Research & Literature

Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial.

Shinnar S, Cnaan A, Hu F, et al.

Neurology 2015; (85(13)):1108-14 doi:10.1212/WNL.0000000000001971.

Focal EEG features and therapeutic response in patients with juvenile absence and myoclonic epilepsy.

Japaridze G, Kasradze S, Lomidze G, et al.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2016; (127(2)):1182-1187 doi:10.1016/j.clinph.2015.11.048.

Cortical and subcortical brain alterations in Juvenile Absence Epilepsy.

Tondelli M, Vaudano AE, Ruggieri A, Meletti S

NeuroImage. Clinical 2016; (12()):306-11 doi:10.1016/j.nicl.2016.07.007.

Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Brigo F, Igwe SC

The Cochrane database of systematic reviews 2017; (2()):CD003032 doi:10.1002/14651858.CD003032.pub3.

Long-term outcome in adolescent-onset generalized genetic epilepsies.

Vorderwülbecke BJ, Kowski AB, Kirschbaum A, et al.

Epilepsia 2017; (58(7)):1244-1250 doi:10.1111/epi.13761.

Pretreatment behavior and subsequent medication effects in childhood absence epilepsy.

Shinnar RC, Shinnar S, Cnaan A, et al.

Neurology 2017; (89(16)):1698-1706 doi:10.1212/WNL.0000000000004514.

Absence epilepsy beyond adolescence: an outcome analysis after 45 years of follow-up.

Holtkamp M, Janz D, Kirschbaum A, et al.

Journal of neurology, neurosurgery, and psychiatry 2018; (89(6)):603-610 doi:10.1136/jnnp-2017-317052.

Relapse after treatment withdrawal of antiepileptic drugs for Juvenile Absence Epilepsy and Juvenile Myoclonic Epilepsy.

Healy L, Moran M, Singhal S, et al.

Seizure 2018; (59()):116-122 doi:10.1016/j.seizure.2018.05.015.

Generalized polyspike train: An EEG biomarker of drug-resistant idiopathic generalized epilepsy.

Sun Y, Seneviratne U, Perucca P, et al.

Neurology 2018; (91(19)):e1822-e1830 doi:10.1212/WNL.0000000000006472.

Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Brigo F, Igwe SC, Lattanzi S

The Cochrane database of systematic reviews 2019; (2()):CD003032 doi:10.1002/14651858.CD003032.pub4.

Alternatives to valproate in girls and women of childbearing potential with Idiopathic Generalized Epilepsies: state of the art and guidance for the clinician proposed by the Epilepsy and Gender Commission of the Italian League Against Epilepsy (LICE).

Mostacci B, Ranzato F, Giuliano L, et al.

Seizure 2021; (85()):26-38 doi:10.1016/j.seizure.2020.12.005.

Levetiracetam as first-line monotherapy for Idiopathic Generalized Epilepsy in women.

Ballvé A, Salas-Puig J, Quintana M, et al.

Acta neurologica Scandinavica 2021; (143(4)):407-412 doi:10.1111/ane.13389.

Unmasking the entity of 'drug-resistant' perioral myoclonia with absences: the twitches, darts and domes!

Rudrabhatla PK, Er S, Radhakrishnan A, Menon RN

Epileptic disorders : international epilepsy journal with videotape 2021; (23(2)):313-324 doi:10.1684/epd.2021.1265.

Involvement of ADGRV1 Gene in Familial Forms of Genetic Generalized Epilepsy.

Dahawi M, Elmagzoub MS, A Ahmed E, et al.

Frontiers in neurology 2021; (12()):738272 doi:10.3389/fneur.2021.738272.

Different circuitry dysfunction in drug-naive patients with juvenile myoclonic epilepsy and juvenile absence epilepsy.

Canafoglia L, Viganò I, Ferlazzo E, et al.

Epilepsy & behavior : E&B 2021; (125()):108443 doi:10.1016/j.yebeh.2021.108443.

Case Report: Behavioral Disorder Following Hemispherotomy: A Valproate Effect?

Makridis KL, Triller S, Atalay DA, et al.

Frontiers in neurology 2021; (12()):764376 doi:10.3389/fneur.2021.764376.

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions.

Hirsch E, French J, Scheffer IE, et al.

Epilepsia 2022; (63(6)):1475-1499 doi:10.1111/epi.17236.

School performance and psychiatric comorbidity in juvenile absence epilepsy and juvenile myoclonic epilepsy: a Danish population-based cohort study.

Boesen MS, Børresen ML, Christensen SK, et al.

Journal of neurology 2022; (269(9)):4997-5007 doi:10.1007/s00415-022-11147-2.

Clinical and Electrophysiological Features Predicting Response to Antiseizure Medications in Juvenile Absence Epilepsy.

Karaoğlu P, Tekin HG

Neuropediatrics 2023; (54(1)):2-5 doi:10.1055/s-0042-1757709.

A cross-sectional investigation of cognition and epileptiform discharges in juvenile absence epilepsy.

Dharan AL, Bowden SC, Peterson A, et al.

Epilepsia 2023; (64(3)):742-753 doi:10.1111/epi.17505.

Case report: Progressive skin rash and lymphadenopathy associated with lamotrigine-valproic acid combination in a bipolar adolescent.

Duan Y, Qiu F, Zhou J, et al.

Frontiers in pharmacology 2023; (14()):1106423 doi:10.3389/fphar.2023.1106423.

Changes in awake and sleep electroencephalography characteristics after 1-year treatment for childhood and juvenile absence epilepsy.

Edizer S, Baysal BT, Ünalp A, Yılmaz Ü

Seizure 2023; (110()):244-252 doi:10.1016/j.seizure.2023.06.023.

Cognitive phenotype of juvenile absence epilepsy: An investigation of patients and unaffected siblings.

Caciagli L, Ratcliffe C, Xiao F, et al.

Epilepsia 2023; (64(10)):2792-2805 doi:10.1111/epi.17719.

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture.

Nature genetics 2023; (55(9)):1471-1482 doi:10.1038/s41588-023-01485-w.

Care of pharmaco-resistant absence seizures in childhood.

Le Roux M, Benallegue N, Gueden S, et al.

Revue neurologique 2024; (180(4)):251-255 doi:10.1016/j.neurol.2024.01.002.

Safety update: valproate safety and educational materials.

Drug and therapeutics bulletin 2024; (62(4)):53 doi:10.1136/dtb.2024.000013.

Drug-resistant generalized epilepsies: Revisiting the frontiers of idiopathic generalized epilepsies.

Gauer L, Baer S, Valenti-Hirsch MP, et al.

Revue neurologique 2024; (180(4)):290-297 doi:10.1016/j.neurol.2024.03.001.

Generalized spike-waves in idiopathic generalized epilepsies: Does their frequency matter?

Asadi-Pooya AA, Farazdaghi M

Brain and behavior 2024; (14(10)):e70023 doi:10.1002/brb3.70023.

Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy.

Gavnholt L, Gesche J, Cerulli Irelli E, et al.

Epilepsia 2025; (66(3)):700-711 doi:10.1111/epi.18225.

A Narrative Review on the Effect of Valproic Acid on the Placenta.

Brown LTL, Pereira D, Winn LM

Birth defects research 2025; (117(4)):e2471 doi:10.1002/bdr2.2471.

Genetic Animal Models of Idiopathic Generalized Epilepsies: What Can We Learn from Them?

Lakaye B, Nguyen L

Biomedicines 2025; (13(6)) doi:10.3390/biomedicines13061301.

Voxel-based meta-analysis of gray matter abnormalities in idiopathic generalized epilepsy.

Huang X, Mao L, Lin Q, et al.

Cerebral cortex (New York, N.Y. : 1991) 2025; (35(8)) doi:10.1093/cercor/bhaf201.

Long-term seizure outcomes and the likelihood of antiseizure medication withdrawal in patients with juvenile absence epilepsy: A 10-year follow-up study.

Wang X, Zhang X, Wei J, et al.

Seizure 2025; (132()):117-124 doi:10.1016/j.seizure.2025.09.005.

Syndrome-specific and familial imaging traits in juvenile absence epilepsy.

Xiao F, Caciagli L, Delazer L, et al.

Epilepsia 2026; (67(4)):1887-1900 doi:10.1002/epi.70094.