11864-017-0511-z.

ICCS/ESCCA consensus guidelines to detect GPI-deficient cells in paroxysmal nocturnal hemoglobinuria (PNH) and related disorders part 1 - clinical utility.

Dezern AE, Borowitz MJ

Cytometry. Part B, Clinical cytometry 2018; (94(1)):16-22 doi:10.1002/cyto.b.21608.

Mesenchymal Stem Cell Benefits Observed in Bone Marrow Failure and Acquired Aplastic Anemia.

Gonzaga VF, Wenceslau CV, Lisboa GS, et al.

Stem cells international 2017; (2017()):8076529 doi:10.1155/2017/8076529.

Hepatitis-associated Aplastic Anemia Treated Successfully With Antithymocyte Globulin.

Ji H, Chen L, Sun X, et al.

Journal of pediatric hematology/oncology 2018; (40(6)):e355-e358 doi:10.1097/MPH.0000000000001141.

Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.

Georges GE, Doney K, Storb R

Blood advances 2018; (2(15)):2020-2028 doi:10.1182/bloodadvances.2018021162.

Revisiting acquired aplastic anaemia: current concepts in diagnosis and management.

Clucas DB, Fox LC, Wood EM, et al.

Internal medicine journal 2019; (49(2)):152-159 doi:10.1111/imj.14140.

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Alvarado LJ, Huntsman HD, Cheng H, et al.

Blood 2019; (133(19)):2043-2055 doi:10.1182/blood-2018-11-884486.

Treatment of menorrhagia due to aplastic anemia by hysteroscopic resection of endometrial functional layer and levonorgestrel-releasing intra-uterine system: Three case reports.

Yang H, Xu X, Jiang X, Yao Z

Medicine 2019; (98(17)):e15156 doi:10.1097/MD.0000000000015156.

Oncologic Emergencies: The Fever With Too Few Neutrophils.

Long B, Koyfman A

The Journal of emergency medicine 2019; (57(5)):689-700 doi:10.1016/j.jemermed.2019.08.009.

Comparison of flow-FISH and MM-qPCR telomere length assessment techniques for the screening of telomeropathies.

Ferreira MSV, Kirschner M, Halfmeyer I, et al.

Annals of the New York Academy of Sciences 2020; (1466(1)):93-103 doi:10.1111/nyas.14248.

Emergency Ambulatory Management of Low-Risk Febrile Neutropenia: Multinational Association for Supportive Care in Cancer Fits-Real-World Experience From a UK Cancer Center.

Marshall W, Campbell G, Knight T, et al.

The Journal of emergency medicine 2020; (58(3)):444-448 doi:10.1016/j.jemermed.2019.09.032.

Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.

Durrani J, Maciejewski JP

Hematology. American Society of Hematology. Education Program 2019; (2019(1)):97-104 doi:10.1182/hematology.2019000019.

Clinical impact of dysplastic changes in acquired aplastic anemia: A systematic study of bone marrow biopsies in children and adults.

Marchesi RF, Velloso EDRP, Garanito MP, et al.

Annals of diagnostic pathology 2020; (45()):151459 doi:10.1016/j.anndiagpath.2019.151459.

Clinical Profile and Microbiologic Spectrum of Febrile Neutropenic Episodes in Children With Severe Aplastic Anemia.

Samanta A, Chandra J, Kaur R, et al.

Journal of pediatric hematology/oncology 2020; (42(3)):193-197 doi:10.1097/MPH.0000000000001631.

Haploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation (SAAWP of EBMT).

ElGohary G, El Fakih R, de Latour R, et al.

Bone marrow transplantation 2020; (55(10)):1906-1917 doi:10.1038/s41409-020-0897-2.

Ambulatory management in low risk neutropenic sepsis - A plea for integrated acute cancer care.

Marshall E

Acute medicine 2019; (18(1)):6-7.

Aplastic anaemia: Current concepts in diagnosis and management.

Furlong E, Carter T

Journal of paediatrics and child health 2020; (56(7)):1023-1028 doi:10.1111/jpc.14996.

Novel therapeutic choices in immune aplastic anemia.

Scheinberg P

F1000Research 2020; (9()) doi:10.12688/f1000research.22214.1.

New-onset Post-transplant Diabetes and Therapy in Long-term Survivors After Allogeneic Hematopoietic Stem Cell Transplantation.

Dalla Via V, Halter JP, Gerull S, et al.

In vivo (Athens, Greece) 2020; (34(6)):3545-3549 doi:10.21873/invivo.12197.

An Antithymocyte Globulin-Free Conditioning Regimen Using Fludarabine and Cyclophosphamide Is Associated with Good Outcomes in Patients Undergoing Matched Related Family Donor Transplantation for Aplastic Anemia.

George B, Lionel S, Selvarajan S, et al.

Transplantation and cellular therapy 2021; (27(5)):409.e1-409.e6 doi:10.1016/j.jtct.2021.01.029.

Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium.

Shimano KA, Narla A, Rose MJ, et al.

American journal of hematology 2021; (96(11)):1491-1504 doi:10.1002/ajh.26310.

The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis.

Shah YB, Priore SF, Li Y, et al.

Blood advances 2021; (5(16)):3216-3226 doi:10.1182/bloodadvances.2021004201.

Long-term outcomes in patients with severe aplastic anemia treated with immunosuppression and eltrombopag: a phase 2 study.

Patel BA, Groarke EM, Lotter J, et al.

Blood 2022; (139(1)):34-43 doi:10.1182/blood.2021012130.

The clinical and laboratory evaluation of patients with suspected hypocellular marrow failure.

Keel S, Geddis A

Hematology. American Society of Hematology. Education Program 2021; (2021(1)):134-142 doi:10.1182/hematology.2021000244.

Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia.

Peffault de Latour R, Kulasekararaj A, Iacobelli S, et al.

The New England journal of medicine 2022; (386(1)):11-23 doi:10.1056/NEJMoa2109965.

Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.

Kawano N, Nakamura S, Mochida K, et al.

Internal medicine (Tokyo, Japan) 2022; (61(18)):2771-2774 doi:10.2169/internalmedicine.8618-21.

Next-generation sequencing reveals novel variants and large deletion in FANCA gene in Polish family with Fanconi anemia.

Repczynska A, Julga K, Skalska-Sadowska J, et al.

Orphanet journal of rare diseases 2022; (17(1)):282 doi:10.1186/s13023-022-02424-4.

Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria.

Gurnari C, Pagliuca S, Prata PH, et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023; (41(1)):132-142 doi:10.1200/JCO.22.00710.

Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities.

Olson TS, Frost BF, Duke JL, et al.

JCI insight 2022; (7(22)).

[Clinical characteristics and prediction model of early death in severe/very severe aplastic anemia with immunosuppressive therapy].

Chen M, Zhuang JL, Yang C, et al.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2022; (43(11)):916-920 doi:10.3760/cma.j.issn.0253-2727.2022.11.006.

High Overall and GVHD-Free Survival in Patients with Aplastic Anemia Receiving in vivo T-cell Depletion Transplants and Long-Term Complications.

Salas MQ, Atenafu EG, Lam W, et al.

Blood cell therapy 2020; (3(3)):48-58 doi:10.31547/bct-2020-001.

Clinical characteristics of antithyroid drug-induced aplastic anemia cases over the past 30 years.

Cheng Y, Xia XY, Zhang W, et al.

Frontiers in endocrinology 2023; (14()):1064723 doi:10.3389/fendo.2023.1064723.

Allogeneic hematopoietic stem cell transplantation for acquired severe aplastic anemia: a summary of a 20-year experience.

Zielińska P, Noster I, Wieczorkiewicz-Kabut A, et al.

Polish archives of internal medicine 2023; (133(7-8)) doi:10.20452/pamw.16448.

Identification of Adult Patients With Classical Dyskeratosis Congenita or Cryptic Telomere Biology Disorder by Telomere Length Screening Using Age-modified Criteria.

Tometten M, Kirschner M, Meyer R, et al.

HemaSphere 2023; (7(5)):e874 doi:10.1097/HS9.0000000000000874.

Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist.

Li J, Bledsoe JR

Seminars in diagnostic pathology 2023; (40(6)):429-442 doi:10.1053/j.semdp.2023.06.006.

Cytogenetics in the management of bone marrow failure syndromes: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).

Cuccuini W, Collonge-Rame MA, Auger N, et al.

Current research in translational medicine 2023; (71(4)):103423 doi:10.1016/j.retram.2023.103423.

Peripheral blood stem cell transplantation vs. bone marrow transplantation for aplastic anemia: a systematic review and meta-analysis.

Zhang Z, Zhou X, Cheng Z, Hu Y

Frontiers in medicine 2023; (10()):1289180 doi:10.3389/fmed.2023.1289180.

Experience of life quality from patients with aplastic anemia: a descriptive qualitative study.

Liu T, Pan Y, Ye M, et al.

Orphanet journal of rare diseases 2023; (18(1)):393 doi:10.1186/s13023-023-02993-y.

All Roads Lead to Interferon-γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia.

Serio B, Giudice V, Selleri C

Medicina (Kaunas, Lithuania) 2023; (59(12)) doi:10.3390/medicina59122170.

Relapse and transformation to myelodysplastic syndrome and acute myeloid leukemia following immunosuppressive therapy for aplastic anemia is more common as compared to allogeneic stem cell transplantation with a negative impact on survival.

Chattopadhyay S, Lionel S, Selvarajan S, et al.

Annals of hematology 2024; (103(3)):749-758 doi:10.1007/s00277-024-05621-2.

Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline.

Kulasekararaj A, Cavenagh J, Dokal I, et al.

British journal of haematology 2024; (204(3)):784-804 doi:10.1111/bjh.19236.

Bone marrow CD8+ Trm cells induced by IL-15 and CD16+ monocytes contribute to HSPC destruction in human severe aplastic anemia.

Long J, You X, Yang Q, et al.

Clinical immunology (Orlando, Fla.) 2024; (263()):110223 doi:10.1016/j.clim.2024.110223.

Modified Delphi panel consensus recommendations for management of severe aplastic anemia.

Babushok DV, DeZern AE, de Castro CM, et al.

Blood advances 2024; (8(15)):3946-3960 doi:10.1182/bloodadvances.2023011642.

Efficacy and safety of outpatient fludarabine, cyclophosphamide, and rituximab based allogeneic hematopoietic cell transplantation in adults with severe aplastic anemia.

Gilmore RM, Abernathy K, Shultes K, et al.

Bone marrow transplantation 2024; (59(9)):1275-1279 doi:10.1038/s41409-024-02323-1.

Diagnosis and management of acquired aplastic anemia in childhood. Guidelines from the Marrow Failure Study Group of the Pediatric Haemato-Oncology Italian Association (AIEOP).

Guarina A, Farruggia P, Mariani E, et al.

Blood cells, molecules & diseases 2024; (108()):102860 doi:10.1016/j.bcmd.2024.102860.

A patient with axial spondylarthritis who experienced pancytopenia while receiving anti-TNF therapy.

Ozbayrak SS, Mesci N, Sezgin MO, Kulcu DG

Clinical rheumatology 2024; (43(8)):2701-2705 doi:10.1007/s10067-024-07054-8.

Cyclophosphamide and horse anti-thymocyte globulin versus fludarabine, reduced cyclophosphamide and rabbit anti-thymocyte globulin conditioning regimen for allogeneic hematopoietic stem cell transplantation from matched sibling donors in patients with acquired aplastic anemia.

Ben Abdeljelil N, Ben Yaiche I, Ouerghi R, et al.

Expert review of hematology 2024; (17(8)):527-538 doi:10.1080/17474086.2024.2381572.

Allogeneic Hematopoietic Cell Transplantation for the Treatment of Severe Aplastic Anemia: Evidence-Based Guidelines From the American Society for Transplantation and Cellular Therapy.

Iftikhar R, DeFilipp Z, DeZern AE, et al.

Transplantation and cellular therapy 2024; (30(12)):1155-1170 doi:10.1016/j.jtct.2024.09.017.

Monitoring and Treatment of Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia in Asia: An Expert Consensus.

Wong RSM, Ho Jang J, Wong LLL, et al.

International journal of molecular sciences 2024; (25(22)) doi:10.3390/ijms252212160.

Comparable survival outcomes in HLA-Matched and haploidentical hematopoietic stem cell transplantation for severe aplastic anemia patients aged 40-50: A CBMTR Registry-based propensity score matching analysis over the last decade.

Xu ZL, Zhang YP, Ye BD, et al.

Cancer letters 2025; (621()):217594 doi:10.1016/j.canlet.2025.217594.

Acute hepatitis A-associated aplastic anemia in a pediatric: a case report from Syria.

Albostani A, Haj Ahmad NA, Aljnidy N, et al.

Annals of medicine and surgery (2012) 2025; (87(4)):2406-2410 doi:10.1097/MS9.0000000000003107.

Eltrombopag in combination with immunosuppressive therapy in pediatric severe aplastic anemia: phase 2 ESCALATE trial.

Shimamura A, Maschan A, Bennett C, et al.

Blood advances 2025; (9(15)):3728-3738 doi:10.1182/bloodadvances.2024015102.

Post-traumatic growth experience with kinship hematopoietic stem cells transplantation in patients with aplastic anemia: A qualitative study.

Huang X, Xu Y, Pan Y, et al.

PloS one 2025; (20(7)):e0322087 doi:10.1371/journal.pone.0322087.

Management of Neutropenic Fever in Persons with Cancer.

Doyle-Lindrud S

The Nursing clinics of North America 2025; (60(3)):479-489 doi:10.1016/j.cnur.2024.09.004.

Somatic mutations and the efficacy of immunosuppressive therapy in severe/very severe aplastic anemia and transfusion-dependent nonsevere aplastic anemia.

Ye L, Zhang L, Zhang D, et al.

Annals of hematology 2025; (104(8)):3981-3992 doi:10.1007/s00277-025-06393-z.

Development and Validation of the PASS Score: A Simplified Tool to Diagnose Acquired Aplastic Anemia in Adults.

Aleixo G, Cheon H, Zheng J, et al.

Research square 2026; doi:10.21203/rs.3.rs-7725283/v1.

The Role of IFN-γ-Mediated Immune Cell Crosstalk in the Pathogenesis of Aplastic Anemia.

Tan S, Li Y, Chen Y, Sun W

Journal of immunology research 2026; (2026(1)):e2216487 doi:10.1155/jimr/2216487.

American Society of Hematology 2026 guidelines for the diagnosis and management of severe and very severe acquired aplastic anemia.

Scheinberg P, O'Neal DA, Basquiera AL, et al.

Blood advances 2026; (10(17)):5962-5990 doi:10.1182/bloodadvances.2025019051.

Clonal Selection and Evolution after Treatment of Severe Aplastic Anemia.

Gutierrez-Rodrigues F, Groarke EM, Miao R, et al.

NEJM evidence 2026; (5(5)):EVIDoa2500171 doi:10.1056/EVIDoa2500171.

High-resolution single-cell mapping of clonal hematopoiesis and structural variation in aplastic anemia.

Yoshida M, Sahoo SS, Arnold PY, et al.

Nature genetics 2026; (58(5)):1073-1086 doi:10.1038/s41588-026-02587-x.

How I utilize somatic alterations in the diagnosis, risk stratification, and therapy of hypocellular bone marrow failure.

Groarke EM, Gutierrez-Rodrigues F, Patel BA

Blood 2026; (148(7)):818-830 doi:10.1182/blood.2025029923.

Cyclosporine in hematological disorders: mechanisms, clinical practice and emerging advances.

Tan Z, Hu J, Ye B, Liu W

Annals of hematology 2026; (105(8)).

How we Investigate Bone Marrow Failure Syndromes in Pediatric Patients.

Catto MB, Young DJ, Catto LFB

Pediatric hematology and oncology 2026; (43(5)):268-290 doi:10.1080/08880018.2026.2676558.

Successful Surgical Management of Chronic Subdural Hematoma in a Patient With Severe Thrombocytopenia due to Aplastic Anemia: A Case Report.

Fu Z, Lu J, Deng X

Clinical case reports 2026; (14(7)):e73076 doi:10.1002/ccr3.73076.

Eltrombopag Added to Standard Immunosuppressive Treatment as Front-Line Therapy for Severe Aplastic Anemia: Long-Term Outcomes of the Phase-3 Randomized Superiority EBMT-SAAWP RACE Study.

Risitano AM, Iacobelli S, Kulasekararaj A, et al.

American journal of hematology 2026; (101(10)):2520-2532 doi:10.1002/ajh.70445.

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments.

Fattizzo B, Marchetti M, Cannizzo E, et al.

European journal of haematology 2026; doi:10.1111/ejh.70294.

Patterns of clonal hematopoiesis in aplastic anemia under immunosuppressive therapy.

Tian L, Zhang L, Li R, et al.

Leukemia 2026; doi:10.1038/s41375-026-03048-4.

Carbimazole-Induced Severe Acquired Aplastic Anemia in a Patient with Graves' Disease: A Case Report.

Alghamdi RA, Alshankiti HA, Al-Marzouki AF, Daous YM

Reports (MDPI) 2026; (9(3)) doi:10.3390/reports9030287.