Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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Mayo Clinic
Rochester, United States
Vanderbilt University Medical Center
Nashville, United States
Beth Israel Deaconess Medical Center
Boston, United States
New York University
New York, United States
Innsbruck Medical University
Innsbruck, Austria
National Hospital for Neurology and Neurosurgery
London, United Kingdom
Mayo Clinic in Florida
Jacksonville, United States
Istituto delle Scienze Neurologiche di Bologna
Bologna, Italy
University of Calgary
Calgary, Canada
Vanderbilt University
Nashville, United States
References
References (105)
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Fludrocortisone Is Associated With a Higher Risk of All-Cause Hospitalizations Compared With Midodrine in Patients With Orthostatic Hypotension.
Grijalva CG, Biaggioni I, Griffin MR, Shibao CA
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Evidence-based treatment of neurogenic orthostatic hypotension and related symptoms.
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Neuropathology of autonomic dysfunction in synucleinopathies.
Coon EA, Cutsforth-Gregory JK, Benarroch EE
Movement disorders : official journal of the Movement Disorder Society 2018; (33(3)):349-358 doi:10.1002/mds.27186.
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Value of urodynamic findings in predicting upper urinary tract damage in neuro-urological patients: A systematic review.
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Neurourology and urodynamics 2018; (37(5)):1522-1540 doi:10.1002/nau.23501.
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Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies.
Norcliffe-Kaufmann L, Kaufmann H, Palma JA, et al.
Annals of neurology 2018; (83(3)):522-531 doi:10.1002/ana.25170.
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Monoclonal gammopathy of undetermined significance in systemic transthyretin amyloidosis (ATTR).
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Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies.
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Movement disorders : official journal of the Movement Disorder Society 2018; (33(3)):372-390 doi:10.1002/mds.27344.
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Application of clean intermittent catheterization for neurogenic bladder in infants less than 1 year old.
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Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS) : Endorsed by the European Academy of Neurology (EAN) and the European Society of Hypertension (ESH).
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Surveillance and management of urologic complications after spinal cord injury.
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Diabetic Gastroparesis: Principles and Current Trends in Management.
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Diabetes therapy : research, treatment and education of diabetes and related disorders 2018; (9(Suppl 1)):1-42 doi:10.1007/s13300-018-0454-9.
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Early urological care of patients with spinal cord injury.
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Orthostatic Hypotension in the Hypertensive Patient.
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American journal of hypertension 2018; (31(12)):1255-1259 doi:10.1093/ajh/hpy089.
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The natural history of idiopathic autonomic failure: The IAF-BO cohort study.
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A pilot randomized-controlled trial of the urodynamic efficacy of mirabegron for patients with neurogenic lower urinary tract dysfunction.
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Neurourology and urodynamics 2018; (37(8)):2810-2817 doi:10.1002/nau.23774.
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Ganglionic Antibody Level as a Predictor of Severity of Autonomic Failure.
Cutsforth-Gregory JK, McKeon A, Coon EA, et al.
Mayo Clinic proceedings 2018; (93(10)):1440-1447 doi:10.1016/j.mayocp.2018.05.033.
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Orthostatic Hypotension: JACC State-of-the-Art Review.
Freeman R, Abuzinadah AR, Gibbons C, et al.
Journal of the American College of Cardiology 2018; (72(11)):1294-1309 doi:10.1016/j.jacc.2018.05.079.
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Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.
Donadio V, Incensi A, El-Agnaf O, et al.
Scientific reports 2018; (8(1)):14246 doi:10.1038/s41598-018-32588-8.
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Chemical pharmacotherapy for the treatment of orthostatic hypotension.
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Expert opinion on pharmacotherapy 2019; (20(2)):187-199 doi:10.1080/14656566.2018.1543404.
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Thermoregulation in neuropathies.
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Handbook of clinical neurology 2018; (157()):777-787 doi:10.1016/B978-0-444-64074-1.00048-3.
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An updated normative data set from the autonomic reflex screen representative of Southwestern Ontario.
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Canadian journal of physiology and pharmacology 2019; (97(2)):107-111 doi:10.1139/cjpp-2018-0611.
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A Modern Primer on Light Chain Amyloidosis in 592 Patients With Mass Spectrometry-Verified Typing.
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Autonomic uprising: the tilt table test in autonomic medicine.
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Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2019; (29(2)):215-230 doi:10.1007/s10286-019-00598-9.
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Management of supine hypertension in patients with neurogenic orthostatic hypotension: scientific statement of the American Autonomic Society, European Federation of Autonomic Societies, and the European Society of Hypertension.
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What do we really know about supine hypertension in patients with orthostatic hypotension.
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Autonomic Dysfunction in α-Synucleinopathies.
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Diabetic Gastroparesis.
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Autoimmune autonomic neuropathies and ganglionopathies: epidemiology, pathophysiology, and therapeutic advances.
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Role of nurses and nurse practitioners in the recognition, diagnosis, and management of neurogenic orthostatic hypotension: a narrative review.
Biswas D, Karabin B, Turner D
International journal of general medicine 2019; (12()):173-184 doi:10.2147/IJGM.S170655.
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Pure autonomic failure.
Kabir MA, Chelimsky TC
Handbook of clinical neurology 2019; (161()):413-422 doi:10.1016/B978-0-444-64142-7.00064-3.
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Orthostatic hypotension in hereditary transthyretin amyloidosis: epidemiology, diagnosis and management.
Palma JA, Gonzalez-Duarte A, Kaufmann H
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2019; (29(Suppl 1)):33-44 doi:10.1007/s10286-019-00623-x.
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Consensus document on the multidisciplinary management of neurogenic lower urinary tract dysfunction in patients with multiple sclerosis.
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Neurourology and urodynamics 2020; (39(2)):762-770 doi:10.1002/nau.24276.
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Sweating Disorders.
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Management of Orthostatic Hypotension.
Palma JA, Kaufmann H
Continuum (Minneapolis, Minn.) 2020; (26(1)):154-177 doi:10.1212/CON.0000000000000816.
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Gastrointestinal autonomic neuropathy in diabetes.
Marathe CS, Jones KL, Wu T, et al.
Autonomic neuroscience : basic & clinical 2020; (229()):102718 doi:10.1016/j.autneu.2020.102718.
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Cardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies.
Lamotte G, Holmes C, Sullivan P, et al.
Annals of clinical and translational neurology 2020; (7(12)):2450-2460 doi:10.1002/acn3.51243.
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Trick or Treat? Licorice-Induced Hypokalemia: A Case Report.
Benge E, Shah P, Yamaguchi L, Josef V
Cureus 2020; (12(11)):e11656 doi:10.7759/cureus.11656.
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Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.
Cheshire WP, Freeman R, Gibbons CH, et al.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2021; (132(2)):666-682 doi:10.1016/j.clinph.2020.11.024.
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Local Passive Heat for the Treatment of Hypertension in Autonomic Failure.
Okamoto LE, Celedonio JE, Smith EC, et al.
Journal of the American Heart Association 2021; (10(7)):e018979 doi:10.1161/JAHA.120.018979.
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Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives.
Kornum DS, Terkelsen AJ, Bertoli D, et al.
Journal of clinical medicine 2021; (10(7)) doi:10.3390/jcm10071392.
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Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, et al.
Arquivos brasileiros de cardiologia 2021; (116(4)):814-835 doi:10.36660/abc.20200420.
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Perspectives on urological care in multiple sclerosis patients.
Moussa M, Abou Chakra M, Papatsoris AG, et al.
Intractable & rare diseases research 2021; (10(2)):62-74 doi:10.5582/irdr.2021.01029.
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Fludrocortisone for orthostatic hypotension.
Veazie S, Peterson K, Ansari Y, et al.
The Cochrane database of systematic reviews 2021; (5()):CD012868 doi:10.1002/14651858.CD012868.pub2.
PMID: 34000076 - 63
Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2 /D3 receptor antagonist, in patients with gastroparesis.
Kuo B, Scimia C, Dukes G, et al.
Alimentary pharmacology & therapeutics 2021; (54(3)):267-280 doi:10.1111/apt.16451.
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Neurogenic orthostatic hypotension with Parkinson's disease as a cause of syncope: A case report.
Li Y, Wang M, Liu XL, et al.
World journal of clinical cases 2021; (9(21)):6073-6080 doi:10.12998/wjcc.v9.i21.6073.
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Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies.
González-Duarte A, Varma-Doyle A, Freeman R
Current opinion in neurology 2021; (34(5)):675-682 doi:10.1097/WCO.0000000000000985.
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Droxidopa Persistence in Neurogenic Orthostatic Hypotension May Be Affected by Titration Approach.
Amjad F, Polenchar B, Favit A
International journal of general medicine 2021; (14()):4485-4490 doi:10.2147/IJGM.S304012.
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Gastroparesis.
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Current opinion in gastroenterology 2021; (37(6)):596-601 doi:10.1097/MOG.0000000000000782.
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Blood pressure regulation in autonomic failure by dietary sodium, blood volume and posture.
Biaggioni I
Autonomic neuroscience : basic & clinical 2021; (236()):102891 doi:10.1016/j.autneu.2021.102891.
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Standardized Autonomic Testing in Patients With Probable Radiation-Induced Afferent Baroreflex Failure.
Lamotte G, Coon EA, Suarez MD, et al.
Hypertension (Dallas, Tex. : 1979) 2022; (79(1)):50-56 doi:10.1161/HYPERTENSIONAHA.121.17805.
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The Efficacy and Safety of Mirabegron for the Treatment of Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review and Meta-analysis.
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Frontiers in pharmacology 2021; (12()):756582 doi:10.3389/fphar.2021.756582.
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Orthostatic Hypotension: A Practical Approach.
Kim MJ, Farrell J
American family physician 2022; (105(1)):39-49.
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Oral and intravenous hydration in the treatment of orthostatic hypotension and postural tachycardia syndrome.
Snapper H, Cheshire WP
Autonomic neuroscience : basic & clinical 2022; (238()):102951 doi:10.1016/j.autneu.2022.102951.
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Paraneoplastic autoimmune autonomic ganglionopathy as the first symptom of bladder cancer: a case report and review of literature.
de Rojas Leal C, Lage-Sánchez JM, Pinel-Ríos J, et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2022; (43(8)):4841-4845 doi:10.1007/s10072-022-06075-y.
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Supine hypertension: A state of the art.
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Autonomic neuroscience : basic & clinical 2022; (241()):102988 doi:10.1016/j.autneu.2022.102988.
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[Dizziness upon standing: consider autonomic dysfunction].
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Nederlands tijdschrift voor geneeskunde 2022; (166()).
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Diagnosing Premotor Multiple System Atrophy: Natural History and Autonomic Testing in an Autopsy-Confirmed Cohort.
Vichayanrat E, Valerio F, Koay S, et al.
Neurology 2022; (99(11)):e1168-e1177 doi:10.1212/WNL.0000000000200861.
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[Cardiac amyloidosis: State of art in 2022].
Oghina S, Delbarre MA, Poullot E, et al.
La Revue de medecine interne 2022; (43(9)):537-544 doi:10.1016/j.revmed.2022.04.036.
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Establishment of Normative Data for Autonomic Function Tests in Indian Population.
Singh S, Jaison V, Khatter H, et al.
Annals of Indian Academy of Neurology 2022; (25(3)):457-463 doi:10.4103/aian.aian_579_21.
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Updates on the Diagnosis and Treatment of Peripheral Autonomic Neuropathies.
Lamotte G, Sandroni P
Current neurology and neuroscience reports 2022; (22(12)):823-837 doi:10.1007/s11910-022-01240-4.
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Quantitative gastrointestinal function and corresponding symptom profiles in autonomic neuropathy.
Langford JS, Tokita E, Martindale C, et al.
Frontiers in neurology 2022; (13()):1027348 doi:10.3389/fneur.2022.1027348.
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Immunoglobulin Light Chain Amyloidosis: Diagnosis and Risk Assessment.
Zanwar S, Gertz MA, Muchtar E
Journal of the National Comprehensive Cancer Network : JNCCN 2023; (21(1)):83-90 doi:10.6004/jnccn.2022.7077.
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Autonomic failure: Clinicopathologic, physiologic, and genetic aspects.
Younger DS
Handbook of clinical neurology 2023; (195()):55-102 doi:10.1016/B978-0-323-98818-6.00020-0.
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Non-Pharmacological Treatment of Autonomic Dysfunction in Parkinson's Disease and Other Synucleinopathies.
Palma JA, Thijs RD
Journal of Parkinson's disease 2024; (14(s1)):S81-S92 doi:10.3233/JPD-230173.
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Midodrine-Induced Nightmares in the Treatment of Orthostatic Hypotension: A Case Report.
Tran L, Brodeur M
The Senior care pharmacist 2023; (38(12)):501-505 doi:10.4140/TCP.n.2023.501.
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Abnormal dopamine transporter imaging in pure autonomic failure: a potential biomarker of central nervous system involvement.
Alnasser Alsukhni R, Vichayanrat E, Koay S, et al.
European journal of neurology 2024; (31(3)):e16169 doi:10.1111/ene.16169.
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Immunoglobulin light chain amyloidosis: 2024 update on diagnosis, prognosis, and treatment.
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American journal of hematology 2024; (99(2)):309-324 doi:10.1002/ajh.27177.
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Unveiling autonomic failure in synucleinopathies: Significance in diagnosis and treatment.
Clement G, Cavillon G, Vuillier F, et al.
Revue neurologique 2024; (180(1-2)):79-93 doi:10.1016/j.neurol.2023.12.004.
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Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study.
Millar Vernetti P, Norcliffe-Kaufmann L, Palma JA, et al.
Brain : a journal of neurology 2024; (147(7)):2440-2448 doi:10.1093/brain/awae033.
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Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies.
Gibbons CH, Levine T, Adler C, et al.
JAMA 2024; (331(15)):1298-1306 doi:10.1001/jama.2024.0792.
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Autonomic Dysfunction from Diagnosis to Treatment.
Peltier AC
Primary care 2024; (51(2)):359-373 doi:10.1016/j.pop.2024.02.006.
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Pelvic autonomic dysfunction is common in patients with pure autonomic failure.
Vichayanrat E, Hentzen C, Simeoni S, et al.
European journal of neurology 2024; (31(12)):e16486 doi:10.1111/ene.16486.
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Head-Up Tilt Sleeping to Treat Orthostatic Intolerance in a Patient with Advanced Parkinson's Disease: A Case Report.
van der Stam AH, Shmuely S, de Vries NM, et al.
Case reports in neurology 2024; (16(1)):256-261 doi:10.1159/000541424.
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Cutaneous phosphorylated-synuclein: an early diagnostic biomarker for pure autonomic failure.
Koay S, Provitera V, Caporaso G, et al.
Journal of neurology, neurosurgery, and psychiatry 2025; (96(5)):500-507 doi:10.1136/jnnp-2024-334615.
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The phenotype of "pure" autonomic failure.
Coon EA, Badihian N, McCarter SJ, et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2025; (35(3)):477-485 doi:10.1007/s10286-025-01121-z.
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Pure autonomic failure: a natural history study of the Queen Square cohort.
Chiaro G, Vichayanrat E, Koay S, et al.
Brain : a journal of neurology 2026; (149(2)):606-619 doi:10.1093/brain/awaf191.
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Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure.
Koay S, Vichayanrat E, Bremner F, et al.
Annals of clinical and translational neurology 2025; (12(11)):2170-2180 doi:10.1002/acn3.70140.
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Clinical insights into diabetic gastroparesis: gastric scintigraphy-based diagnosis and treatment outcomes.
Wifi MN, El-Sherbiny M, Mohamed RS, et al.
BMC gastroenterology 2025; (25(1)):640 doi:10.1186/s12876-025-03977-x.
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Autonomic Neuropathies.
Cook GA, Kissel JT, Dimachkie MM
Neurologic clinics 2025; (43(4)):851-872 doi:10.1016/j.ncl.2025.05.013.
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