Research & Literature

Lanreotide Reduces Liver Volume, But Might Not Improve Muscle Wasting or Weight Loss, in Patients With Symptomatic Polycystic Liver Disease.

Temmerman F, Ho TA, Vanslembrouck R, et al.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2015; (13(13)):2353-9.e1.

Somatostatin analogues improve health-related quality of life in polycystic liver disease: a pooled analysis of two randomised, placebo-controlled trials.

Neijenhuis MK, Gevers TJ, Nevens F, et al.

Alimentary pharmacology & therapeutics 2015; (42(5)):591-8 doi:10.1111/apt.13301.

Clinical Correlates of Mass Effect in Autosomal Dominant Polycystic Kidney Disease.

Kim H, Park HC, Ryu H, et al.

PloS one 2015; (10(12)):e0144526 doi:10.1371/journal.pone.0144526.

Combined liver-kidney transplantation for polycystic liver and kidney disease: analysis from the United Network for Organ Sharing dataset.

Coquillard C, Berger J, Daily M, et al.

Liver international : official journal of the International Association for the Study of the Liver 2016; (36(7)):1018-25 doi:10.1111/liv.13041.

Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease.

Porath B, Gainullin VG, Cornec-Le Gall E, et al.

American journal of human genetics 2016; (98(6)):1193-1207 doi:10.1016/j.ajhg.2016.05.004.

Prediction of hepatic cyst recurrence after minocycline hydrochloride aspiration sclerotherapy using cyst computed tomography values.

Iijima T, Suwabe T, Sumida K, et al.

Hepatology research : the official journal of the Japan Society of Hepatology 2017; (47(5)):419-424 doi:10.1111/hepr.12763.

Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes.

Rajoriya N, Tripathi D, Leithead JA, et al.

World journal of gastroenterology 2016; (22(45)):9966-9973 doi:10.3748/wjg.v22.i45.9966.

Isolated polycystic liver disease genes define effectors of polycystin-1 function.

Besse W, Dong K, Choi J, et al.

The Journal of clinical investigation 2017; (127(5)):1772-1785 doi:10.1172/JCI90129.

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.

Masyuk TV, Masyuk AI, Lorenzo Pisarello M, et al.

Hepatology (Baltimore, Md.) 2017; (66(4)):1197-1218 doi:10.1002/hep.29284.

The safety of available treatments options for neuroendocrine tumors.

Faggiano A, Lo Calzo F, Pizza G, et al.

Expert opinion on drug safety 2017; (16(10)):1149-1161 doi:10.1080/14740338.2017.1354984.

Polycystic liver disease: Hepatic venous outflow obstruction lesions of the noncystic parenchyma have major consequences.

Barbier L, Ronot M, Aussilhou B, et al.

Hepatology (Baltimore, Md.) 2018; (68(2)):652-662 doi:10.1002/hep.29582.

Impact of liver volume on polycystic liver disease-related symptoms and quality of life.

Neijenhuis MK, Kievit W, Verheesen SM, et al.

United European gastroenterology journal 2018; (6(1)):81-88 doi:10.1177/2050640617705577.

Comparison of the Recurrence Rates of Nonparasitic Hepatic Cysts Treated With Laparoscopy or With Open Fenestration: A Meta-Analysis.

Zhang JY, Liu Y, Liu HY, et al.

Surgical laparoscopy, endoscopy & percutaneous techniques 2018; (28(2)):67-72 doi:10.1097/SLE.0000000000000516.

Treatment of polycystic liver disease. Update on the management.

Aussilhou B, Dokmak S, Dondero F, et al.

Journal of visceral surgery 2018; (155(6)):471-481 doi:10.1016/j.jviscsurg.2018.07.004.

Severity in polycystic liver disease is associated with aetiology and female gender: Results of the International PLD Registry.

van Aerts RMM, Kievit W, de Jong ME, et al.

Liver international : official journal of the International Association for the Study of the Liver 2019; (39(3)):575-582 doi:10.1111/liv.13965.

Clinical response after laparoscopic fenestration of symptomatic hepatic cysts: a systematic review and meta-analysis.

Bernts LHP, Echternach SG, Kievit W, et al.

Surgical endoscopy 2019; (33(3)):691-704 doi:10.1007/s00464-018-6490-8.

TIMING AND TREATMENT OPTIONS IN ADULT POLYCYSTIC LIVER DISEASE: A RARE FAMILIAR CASE AS EXAMPLE.

Salceda JA, Bracco R, Fernandez D

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery 2018; (31(4)):e1411 doi:10.1590/0102-672020180001e1411.

Symptom relief and not cyst reduction determines treatment success in aspiration sclerotherapy of hepatic cysts.

Neijenhuis MK, Wijnands TFM, Kievit W, et al.

European radiology 2019; (29(6)):3062-3068 doi:10.1007/s00330-018-5851-y.

Long-term results of liver transplantation for polycystic liver disease: Single-center experience in China.

Ding F, Tang H, Zhao H, et al.

Experimental and therapeutic medicine 2019; (17(5)):4183-4189 doi:10.3892/etm.2019.7449.

Lanreotide Reduces Liver Growth In Patients With Autosomal Dominant Polycystic Liver and Kidney Disease.

van Aerts RMM, Kievit W, D'Agnolo HMA, et al.

Gastroenterology 2019; (157(2)):481-491.e7 doi:10.1053/j.gastro.2019.04.018.

Automatic Measurement of Kidney and Liver Volumes from MR Images of Patients Affected by Autosomal Dominant Polycystic Kidney Disease.

van Gastel MDA, Edwards ME, Torres VE, et al.

Journal of the American Society of Nephrology : JASN 2019; (30(8)):1514-1522 doi:10.1681/ASN.2018090902.

Polycystic liver disease: Classification, diagnosis, treatment process, and clinical management.

Zhang ZY, Wang ZM, Huang Y

World journal of hepatology 2020; (12(3)):72-83 doi:10.4254/wjh.v12.i3.72.

Symptom relief and quality of life after combined partial hepatectomy and cyst fenestration in highly symptomatic polycystic liver disease.

Bernts LHP, Neijenhuis MK, Edwards ME, et al.

Surgery 2020; (168(1)):25-32 doi:10.1016/j.surg.2020.02.014.

Highly Variable Expression of ESR1 Splice Variants in Human Liver: Implication in the Liver Gene Expression Regulation and Inter-Person Variability in Drug Metabolism and Liver Related Diseases.

Sun JW, Collins JM, Ling D, Wang D

Journal of molecular and genetic medicine : an international journal of biomedical research 2019; (13(3)).

Management of Autosomal Dominant Polycystic Kidney Disease (ADPKD) During Pregnancy: Risks and Challenges.

McBride L, Wilkinson C, Jesudason S

International journal of women's health 2020; (12()):409-422 doi:10.2147/IJWH.S204997.

Prevalence of Inferior Vena Cava Compression in ADPKD.

Yin X, Blumenfeld JD, Riyahi S, et al.

Kidney international reports 2021; (6(1)):168-178 doi:10.1016/j.ekir.2020.10.027.

Partial major hepatectomy with cyst fenestration for polycystic liver disease: Indications, short and long-term outcomes.

Boillot O, Cayot B, Guillaud O, et al.

Clinics and research in hepatology and gastroenterology 2021; (45(3)):101670 doi:10.1016/j.clinre.2021.101670.

Liver transplantation in adult polycystic liver disease: the Ontario experience.

Alsager M, Neong SF, Gandhi R, et al.

BMC gastroenterology 2021; (21(1)):115 doi:10.1186/s12876-021-01703-x.

Predicting liver cyst severity by mutations in patients with autosomal-dominant polycystic kidney disease.

Kataoka H, Watanabe S, Sato M, et al.

Hepatology international 2021; (15(3)):791-803 doi:10.1007/s12072-021-10176-9.

Estrogens in polycystic liver disease: A target for future therapies?

Aapkes SE, Bernts LHP, Barten TRM, et al.

Liver international : official journal of the International Association for the Study of the Liver 2021; (41(9)):2009-2019 doi:10.1111/liv.14986.

Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication.

Shehi E, Fortuzi K, Ghazanfar H, et al.

Case reports in gastroenterology 2021; (15(3)):904-909 doi:10.1159/000519276.

Abdominal wall hernia is a frequent complication of polycystic liver disease and associated with hepatomegaly.

Barten TRM, Bökkerink RMP, Venderink W, et al.

Liver international : official journal of the International Association for the Study of the Liver 2022; (42(4)):871-878 doi:10.1111/liv.15177.

Polycystic Kidney/Liver Disease.

Roediger R, Dieterich D, Chanumolu P, Deshpande P

Clinics in liver disease 2022; (26(2)):229-243 doi:10.1016/j.cld.2022.01.009.

Genetics, pathobiology and therapeutic opportunities of polycystic liver disease.

Olaizola P, Rodrigues PM, Caballero-Camino FJ, et al.

Nature reviews. Gastroenterology & hepatology 2022; (19(9)):585-604 doi:10.1038/s41575-022-00617-7.

Molecular Mechanisms of Isolated Polycystic Liver Diseases.

Yu Z, Shen X, Hu C, et al.

Frontiers in genetics 2022; (13()):846877 doi:10.3389/fgene.2022.846877.

Evidence of nonsurgical treatment for polycystic liver disease.

Yoo JJ, Jo HI, Jung EA, et al.

Therapeutic advances in chronic disease 2022; (13()):20406223221112563 doi:10.1177/20406223221112563.

Benign liver lesions 2022: Guideline for clinical practice of Associazione Italiana Studio del Fegato (AISF), Società Italiana di Radiologia Medica e Interventistica (SIRM), Società Italiana di Chirurgia (SIC), Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB), Associazione Italiana di Chirurgia Epatobilio-Pancreatica (AICEP), Società Italiana Trapianti d'Organo (SITO), Società Italiana di Anatomia Patologica e Citologia Diagnostica (SIAPEC-IAP) - Part I - Cystic lesions.

Pompili M, Ardito F, Brunetti E, et al.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2022; (54(11)):1469-1478 doi:10.1016/j.dld.2022.08.030.

Polycystic Liver Disease: Pathophysiology, Diagnosis and Treatment.

Norcia LF, Watanabe EM, Hamamoto Filho PT, et al.

Hepatic medicine : evidence and research 2022; (14()):135-161 doi:10.2147/HMER.S377530.

A SEC61A1 variant is associated with autosomal dominant polycystic liver disease.

Schlevogt B, Schlieper V, Krader J, et al.

Liver international : official journal of the International Association for the Study of the Liver 2023; (43(2)):401-412 doi:10.1111/liv.15493.

Validation of a semi-automatic method to measure total liver volumes in polycystic liver disease on computed tomography - high speed and accuracy.

Aapkes SE, Barten TRM, Coudyzer W, et al.

European radiology 2023; (33(5)):3222-3231 doi:10.1007/s00330-022-09346-6.

Questionnaire PLD-complaint-specific assessment identifies need for therapy in polycystic liver disease: A multi-centric prospective study.

Billiet A, Temmerman F, Coudyzer W, et al.

United European gastroenterology journal 2023; (11(7)):633-641 doi:10.1002/ueg2.12387.

A BBS4 mutation causes autosomal dominant polycystic liver disease.

Cui Y, Xu W, Liu J, et al.

Genes & diseases 2024; (11(1)):72-75 doi:10.1016/j.gendis.2023.02.042.

Novel α-1,3-Glucosyltransferase Variants and Their Broad Clinical Polycystic Liver Disease Spectrum.

Boerrigter MM, Te Morsche RHM, Venselaar H, et al.

Genes 2023; (14(8)) doi:10.3390/genes14081652.

A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease.

Waddell SH, Yao Y, Olaizola P, et al.

Science translational medicine 2023; (15(713)):eabq5930 doi:10.1126/scitranslmed.abq5930.

Higher need for polycystic liver disease therapy in female patients: Sex-specific association between liver volume and need for therapy.

Barten TRM, Atsma F, van der Meer AJ, et al.

Hepatology (Baltimore, Md.) 2024; (79(3)):551-559 doi:10.1097/HEP.0000000000000602.

Operative Outcomes for Polycystic Liver Disease: Results of a Large Contemporary Series.

Smith SR, Matar AJ, Polireddy K, et al.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023; (27(11)):2444-2450 doi:10.1007/s11605-023-05843-1.

Extrarenal Manifestations: Polycystic Liver Disease and Its Complications.

Bugazia S, Hogan MC

Advances in kidney disease and health 2023; (30(5)):440-453 doi:10.1053/j.akdh.2023.10.004.

A Case Report of the Coexistence of Gastric Cancer With Polycystic Kidney and Liver Disease: Unveiling the Complexity.

Girme A, Gupta V

Cureus 2024; (16(2)):e53574 doi:10.7759/cureus.53574.

Polycystic intrahepatic infection caused by Enterococcus casseliflavus: a case report and literature review.

Xu S, Huang B, Cao Y, et al.

BMC nephrology 2024; (25(1)):88 doi:10.1186/s12882-024-03531-z.

Navigating PRKCSH's impact on cancer: from N-linked glycosylation to death pathway and anti-tumor immunity.

Cressey R, Han MTT, Khaodee W, et al.

Frontiers in oncology 2024; (14()):1378694 doi:10.3389/fonc.2024.1378694.

Liver manifestations in autosomal dominant polycystic kidney disease (ADPKD) and their impact on quality of life.

Arjune S, Todorova P, Bartram MP, et al.

Clinical kidney journal 2025; (18(1)):sfae363 doi:10.1093/ckj/sfae363.

Effects of Pregnancy on Liver and Kidney Cyst Growth Rates in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study.

Bazojoo V, Davoudi V, Blumenfeld JD, et al.

Journal of clinical medicine 2025; (14(11)) doi:10.3390/jcm14113688.

A red flag and a red herring-dual pathology of isolated polycystic liver disease with underlying epithelioid angiosarcoma resulting in recurrent hepatic cyst haemorrhage.

Wu MY, Chui JN, Gofton C, et al.

Journal of surgical case reports 2025; (2025(7)):rjaf400 doi:10.1093/jscr/rjaf400.

Key Aspects in the Nutritional Management of Polycystic Liver Disease Patients.

Khan S, Di Cola S, Lai S, et al.

Nutrients 2025; (17(14)) doi:10.3390/nu17142380.

CT-guided percutaneous aspiration and bleomycin sclerotherapy for symptomatic hepatic cysts: technique and three-year outcomes.

Li L, Lao YH, Han QL

Frontiers in medicine 2025; (12()):1687375 doi:10.3389/fmed.2025.1687375.

Medical Management of Polycystic Liver Disease: A Position Statement From the European Reference Network on Hepatological Diseases.

Heinrich S, de Matos AMC, Colmenero J, et al.

Liver international : official journal of the International Association for the Study of the Liver 2026; (46(1)):e70451 doi:10.1111/liv.70451.

Case Report: Budd-Chiari-like syndrome in a cat with polycystic kidney and liver disease.

Lee ES, Jang YS, Han JI, et al.

Frontiers in veterinary science 2025; (12()):1701832 doi:10.3389/fvets.2025.1701832.

Polycystic liver disease: Evidence-based management and critical gaps in surgical decision-making.

Florou E, Prachalias A, Srinivasan P

American journal of surgery 2026; (254()):116856 doi:10.1016/j.amjsurg.2026.116856.

Giant polycystic liver disease with thoracic involvement: An anaesthesia and surgical challenge in liver transplantation.

Arias Salazar M, Mileo FG, Chullo G, et al.

Revista espanola de anestesiologia y reanimacion 2026; (73(5)):502025 doi:10.1016/j.redare.2026.502025.